AU3421493A - Use of spiperone or spiperone derivatives as immunosuppressant agents - Google Patents

Use of spiperone or spiperone derivatives as immunosuppressant agents

Info

Publication number
AU3421493A
AU3421493A AU34214/93A AU3421493A AU3421493A AU 3421493 A AU3421493 A AU 3421493A AU 34214/93 A AU34214/93 A AU 34214/93A AU 3421493 A AU3421493 A AU 3421493A AU 3421493 A AU3421493 A AU 3421493A
Authority
AU
Australia
Prior art keywords
spiperone
derivatives
immunosuppressant agents
immunosuppressant
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU34214/93A
Inventor
Kenneth A. Arndt
Stephen J. Galli
Peter C. Meltzer
Raj K Razdan
Howard P Sard
Richard J Sharpe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beth Israel Deaconess Medical Center Inc
Original Assignee
Beth Israel Hospital Association
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/815,283 external-priority patent/US5290783A/en
Priority claimed from US07/831,429 external-priority patent/US5244902A/en
Priority claimed from US07/893,536 external-priority patent/US5703088A/en
Priority claimed from US07/893,534 external-priority patent/US5574041A/en
Application filed by Beth Israel Hospital Association filed Critical Beth Israel Hospital Association
Publication of AU3421493A publication Critical patent/AU3421493A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU34214/93A 1991-12-27 1992-12-23 Use of spiperone or spiperone derivatives as immunosuppressant agents Abandoned AU3421493A (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US831429 1986-02-20
US815283 1991-12-27
US07/815,283 US5290783A (en) 1990-03-16 1991-12-27 Use of spiperone derivatives as immunosuppressant agents
US07/831,429 US5244902A (en) 1989-08-21 1992-02-05 Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US07/893,536 US5703088A (en) 1989-08-21 1992-06-04 Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US893536 1992-06-04
US893534 1992-06-04
US07/893,534 US5574041A (en) 1990-03-16 1992-06-04 Use of spiperone derivatives as immunosuppressant agents

Publications (1)

Publication Number Publication Date
AU3421493A true AU3421493A (en) 1993-07-28

Family

ID=27505847

Family Applications (1)

Application Number Title Priority Date Filing Date
AU34214/93A Abandoned AU3421493A (en) 1991-12-27 1992-12-23 Use of spiperone or spiperone derivatives as immunosuppressant agents

Country Status (5)

Country Link
EP (1) EP0661972A1 (en)
JP (1) JPH08500326A (en)
AU (1) AU3421493A (en)
CA (1) CA2126678A1 (en)
WO (1) WO1993012789A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703088A (en) * 1989-08-21 1997-12-30 Beth Israel Deaconess Medical Center, Inc. Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5693645A (en) * 1992-12-23 1997-12-02 Beth Israel Deaconess Medical Center, Inc. Use of spiperone or spiperone derivatives as immunosuppressant agents
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
WO1997023221A1 (en) * 1995-12-21 1997-07-03 Eli Lilly And Company Method for treating dermatitis
WO1999059997A1 (en) * 1998-05-18 1999-11-25 Novo Nordisk A/S Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
US6277991B1 (en) 1998-05-18 2001-08-21 Novo Nordisk A/S 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
WO2004019921A2 (en) * 2002-08-29 2004-03-11 University Of Southampton Use of apoptosis inducing agents in the preparation of a medicament for the treatment of liver diseases
AU2003268512A1 (en) 2002-09-09 2004-03-29 Janssen Pharmaceutica N.V. Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
EA200970517A1 (en) 2006-11-28 2009-12-30 Янссен Фармацевтика Н.В. SALTS OF 3- (3-AMINO-2- (R) -HYDROXYPROPYL) -1- (4-FTORPHENYL) -8- (8-METHYNNAFTALIN-1-ILMETYL) -1,3,8-TRIAZASPIRO [4,5] DECAN -4-SHE
WO2008124209A1 (en) 2007-04-09 2008-10-16 Janssen Pharmaceutica, N.V. 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
EP3621618A4 (en) * 2017-05-12 2021-01-27 Millennium Pharmaceuticals, Inc. Treatment of gastroparesis with triazaspiro(4.5)decanone

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155669A (en) * 1962-06-22 1964-11-03 Res Lab Dr C Janssen N V 2, 4, 8-triaza-spiro (4, 5) dec-2-enes
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
CA2065375A1 (en) * 1989-08-21 1991-02-22 Richard J. Sharpe Method and composition for the treatment of cutaneous, ocular, and mucosal hypersensitivity, inflammation, and hyperproliferative conditions using topical preparations of serotonin antagonists
CA2077907C (en) * 1990-03-16 1998-06-09 Richard J. Sharpe Use of spiperone as an immunosuppressant and anti-inflammatory agent

Also Published As

Publication number Publication date
WO1993012789A1 (en) 1993-07-08
JPH08500326A (en) 1996-01-16
CA2126678A1 (en) 1993-07-08
EP0661972A4 (en) 1994-10-27
EP0661972A1 (en) 1995-07-12

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