YU64296A - Postupak sinteze benzimidazolskog jedinjenja - Google Patents

Postupak sinteze benzimidazolskog jedinjenja

Info

Publication number
YU64296A
YU64296A YU64296A YU64296A YU64296A YU 64296 A YU64296 A YU 64296A YU 64296 A YU64296 A YU 64296A YU 64296 A YU64296 A YU 64296A YU 64296 A YU64296 A YU 64296A
Authority
YU
Yugoslavia
Prior art keywords
synthesis
benzyimidazole
metod
compound
reaction
Prior art date
Application number
YU64296A
Other languages
English (en)
Other versions
YU49420B (sh
Inventor
Anders Gustavsson
Ake Kallstrom
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Publication of YU64296A publication Critical patent/YU64296A/sh
Publication of YU49420B publication Critical patent/YU49420B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Postupak dobijanja omeprazola iz pirmetil alkohola, preko pirmetilhlorida i primetazola, za koga je karakteristično da se ceo niz reakcija sinteze obavlja bez ikakvog izolovanja ili prečišćavanja intermedijara. Dalje, reakcija se obavlja u jedinstvenom sistemu rastvarača koji je zajednički za ceo niz reakcija sinteze, a inertan je prema reaktantima nastalim tokom postupka i korišćenim u postupku. Postupak u skladu sa sadašnjim pronalaskom može takodje da sadrži i dodatni korak prečišćavanja.
YU64296A 1995-12-15 1996-12-04 Postupak sinteze benzimidazolskog jedinjenja YU49420B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9504503A SE521100C2 (sv) 1995-12-15 1995-12-15 Förfarande för framställning av en bensimidazolförening

Publications (2)

Publication Number Publication Date
YU64296A true YU64296A (sh) 1999-07-28
YU49420B YU49420B (sh) 2006-01-16

Family

ID=20400614

Family Applications (1)

Application Number Title Priority Date Filing Date
YU64296A YU49420B (sh) 1995-12-15 1996-12-04 Postupak sinteze benzimidazolskog jedinjenja

Country Status (40)

Country Link
US (1) US5958955A (sh)
EP (1) EP0868423B1 (sh)
JP (1) JP3523267B2 (sh)
KR (1) KR100433436B1 (sh)
CN (1) CN1113879C (sh)
AR (1) AR004834A1 (sh)
AT (1) ATE205201T1 (sh)
AU (1) AU704422B2 (sh)
CA (1) CA2238864C (sh)
CO (1) CO4750654A1 (sh)
CZ (1) CZ288661B6 (sh)
DE (2) DE868423T1 (sh)
DK (1) DK0868423T3 (sh)
DZ (1) DZ2137A1 (sh)
EE (1) EE03768B1 (sh)
EG (1) EG23859A (sh)
ES (1) ES2125210T3 (sh)
HK (1) HK1010539A1 (sh)
HR (1) HRP960581B1 (sh)
HU (1) HUP9900110A3 (sh)
IL (1) IL124856A (sh)
IS (1) IS1891B (sh)
MA (1) MA24026A1 (sh)
MX (1) MX9804603A (sh)
MY (1) MY115661A (sh)
NO (1) NO314306B1 (sh)
NZ (1) NZ324482A (sh)
PL (1) PL186132B1 (sh)
PT (1) PT868423E (sh)
RU (1) RU2166502C2 (sh)
SE (1) SE521100C2 (sh)
SI (1) SI0868423T1 (sh)
SK (1) SK282347B6 (sh)
TN (1) TNSN96148A1 (sh)
TR (1) TR199801070T2 (sh)
TW (1) TW460474B (sh)
UA (1) UA62921C2 (sh)
WO (1) WO1997022603A1 (sh)
YU (1) YU49420B (sh)
ZA (1) ZA9610067B (sh)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE521100C2 (sv) * 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
SK283805B6 (sk) 1996-09-09 2004-02-03 Slovakofarma, A. S. Spôsob prípravy omeprazolu
US6303787B1 (en) * 1998-05-27 2001-10-16 Natco Pharma Limited Intermediates and an improved process for the preparation of Omeprazole employing the said intermediates
SI20019A (sl) * 1998-07-13 2000-02-29 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola
US6166213A (en) * 1998-08-11 2000-12-26 Merck & Co., Inc. Omeprazole process and compositions thereof
IL142703A (en) 1998-11-10 2006-04-10 Astrazeneca Ab Crystalline form of omeprazole
UA72748C2 (en) 1998-11-10 2005-04-15 Astrazeneca Ab A novel crystalline form of omeprazole
DE19951960C2 (de) 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
CA2472103A1 (en) * 2002-01-25 2003-08-07 Santarus, Inc. Transmucosal delivery of proton pump inhibitors
SE0203092D0 (en) 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
ZA200706613B (en) * 2004-12-16 2009-03-25 Cipla Ltd Process
CN100393712C (zh) * 2006-01-23 2008-06-11 中国科学院成都有机化学有限公司 苯并咪唑型质子泵抑止剂及其前体的改进制备和分离纯化方法
WO2007122686A1 (ja) * 2006-04-14 2007-11-01 Eisai R & D Management Co., Ltd. ベンズイミダゾール化合物
EP2125783A2 (en) * 2007-02-21 2009-12-02 Cipla Limited Process for the preparation of esomeprazole magnesium dihydrate
CN101492459B (zh) * 2008-01-25 2011-04-27 山东轩竹医药科技有限公司 含烷氧乙酰基二氢异噁唑并吡啶化合物
CN101497603B (zh) * 2008-01-30 2012-11-07 山东轩竹医药科技有限公司 含有被烷氧烷胺氧基取代的吡啶的苯并咪唑衍生物
CN103664885A (zh) * 2013-12-12 2014-03-26 武汉工程大学 苯并咪唑型质子泵抑制剂中间体的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US461997A (en) * 1891-10-27 Sand-pump or other pipes
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
US4619997A (en) * 1984-09-06 1986-10-28 The Upjohn Company Substituted 2-pyridylmethylthio and sulfinyl-benzimidazoles as gastric antisecretory agents
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
WO1993006097A1 (en) * 1991-09-20 1993-04-01 Merck & Co., Inc. Novel process for the preparation of anti-ulcer agents
SE521100C2 (sv) * 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening

Also Published As

Publication number Publication date
AR004834A1 (es) 1999-03-10
CA2238864C (en) 2006-01-24
YU49420B (sh) 2006-01-16
TNSN96148A1 (fr) 2005-03-15
PT868423E (pt) 2002-02-28
EE9800183A (et) 1998-12-15
ZA9610067B (en) 1997-06-17
US5958955A (en) 1999-09-28
MY115661A (en) 2003-08-30
MA24026A1 (fr) 1997-07-01
DE69615052T2 (de) 2002-06-27
RU2166502C2 (ru) 2001-05-10
HRP960581B1 (en) 2001-12-31
HK1010539A1 (en) 1999-06-25
ES2125210T3 (es) 2002-02-01
SI0868423T1 (en) 2002-04-30
CN1113879C (zh) 2003-07-09
HUP9900110A3 (en) 2002-10-28
CA2238864A1 (en) 1997-06-26
NO982624D0 (no) 1998-06-08
SE9504503L (sv) 1997-06-16
DK0868423T3 (da) 2001-12-03
KR100433436B1 (ko) 2004-07-16
TW460474B (en) 2001-10-21
EP0868423B1 (en) 2001-09-05
CZ288661B6 (cs) 2001-08-15
CO4750654A1 (es) 1999-03-31
CN1204332A (zh) 1999-01-06
WO1997022603A1 (en) 1997-06-26
EE03768B1 (et) 2002-06-17
NO314306B1 (no) 2003-03-03
UA62921C2 (en) 2004-01-15
IL124856A0 (en) 1999-01-26
DE868423T1 (de) 1999-06-02
AU704422B2 (en) 1999-04-22
CZ168598A3 (cs) 1998-09-16
IS1891B (is) 2003-09-19
EP0868423A1 (en) 1998-10-07
ATE205201T1 (de) 2001-09-15
PL186132B1 (pl) 2003-10-31
NO982624L (no) 1998-06-08
HUP9900110A2 (hu) 2000-03-28
SK282347B6 (sk) 2002-01-07
TR199801070T2 (xx) 1998-08-21
AU1155097A (en) 1997-07-14
PL327334A1 (en) 1998-12-07
NZ324482A (en) 2000-04-28
ES2125210T1 (es) 1999-03-01
SE521100C2 (sv) 2003-09-30
HRP960581A2 (en) 1998-02-28
DZ2137A1 (fr) 2002-10-23
JP3523267B2 (ja) 2004-04-26
SK76898A3 (en) 1998-12-02
MX9804603A (es) 1998-10-31
EG23859A (en) 2007-11-18
IL124856A (en) 2002-12-01
IS4750A (is) 1998-05-22
JP2000502101A (ja) 2000-02-22
DE69615052D1 (de) 2001-10-11
SE9504503D0 (sv) 1995-12-15
KR20000064399A (ko) 2000-11-06

Similar Documents

Publication Publication Date Title
YU64296A (sh) Postupak sinteze benzimidazolskog jedinjenja
NZ337861A (en) N-heterocyclic derivatives for treating multiple sclerosis, HIV dementia, Parkinson's disease, meningitis, atherosclerosis, cancer, inflammatory skin diseases
DE69635779D1 (de) Stereoselektive ringöffnungsreaktionen
ATE181074T1 (de) Vinylen-azaindolderivate und verfahren zu ihrer herstellung
DE69535421D1 (de) Verfahren zur Herstellung von Wasserstoffperoxid bei direkter Synthese aus Wasserstoff und Sauerstoff
NO982251L (no) FremgangsmÕte for fremstilling av rent melamin
NO962524D0 (no) Omdannelse av bisnoralkohol til bisnoraldehyd
MY133573A (en) Method for the synthesis of a benzimidazole compound
DE69802453D1 (de) Herstellung von bioaktiven Verbindungen durch Plasmasynthese
DK0863857T3 (da) Fremgangsmåde til perfluoralkylering og reaktant til iværksættelse af denne fremgangsmåde
SE9504618D0 (sv) New Compounds
ATE242262T1 (de) Verfahren zur lichtgesteuerten biochip-synthese
NO953976D0 (no) Deallyleringsreagens og fremgangsmåte for deallylering ved anvendelse av det nevnte reagens
DK1250335T3 (da) Fremgangsmåde og mellemprodukter til fremstilling af imidazopyridiner
ATE245161T1 (de) Verfahren zur synthese von phosphororganischen verbindungen
DE69409578D1 (de) Verfahren für die Synthese von 9-(2-Hydroxyethoxymethyl)guanin
DE69007577D1 (de) Verfahren zur Synthese von niedrigen Olefinen aus Methanol.
GB9516143D0 (en) Improved chemical synthesis
ATE244262T1 (de) Verfahren zur herstellung von peptidzwischenprodukten
TH26736B (th) วิธีสำหรับการสังเคราะห์สารประกอบเบมซิมิดาโซล
ID18620A (id) Proses-proses untuk memproduksi 1,6-heksanadiol
TH26736A (th) วิธีสำหรับการสังเคราะห์สารประกอบเบมซิมิดาโซล
MX9604347A (es) Derivados del acido 2-(4-pirazoliloxi-pirimidin-5-il) acetico.
DK1303529T3 (da) Fremgangsmåde og indretning til fremstilling af oligomerer og arrays af oligomerer samt anvendelse af indretningen
DK0705266T3 (da) Fremgangsmåde til fremstilling af et imidazolderivat.