SE437375B - Sett att framstella nya hogervridande isomerer av asymmetrisk spirohydantoin - Google Patents
Sett att framstella nya hogervridande isomerer av asymmetrisk spirohydantoinInfo
- Publication number
- SE437375B SE437375B SE7803626A SE7803626A SE437375B SE 437375 B SE437375 B SE 437375B SE 7803626 A SE7803626 A SE 7803626A SE 7803626 A SE7803626 A SE 7803626A SE 437375 B SE437375 B SE 437375B
- Authority
- SE
- Sweden
- Prior art keywords
- spirohydantoin
- compounds
- spiro
- acid
- fluoro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/799,586 US4130714A (en) | 1977-05-23 | 1977-05-23 | Hydantoin therapeutic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
SE7803626L SE7803626L (sv) | 1978-11-24 |
SE437375B true SE437375B (sv) | 1985-02-25 |
Family
ID=25176274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7803626A SE437375B (sv) | 1977-05-23 | 1978-03-30 | Sett att framstella nya hogervridande isomerer av asymmetrisk spirohydantoin |
Country Status (37)
Country | Link |
---|---|
US (1) | US4130714A (fr) |
JP (1) | JPS6035350B2 (fr) |
AR (1) | AR219531A1 (fr) |
AT (1) | AT357170B (fr) |
AU (1) | AU499518B1 (fr) |
BE (1) | BE867248A (fr) |
CA (1) | CA1088073A (fr) |
CH (1) | CH631455A5 (fr) |
CS (1) | CS200550B2 (fr) |
DD (1) | DD137107A5 (fr) |
DE (2) | DE2821966C2 (fr) |
DK (1) | DK147941C (fr) |
EG (1) | EG13691A (fr) |
ES (1) | ES470070A1 (fr) |
FI (1) | FI62838C (fr) |
FR (1) | FR2392024A1 (fr) |
GB (1) | GB1572688A (fr) |
GR (1) | GR68694B (fr) |
HK (1) | HK53981A (fr) |
HU (1) | HU177718B (fr) |
IE (1) | IE47273B1 (fr) |
IL (1) | IL54754A (fr) |
IN (1) | IN147854B (fr) |
IT (1) | IT1096306B (fr) |
KE (1) | KE3168A (fr) |
LU (1) | LU79685A1 (fr) |
MY (1) | MY8200156A (fr) |
NL (1) | NL7804158A (fr) |
NO (1) | NO150206C (fr) |
NZ (1) | NZ187334A (fr) |
PH (1) | PH13828A (fr) |
PL (1) | PL110460B1 (fr) |
PT (1) | PT68071B (fr) |
SE (1) | SE437375B (fr) |
SU (1) | SU873885A3 (fr) |
YU (1) | YU40829B (fr) |
ZA (1) | ZA782919B (fr) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1088945A (fr) * | 1976-10-18 | 1980-11-04 | Pfizer Limited | Derives de l'hydantoine utilises comme agents therapeutiques |
US4181728A (en) * | 1978-11-16 | 1980-01-01 | Pfizer Inc. | Spiro-polycyclicimidazolidinedione derivatives |
US4181729A (en) * | 1979-03-21 | 1980-01-01 | Pfizer Inc. | Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives |
US4210667A (en) * | 1979-04-19 | 1980-07-01 | Pfizer Inc. | Pharmaceutical preparations containing coumarin carboxylic acid derivatives |
US4490381A (en) * | 1979-11-13 | 1984-12-25 | Imperial Chemical Industries Plc | 1'-Substituted spiro[imidazolidine-4,3'-indoline]2,2',5-triones |
US4248882A (en) * | 1980-02-12 | 1981-02-03 | Pfizer Inc. | Treating diabetes-associated complications with hydantoin amines |
US4286098A (en) * | 1980-03-28 | 1981-08-25 | Pfizer Inc. | Process for the preparation of chiral hydantoins |
JPS5745185A (en) * | 1980-07-21 | 1982-03-13 | Eisai Co Ltd | Hydantoin derivative and its preparation |
US4419521A (en) * | 1981-11-12 | 1983-12-06 | Pfizer Inc. | 6-Halo-4-chromanamines useful as intermediates to make chiral hydantoins |
JPS58124788A (ja) * | 1982-01-20 | 1983-07-25 | Eisai Co Ltd | 光学活性ヒダントイン誘導体,その製造方法ならびにそれを含有する治療用薬剤 |
US4436745A (en) | 1982-04-15 | 1984-03-13 | Alcon Laboratories, Inc. | Method of inhibiting aldose reductase activity |
US4438272A (en) | 1982-04-15 | 1984-03-20 | Alcon Laboratories, Inc. | Spiro-(fluoren-9,4'-imidazolidine)-2',5'-diones |
US4540700A (en) * | 1982-04-15 | 1985-09-10 | Alcon Laboratories, Inc. | Treatment of diabetic complications with certain spiro-imidazolidine-diones |
US4464385A (en) * | 1982-04-15 | 1984-08-07 | Alcon Laboratories, Inc. | Treatment of diabetic complications with hydantoins |
US4431828A (en) * | 1982-11-10 | 1984-02-14 | Pfizer Inc. | Regeneration of 6-fluoro-4-chromanone from by-products in the synthesis of sorbinil |
US4528387A (en) * | 1982-11-10 | 1985-07-09 | Pfizer Inc. | Sorbinil by optical resolution of precursor 6-fluoro-4-ureidochroman-4-carboxylic acid |
US4556670A (en) * | 1982-12-06 | 1985-12-03 | Pfizer Inc. | Spiro-3-hetero-azolones for treatment of diabetic complications |
US4474967A (en) * | 1983-04-27 | 1984-10-02 | Pfizer Inc. | 8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione |
US4537892A (en) * | 1983-09-14 | 1985-08-27 | Alcon Laboratories, Inc. | Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase |
US5153211A (en) * | 1983-09-14 | 1992-10-06 | Alcon Laboratories, Inc. | Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase |
DE3561198D1 (en) * | 1984-03-23 | 1988-01-28 | Pfizer | Spiro-indenes and spiro-1,2-dihydro-naphthalenes for treatment of diabetic complications |
US4600717A (en) * | 1984-04-11 | 1986-07-15 | Alcon Laboratories, Inc. | Aldose reductase inhibitors useful in ophthalmic wound healing |
US4717725A (en) * | 1984-04-11 | 1988-01-05 | Alcon Laboratories, Inc. | Ophthalmic wound healing with aldose reductase inhibitors |
JPH06772B2 (ja) * | 1984-07-09 | 1994-01-05 | 鐘淵化学工業株式会社 | 3―(4―フルオロフエノキシ)プロピオニトリルを用いる6―フルオロ―4―クロマノンの製造法 |
US4680306A (en) * | 1984-07-20 | 1987-07-14 | Pfizer Inc. | Sprio-imidazolones for treatment of diabetes complications |
US4656169A (en) * | 1984-08-14 | 1987-04-07 | Pfizer Inc. | Tetracyclic spiro-hydantoin aldose reductase inhibitors and compositions |
ATE37371T1 (de) * | 1984-08-20 | 1988-10-15 | Pfizer | Verfahren zur herstellung asymmetrischer hydantoine. |
US4620019A (en) * | 1984-08-23 | 1986-10-28 | Pfizer Inc. | S-6-fluoro-4-aminochroman-4-carboxylic acid derivatives useful as intermediates for sorbinil |
US4609663A (en) * | 1984-09-11 | 1986-09-02 | Alcon Laboratories, Inc. | Aldose reductase inhibitors useful in glaucoma therapy |
US4551542A (en) * | 1984-09-26 | 1985-11-05 | Pfizer Inc. | Regeneration of 6-fluoro-4-chromanone from 6-fluoro-4-ureidochroman-4-carboxylic acid |
US4966911A (en) * | 1984-11-20 | 1990-10-30 | Washington Research Foundation | Immunoregulatory agents |
US5340829A (en) * | 1984-11-20 | 1994-08-23 | Washington Research Foundation | Immunoregulatory agents |
JPS61200991A (ja) * | 1985-03-04 | 1986-09-05 | Sanwa Kagaku Kenkyusho:Kk | スピロ―3―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤 |
WO1986007353A1 (fr) | 1985-06-14 | 1986-12-18 | Pfizer Inc. | Produit intermediaire utilise dans la producton d'hydantoines asymetriques |
JPS627654U (fr) * | 1985-06-26 | 1987-01-17 | ||
WO1987004344A1 (fr) * | 1986-01-17 | 1987-07-30 | Pfizer Inc. | Derives de l'acide hydroxyacetique pour le traitement de complications diabetiques |
JPS6357588A (ja) * | 1986-08-28 | 1988-03-12 | Sanwa Kagaku Kenkyusho Co Ltd | ヒダントイン誘導体、その塩並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤 |
WO1988006887A1 (fr) * | 1987-03-20 | 1988-09-22 | Alcon Laboratories, Inc. | Utilisation d'inhibiteurs de la reductase aldose afin d'augmenter la sensibilite a l'insuline chez des personnes souffrant de diabetes mellitus |
US4841079A (en) * | 1987-08-07 | 1989-06-20 | Pfizer, Inc. | Process for the production of asymmetric hydantoins |
US4952694A (en) * | 1988-07-27 | 1990-08-28 | Pfizer Inc. | Novel resolution process for racemic spiro-hydantoins |
US5006657A (en) * | 1988-07-27 | 1991-04-09 | Pfizer Inc. | Intermediates in a resolution process for racemic spiro hydantoins |
AU617541B2 (en) * | 1988-10-20 | 1991-11-28 | Wyeth | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
EP0536119A4 (en) * | 1989-02-10 | 1993-08-04 | Washington Research Foundation | Immunoregulatory agents |
US4980357A (en) * | 1990-03-01 | 1990-12-25 | Pfizer Inc. | Azolidinedione derivatives |
US5039672A (en) * | 1990-04-05 | 1991-08-13 | Pfizer Inc. | Heterocyclic compounds as aldose reductase inhibitors |
US5236945A (en) * | 1990-06-11 | 1993-08-17 | Pfizer Inc. | 1H-indazole-3-acetic acids as aldose reductase inhibitors |
US5206367A (en) * | 1992-02-18 | 1993-04-27 | Pfizer Inc. | Preparation of optically active spiro-hydantoins |
KR950703539A (ko) * | 1992-09-28 | 1995-09-20 | 알렌 제이. 스피겔 | 당뇨병 합병증 치료용 치환된 피리미딘(substituted pyrimidines for control or diabetic complications) |
US5521208A (en) * | 1993-07-29 | 1996-05-28 | Alcon Laboratories, Inc. | Compositions and methods for the treatment of the metabolically impaired and for improved compliance |
JP3553086B2 (ja) * | 1997-04-15 | 2004-08-11 | シーエスアイアール | 食欲抑制活性を有する医薬組成物 |
GB2355657B (en) * | 1999-10-27 | 2004-07-28 | Phytopharm Plc | Inhibitors Of Gastric Acid Secretion |
GB2363985B (en) * | 2000-06-30 | 2004-09-29 | Phytopharm Plc | Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use |
EA200300433A1 (ru) | 2000-11-30 | 2003-10-30 | Пфайзер Продактс Инк. | Комбинация гамк-агонистов и ингибиторов альдегидредуктазы |
US20110092566A1 (en) * | 2004-11-19 | 2011-04-21 | Srivastava Satish K | Treatment of cancer with aldose reductase inhibitors |
US8158667B2 (en) | 2006-08-21 | 2012-04-17 | Kador Peter F | Topical treatment of cataracts in dogs |
ES2371393T3 (es) | 2007-03-12 | 2011-12-30 | Zadec Aps | Extracto antidiabético de rooibos. |
EP2848252A3 (fr) | 2007-03-23 | 2015-06-17 | The Board of Regents of the University of Texas System | Inhibiteurs d'aldose-réductase pour le traitement de l'uvéite |
US20090270490A1 (en) * | 2008-04-24 | 2009-10-29 | The Board Of Regents Of The University Of Texas System | Methods involving aldose reductase inhibition |
EP2654749B1 (fr) | 2010-12-23 | 2017-05-10 | The Board of Regents of The University of Texas System | Méthodes de traitement de copd |
UA118035C2 (uk) * | 2013-10-07 | 2018-11-12 | Сінгента Партісіпейшнс Аг | Гербіцидні сполуки |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2683718A (en) * | 1952-01-11 | 1954-07-13 | Searle & Co | Spiro-[xanthene-9, 4'-imidazolidine]-2, 5-dione |
DE1135915B (de) * | 1961-06-29 | 1962-09-06 | Asta Werke Ag Chem Fab | Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine |
CA1088945A (fr) * | 1976-10-18 | 1980-11-04 | Pfizer Limited | Derives de l'hydantoine utilises comme agents therapeutiques |
-
1977
- 1977-05-23 US US05/799,586 patent/US4130714A/en not_active Expired - Lifetime
-
1978
- 1978-03-30 SE SE7803626A patent/SE437375B/sv not_active IP Right Cessation
- 1978-04-15 IN IN272/DEL/78A patent/IN147854B/en unknown
- 1978-04-19 PH PH21026A patent/PH13828A/en unknown
- 1978-04-19 NL NL7804158A patent/NL7804158A/xx active Search and Examination
- 1978-05-11 CS CS783021A patent/CS200550B2/cs unknown
- 1978-05-13 JP JP53057064A patent/JPS6035350B2/ja not_active Expired
- 1978-05-16 PL PL1978206826A patent/PL110460B1/pl unknown
- 1978-05-16 YU YU1169/78A patent/YU40829B/xx unknown
- 1978-05-17 HU HU78PI625A patent/HU177718B/hu not_active IP Right Cessation
- 1978-05-17 SU SU782616255A patent/SU873885A3/ru active
- 1978-05-18 GB GB20352/78A patent/GB1572688A/en not_active Expired
- 1978-05-18 DD DD78205450A patent/DD137107A5/xx unknown
- 1978-05-18 AR AR272227A patent/AR219531A1/es active
- 1978-05-19 DE DE2821966A patent/DE2821966C2/de not_active Expired
- 1978-05-19 BE BE187841A patent/BE867248A/fr not_active IP Right Cessation
- 1978-05-19 AT AT365378A patent/AT357170B/de not_active IP Right Cessation
- 1978-05-19 DE DE2858042A patent/DE2858042C2/de not_active Expired
- 1978-05-19 CA CA303,740A patent/CA1088073A/fr not_active Expired
- 1978-05-20 GR GR56282A patent/GR68694B/el unknown
- 1978-05-20 EG EG320/78A patent/EG13691A/xx active
- 1978-05-22 CH CH552778A patent/CH631455A5/fr not_active IP Right Cessation
- 1978-05-22 IL IL54754A patent/IL54754A/xx not_active IP Right Cessation
- 1978-05-22 ES ES470070A patent/ES470070A1/es not_active Expired
- 1978-05-22 LU LU79685A patent/LU79685A1/fr unknown
- 1978-05-22 ZA ZA00782919A patent/ZA782919B/xx unknown
- 1978-05-22 PT PT68071A patent/PT68071B/pt unknown
- 1978-05-22 NO NO781769A patent/NO150206C/no unknown
- 1978-05-22 FR FR7815032A patent/FR2392024A1/fr active Granted
- 1978-05-22 DK DK226778A patent/DK147941C/da not_active IP Right Cessation
- 1978-05-22 IT IT23672/78A patent/IT1096306B/it active
- 1978-05-22 AU AU36328/78A patent/AU499518B1/en not_active Expired
- 1978-05-22 IE IE1015/78A patent/IE47273B1/en not_active IP Right Cessation
- 1978-05-22 NZ NZ187334A patent/NZ187334A/en unknown
- 1978-05-22 FI FI781613A patent/FI62838C/fi not_active IP Right Cessation
-
1981
- 1981-10-15 KE KE3168A patent/KE3168A/xx unknown
- 1981-11-05 HK HK539/81A patent/HK53981A/xx unknown
-
1982
- 1982-12-30 MY MY156/82A patent/MY8200156A/xx unknown
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