BRPI0315958B8 - composto, composição farmacêutica, processo para a preparação de um composto, novos intermediários e uso do composto - Google Patents

composto, composição farmacêutica, processo para a preparação de um composto, novos intermediários e uso do composto

Info

Publication number
BRPI0315958B8
BRPI0315958B8 BRPI0315958A BR0315958A BRPI0315958B8 BR PI0315958 B8 BRPI0315958 B8 BR PI0315958B8 BR PI0315958 A BRPI0315958 A BR PI0315958A BR 0315958 A BR0315958 A BR 0315958A BR PI0315958 B8 BRPI0315958 B8 BR PI0315958B8
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutically acceptable
compounds
preparing
general formula
Prior art date
Application number
BRPI0315958A
Other languages
English (en)
Other versions
BR0315958A (pt
BRPI0315958B1 (pt
Inventor
Sastri Kambhampati Rama
Satya Nirogi Ramakrishna Venkata
Satya Veerabhadra Vadlamudi Rao Venkata
Jasti Venkateswarlu
Shreekrishna Shirsath Vikas
Original Assignee
Suven Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suven Life Sciences Ltd filed Critical Suven Life Sciences Ltd
Publication of BR0315958A publication Critical patent/BR0315958A/pt
Publication of BRPI0315958B1 publication Critical patent/BRPI0315958B1/pt
Publication of BRPI0315958B8 publication Critical patent/BRPI0315958B8/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/36Oxygen atoms in position 3, e.g. adrenochrome

Abstract

"composto, composição farmacêutica, processo para a preparação de um composto, novos intermediários e uso do composto". a presente invenção refere-se os compostos de 3aminoalcóxindolos substituídos da fórmula geral (i), seus estereoisômeros, seus rádio isótopos, suas formas geométricas, seus n-óxidos, seus polimorfos, seus sais farmaceuticamente aceitáveis, seus solvatos farmaceuticamente aceitáveis, seus metabólitos bio-ativos úteis e qualquer combinação dos acima mencionados. a invenção também revela os processos para a preparação de tais compostos da fórmula geral (i), os seus estereoisômeros, os seus rádio isótopos, as suas formas geométricas, os seus óxidos de n, os seus polimorfos, os seus sais farmaceuticamente aceitáveis, os seus solvatos farmaceuticamente aceitáveis, os seus metabólitos bio ativos úteis e também inclui qualquer combinação dos acima mencionados. também são descritos em adição os vários métodos para a ministração destes compostos da fórmula geral (i), por exemplo as formas de dosagem farmaceuticamente aceitáveis, as suas composições e os seus usos tanto em uma terapia ou em um diagnóstico.
BRPI0315958A 2002-11-28 2003-11-25 composto, composição farmacêutica, processo para a preparação de um composto, novos intermediários e uso do composto BRPI0315958B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN883MA2002 2002-11-28
IN883/MAS/2002 2002-11-28
PCT/IN2003/000370 WO2004048328A2 (en) 2002-11-28 2003-11-25 N-arylsulfonyl-3-aminoalkoxyindoles

Publications (3)

Publication Number Publication Date
BR0315958A BR0315958A (pt) 2005-09-13
BRPI0315958B1 BRPI0315958B1 (pt) 2018-06-26
BRPI0315958B8 true BRPI0315958B8 (pt) 2021-05-25

Family

ID=34362365

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0315958A BRPI0315958B8 (pt) 2002-11-28 2003-11-25 composto, composição farmacêutica, processo para a preparação de um composto, novos intermediários e uso do composto

Country Status (18)

Country Link
US (2) US7507835B2 (pt)
EP (1) EP1567492B1 (pt)
JP (2) JP4782425B2 (pt)
KR (1) KR100776118B1 (pt)
CN (2) CN102249981A (pt)
AU (1) AU2003285759B2 (pt)
BR (1) BRPI0315958B8 (pt)
CA (1) CA2507505C (pt)
CY (1) CY1114241T1 (pt)
EA (1) EA009193B1 (pt)
ES (1) ES2425143T3 (pt)
MX (1) MXPA05005700A (pt)
NO (1) NO331805B1 (pt)
NZ (1) NZ540842A (pt)
PT (1) PT1567492E (pt)
SI (1) SI1567492T1 (pt)
WO (1) WO2004048328A2 (pt)
ZA (1) ZA200504044B (pt)

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PT1567492E (pt) * 2002-11-28 2013-07-22 Suven Life Sciences Ltd N-arilsulfonil-3-aminoalcoxi-indóis
BRPI0316895C1 (pt) * 2002-12-18 2021-05-25 Suven Life Sciences Ltd composto, processo para a preparação do composto, composição farmacêutica e uso do composto
BRPI0417895B8 (pt) 2004-01-02 2021-05-25 Suven Life Sciences Ltd composto, processo para a preparação de um composto e uso do composto
NZ566495A (en) 2005-08-12 2010-06-25 Suven Life Sciences Ltd Aminoaryl sulphonamide derivatives as functional 5-HT6 ligands
WO2007020654A1 (en) 2005-08-16 2007-02-22 Suven Life Sciences An improved process for the preparation of losartan
KR100724095B1 (ko) * 2005-10-21 2007-06-04 한국표준과학연구원 정밀 전류, 전압 및 전력 측정장치
CA2670717C (en) 2007-01-08 2012-01-10 Suven Life Sciences Limited 5-(heterocyclyl)alkyl-n-(arylsulfonyl)indole compounds and their use as 5-ht6 ligands
EP1947085A1 (en) * 2007-01-19 2008-07-23 Laboratorios del Dr. Esteve S.A. Substituted indole sulfonamide compounds, their preparation and use as medicaments
NZ581580A (en) * 2007-05-03 2011-03-31 Suven Life Sciences Ltd Aminoalkoxy aryl sulfonamide compounds and their use as 5-ht6 ligands
NZ585374A (en) * 2007-10-26 2011-09-30 Suven Life Sciences Ltd Amino arylsulfonamide compounds for treating disorders related to 5-HT6 receptor functions
AR072297A1 (es) * 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
EP2149573A1 (en) * 2008-08-01 2010-02-03 Laboratorios Del. Dr. Esteve, S.A. Substituted indole sulfonamide compounds their preparation and use as medicaments
JP5536781B2 (ja) 2008-09-17 2014-07-02 スヴェン・ライフ・サイエンシズ・リミテッド アリールスルホンアミドアミン化合物および5−ht6リガンドとしてのそれらの使用
WO2010032257A1 (en) 2008-09-17 2010-03-25 Suven Life Sciences Limited Aryl indolyl sulfonamide compounds and their use as 5-ht6 ligands
EP2521714B1 (en) 2010-01-05 2015-08-12 Suven Life Sciences Limited Aromatic sulfone compounds useful in the treatment of central nervous disorders
EP2932922B1 (en) * 2012-12-13 2018-09-05 Olympus Corporation Treatment device
DE102013013602A1 (de) * 2013-08-19 2015-02-19 Trützschler GmbH + Co KG Textilmaschinenfabrik Vorrichtung an einer Karde oder Krempel für Baumwolle, Chemiefasern u. dgl. mit einer drehbaren Abstreifwalze
EP3083588B1 (en) 2013-12-20 2020-12-09 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic compounds and their application in pharmaceuticals

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Also Published As

Publication number Publication date
JP4782425B2 (ja) 2011-09-28
NO20052825D0 (no) 2005-06-10
US20090131507A1 (en) 2009-05-21
US20060173193A1 (en) 2006-08-03
EP1567492B1 (en) 2013-05-22
BR0315958A (pt) 2005-09-13
KR20050083963A (ko) 2005-08-26
JP2011116769A (ja) 2011-06-16
EA009193B1 (ru) 2007-12-28
ZA200504044B (en) 2006-07-26
KR100776118B1 (ko) 2007-11-15
JP2006511506A (ja) 2006-04-06
CA2507505A1 (en) 2004-06-10
CN1720227A (zh) 2006-01-11
AU2003285759A1 (en) 2004-06-18
AU2003285759B2 (en) 2010-01-28
PT1567492E (pt) 2013-07-22
CY1114241T1 (el) 2016-08-31
CN102249981A (zh) 2011-11-23
EA200500882A1 (ru) 2005-12-29
SI1567492T1 (sl) 2013-07-31
NO20052825L (no) 2005-08-25
EP1567492A2 (en) 2005-08-31
WO2004048328A2 (en) 2004-06-10
US7718690B2 (en) 2010-05-18
NZ540842A (en) 2008-05-30
MXPA05005700A (es) 2005-08-16
NO331805B1 (no) 2012-04-10
BRPI0315958B1 (pt) 2018-06-26
CA2507505C (en) 2011-10-04
WO2004048328A3 (en) 2004-10-28
US7507835B2 (en) 2009-03-24
ES2425143T3 (es) 2013-10-11

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