SE451838B - Substituerade 4-fenyl-4-oxo-2-butensyraderivat till anvendning som lekemedel samt farmaceutisk komposition innehallande dessa - Google Patents

Substituerade 4-fenyl-4-oxo-2-butensyraderivat till anvendning som lekemedel samt farmaceutisk komposition innehallande dessa

Info

Publication number
SE451838B
SE451838B SE8102220A SE8102220A SE451838B SE 451838 B SE451838 B SE 451838B SE 8102220 A SE8102220 A SE 8102220A SE 8102220 A SE8102220 A SE 8102220A SE 451838 B SE451838 B SE 451838B
Authority
SE
Sweden
Prior art keywords
compounds
formula
hydrogen atom
pharmaceutically acceptable
alkaline earth
Prior art date
Application number
SE8102220A
Other languages
English (en)
Swedish (sv)
Other versions
SE8102220L (sv
Inventor
Y Christidis
R Fournex
C Tournemine
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of SE8102220L publication Critical patent/SE8102220L/xx
Publication of SE451838B publication Critical patent/SE451838B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE8102220A 1980-04-24 1981-04-07 Substituerade 4-fenyl-4-oxo-2-butensyraderivat till anvendning som lekemedel samt farmaceutisk komposition innehallande dessa SE451838B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8009216A FR2481118A1 (fr) 1980-04-24 1980-04-24 Application a titre de medicaments de derives substitues de l'acide phenyl-4-oxo-2-butenoique

Publications (2)

Publication Number Publication Date
SE8102220L SE8102220L (sv) 1981-10-25
SE451838B true SE451838B (sv) 1987-11-02

Family

ID=9241314

Family Applications (2)

Application Number Title Priority Date Filing Date
SE8102220A SE451838B (sv) 1980-04-24 1981-04-07 Substituerade 4-fenyl-4-oxo-2-butensyraderivat till anvendning som lekemedel samt farmaceutisk komposition innehallande dessa
SE8700714A SE463366B (sv) 1980-04-24 1987-02-20 Anvaendning av substituerade 4-fenyl-4-oxo-2-butensyraderivat foer framstaellning av laekemedel foer behandling av sjukdomar i matsmaeltningskanalen och som antiulceroest laekemedel

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE8700714A SE463366B (sv) 1980-04-24 1987-02-20 Anvaendning av substituerade 4-fenyl-4-oxo-2-butensyraderivat foer framstaellning av laekemedel foer behandling av sjukdomar i matsmaeltningskanalen och som antiulceroest laekemedel

Country Status (13)

Country Link
US (1) US4483868A (de)
JP (1) JPS5726641A (de)
AU (1) AU543641B2 (de)
BE (1) BE888540A (de)
CA (1) CA1179601A (de)
CH (1) CH649920A5 (de)
DE (1) DE3116416A1 (de)
FR (1) FR2481118A1 (de)
GB (1) GB2075836B (de)
IT (1) IT1170915B (de)
NL (1) NL8102005A (de)
SE (2) SE451838B (de)
ZA (1) ZA812672B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2504127B1 (fr) * 1981-04-17 1985-07-19 Roussel Uclaf Nouveaux derives d'acides phenyl aliphatique carboxyliques, procede pour leur preparation et leur application comme medicaments
FR2504004A1 (fr) * 1981-04-17 1982-10-22 Roussel Uclaf Application a titre de medicaments de derives d'acides phenyl aliphatique carboxyliques
FR2515037A1 (fr) * 1981-10-22 1983-04-29 Roussel Uclaf A titre de medicaments, certains derives mono-substitues de l'acide 4-phenyl 4-oxo buten-2-oique, ainsi que les compositions les renfermant
IT1171604B (it) * 1981-10-22 1987-06-10 Roussel Maestretti Spa Derivati di acido 4-fenil-4-ossobuten-2-oico dotati di proprieta' farmacologiche e loro procedimento di preparazione
DE3228842A1 (de) * 1982-08-02 1984-02-02 Henkel Kgaa Sebosuppressive kosmetische mittel, enthaltend aryloxobutensaeurederivate sowie neue aryloxobutensaeurederivate
FR2567883B2 (fr) * 1983-01-24 1987-03-06 Roussel Uclaf Nouveaux derives de l'acide trans 4-oxo 2-butenoique substitues en 4 par un radical furyle, eventuellement substitue a titre de medicaments, produits industriels nouveaux et procede de preparation
SE454355B (sv) * 1983-01-24 1988-04-25 Roussel Uclaf Akrylsyraderivat innehallande en furyl-, pyranyl-, bensofuranyl-, oxazolyl- eller isoxazolylgrupp, forfarande for framstellning derav samt farmaceutiska kompositioner innehallande nemnda derivat
US4649157A (en) * 1986-03-28 1987-03-10 G. D. Searle & Co. Pharmaceutical compositions containing 5-phenyl-1,3-dioxoalkenyl compounds
IT1190340B (it) * 1986-06-06 1988-02-16 Roussel Maestretti Spa Derivati dell'acido 4-fenil 4-osso 2-butenoico,loro procedimento di preparazione e loro impiego come prodotti medicinali
DK49688A (da) * 1987-03-20 1988-09-21 Hoffmann La Roche Propiolophenonderivater
HU198292B (en) * 1987-09-25 1989-09-28 Richter Gedeon Vegyeszet Process for producing salicilates and pharmaceutical compositions comprising such active ingredient
JPH04235142A (ja) * 1991-01-09 1992-08-24 Kanegafuchi Chem Ind Co Ltd トランス−β−アロイルアクリル酸エステル類の製造法
JPH064812U (ja) * 1992-06-29 1994-01-21 オンキヨー株式会社 定電流回路
GB9522617D0 (en) * 1995-11-03 1996-01-03 Pharmacia Spa 4-Phenyl-4-oxo-butenoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB588108A (en) * 1944-10-23 1947-05-14 Roche Products Ltd Manufacture of bacteriostatic substances
US2532579A (en) * 1946-08-06 1950-12-05 Du Pont Pest control compositions containing beta-acyl acrylates
US2562208A (en) * 1947-04-14 1951-07-31 Schering Corp Fungistatic composition
DE1282644B (de) * 1962-09-08 1968-11-14 Hoechst Ag Verfahren zur Herstellung von ungesaettigten ª€-Ketocarbonsaeureestern
NL6717403A (de) * 1966-12-30 1968-07-01
GR37790B (el) * 1966-12-30 1969-07-15 F. Hoffmann - La Roche & Co. Aktiengesellschaft Μεθοδος δια την παρασκευην παραγωγων του αρουλακρυλικου οξεος.
DE2047806A1 (en) * 1970-09-29 1972-04-06 Dr Karl Thomae GmbH, 7950 Biberach 3-aroyl-acrylic acids - pharmaceutical intermediates prepd from acetophenones and glyoxylic acid derivs
DE2103749A1 (en) * 1971-01-27 1972-08-10 Dr. Karl Thomae GmbH, 7951 Biberach 3-acyl-acrylic acids prepn - from a ketone and glyoxylic acid (deriv)
DE2116293A1 (de) * 1971-04-02 1972-10-19 Cassella Farbwerke Mainkur Ag, 6000 Frankfurt Ketonderivate und Verfahren zu ihrer Herstellung
US3753997A (en) * 1971-06-07 1973-08-21 A Ash Trifluoromethly substituted-2,6-diphenyl-4-pyridyl carbinolamine antimalarials
US4017517A (en) * 1971-09-13 1977-04-12 Takeda Chemical Industries, Ltd. 2-(Trisubstituted benzoyl)-propionic acid and a method for the production thereof
BE788749A (fr) * 1971-09-13 1973-03-13 Takeda Chemical Industries Ltd Acide 3-(benzoyl trisubstitue)-propionique et son procede de preparation
BE795893A (fr) * 1972-02-28 1973-06-18 Unicler Derives de (methylene dioxy-3,4 phenyl)-1 dimethyl-4,4 pentene-1, leur preparation et leur application en therrapeutique
CH591415A5 (en) * 1972-09-13 1977-09-15 Takeda Chemical Industries Ltd 3-(Tri-substd. benzoyl) propionic acids - as relaxants or spasmolytics for the gall bladder
GB1392100A (en) * 1972-09-13 1975-04-23 Beecham Group Ltd Insecticides
FR2270856B1 (de) * 1974-01-17 1978-07-21 Screen
US3940404A (en) * 1974-03-06 1976-02-24 The United States Of America As Represented By The Secretary Of The Army 2-Substituted phenyl-6-trifluoromethyl-4-pyridyl-carbinolamines
US3953463A (en) * 1974-03-06 1976-04-27 The United States Of America As Represented By The Secretary Of The Army 2-Aryl-6-trifluoromethyl-4-pyridyl-carbinolamine antimalarials
JPS5536434A (en) * 1978-09-07 1980-03-14 Sankyo Co Ltd 4-phenyl-4-oxo-2-butenoic acid derivative and its preparation
ES496382A0 (es) * 1979-10-31 1982-03-01 Byk Gulden Lomberg Chem Fab Procedimiento para la preparacion de acidos oxocarboxilicos sustituidos
FR2481270A1 (fr) * 1980-04-24 1981-10-30 Roussel Uclaf Nouveaux derives substitues de l'acide 4-phenyl 4-oxo 2-hydroxy butanoique, procede pour leur preparation et applications comme medicaments

Also Published As

Publication number Publication date
BE888540A (fr) 1981-10-23
DE3116416C2 (de) 1990-01-18
FR2481118B1 (de) 1983-05-27
SE463366B (sv) 1990-11-12
AU6980381A (en) 1981-10-29
CA1179601A (fr) 1984-12-18
US4483868A (en) 1984-11-20
IT8148336A0 (it) 1981-04-23
JPH0227326B2 (de) 1990-06-15
ZA812672B (en) 1982-04-28
SE8700714D0 (sv) 1987-02-20
GB2075836B (en) 1985-03-13
FR2481118A1 (fr) 1981-10-30
NL8102005A (nl) 1981-11-16
AU543641B2 (en) 1985-04-26
JPS5726641A (en) 1982-02-12
GB2075836A (en) 1981-11-25
DE3116416A1 (de) 1982-04-01
CH649920A5 (fr) 1985-06-28
SE8700714L (sv) 1987-02-20
SE8102220L (sv) 1981-10-25
IT1170915B (it) 1987-06-03

Similar Documents

Publication Publication Date Title
SE451838B (sv) Substituerade 4-fenyl-4-oxo-2-butensyraderivat till anvendning som lekemedel samt farmaceutisk komposition innehallande dessa
FI66368B (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 6,1-dihydro-11-oxodibens(b,e)oxepin-2-aettiksyraderivat
CH533098A (fr) Procédé de préparation de benzopyrones
EP0591046B1 (de) Chromen-Derivate mit einer Trien-Kette zur Verwendung bei der Behandlung der Osteoporose und der entzündlichen Erkrankungen
SE453493B (sv) Nya alifatiska fenylkarboxylsyror sett for framstellning derav, anvendning derav som lekemedel och kompositioner innehallande dem
EP0104959A1 (de) 4-Chinolon-Derivate
JPH01106839A (ja) アルカジエン誘導体類、それらの製造、およびそれらを含有している薬学的組成物
HU207858B (en) Process for producing phenol derivatives inhibiting biosynthesis of lipoxygenaze-originated metabolites of arachidonic acid and pharmaceutical compositions containing them as active component
US4473583A (en) Compositions containing certain derivatives of 4-phenyl-4-oxobuten-2-oic acid and methods of treatment using them
JPS6072843A (ja) ４−フエニル−４−オキソ−２−ブテン酸の新誘導体、それらの製造法、薬剤としての使用及びそれらを含む組成物
US4402978A (en) Gastro-protecting activity of substituted derivatives of 4-phenyl-4-oxo-2-hydroxy-butanoic acid
US4436752A (en) Treatment of gastric and gastro-duodenal disorders with derivatives of phenyl aliphatic carboxylic acids
SU1080743A3 (ru) Способ получени производных диалуровой кислоты
JPH0710863B2 (ja) エーテル化若しくはエステル化しうるジヒドロキシ基により位置２で置換された４―ｏｈキノリンカルボン酸の新規の誘導体、その製造方法、及び医薬としてのその使用
JPS6324498B2 (de)
WO2003099269A1 (en) Cinnamic acid dimers, their preparation and the use thereof for treating neurodegenerative disease
US4254126A (en) 4-Carbethoxy-carbonilamino-pyrimidines and a process for their preparation
FR2518090A1 (fr) Ethers d'oximes a-b insatures, leur procede de preparation et leur utilisation comme medicament
JPH03106870A (ja) 共役γ―オキシブテノライド化合物およびこれを有効成分とする抗潰瘍剤
DK153403B (da) Analogifremgangsmaade til fremstilling af 4-(2-tienylmetylamino)-benzoesyreforbindelser
JPH0121143B2 (de)
JPH09176153A (ja) 新規なチオフェン化合物及びそれらを含む医薬組成物
JPS59139372A (ja) 抗消火器潰瘍剤
NO881221L (no) Styrylketoner.
EP0120304A2 (de) Substituierte 4,10-Dihydro-10-oxothienobenzoxepine und Zwischenprodukte, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 8102220-4

Effective date: 19921108

Format of ref document f/p: F