SE0100902D0 - Compounds - Google Patents
CompoundsInfo
- Publication number
- SE0100902D0 SE0100902D0 SE0100902A SE0100902A SE0100902D0 SE 0100902 D0 SE0100902 D0 SE 0100902D0 SE 0100902 A SE0100902 A SE 0100902A SE 0100902 A SE0100902 A SE 0100902A SE 0100902 D0 SE0100902 D0 SE 0100902D0
- Authority
- SE
- Sweden
- Prior art keywords
- compounds
- inhibitors
- mmp12
- useful
- formula
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- C07D233/78—Radicals substituted by oxygen atoms
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
Priority Applications (117)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0100902A SE0100902D0 (sv) | 2001-03-15 | 2001-03-15 | Compounds |
DK02704031T DK1370556T3 (da) | 2001-03-15 | 2002-03-13 | Metalloproteinaseinhibitorer |
RU2003127735/04A RU2293729C2 (ru) | 2001-03-15 | 2002-03-13 | Ингибиторы металлопротеиназ, их применение и фармацевтические композиции на их основе |
CNB02810093XA CN1269804C (zh) | 2001-03-15 | 2002-03-13 | 金属蛋白酶抑制剂 |
MXPA03008181A MXPA03008181A (es) | 2001-03-15 | 2002-03-13 | Inhibidores de metaloproteinasa. |
US10/471,900 US7427631B2 (en) | 2001-03-15 | 2002-03-13 | Metalloproteinase inhibitors |
SK1096-2003A SK287766B6 (sk) | 2001-03-15 | 2002-03-13 | Metaloproteinázové inhibítory |
AU2002237626A AU2002237626B2 (en) | 2001-03-15 | 2002-03-13 | Metalloproteinase inhibitors |
PCT/SE2002/000478 WO2002074751A1 (en) | 2001-03-15 | 2002-03-13 | Metalloproteinase inhibitors |
AT02704037T ATE484496T1 (de) | 2001-03-15 | 2002-03-13 | Metalloproteinaseinhibitoren |
UA2003098168A UA77408C2 (en) | 2001-03-15 | 2002-03-13 | Metalloproteinase inhibitors, pharmaceutical composition on its base, and use thereof |
PT02704031T PT1370556E (pt) | 2001-03-15 | 2002-03-13 | Inibidores de metaloproteinases |
NZ528140A NZ528140A (en) | 2001-03-15 | 2002-03-13 | Metalloproteinase inhibitors |
CNB02809915XA CN100526307C (zh) | 2001-03-15 | 2002-03-13 | 金属蛋白酶抑制剂 |
KR10-2003-7011982A KR20030082987A (ko) | 2001-03-15 | 2002-03-13 | 메탈로프로테이나제 억제제 |
MXPA03008180A MXPA03008180A (es) | 2001-03-15 | 2002-03-13 | Inhibidores de metaloproteinasa. |
EEP200300445A EE05431B1 (et) | 2001-03-15 | 2002-03-13 | Metalloproteinaasi inhibiitorid |
AT02704031T ATE333454T1 (de) | 2001-03-15 | 2002-03-13 | Metalloproteinaseinhibitoren |
IL15765602A IL157656A0 (en) | 2001-03-15 | 2002-03-13 | Metalloproteinase inhibitors |
US10/471,808 US20040147573A1 (en) | 2001-03-15 | 2002-03-13 | Metalloproteinase inhibitors |
PL02364714A PL364714A1 (en) | 2001-03-15 | 2002-03-13 | Metalloproteinase inhibitors |
CZ20032497A CZ20032497A3 (cs) | 2001-03-15 | 2002-03-13 | Inhibitory metalloproteinasy |
PL02364707A PL364707A1 (en) | 2001-03-15 | 2002-03-13 | Metalloproteinase inhibitors |
PL364706A PL205315B1 (pl) | 2001-03-15 | 2002-03-13 | Pochodne imidazolidynodionu, środek farmaceutyczny i zastosowanie tych pochodnych |
EEP200300451A EE05364B1 (et) | 2001-03-15 | 2002-03-13 | Metalloproteinaasi inhibiitorid |
HU0400194A HUP0400194A3 (en) | 2001-03-15 | 2002-03-13 | Imidazolidindion derivatives as metalloproteinase inhibitors, their use and pharmaceutical compositions containing them |
CA002440631A CA2440631A1 (en) | 2001-03-15 | 2002-03-13 | Metalloproteinase inhibitors |
EP06008158A EP1676846B1 (en) | 2001-03-15 | 2002-03-13 | Hydantoin derivatives as MMP inhibitors |
CA2440473A CA2440473C (en) | 2001-03-15 | 2002-03-13 | Metalloproteinase inhibitors |
MXPA03008177A MXPA03008177A (es) | 2001-03-15 | 2002-03-13 | Inhibidores de metaloproteinasa.. |
PCT/SE2002/000473 WO2002074748A1 (en) | 2001-03-15 | 2002-03-13 | Metalloproteinase inhibitors |
AT06008158T ATE493406T1 (de) | 2001-03-15 | 2002-03-13 | Hydantoinderivate als mmp-inhibitoren |
KR10-2003-7011981A KR20030082986A (ko) | 2001-03-15 | 2002-03-13 | 메탈로프로테이나제 억제제 |
IL15765702A IL157657A0 (en) | 2001-03-15 | 2002-03-13 | Metalloproteinase inhibitors |
EEP200300449A EE200300449A (et) | 2001-03-15 | 2002-03-13 | Metalloproteinaasi inhibiitorid |
DE60237965T DE60237965D1 (en) | 2001-03-15 | 2002-03-13 | Metalloproteinaseinhibitoren |
PCT/SE2002/000472 WO2002074767A1 (en) | 2001-03-15 | 2002-03-13 | Metalloproteinase inhibitors |
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CN2006101061525A CN1962641B (zh) | 2001-03-15 | 2002-03-13 | 金属蛋白酶抑制剂 |
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