JPS5353653A - Hydantoin derivatives medicines - Google Patents

Hydantoin derivatives medicines

Info

Publication number
JPS5353653A
JPS5353653A JP12437177A JP12437177A JPS5353653A JP S5353653 A JPS5353653 A JP S5353653A JP 12437177 A JP12437177 A JP 12437177A JP 12437177 A JP12437177 A JP 12437177A JP S5353653 A JPS5353653 A JP S5353653A
Authority
JP
Japan
Prior art keywords
medicines
hydantoin derivatives
hydantoin
derivatives
derivatives medicines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12437177A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5534132B2 (fr
Inventor
Saajiesu Reinhaado
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/767,803 external-priority patent/US4117230A/en
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of JPS5353653A publication Critical patent/JPS5353653A/ja
Publication of JPS5534132B2 publication Critical patent/JPS5534132B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP12437177A 1976-10-18 1977-10-17 Hydantoin derivatives medicines Granted JPS5353653A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73306276A 1976-10-18 1976-10-18
US05/767,803 US4117230A (en) 1976-10-18 1977-02-11 Hydantoin derivatives as therapeutic agents

Publications (2)

Publication Number Publication Date
JPS5353653A true JPS5353653A (en) 1978-05-16
JPS5534132B2 JPS5534132B2 (fr) 1980-09-04

Family

ID=27112515

Family Applications (3)

Application Number Title Priority Date Filing Date
JP12437177A Granted JPS5353653A (en) 1976-10-18 1977-10-17 Hydantoin derivatives medicines
JP53145925A Expired JPS5940388B2 (ja) 1976-10-18 1978-11-25 ヒダントイン誘導体治療剤
JP53145926A Expired JPS607997B2 (ja) 1976-10-18 1978-11-25 ヒダントイン誘導体治療剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP53145925A Expired JPS5940388B2 (ja) 1976-10-18 1978-11-25 ヒダントイン誘導体治療剤
JP53145926A Expired JPS607997B2 (ja) 1976-10-18 1978-11-25 ヒダントイン誘導体治療剤

Country Status (29)

Country Link
JP (3) JPS5353653A (fr)
AR (1) AR220901A1 (fr)
AT (1) AT356136B (fr)
AU (1) AU504978B2 (fr)
BG (1) BG28847A3 (fr)
CA (1) CA1088945A (fr)
CH (1) CH625511A5 (fr)
DD (1) DD131931A5 (fr)
DE (4) DE2746244C2 (fr)
DK (1) DK150302C (fr)
ES (1) ES463267A1 (fr)
FI (1) FI62307C (fr)
FR (1) FR2367754A1 (fr)
GB (1) GB1566171A (fr)
GR (1) GR70201B (fr)
HK (1) HK53881A (fr)
IE (1) IE45805B1 (fr)
IL (1) IL53094A0 (fr)
KE (1) KE3167A (fr)
LU (1) LU78330A1 (fr)
MX (1) MX4899E (fr)
MY (1) MY8200157A (fr)
NL (1) NL167434C (fr)
NO (1) NO148453C (fr)
NZ (1) NZ185358A (fr)
PH (1) PH15639A (fr)
PT (1) PT67164B (fr)
SE (1) SE437024B (fr)
YU (1) YU40821B (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53144575A (en) * 1977-05-23 1978-12-15 Pfizer Spiroohydantoin
JPS55127376A (en) * 1979-03-21 1980-10-02 Pfizer Phenyl or phenoxy substituted spiroo imidazolidinedione derivative
JPS57197217A (en) * 1981-05-13 1982-12-03 Ici Ltd Medicine for treating or preventing complication of diabetes or galactosemia, novel spiro-bonded pyrrolidin-2,5-dione and manufacture
JPS58213717A (ja) * 1982-01-20 1983-12-12 Eisai Co Ltd ヒダントイン誘導体を含有する治療用薬剤
JPS59500617A (ja) * 1982-04-15 1984-04-12 アルコン・ラボラトリ−ズ・インコ−ポレ−テッド ヒダントイン治療剤
JPS59116274A (ja) * 1982-12-06 1984-07-05 フアイザ−・インコ−ポレ−テツド 糖尿病合併症治療用のスピロ−３−ヘテロ−アゾロン
JPS59205384A (ja) * 1983-04-27 1984-11-20 フアイザ−・インコ−ポレ−テツド ヒダントイン誘導体
JPS61109789A (ja) * 1984-10-30 1986-05-28 フアイザー・インコーポレーテツド スピロ‐ヘテロアゾロン化合物類
JPS61200991A (ja) * 1985-03-04 1986-09-05 Sanwa Kagaku Kenkyusho:Kk スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤
JPS6357588A (ja) * 1986-08-28 1988-03-12 Sanwa Kagaku Kenkyusho Co Ltd ヒダントイン誘導体、その塩並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤
JPS63253086A (ja) * 1980-03-28 1988-10-20 フアイザー・インコーポレーテツド 偏光性ヒダントイン類

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4127665A (en) * 1978-01-18 1978-11-28 Pfizer Inc. Thienohydantoin derivatives
US4147797A (en) * 1978-08-11 1979-04-03 Pfizer Inc. Spiro-furanohydantoin derivatives
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
US4181728A (en) * 1978-11-16 1980-01-01 Pfizer Inc. Spiro-polycyclicimidazolidinedione derivatives
US4235911A (en) * 1979-06-13 1980-11-25 Pfizer Inc. Hydantoin derivatives
US4283409A (en) * 1979-10-29 1981-08-11 Pfizer Inc. Imidazolone derivatives
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation
US4575507A (en) * 1985-05-29 1986-03-11 Pfizer Inc. Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
HU204832B (en) * 1987-09-04 1992-02-28 Pfizer Process for producing spiro-(imidazolidine-4,4'-pyrano/2,3-b/pyridine) derivatives and pharmaceutical compositions comprising same
GB2355264A (en) 1999-09-30 2001-04-18 Merck & Co Inc Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
CN1659136A (zh) * 2002-04-18 2005-08-24 弗吉尼亚大学专利基金会 新的钠通道阻滞剂
FR2955107B1 (fr) 2010-01-08 2012-03-02 Servier Lab Nouveaux derives thiochromanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB818724A (en) * 1956-10-18 1959-08-19 Ici Ltd Hydantoin derivatives
DE1135915B (de) * 1961-06-29 1962-09-06 Asta Werke Ag Chem Fab Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine
US3532744A (en) * 1967-07-28 1970-10-06 American Home Prod 1- and 2-amino substituted indane and tetralene carboxylic acids
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
DE2449030A1 (de) * 1974-10-11 1976-05-20 Schering Ag Neue pyridin-derivate
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53144575A (en) * 1977-05-23 1978-12-15 Pfizer Spiroohydantoin
JPS6035350B2 (ja) * 1977-05-23 1985-08-14 フアイザ−・インコ−ポレ−テツド 右旋性スピローヒダントイン
JPS55127376A (en) * 1979-03-21 1980-10-02 Pfizer Phenyl or phenoxy substituted spiroo imidazolidinedione derivative
JPH0141629B2 (fr) * 1979-03-21 1989-09-06 Pfizer
JPS63253086A (ja) * 1980-03-28 1988-10-20 フアイザー・インコーポレーテツド 偏光性ヒダントイン類
JPS57197217A (en) * 1981-05-13 1982-12-03 Ici Ltd Medicine for treating or preventing complication of diabetes or galactosemia, novel spiro-bonded pyrrolidin-2,5-dione and manufacture
JPS58213717A (ja) * 1982-01-20 1983-12-12 Eisai Co Ltd ヒダントイン誘導体を含有する治療用薬剤
JPH0451527B2 (fr) * 1982-01-20 1992-08-19 Eisai Co Ltd
JPS59500617A (ja) * 1982-04-15 1984-04-12 アルコン・ラボラトリ−ズ・インコ−ポレ−テッド ヒダントイン治療剤
JPH0251548B2 (fr) * 1982-12-06 1990-11-07 Pfizer
JPS59116274A (ja) * 1982-12-06 1984-07-05 フアイザ−・インコ−ポレ−テツド 糖尿病合併症治療用のスピロ−３−ヘテロ−アゾロン
JPS59205384A (ja) * 1983-04-27 1984-11-20 フアイザ−・インコ−ポレ−テツド ヒダントイン誘導体
JPS61109789A (ja) * 1984-10-30 1986-05-28 フアイザー・インコーポレーテツド スピロ‐ヘテロアゾロン化合物類
JPS61200991A (ja) * 1985-03-04 1986-09-05 Sanwa Kagaku Kenkyusho:Kk スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤
JPH0372226B2 (fr) * 1985-03-04 1991-11-18 Sanwa Kagaku Kenkyusho Co
JPS6357588A (ja) * 1986-08-28 1988-03-12 Sanwa Kagaku Kenkyusho Co Ltd ヒダントイン誘導体、その塩並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤
JPH0372227B2 (fr) * 1986-08-28 1991-11-18 Sanwa Kagaku Kenkyusho Co

Also Published As

Publication number Publication date
DK150302B (da) 1987-02-02
FR2367754A1 (fr) 1978-05-12
SE437024B (sv) 1985-02-04
AR220901A1 (es) 1980-12-15
NO773548L (no) 1978-04-19
DK461377A (da) 1978-04-19
MY8200157A (en) 1982-12-31
JPS5495570A (en) 1979-07-28
PT67164B (en) 1979-03-20
AU504978B2 (en) 1979-11-01
IL53094A0 (en) 1977-12-30
DE2759543C2 (fr) 1987-04-09
SE7711053L (sv) 1978-04-19
JPS5940388B2 (ja) 1984-09-29
IE45805B1 (en) 1982-12-01
DE2759542C2 (fr) 1988-07-07
YU244277A (en) 1982-08-31
ES463267A1 (es) 1978-07-16
JPS5495575A (en) 1979-07-28
DK150302C (da) 1987-09-28
DE2746244A1 (de) 1978-04-20
GR70201B (fr) 1982-08-31
BG28847A3 (en) 1980-07-15
YU40821B (en) 1986-06-30
MX4899E (es) 1982-12-14
DD131931A5 (de) 1978-08-09
HK53881A (en) 1981-11-13
CA1088945A (fr) 1980-11-04
NO148453C (no) 1983-10-12
ATA745977A (de) 1979-09-15
IE45805L (en) 1978-04-18
JPS5534132B2 (fr) 1980-09-04
CH625511A5 (en) 1981-09-30
LU78330A1 (fr) 1979-06-01
NO148453B (no) 1983-07-04
AT356136B (de) 1980-04-10
AU2943177A (en) 1979-04-12
PT67164A (en) 1977-11-01
NL167434C (nl) 1981-12-16
DE2746244C2 (de) 1983-05-19
FI773060A (fi) 1978-04-19
PH15639A (en) 1983-03-11
FR2367754B1 (fr) 1982-07-09
GB1566171A (en) 1980-04-30
NL167434B (nl) 1981-07-16
DE2759927C2 (de) 1986-12-04
NZ185358A (en) 1979-06-08
FI62307C (fi) 1982-12-10
KE3167A (en) 1981-11-06
JPS607997B2 (ja) 1985-02-28
NL7711358A (nl) 1978-04-20
FI62307B (fi) 1982-08-31

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