FR2392024A1 - Nouveaux isomeres dextrogyres de spiro-hydantoines asymetriques et compositions pharmaceutiques les contenant - Google Patents

Nouveaux isomeres dextrogyres de spiro-hydantoines asymetriques et compositions pharmaceutiques les contenant

Info

Publication number
FR2392024A1
FR2392024A1 FR7815032A FR7815032A FR2392024A1 FR 2392024 A1 FR2392024 A1 FR 2392024A1 FR 7815032 A FR7815032 A FR 7815032A FR 7815032 A FR7815032 A FR 7815032A FR 2392024 A1 FR2392024 A1 FR 2392024A1
Authority
FR
France
Prior art keywords
spiro
dextrogyre
asymetric
hydantoins
isomers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7815032A
Other languages
English (en)
Other versions
FR2392024B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of FR2392024A1 publication Critical patent/FR2392024A1/fr
Application granted granted Critical
Publication of FR2392024B1 publication Critical patent/FR2392024B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

L'invention a trait au domaine de la chimie médicale. Elle concerne plusieurs nouveaux composés dextrogyres de spiro-hydantoïne obtenus par dédoublement des composés dl correspondants initialement formés par synthèse en condensant tout d'abord le composé cyclique carbonylique tel que la 4-chromanone ou la thiochromane-4-one correspondante, selon le cas, avec le cyanure de potassium et le carbonate d'ammonium. Les dérivés optiquement actifs d'hydantoïne ainsi obtenus tels que la d-6-fluoro-spiro- Øchromane-4,4'-imidazolidineõ- 2'-5'-dione et la d-6'-fluoro-spiro- Øimidazolidine-4,4'-thio-chromateõ-2,5-dione, sont particulièrement intéressants à utiliser pour prévenir ou combattre des complications chroniques du diabète.
FR7815032A 1977-05-23 1978-05-22 Nouveaux isomeres dextrogyres de spiro-hydantoines asymetriques et compositions pharmaceutiques les contenant Granted FR2392024A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/799,586 US4130714A (en) 1977-05-23 1977-05-23 Hydantoin therapeutic agents

Publications (2)

Publication Number Publication Date
FR2392024A1 true FR2392024A1 (fr) 1978-12-22
FR2392024B1 FR2392024B1 (fr) 1981-07-24

Family

ID=25176274

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7815032A Granted FR2392024A1 (fr) 1977-05-23 1978-05-22 Nouveaux isomeres dextrogyres de spiro-hydantoines asymetriques et compositions pharmaceutiques les contenant

Country Status (37)

Country Link
US (1) US4130714A (fr)
JP (1) JPS6035350B2 (fr)
AR (1) AR219531A1 (fr)
AT (1) AT357170B (fr)
AU (1) AU499518B1 (fr)
BE (1) BE867248A (fr)
CA (1) CA1088073A (fr)
CH (1) CH631455A5 (fr)
CS (1) CS200550B2 (fr)
DD (1) DD137107A5 (fr)
DE (2) DE2858042C2 (fr)
DK (1) DK147941C (fr)
EG (1) EG13691A (fr)
ES (1) ES470070A1 (fr)
FI (1) FI62838C (fr)
FR (1) FR2392024A1 (fr)
GB (1) GB1572688A (fr)
GR (1) GR68694B (fr)
HK (1) HK53981A (fr)
HU (1) HU177718B (fr)
IE (1) IE47273B1 (fr)
IL (1) IL54754A (fr)
IN (1) IN147854B (fr)
IT (1) IT1096306B (fr)
KE (1) KE3168A (fr)
LU (1) LU79685A1 (fr)
MY (1) MY8200156A (fr)
NL (1) NL7804158A (fr)
NO (1) NO150206C (fr)
NZ (1) NZ187334A (fr)
PH (1) PH13828A (fr)
PL (1) PL110460B1 (fr)
PT (1) PT68071B (fr)
SE (1) SE437375B (fr)
SU (1) SU873885A3 (fr)
YU (1) YU40829B (fr)
ZA (1) ZA782919B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2367754A1 (fr) * 1976-10-18 1978-05-12 Pfizer Nouveaux derives d'hydantoine et composition pharmaceutique les contenant
FR2487353A1 (fr) * 1980-07-21 1982-01-29 Eisai Co Ltd Derives d'hydantoine, leur procede de preparation et leur application therapeutique

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4181728A (en) * 1978-11-16 1980-01-01 Pfizer Inc. Spiro-polycyclicimidazolidinedione derivatives
US4181729A (en) * 1979-03-21 1980-01-01 Pfizer Inc. Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
US4210667A (en) * 1979-04-19 1980-07-01 Pfizer Inc. Pharmaceutical preparations containing coumarin carboxylic acid derivatives
IE50332B1 (en) * 1979-11-13 1986-04-02 Ici Ltd 1'-substituted-spiro(imidazolidine-4,3'-indoline)-2,2',5-triones,processes for their manufacture and pharmaceutical compositions thereof
US4248882A (en) * 1980-02-12 1981-02-03 Pfizer Inc. Treating diabetes-associated complications with hydantoin amines
US4286098A (en) * 1980-03-28 1981-08-25 Pfizer Inc. Process for the preparation of chiral hydantoins
US4419521A (en) * 1981-11-12 1983-12-06 Pfizer Inc. 6-Halo-4-chromanamines useful as intermediates to make chiral hydantoins
JPS58124788A (ja) * 1982-01-20 1983-07-25 Eisai Co Ltd 光学活性ヒダントイン誘導体，その製造方法ならびにそれを含有する治療用薬剤
US4464385A (en) * 1982-04-15 1984-08-07 Alcon Laboratories, Inc. Treatment of diabetic complications with hydantoins
US4540700A (en) * 1982-04-15 1985-09-10 Alcon Laboratories, Inc. Treatment of diabetic complications with certain spiro-imidazolidine-diones
US4438272A (en) 1982-04-15 1984-03-20 Alcon Laboratories, Inc. Spiro-(fluoren-9,4'-imidazolidine)-2',5'-diones
US4436745A (en) 1982-04-15 1984-03-13 Alcon Laboratories, Inc. Method of inhibiting aldose reductase activity
US4431828A (en) * 1982-11-10 1984-02-14 Pfizer Inc. Regeneration of 6-fluoro-4-chromanone from by-products in the synthesis of sorbinil
US4528387A (en) * 1982-11-10 1985-07-09 Pfizer Inc. Sorbinil by optical resolution of precursor 6-fluoro-4-ureidochroman-4-carboxylic acid
US4556670A (en) * 1982-12-06 1985-12-03 Pfizer Inc. Spiro-3-hetero-azolones for treatment of diabetic complications
US4474967A (en) * 1983-04-27 1984-10-02 Pfizer Inc. 8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione
US5153211A (en) * 1983-09-14 1992-10-06 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
US4537892A (en) * 1983-09-14 1985-08-27 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
EP0159143B1 (fr) * 1984-03-23 1987-12-16 Pfizer Inc. Spiro-indènes et spiro-dihydro-1,2-naphtalènes pour le traitement de complications diabétiques
US4717725A (en) * 1984-04-11 1988-01-05 Alcon Laboratories, Inc. Ophthalmic wound healing with aldose reductase inhibitors
US4600717A (en) * 1984-04-11 1986-07-15 Alcon Laboratories, Inc. Aldose reductase inhibitors useful in ophthalmic wound healing
JPH06772B2 (ja) * 1984-07-09 1994-01-05 鐘淵化学工業株式会社 ３―（４―フルオロフエノキシ）プロピオニトリルを用いる６―フルオロ―４―クロマノンの製造法
WO1986000807A1 (fr) * 1984-07-20 1986-02-13 Pfizer Inc. Spiro-imidazolones pour le traitement des complications a la suite de diabete
US4656169A (en) * 1984-08-14 1987-04-07 Pfizer Inc. Tetracyclic spiro-hydantoin aldose reductase inhibitors and compositions
ATE37371T1 (de) * 1984-08-20 1988-10-15 Pfizer Verfahren zur herstellung asymmetrischer hydantoine.
US4620019A (en) * 1984-08-23 1986-10-28 Pfizer Inc. S-6-fluoro-4-aminochroman-4-carboxylic acid derivatives useful as intermediates for sorbinil
US4609663A (en) * 1984-09-11 1986-09-02 Alcon Laboratories, Inc. Aldose reductase inhibitors useful in glaucoma therapy
US4551542A (en) * 1984-09-26 1985-11-05 Pfizer Inc. Regeneration of 6-fluoro-4-chromanone from 6-fluoro-4-ureidochroman-4-carboxylic acid
US5340829A (en) * 1984-11-20 1994-08-23 Washington Research Foundation Immunoregulatory agents
US4966911A (en) * 1984-11-20 1990-10-30 Washington Research Foundation Immunoregulatory agents
JPS61200991A (ja) * 1985-03-04 1986-09-05 Sanwa Kagaku Kenkyusho:Kk スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤
WO1986007353A1 (fr) 1985-06-14 1986-12-18 Pfizer Inc. Produit intermediaire utilise dans la producton d'hydantoines asymetriques
JPS627654U (fr) * 1985-06-26 1987-01-17
WO1987004344A1 (fr) * 1986-01-17 1987-07-30 Pfizer Inc. Derives de l'acide hydroxyacetique pour le traitement de complications diabetiques
JPS6357588A (ja) * 1986-08-28 1988-03-12 Sanwa Kagaku Kenkyusho Co Ltd ヒダントイン誘導体、その塩並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤
CA1310269C (fr) * 1987-03-20 1992-11-17 Billie M. York, Jr. Utilisation d'inhibiteurs de la reductase de l'aldose pour accroitre la sensibilite a l'insuline dans le diabete sucre
US4841079A (en) * 1987-08-07 1989-06-20 Pfizer, Inc. Process for the production of asymmetric hydantoins
US4952694A (en) * 1988-07-27 1990-08-28 Pfizer Inc. Novel resolution process for racemic spiro-hydantoins
US5006657A (en) * 1988-07-27 1991-04-09 Pfizer Inc. Intermediates in a resolution process for racemic spiro hydantoins
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
JPH05508386A (ja) * 1989-02-10 1993-11-25 ワシントン　リサーチ　ファンデション 免疫調整剤
US4980357A (en) * 1990-03-01 1990-12-25 Pfizer Inc. Azolidinedione derivatives
US5039672A (en) * 1990-04-05 1991-08-13 Pfizer Inc. Heterocyclic compounds as aldose reductase inhibitors
US5236945A (en) * 1990-06-11 1993-08-17 Pfizer Inc. 1H-indazole-3-acetic acids as aldose reductase inhibitors
US5206367A (en) * 1992-02-18 1993-04-27 Pfizer Inc. Preparation of optically active spiro-hydantoins
WO1994007867A1 (fr) * 1992-09-28 1994-04-14 Pfizer Inc. Pyrimidines substituees pour le controle des complications diabetiques
US5521208A (en) * 1993-07-29 1996-05-28 Alcon Laboratories, Inc. Compositions and methods for the treatment of the metabolically impaired and for improved compliance
KR100891756B1 (ko) * 1997-04-15 2009-04-07 씨에스아이알 식욕 억제 활성을 갖는 약학 조성물
GB2396815B (en) * 1999-10-27 2004-09-08 Phytopharm Plc A composition comprising a pregnenone derivative and an NSAID
GB2363985B (en) * 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
IL155710A0 (en) 2000-11-30 2003-11-23 Pfizer Prod Inc Combination of gaba agonists and aldose reductase inhibitors
US20110092566A1 (en) * 2004-11-19 2011-04-21 Srivastava Satish K Treatment of cancer with aldose reductase inhibitors
US8158667B2 (en) 2006-08-21 2012-04-17 Kador Peter F Topical treatment of cataracts in dogs
ATE518544T1 (de) 2007-03-12 2011-08-15 Zadec Aps Rotbusch-extrakt gegen diabetes
WO2008118844A1 (fr) 2007-03-23 2008-10-02 The Board Of Regents Of The University Of Texas System Procédés engageant des inhibiteurs d'aldose réductase
US20090270490A1 (en) * 2008-04-24 2009-10-29 The Board Of Regents Of The University Of Texas System Methods involving aldose reductase inhibition
CA2822672C (fr) 2010-12-23 2018-06-05 The Board Of Regents Of The University Of Texas System Methodes de traitement de copd
UA118035C2 (uk) * 2013-10-07 2018-11-12 Сінгента Партісіпейшнс Аг Гербіцидні сполуки

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1135915B (de) * 1961-06-29 1962-09-06 Asta Werke Ag Chem Fab Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine
FR2367754A1 (fr) * 1976-10-18 1978-05-12 Pfizer Nouveaux derives d'hydantoine et composition pharmaceutique les contenant

Family Cites Families (1)

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US2683718A (en) * 1952-01-11 1954-07-13 Searle & Co Spiro-[xanthene-9, 4'-imidazolidine]-2, 5-dione

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1135915B (de) * 1961-06-29 1962-09-06 Asta Werke Ag Chem Fab Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine
FR2367754A1 (fr) * 1976-10-18 1978-05-12 Pfizer Nouveaux derives d'hydantoine et composition pharmaceutique les contenant

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2367754A1 (fr) * 1976-10-18 1978-05-12 Pfizer Nouveaux derives d'hydantoine et composition pharmaceutique les contenant
FR2487353A1 (fr) * 1980-07-21 1982-01-29 Eisai Co Ltd Derives d'hydantoine, leur procede de preparation et leur application therapeutique

Also Published As

Publication number Publication date
ATA365378A (de) 1979-11-15
NO150206C (no) 1984-09-05
BE867248A (fr) 1978-11-20
PT68071A (en) 1978-06-01
DD137107A5 (de) 1979-08-15
SE7803626L (sv) 1978-11-24
AU499518B1 (en) 1979-04-26
HU177718B (en) 1981-12-28
FI62838B (fi) 1982-11-30
AT357170B (de) 1980-06-25
DE2821966A1 (de) 1978-11-30
DK147941B (da) 1985-01-14
LU79685A1 (fr) 1979-12-06
FI781613A (fi) 1978-11-24
DK147941C (da) 1985-08-26
ES470070A1 (es) 1979-01-01
NO781769L (no) 1978-11-24
IN147854B (fr) 1980-07-19
NZ187334A (en) 1984-04-27
MY8200156A (en) 1982-12-31
PH13828A (en) 1980-10-07
DK226778A (da) 1978-11-24
GB1572688A (en) 1980-07-30
SU873885A3 (ru) 1981-10-15
HK53981A (en) 1981-11-13
EG13691A (en) 1982-12-31
AR219531A1 (es) 1980-08-29
DE2858042C2 (de) 1983-11-24
KE3168A (en) 1981-11-06
CS200550B2 (en) 1980-09-15
FI62838C (fi) 1983-03-10
JPS6035350B2 (ja) 1985-08-14
IT1096306B (it) 1985-08-26
US4130714A (en) 1978-12-19
PT68071B (en) 1979-10-26
CH631455A5 (fr) 1982-08-13
SE437375B (sv) 1985-02-25
IL54754A (en) 1982-04-30
IL54754A0 (en) 1978-07-31
CA1088073A (fr) 1980-10-21
JPS53144575A (en) 1978-12-15
PL110460B1 (en) 1980-07-31
NL7804158A (nl) 1978-11-27
IE47273B1 (en) 1984-02-08
IT7823672A0 (it) 1978-05-22
YU40829B (en) 1986-06-30
DE2821966C2 (de) 1983-06-01
FR2392024B1 (fr) 1981-07-24
ZA782919B (en) 1979-06-27
IE781015L (en) 1978-11-23
GR68694B (fr) 1982-02-01
YU116978A (en) 1983-02-28
PL206826A1 (pl) 1979-04-23
NO150206B (no) 1984-05-28

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