DE69018876T2 - Pyridazinon-Derivate. - Google Patents

Pyridazinon-Derivate.

Info

Publication number
DE69018876T2
DE69018876T2 DE69018876T DE69018876T DE69018876T2 DE 69018876 T2 DE69018876 T2 DE 69018876T2 DE 69018876 T DE69018876 T DE 69018876T DE 69018876 T DE69018876 T DE 69018876T DE 69018876 T2 DE69018876 T2 DE 69018876T2
Authority
DE
Germany
Prior art keywords
compounds
pyrido
pyridazine
oxo
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69018876T
Other languages
English (en)
Other versions
DE69018876D1 (de
Inventor
Banavara Lakshmana Mylari
William James Zembrowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of DE69018876D1 publication Critical patent/DE69018876D1/de
Publication of DE69018876T2 publication Critical patent/DE69018876T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
DE69018876T 1989-05-11 1990-05-10 Pyridazinon-Derivate. Expired - Fee Related DE69018876T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/350,417 US4996204A (en) 1989-05-11 1989-05-11 Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors

Publications (2)

Publication Number Publication Date
DE69018876D1 DE69018876D1 (de) 1995-06-01
DE69018876T2 true DE69018876T2 (de) 1995-08-24

Family

ID=23376622

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69018876T Expired - Fee Related DE69018876T2 (de) 1989-05-11 1990-05-10 Pyridazinon-Derivate.

Country Status (18)

Country Link
US (1) US4996204A (de)
EP (1) EP0401981B1 (de)
JP (1) JPH0631235B2 (de)
KR (1) KR920003559B1 (de)
AT (1) ATE121743T1 (de)
AU (1) AU611610B2 (de)
CA (1) CA2016326C (de)
DE (1) DE69018876T2 (de)
DK (1) DK0401981T3 (de)
ES (1) ES2071016T3 (de)
FI (1) FI93013C (de)
HU (1) HU206714B (de)
IE (1) IE66029B1 (de)
IL (1) IL94302A (de)
NO (1) NO173938C (de)
NZ (1) NZ233599A (de)
PT (1) PT93984B (de)
ZA (1) ZA903564B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954629A (en) * 1989-05-11 1990-09-04 Pfizer Inc. Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof
US5716954A (en) * 1991-10-09 1998-02-10 Syntex U.S.A. Inc. Benzopyridazinone and pyridopyridazinone compounds
JP2789134B2 (ja) * 1992-09-28 1998-08-20 ファイザー・インク． 糖尿病の合併症を制御する置換ピリミジン類
GB9314412D0 (en) * 1993-07-13 1993-08-25 Rhone Poulenc Agriculture New compositions of matter
JP3494990B2 (ja) 1998-03-31 2004-02-09 ザ インスティテューツ フォア ファーマスーティカル ディスカヴァリー エルエルシー 置換されたインドールアルカノール酸
TNSN99224A1 (fr) 1998-12-01 2005-11-10 Inst For Pharm Discovery Inc Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique
EE200300249A (et) * 2000-11-30 2003-10-15 Pfizer Products Inc. GABA agonistide ja aldoosreduktaasi inhibiitoritekombinatsioon
EP1236720B1 (de) 2001-02-28 2005-06-15 Pfizer Products Inc. Sulfonyl-pyridazinon-derivate zur verwendung als aldose-reduktase-inhibitoren
PT1373259E (pt) * 2001-03-30 2005-03-31 Pfizer Prod Inc Inibidores piridazinona de aldose reductase
AU2002236131B2 (en) * 2001-04-30 2005-04-14 Pfizer Products Inc. Combinations of aldose reductase inhibitors and cyclooxygenase-2 inhibitors
AU761191B2 (en) 2001-05-24 2003-05-29 Pfizer Products Inc. Therapies for tissue damage resulting from ischemia
US7572910B2 (en) * 2003-02-20 2009-08-11 Pfizer, Inc. Pyridazinone aldose reductase inhibitors
US8916563B2 (en) 2010-07-16 2014-12-23 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
CA2804640C (en) * 2010-07-16 2018-09-25 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
HUE052101T2 (hu) 2016-06-21 2021-04-28 Univ Columbia Aldóz reduktáz inhibitorok és ezek alkalmazása
CA3071114A1 (en) 2017-07-28 2019-01-31 Applied Therapeutics Inc. Compositions and methods for treating galactosemia

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
DE2708187A1 (de) * 1977-02-25 1978-08-31 Thomae Gmbh Dr K Neue pyrido-pyridazin-one
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
US4209527A (en) * 1979-05-16 1980-06-24 Pfizer Inc. Benzimidazolone derivatives
CA1160518A (en) * 1979-07-06 1984-01-17 E. I. Du Pont De Nemours And Company Coated cookware with fep topcoat
ES2032749T3 (es) * 1985-11-07 1993-03-01 Pfizer Inc. Acidos oxoftalazinil-aceticos heterociclicos.
US4954629A (en) * 1989-05-11 1990-09-04 Pfizer Inc. Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof

Also Published As

Publication number Publication date
DK0401981T3 (da) 1995-09-04
JPH035481A (ja) 1991-01-11
FI93013C (fi) 1995-02-10
KR920003559B1 (ko) 1992-05-04
NO902070L (no) 1990-11-12
NZ233599A (en) 1991-07-26
HU206714B (en) 1992-12-28
ZA903564B (en) 1992-08-26
JPH0631235B2 (ja) 1994-04-27
FI93013B (fi) 1994-10-31
NO173938C (no) 1994-02-23
FI902335A0 (fi) 1990-05-10
HUT54683A (en) 1991-03-28
IL94302A (en) 1994-01-25
IE901701L (en) 1990-11-11
KR900018092A (ko) 1990-12-20
EP0401981A1 (de) 1990-12-12
CA2016326C (en) 1995-05-30
CA2016326A1 (en) 1990-11-11
ATE121743T1 (de) 1995-05-15
NO173938B (no) 1993-11-15
IE66029B1 (en) 1995-11-29
ES2071016T3 (es) 1995-06-16
AU5490590A (en) 1990-11-15
US4996204A (en) 1991-02-26
PT93984B (pt) 1996-11-29
IL94302A0 (en) 1991-03-10
PT93984A (pt) 1991-01-08
AU611610B2 (en) 1991-06-13
DE69018876D1 (de) 1995-06-01
HU902996D0 (en) 1990-09-28
NO902070D0 (no) 1990-05-10
EP0401981B1 (de) 1995-04-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee