SE521100C2 - Förfarande för framställning av en bensimidazolförening - Google Patents

Förfarande för framställning av en bensimidazolförening

Info

Publication number
SE521100C2
SE521100C2 SE9504503A SE9504503A SE521100C2 SE 521100 C2 SE521100 C2 SE 521100C2 SE 9504503 A SE9504503 A SE 9504503A SE 9504503 A SE9504503 A SE 9504503A SE 521100 C2 SE521100 C2 SE 521100C2
Authority
SE
Sweden
Prior art keywords
methoxy
pyridinyl
dimethyl
methyl
process according
Prior art date
Application number
SE9504503A
Other languages
English (en)
Swedish (sv)
Other versions
SE9504503D0 (sv
SE9504503L (sv
Inventor
Anders Gustavsson
Aake Kaellstroem
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9504503A priority Critical patent/SE521100C2/sv
Publication of SE9504503D0 publication Critical patent/SE9504503D0/xx
Priority to UA98052782A priority patent/UA62921C2/uk
Priority to ZA9610067A priority patent/ZA9610067B/xx
Priority to ARP960105459A priority patent/AR004834A1/es
Priority to TNTNSN96148A priority patent/TNSN96148A1/fr
Priority to TW085114881A priority patent/TW460474B/zh
Priority to MA24415A priority patent/MA24026A1/fr
Priority to YU64296A priority patent/YU49420B/sh
Priority to DZ960182A priority patent/DZ2137A1/fr
Priority to CN96199057A priority patent/CN1113879C/zh
Priority to EE9800183A priority patent/EE03768B1/xx
Priority to AT96942702T priority patent/ATE205201T1/de
Priority to TR1998/01070T priority patent/TR199801070T2/xx
Priority to DE0868423T priority patent/DE868423T1/de
Priority to DE69615052T priority patent/DE69615052T2/de
Priority to PL96327334A priority patent/PL186132B1/pl
Priority to JP52269797A priority patent/JP3523267B2/ja
Priority to CA002238864A priority patent/CA2238864C/en
Priority to PCT/SE1996/001603 priority patent/WO1997022603A1/en
Priority to IL12485696A priority patent/IL124856A/en
Priority to SK768-98A priority patent/SK282347B6/sk
Priority to HU9900110A priority patent/HUP9900110A3/hu
Priority to ES96942702T priority patent/ES2125210T3/es
Priority to CZ19981685A priority patent/CZ288661B6/cs
Priority to KR10-1998-0704454A priority patent/KR100433436B1/ko
Priority to SI9630367T priority patent/SI0868423T1/xx
Priority to PT96942702T priority patent/PT868423E/pt
Priority to US08/776,222 priority patent/US5958955A/en
Priority to AU11550/97A priority patent/AU704422B2/en
Priority to DK96942702T priority patent/DK0868423T3/da
Priority to RU98110659/04A priority patent/RU2166502C2/ru
Priority to EP96942702A priority patent/EP0868423B1/en
Priority to NZ324482A priority patent/NZ324482A/xx
Priority to HR960581A priority patent/HRP960581B1/xx
Priority to CO96065025A priority patent/CO4750654A1/es
Priority to MYPI96005252A priority patent/MY115661A/en
Priority to EG112296A priority patent/EG23859A/xx
Publication of SE9504503L publication Critical patent/SE9504503L/xx
Priority to IS4750A priority patent/IS1891B/is
Priority to NO19982624A priority patent/NO314306B1/no
Priority to MX9804603A priority patent/MX9804603A/es
Priority to HK98111601A priority patent/HK1010539A1/xx
Publication of SE521100C2 publication Critical patent/SE521100C2/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SE9504503A 1995-12-15 1995-12-15 Förfarande för framställning av en bensimidazolförening SE521100C2 (sv)

Priority Applications (41)

Application Number Priority Date Filing Date Title
SE9504503A SE521100C2 (sv) 1995-12-15 1995-12-15 Förfarande för framställning av en bensimidazolförening
UA98052782A UA62921C2 (en) 1995-12-15 1996-05-12 A process for the synthesis of benzimidazole compound
ZA9610067A ZA9610067B (en) 1995-12-15 1996-11-29 Method for the synthesis of a benzimidazole compound
ARP960105459A AR004834A1 (es) 1995-12-15 1996-12-02 Procedimiento de la manufactura de (5-metoxi-2[[(4-metoxi-3,5-dimetil-2- piridinil)-metil]-sulfinil]-1h-bencimidazol (omeprazol)
TNTNSN96148A TNSN96148A1 (fr) 1995-12-15 1996-12-02 Methode pour la synthese d'un benzimidazole.
TW085114881A TW460474B (en) 1995-12-15 1996-12-03 Process for the manufacture of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulphinyl]-1H-benzimidazole
MA24415A MA24026A1 (fr) 1995-12-15 1996-12-04 Methode pour la synthese d'un benzimidazole
YU64296A YU49420B (sh) 1995-12-15 1996-12-04 Postupak sinteze benzimidazolskog jedinjenja
DZ960182A DZ2137A1 (fr) 1995-12-15 1996-12-04 Méthode pour la synthèse d'un benzimidazole.
NZ324482A NZ324482A (en) 1995-12-15 1996-12-05 Process for the synthesis of omeprazole
SK768-98A SK282347B6 (sk) 1995-12-15 1996-12-05 Spôsob prípravy benzimidazolovej zlúčeniny
PT96942702T PT868423E (pt) 1995-12-15 1996-12-05 Metodo para a sintese de um composto de benzimidazole
AT96942702T ATE205201T1 (de) 1995-12-15 1996-12-05 Verfahren zur herstellung einer benzimidazolverbindung
TR1998/01070T TR199801070T2 (xx) 1995-12-15 1996-12-05 Benzimidazol bile�i�inin sentezi i�in bir y�ntem
DE0868423T DE868423T1 (de) 1995-12-15 1996-12-05 Verfahren zur herstellung einer benzimidazolverbindung
DE69615052T DE69615052T2 (de) 1995-12-15 1996-12-05 Verfahren zur herstellung einer benzimidazolverbindung
PL96327334A PL186132B1 (pl) 1995-12-15 1996-12-05 Sposób wytwarzania 5-metoksy-2-[[(4-metoksy-3,5-dimetylo-2-pirydynylo)metylo]sulfinylo]-1H-benzimidazolu
JP52269797A JP3523267B2 (ja) 1995-12-15 1996-12-05 ベンゾイミダゾール化合物の合成法
CA002238864A CA2238864C (en) 1995-12-15 1996-12-05 Method for the synthesis of a benzimidazole compound
PCT/SE1996/001603 WO1997022603A1 (en) 1995-12-15 1996-12-05 Method for the synthesis of a benzimidazole compound
IL12485696A IL124856A (en) 1995-12-15 1996-12-05 Process for the production of omeprazole
CN96199057A CN1113879C (zh) 1995-12-15 1996-12-05 苯并咪唑化合物的合成方法
HU9900110A HUP9900110A3 (en) 1995-12-15 1996-12-05 Novel process for the synthesis of omeprazole
ES96942702T ES2125210T3 (es) 1995-12-15 1996-12-05 Metodo para la sintesis de un compuesto de bencimidazol.
CZ19981685A CZ288661B6 (cs) 1995-12-15 1996-12-05 Způsob výroby 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazolu
KR10-1998-0704454A KR100433436B1 (ko) 1995-12-15 1996-12-05 벤즈이미다졸화합물의합성방법
SI9630367T SI0868423T1 (en) 1995-12-15 1996-12-05 Method for the synthesis of a benzimidazole compound
EE9800183A EE03768B1 (et) 1995-12-15 1996-12-05 Meetod bensimidasoolühendi sünteesiks
US08/776,222 US5958955A (en) 1995-12-15 1996-12-05 Method for the synthesis of a benzimidazole compound
AU11550/97A AU704422B2 (en) 1995-12-15 1996-12-05 Method for the synthesis of a benzimidazole compound
DK96942702T DK0868423T3 (da) 1995-12-15 1996-12-05 Fremgangsmåde til syntese af en benzimidazolforbindelse
RU98110659/04A RU2166502C2 (ru) 1995-12-15 1996-12-05 Способ производства 5-метокси-2-[[(4-метокси-3,5-диметил-2-пиридинил)-метил]сульфинил]-1н-бенз имидазола
EP96942702A EP0868423B1 (en) 1995-12-15 1996-12-05 Method for the synthesis of a benzimidazole compound
HR960581A HRP960581B1 (en) 1995-12-15 1996-12-09 Method for the synthesis of a benzimidazole compound
CO96065025A CO4750654A1 (es) 1995-12-15 1996-12-11 Proceso para la sintesis de un compuesto omeprazol
MYPI96005252A MY115661A (en) 1995-12-15 1996-12-13 Method for the synthesis of a benzimidazole compound
EG112296A EG23859A (en) 1995-12-15 1996-12-14 Method for the synthesis of a benzimidazole compound
IS4750A IS1891B (is) 1995-12-15 1998-05-22 Aðferð við að nýmynda bensimídasólefnasamband
NO19982624A NO314306B1 (no) 1995-12-15 1998-06-08 Fremgangsmåte for syntese av benzimidazolforbindelse
MX9804603A MX9804603A (es) 1995-12-15 1998-06-09 Metodo para la sintesis de un compuesto de benzimidazol.
HK98111601A HK1010539A1 (en) 1995-12-15 1998-10-29 Method for the synthesis of a benzimidazole compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9504503A SE521100C2 (sv) 1995-12-15 1995-12-15 Förfarande för framställning av en bensimidazolförening

Publications (3)

Publication Number Publication Date
SE9504503D0 SE9504503D0 (sv) 1995-12-15
SE9504503L SE9504503L (sv) 1997-06-16
SE521100C2 true SE521100C2 (sv) 2003-09-30

Family

ID=20400614

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9504503A SE521100C2 (sv) 1995-12-15 1995-12-15 Förfarande för framställning av en bensimidazolförening

Country Status (40)

Country Link
US (1) US5958955A (cs)
EP (1) EP0868423B1 (cs)
JP (1) JP3523267B2 (cs)
KR (1) KR100433436B1 (cs)
CN (1) CN1113879C (cs)
AR (1) AR004834A1 (cs)
AT (1) ATE205201T1 (cs)
AU (1) AU704422B2 (cs)
CA (1) CA2238864C (cs)
CO (1) CO4750654A1 (cs)
CZ (1) CZ288661B6 (cs)
DE (2) DE868423T1 (cs)
DK (1) DK0868423T3 (cs)
DZ (1) DZ2137A1 (cs)
EE (1) EE03768B1 (cs)
EG (1) EG23859A (cs)
ES (1) ES2125210T3 (cs)
HK (1) HK1010539A1 (cs)
HR (1) HRP960581B1 (cs)
HU (1) HUP9900110A3 (cs)
IL (1) IL124856A (cs)
IS (1) IS1891B (cs)
MA (1) MA24026A1 (cs)
MX (1) MX9804603A (cs)
MY (1) MY115661A (cs)
NO (1) NO314306B1 (cs)
NZ (1) NZ324482A (cs)
PL (1) PL186132B1 (cs)
PT (1) PT868423E (cs)
RU (1) RU2166502C2 (cs)
SE (1) SE521100C2 (cs)
SI (1) SI0868423T1 (cs)
SK (1) SK282347B6 (cs)
TN (1) TNSN96148A1 (cs)
TR (1) TR199801070T2 (cs)
TW (1) TW460474B (cs)
UA (1) UA62921C2 (cs)
WO (1) WO1997022603A1 (cs)
YU (1) YU49420B (cs)
ZA (1) ZA9610067B (cs)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE521100C2 (sv) * 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
SK283805B6 (sk) 1996-09-09 2004-02-03 Slovakofarma, A. S. Spôsob prípravy omeprazolu
US6303787B1 (en) * 1998-05-27 2001-10-16 Natco Pharma Limited Intermediates and an improved process for the preparation of Omeprazole employing the said intermediates
SI20019A (sl) * 1998-07-13 2000-02-29 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola
US6166213A (en) * 1998-08-11 2000-12-26 Merck & Co., Inc. Omeprazole process and compositions thereof
UA72748C2 (en) 1998-11-10 2005-04-15 Astrazeneca Ab A novel crystalline form of omeprazole
IL142703A (en) 1998-11-10 2006-04-10 Astrazeneca Ab Crystalline form of omeprazole
DE19951960C2 (de) 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
MXPA04007169A (es) * 2002-01-25 2004-10-29 Santarus Inc Suministro transmucosal de inhibidores de bomba de protones.
SE0203092D0 (en) 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
DE112005003147T5 (de) * 2004-12-16 2008-01-17 Cipla Ltd. Verfahren
CN100393712C (zh) * 2006-01-23 2008-06-11 中国科学院成都有机化学有限公司 苯并咪唑型质子泵抑止剂及其前体的改进制备和分离纯化方法
WO2007122686A1 (ja) * 2006-04-14 2007-11-01 Eisai R & D Management Co., Ltd. ベンズイミダゾール化合物
CA2678702A1 (en) * 2007-02-21 2008-08-28 Cipla Limited Process for the preparation of esomeprazole magnesium dihydrate
CN101492459B (zh) * 2008-01-25 2011-04-27 山东轩竹医药科技有限公司 含烷氧乙酰基二氢异噁唑并吡啶化合物
CN101497603B (zh) * 2008-01-30 2012-11-07 山东轩竹医药科技有限公司 含有被烷氧烷胺氧基取代的吡啶的苯并咪唑衍生物
CN103664885A (zh) * 2013-12-12 2014-03-26 武汉工程大学 苯并咪唑型质子泵抑制剂中间体的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US461997A (en) * 1891-10-27 Sand-pump or other pipes
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
US4619997A (en) * 1984-09-06 1986-10-28 The Upjohn Company Substituted 2-pyridylmethylthio and sulfinyl-benzimidazoles as gastric antisecretory agents
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
NZ244301A (en) * 1991-09-20 1994-08-26 Merck & Co Inc Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds
SE521100C2 (sv) * 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening

Also Published As

Publication number Publication date
HUP9900110A2 (hu) 2000-03-28
KR100433436B1 (ko) 2004-07-16
CZ168598A3 (cs) 1998-09-16
JP2000502101A (ja) 2000-02-22
IL124856A (en) 2002-12-01
EP0868423B1 (en) 2001-09-05
DE69615052T2 (de) 2002-06-27
IL124856A0 (en) 1999-01-26
US5958955A (en) 1999-09-28
HUP9900110A3 (en) 2002-10-28
HRP960581A2 (en) 1998-02-28
EG23859A (en) 2007-11-18
DZ2137A1 (fr) 2002-10-23
SI0868423T1 (en) 2002-04-30
CA2238864C (en) 2006-01-24
NO314306B1 (no) 2003-03-03
UA62921C2 (en) 2004-01-15
AR004834A1 (es) 1999-03-10
CA2238864A1 (en) 1997-06-26
ATE205201T1 (de) 2001-09-15
DK0868423T3 (da) 2001-12-03
MX9804603A (es) 1998-10-31
PL327334A1 (en) 1998-12-07
CO4750654A1 (es) 1999-03-31
MA24026A1 (fr) 1997-07-01
RU2166502C2 (ru) 2001-05-10
ES2125210T3 (es) 2002-02-01
CN1204332A (zh) 1999-01-06
SE9504503D0 (sv) 1995-12-15
MY115661A (en) 2003-08-30
YU64296A (sh) 1999-07-28
NO982624D0 (no) 1998-06-08
SK282347B6 (sk) 2002-01-07
PL186132B1 (pl) 2003-10-31
CN1113879C (zh) 2003-07-09
TNSN96148A1 (fr) 2005-03-15
WO1997022603A1 (en) 1997-06-26
AU1155097A (en) 1997-07-14
JP3523267B2 (ja) 2004-04-26
AU704422B2 (en) 1999-04-22
EP0868423A1 (en) 1998-10-07
TW460474B (en) 2001-10-21
NZ324482A (en) 2000-04-28
HK1010539A1 (en) 1999-06-25
DE69615052D1 (de) 2001-10-11
PT868423E (pt) 2002-02-28
IS1891B (is) 2003-09-19
KR20000064399A (ko) 2000-11-06
HRP960581B1 (en) 2001-12-31
TR199801070T2 (xx) 1998-08-21
EE9800183A (et) 1998-12-15
ES2125210T1 (es) 1999-03-01
DE868423T1 (de) 1999-06-02
NO982624L (no) 1998-06-08
EE03768B1 (et) 2002-06-17
YU49420B (sh) 2006-01-16
SK76898A3 (en) 1998-12-02
ZA9610067B (en) 1997-06-17
IS4750A (is) 1998-05-22
SE9504503L (sv) 1997-06-16
CZ288661B6 (cs) 2001-08-15

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