CA1088945A - Derives de l'hydantoine utilises comme agents therapeutiques - Google Patents

Derives de l'hydantoine utilises comme agents therapeutiques

Info

Publication number
CA1088945A
CA1088945A CA287,868A CA287868A CA1088945A CA 1088945 A CA1088945 A CA 1088945A CA 287868 A CA287868 A CA 287868A CA 1088945 A CA1088945 A CA 1088945A
Authority
CA
Canada
Prior art keywords
spiro
dione
imidazolidine
hydrogen
lower alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA287,868A
Other languages
English (en)
Inventor
Reinhard Sarges
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/767,803 external-priority patent/US4117230A/en
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of CA1088945A publication Critical patent/CA1088945A/fr
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/12Ophthalmic agents for cataracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA287,868A 1976-10-18 1977-09-30 Derives de l'hydantoine utilises comme agents therapeutiques Expired CA1088945A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US73306276A 1976-10-18 1976-10-18
US733,062 1976-10-18
US05/767,803 US4117230A (en) 1976-10-18 1977-02-11 Hydantoin derivatives as therapeutic agents
US767,803 1977-02-11

Publications (1)

Publication Number Publication Date
CA1088945A true CA1088945A (fr) 1980-11-04

Family

ID=27112515

Family Applications (1)

Application Number Title Priority Date Filing Date
CA287,868A Expired CA1088945A (fr) 1976-10-18 1977-09-30 Derives de l'hydantoine utilises comme agents therapeutiques

Country Status (29)

Country Link
JP (3) JPS5353653A (fr)
AR (1) AR220901A1 (fr)
AT (1) AT356136B (fr)
AU (1) AU504978B2 (fr)
BG (1) BG28847A3 (fr)
CA (1) CA1088945A (fr)
CH (1) CH625511A5 (fr)
DD (1) DD131931A5 (fr)
DE (4) DE2746244C2 (fr)
DK (1) DK150302C (fr)
ES (1) ES463267A1 (fr)
FI (1) FI62307C (fr)
FR (1) FR2367754A1 (fr)
GB (1) GB1566171A (fr)
GR (1) GR70201B (fr)
HK (1) HK53881A (fr)
IE (1) IE45805B1 (fr)
IL (1) IL53094A0 (fr)
KE (1) KE3167A (fr)
LU (1) LU78330A1 (fr)
MX (1) MX4899E (fr)
MY (1) MY8200157A (fr)
NL (1) NL167434C (fr)
NO (1) NO148453C (fr)
NZ (1) NZ185358A (fr)
PH (1) PH15639A (fr)
PT (1) PT67164B (fr)
SE (1) SE437024B (fr)
YU (1) YU40821B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents
US4127665A (en) * 1978-01-18 1978-11-28 Pfizer Inc. Thienohydantoin derivatives
US4147797A (en) * 1978-08-11 1979-04-03 Pfizer Inc. Spiro-furanohydantoin derivatives
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
US4181728A (en) * 1978-11-16 1980-01-01 Pfizer Inc. Spiro-polycyclicimidazolidinedione derivatives
US4181729A (en) * 1979-03-21 1980-01-01 Pfizer Inc. Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
US4235911A (en) * 1979-06-13 1980-11-25 Pfizer Inc. Hydantoin derivatives
US4283409A (en) * 1979-10-29 1981-08-11 Pfizer Inc. Imidazolone derivatives
US4286098A (en) * 1980-03-28 1981-08-25 Pfizer Inc. Process for the preparation of chiral hydantoins
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation
EP0065392B1 (fr) * 1981-05-13 1985-02-13 Imperial Chemical Industries Plc Compositions pharmaceutiques contenant des dérivés de la spiro-succinimide
JPS58213717A (ja) * 1982-01-20 1983-12-12 Eisai Co Ltd ヒダントイン誘導体を含有する治療用薬剤
JPS59500617A (ja) * 1982-04-15 1984-04-12 アルコン・ラボラトリ−ズ・インコ−ポレ−テッド ヒダントイン治療剤
HU193191B (en) * 1982-12-06 1987-08-28 Pfizer Process for preparing spiro-hetero-azolones
US4474967A (en) * 1983-04-27 1984-10-02 Pfizer Inc. 8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione
WO1986002647A1 (fr) * 1984-10-30 1986-05-09 Pfizer Inc. Utilisation de spiro-heteroazolones dans le traitement des complications dues au diabete
JPS61200991A (ja) * 1985-03-04 1986-09-05 Sanwa Kagaku Kenkyusho:Kk スピロ―3―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤
US4575507A (en) * 1985-05-29 1986-03-11 Pfizer Inc. Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
JPS6357588A (ja) * 1986-08-28 1988-03-12 Sanwa Kagaku Kenkyusho Co Ltd ヒダントイン誘導体、その塩並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤
HU204832B (en) * 1987-09-04 1992-02-28 Pfizer Process for producing spiro-(imidazolidine-4,4'-pyrano/2,3-b/pyridine) derivatives and pharmaceutical compositions comprising same
GB2355264A (en) 1999-09-30 2001-04-18 Merck & Co Inc Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
CN1659136A (zh) * 2002-04-18 2005-08-24 弗吉尼亚大学专利基金会 新的钠通道阻滞剂
FR2955107B1 (fr) 2010-01-08 2012-03-02 Servier Lab Nouveaux derives thiochromanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB818724A (en) * 1956-10-18 1959-08-19 Ici Ltd Hydantoin derivatives
DE1135915B (de) * 1961-06-29 1962-09-06 Asta Werke Ag Chem Fab Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine
US3532744A (en) * 1967-07-28 1970-10-06 American Home Prod 1- and 2-amino substituted indane and tetralene carboxylic acids
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
DE2449030A1 (de) * 1974-10-11 1976-05-20 Schering Ag Neue pyridin-derivate
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents

Also Published As

Publication number Publication date
DK150302B (da) 1987-02-02
FR2367754A1 (fr) 1978-05-12
SE437024B (sv) 1985-02-04
AR220901A1 (es) 1980-12-15
NO773548L (no) 1978-04-19
DK461377A (da) 1978-04-19
MY8200157A (en) 1982-12-31
JPS5495570A (en) 1979-07-28
PT67164B (en) 1979-03-20
AU504978B2 (en) 1979-11-01
IL53094A0 (en) 1977-12-30
DE2759543C2 (fr) 1987-04-09
SE7711053L (sv) 1978-04-19
JPS5940388B2 (ja) 1984-09-29
IE45805B1 (en) 1982-12-01
JPS5353653A (en) 1978-05-16
DE2759542C2 (fr) 1988-07-07
YU244277A (en) 1982-08-31
ES463267A1 (es) 1978-07-16
JPS5495575A (en) 1979-07-28
DK150302C (da) 1987-09-28
DE2746244A1 (de) 1978-04-20
GR70201B (fr) 1982-08-31
BG28847A3 (en) 1980-07-15
YU40821B (en) 1986-06-30
MX4899E (es) 1982-12-14
DD131931A5 (de) 1978-08-09
HK53881A (en) 1981-11-13
NO148453C (no) 1983-10-12
ATA745977A (de) 1979-09-15
IE45805L (en) 1978-04-18
JPS5534132B2 (fr) 1980-09-04
CH625511A5 (en) 1981-09-30
LU78330A1 (fr) 1979-06-01
NO148453B (no) 1983-07-04
AT356136B (de) 1980-04-10
AU2943177A (en) 1979-04-12
PT67164A (en) 1977-11-01
NL167434C (nl) 1981-12-16
DE2746244C2 (de) 1983-05-19
FI773060A (fi) 1978-04-19
PH15639A (en) 1983-03-11
FR2367754B1 (fr) 1982-07-09
GB1566171A (en) 1980-04-30
NL167434B (nl) 1981-07-16
DE2759927C2 (de) 1986-12-04
NZ185358A (en) 1979-06-08
FI62307C (fi) 1982-12-10
KE3167A (en) 1981-11-06
JPS607997B2 (ja) 1985-02-28
NL7711358A (nl) 1978-04-20
FI62307B (fi) 1982-08-31

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Legal Events

Date Code Title Description
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