SE0100902D0 - Compounds - Google Patents

Compounds

Info

Publication number
SE0100902D0
SE0100902D0 SE0100902A SE0100902A SE0100902D0 SE 0100902 D0 SE0100902 D0 SE 0100902D0 SE 0100902 A SE0100902 A SE 0100902A SE 0100902 A SE0100902 A SE 0100902A SE 0100902 D0 SE0100902 D0 SE 0100902D0
Authority
SE
Sweden
Prior art keywords
compounds
inhibitors
mmp12
useful
formula
Prior art date
Application number
SE0100902A
Other languages
English (en)
Swedish (sv)
Inventor
Anders Eriksson
Matti Lepistoe
Michael Lundkvist
Af Rosenschoeld Magnus Munck
Pavol Zlatoidsky
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to SE0100902A priority Critical patent/SE0100902D0/xx
Publication of SE0100902D0 publication Critical patent/SE0100902D0/xx
Priority to EEP200300449A priority patent/EE200300449A/xx
Priority to EP02704034A priority patent/EP1370536A1/en
Priority to DK02704031T priority patent/DK1370556T3/da
Priority to CZ20032497A priority patent/CZ20032497A3/cs
Priority to NZ528140A priority patent/NZ528140A/en
Priority to HU0400194A priority patent/HUP0400194A3/hu
Priority to SK1095-2003A priority patent/SK10952003A3/sk
Priority to EP06008158A priority patent/EP1676846B1/en
Priority to SK1093-2003A priority patent/SK10932003A3/sk
Priority to JP2002573776A priority patent/JP2004527515A/ja
Priority to UA2003098170A priority patent/UA77667C2/uk
Priority to PCT/SE2002/000475 priority patent/WO2002074750A1/en
Priority to UA2003098171A priority patent/UA78502C2/uk
Priority to KR10-2003-7011989A priority patent/KR20030082990A/ko
Priority to EP02704031A priority patent/EP1370556B1/en
Priority to CZ20032502A priority patent/CZ20032502A3/cs
Priority to RU2003127735/04A priority patent/RU2293729C2/ru
Priority to EP02704037A priority patent/EP1370537B1/en
Priority to US10/471,900 priority patent/US7427631B2/en
Priority to IL15765602A priority patent/IL157656A0/xx
Priority to MXPA03008181A priority patent/MXPA03008181A/es
Priority to BR0207983-6A priority patent/BR0207983A/pt
Priority to IL15765702A priority patent/IL157657A0/xx
Priority to NZ528106A priority patent/NZ528106A/en
Priority to ES02704037T priority patent/ES2352246T3/es
Priority to AT02704037T priority patent/ATE484496T1/de
Priority to MXPA03008180A priority patent/MXPA03008180A/es
Priority to PCT/SE2002/000478 priority patent/WO2002074751A1/en
Priority to DE60237965T priority patent/DE60237965D1/de
Priority to BR0208105-9A priority patent/BR0208105A/pt
Priority to CN2006101061525A priority patent/CN1962641B/zh
Priority to CZ20032499A priority patent/CZ20032499A3/cs
Priority to NZ528107A priority patent/NZ528107A/en
Priority to MXPA03008191A priority patent/MXPA03008191A/es
Priority to AU2002237632A priority patent/AU2002237632B2/en
Priority to CA002440632A priority patent/CA2440632A1/en
Priority to ES06008158T priority patent/ES2357138T3/es
Priority to EP02704032A priority patent/EP1370534A1/en
Priority to EEP200300439A priority patent/EE200300439A/xx
Priority to KR10-2003-7011982A priority patent/KR20030082987A/ko
Priority to RU2003127733/04A priority patent/RU2285695C2/ru
Priority to CNA028100417A priority patent/CN1509275A/zh
Priority to US10/471,500 priority patent/US20040106659A1/en
Priority to US10/471,810 priority patent/US7368465B2/en
Priority to CA2440630A priority patent/CA2440630C/en
Priority to CNB02810093XA priority patent/CN1269804C/zh
Priority to RU2003127734/04A priority patent/RU2288228C2/ru
Priority to SK1096-2003A priority patent/SK287766B6/sk
Priority to JP2002573759A priority patent/JP2004527511A/ja
Priority to AT06008158T priority patent/ATE493406T1/de
Priority to RU2003127732/04A priority patent/RU2003127732A/ru
Priority to CNB02809915XA priority patent/CN100526307C/zh
Priority to PT02704031T priority patent/PT1370556E/pt
Priority to KR1020037011987A priority patent/KR100886315B1/ko
Priority to CNB028097882A priority patent/CN1304377C/zh
Priority to MXPA03008177A priority patent/MXPA03008177A/es
Priority to IL15757002A priority patent/IL157570A0/xx
Priority to BR0208104-0A priority patent/BR0208104A/pt
Priority to EEP200300451A priority patent/EE05364B1/xx
Priority to BR0207984-4A priority patent/BR0207984A/pt
Priority to EEP200300445A priority patent/EE05431B1/xx
Priority to SI200230386T priority patent/SI1370556T1/sl
Priority to JP2002573760A priority patent/JP4390457B2/ja
Priority to PL02364707A priority patent/PL364707A1/xx
Priority to PCT/SE2002/000473 priority patent/WO2002074748A1/en
Priority to MYPI20020910A priority patent/MY136789A/en
Priority to AT02704031T priority patent/ATE333454T1/de
Priority to CNA200910147512XA priority patent/CN101602731A/zh
Priority to PL02364714A priority patent/PL364714A1/xx
Priority to DE60213216T priority patent/DE60213216T2/de
Priority to SK1092-2003A priority patent/SK287834B6/sk
Priority to CA002440631A priority patent/CA2440631A1/en
Priority to MYPI20020904A priority patent/MY136141A/en
Priority to KR10-2003-7011981A priority patent/KR20030082986A/ko
Priority to PL02365099A priority patent/PL365099A1/xx
Priority to US10/471,808 priority patent/US20040147573A1/en
Priority to UA2003098168A priority patent/UA77408C2/uk
Priority to CA2440473A priority patent/CA2440473C/en
Priority to HU0400327A priority patent/HUP0400327A3/hu
Priority to ES02704031T priority patent/ES2267986T3/es
Priority to PCT/SE2002/000472 priority patent/WO2002074767A1/en
Priority to AU2002237626A priority patent/AU2002237626B2/en
Priority to CZ20032500A priority patent/CZ20032500A3/cs
Priority to HU0400202A priority patent/HUP0400202A3/hu
Priority to JP2002573757A priority patent/JP2004523581A/ja
Priority to IL15765202A priority patent/IL157652A0/xx
Priority to HU0400206A priority patent/HUP0400206A3/hu
Priority to KR1020087017665A priority patent/KR100879905B1/ko
Priority to DE60238794T priority patent/DE60238794D1/de
Priority to PL364706A priority patent/PL205315B1/pl
Priority to ARP020100944A priority patent/AR035443A1/es
Priority to ARP020100943A priority patent/AR035695A1/es
Priority to ZA200306731A priority patent/ZA200306731B/en
Priority to ZA200306734A priority patent/ZA200306734B/en
Priority to ZA200306732A priority patent/ZA200306732B/en
Priority to IL157656A priority patent/IL157656A/en
Priority to IL157652A priority patent/IL157652A/en
Priority to ZA200306737A priority patent/ZA200306737B/en
Priority to IS6942A priority patent/IS6942A/is
Priority to IS6943A priority patent/IS6943A/is
Priority to IS6946A priority patent/IS6946A/is
Priority to IS6944A priority patent/IS6944A/is
Priority to NO20034025A priority patent/NO20034025L/no
Priority to NO20034044A priority patent/NO20034044L/no
Priority to NO20034045A priority patent/NO327114B1/no
Priority to NO20034042A priority patent/NO326087B1/no
Priority to HK04102796A priority patent/HK1059932A1/xx
Priority to HK06112181.8A priority patent/HK1091492A1/xx
Priority to HK04102888.7A priority patent/HK1060121A1/xx
Priority to CY20061101477T priority patent/CY1107525T1/el
Priority to US11/928,040 priority patent/US7625934B2/en
Priority to US12/114,901 priority patent/US7666892B2/en
Priority to US12/115,785 priority patent/US7754750B2/en
Priority to JP2009256358A priority patent/JP5140058B2/ja
Priority to US12/693,852 priority patent/US8153673B2/en
Priority to US12/830,763 priority patent/US20110003853A1/en

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72Two oxygen atoms, e.g. hydantoin
    • C07D233/76Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78Radicals substituted by oxygen atoms
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    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72Two oxygen atoms, e.g. hydantoin
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    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07ORGANIC CHEMISTRY
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    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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SE0100902A 2001-03-15 2001-03-15 Compounds SE0100902D0 (sv)

Priority Applications (117)

Application Number Priority Date Filing Date Title
SE0100902A SE0100902D0 (sv) 2001-03-15 2001-03-15 Compounds
EEP200300449A EE200300449A (et) 2001-03-15 2002-03-13 Metalloproteinaasi inhibiitorid
EP02704034A EP1370536A1 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
DK02704031T DK1370556T3 (da) 2001-03-15 2002-03-13 Metalloproteinaseinhibitorer
CZ20032497A CZ20032497A3 (cs) 2001-03-15 2002-03-13 Inhibitory metalloproteinasy
NZ528140A NZ528140A (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
HU0400194A HUP0400194A3 (en) 2001-03-15 2002-03-13 Imidazolidindion derivatives as metalloproteinase inhibitors, their use and pharmaceutical compositions containing them
SK1095-2003A SK10952003A3 (sk) 2001-03-15 2002-03-13 Metaloproteinázové inhibítory
EP06008158A EP1676846B1 (en) 2001-03-15 2002-03-13 Hydantoin derivatives as MMP inhibitors
SK1093-2003A SK10932003A3 (sk) 2001-03-15 2002-03-13 Metaloproteinázové inhibítory
JP2002573776A JP2004527515A (ja) 2001-03-15 2002-03-13 メタロプロテイナーゼ阻害剤
UA2003098170A UA77667C2 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors, pharmaceutical composition and use thereof
PCT/SE2002/000475 WO2002074750A1 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
UA2003098171A UA78502C2 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors, use thereof, and pharmaceutical composition based thereon
KR10-2003-7011989A KR20030082990A (ko) 2001-03-15 2002-03-13 메탈로프로테이나제 억제제
EP02704031A EP1370556B1 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
CZ20032502A CZ20032502A3 (cs) 2001-03-15 2002-03-13 Inhibitory metalloproteinasy
RU2003127735/04A RU2293729C2 (ru) 2001-03-15 2002-03-13 Ингибиторы металлопротеиназ, их применение и фармацевтические композиции на их основе
EP02704037A EP1370537B1 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
US10/471,900 US7427631B2 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
IL15765602A IL157656A0 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
MXPA03008181A MXPA03008181A (es) 2001-03-15 2002-03-13 Inhibidores de metaloproteinasa.
BR0207983-6A BR0207983A (pt) 2001-03-15 2002-03-13 Inibidores de metaloproteinase
IL15765702A IL157657A0 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
NZ528106A NZ528106A (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
ES02704037T ES2352246T3 (es) 2001-03-15 2002-03-13 Inhibidores de metaloproteinasas.
AT02704037T ATE484496T1 (de) 2001-03-15 2002-03-13 Metalloproteinaseinhibitoren
MXPA03008180A MXPA03008180A (es) 2001-03-15 2002-03-13 Inhibidores de metaloproteinasa.
PCT/SE2002/000478 WO2002074751A1 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
DE60237965T DE60237965D1 (en) 2001-03-15 2002-03-13 Metalloproteinaseinhibitoren
BR0208105-9A BR0208105A (pt) 2001-03-15 2002-03-13 Inibidores de metaloproteinase
CN2006101061525A CN1962641B (zh) 2001-03-15 2002-03-13 金属蛋白酶抑制剂
CZ20032499A CZ20032499A3 (cs) 2001-03-15 2002-03-13 Inhibitory metaloproteinasy
NZ528107A NZ528107A (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
MXPA03008191A MXPA03008191A (es) 2001-03-15 2002-03-13 Inhibidores de metaloproteinasa.
AU2002237632A AU2002237632B2 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
CA002440632A CA2440632A1 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
ES06008158T ES2357138T3 (es) 2001-03-15 2002-03-13 Derivados de hidantoína como inhibidores de mmp.
EP02704032A EP1370534A1 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
EEP200300439A EE200300439A (et) 2001-03-15 2002-03-13 Metalloproteinaasi inhibiitorid
KR10-2003-7011982A KR20030082987A (ko) 2001-03-15 2002-03-13 메탈로프로테이나제 억제제
RU2003127733/04A RU2285695C2 (ru) 2001-03-15 2002-03-13 Производные имидазолидин-2,4-диона, содержащие их фармацевтические композиции и их применение
CNA028100417A CN1509275A (zh) 2001-03-15 2002-03-13 金属蛋白酶抑制剂
US10/471,500 US20040106659A1 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
US10/471,810 US7368465B2 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
CA2440630A CA2440630C (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
CNB02810093XA CN1269804C (zh) 2001-03-15 2002-03-13 金属蛋白酶抑制剂
RU2003127734/04A RU2288228C2 (ru) 2001-03-15 2002-03-13 Ингибиторы металлопротеиназ, их применение и фармацевтические композиции на их основе
SK1096-2003A SK287766B6 (sk) 2001-03-15 2002-03-13 Metaloproteinázové inhibítory
JP2002573759A JP2004527511A (ja) 2001-03-15 2002-03-13 メタロプロテイナーゼ阻害剤
AT06008158T ATE493406T1 (de) 2001-03-15 2002-03-13 Hydantoinderivate als mmp-inhibitoren
RU2003127732/04A RU2003127732A (ru) 2001-03-15 2002-03-13 Ингибиторы металлопротеиназ
CNB02809915XA CN100526307C (zh) 2001-03-15 2002-03-13 金属蛋白酶抑制剂
PT02704031T PT1370556E (pt) 2001-03-15 2002-03-13 Inibidores de metaloproteinases
KR1020037011987A KR100886315B1 (ko) 2001-03-15 2002-03-13 메탈로프로테이나제 억제제
CNB028097882A CN1304377C (zh) 2001-03-15 2002-03-13 金属蛋白酶抑制剂
MXPA03008177A MXPA03008177A (es) 2001-03-15 2002-03-13 Inhibidores de metaloproteinasa..
IL15757002A IL157570A0 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
BR0208104-0A BR0208104A (pt) 2001-03-15 2002-03-13 Inibidores de metaloproteinase
EEP200300451A EE05364B1 (et) 2001-03-15 2002-03-13 Metalloproteinaasi inhibiitorid
BR0207984-4A BR0207984A (pt) 2001-03-15 2002-03-13 Inibidores de metaloproteinase
EEP200300445A EE05431B1 (et) 2001-03-15 2002-03-13 Metalloproteinaasi inhibiitorid
SI200230386T SI1370556T1 (sl) 2001-03-15 2002-03-13 Metaloproteinazni inhibitorji
JP2002573760A JP4390457B2 (ja) 2001-03-15 2002-03-13 メタロプロテイナーゼ阻害剤
PL02364707A PL364707A1 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
PCT/SE2002/000473 WO2002074748A1 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
MYPI20020910A MY136789A (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
AT02704031T ATE333454T1 (de) 2001-03-15 2002-03-13 Metalloproteinaseinhibitoren
CNA200910147512XA CN101602731A (zh) 2001-03-15 2002-03-13 金属蛋白酶抑制剂
PL02364714A PL364714A1 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
DE60213216T DE60213216T2 (de) 2001-03-15 2002-03-13 Metalloproteinaseinhibitoren
SK1092-2003A SK287834B6 (sk) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
CA002440631A CA2440631A1 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
MYPI20020904A MY136141A (en) 2001-03-15 2002-03-13 Novel hydantoin derivatives and pharmaceutical compositions useful as metalloproteinase inhibitors
KR10-2003-7011981A KR20030082986A (ko) 2001-03-15 2002-03-13 메탈로프로테이나제 억제제
PL02365099A PL365099A1 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
US10/471,808 US20040147573A1 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
UA2003098168A UA77408C2 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors, pharmaceutical composition on its base, and use thereof
CA2440473A CA2440473C (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
HU0400327A HUP0400327A3 (en) 2001-03-15 2002-03-13 Azole derivatives having metalloproteinase inhibitor effect pharmaceutical compositions containing them and their use
ES02704031T ES2267986T3 (es) 2001-03-15 2002-03-13 Inhibidores de metaloproteinasas.
PCT/SE2002/000472 WO2002074767A1 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
AU2002237626A AU2002237626B2 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
CZ20032500A CZ20032500A3 (cs) 2001-03-15 2002-03-13 Inhibitory metalloproteinasy
HU0400202A HUP0400202A3 (en) 2001-03-15 2002-03-13 Imidazolidindion derivatives having metalloproteinase inhibitor effect, their use and pharmaceutical compositions containing them
JP2002573757A JP2004523581A (ja) 2001-03-15 2002-03-13 メタロプロテイナーゼ阻害剤
IL15765202A IL157652A0 (en) 2001-03-15 2002-03-13 Metalloproteinase inhibitors
HU0400206A HUP0400206A3 (en) 2001-03-15 2002-03-13 Imidazolidindion derivatives having metalloproteinase inhibitor effect a their use for preparation of pharmaceutical compositions and pharmaceutical compositions containing them
KR1020087017665A KR100879905B1 (ko) 2001-03-15 2002-03-13 메탈로프로테이나제 억제제
DE60238794T DE60238794D1 (de) 2001-03-15 2002-03-13 Hydantoinderivate als MMP-Inhibitoren
PL364706A PL205315B1 (pl) 2001-03-15 2002-03-13 Pochodne imidazolidynodionu, środek farmaceutyczny i zastosowanie tych pochodnych
ARP020100944A AR035443A1 (es) 2001-03-15 2002-03-15 Compuestos inhibidores de metaloproteinasa, composicion farmaceutica, metodo de tratamiento, y uso de estos compuestos para la preparacion de medicamentos.
ARP020100943A AR035695A1 (es) 2001-03-15 2002-03-15 Compuestos inhibidores de metaloproteinasa, composicion farmaceutica, metodo de tratamiento, y uso de estos compuestos para la preparacion de medicamentos
ZA200306731A ZA200306731B (en) 2001-03-15 2003-08-28 Metalloproteinase inhibitors.
ZA200306734A ZA200306734B (en) 2001-03-15 2003-08-28 Metalloproteinase inhibitors.
ZA200306732A ZA200306732B (en) 2001-03-15 2003-08-28 Metalloproteinase inhibitors.
IL157656A IL157656A (en) 2001-03-15 2003-08-28 Metalloproteinase inhibitors, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for the treatment of diseases mediated by metalloproteinase enzymes
IL157652A IL157652A (en) 2001-03-15 2003-08-28 Metalloproteinase inhibitors, compositions comprising them and uses thereof for the preparation of medicaments for treating diseases or conditions mediated by metalloproteinase enzymes
ZA200306737A ZA200306737B (en) 2001-03-15 2003-08-28 Metalloproteinase inhibitors.
IS6942A IS6942A (is) 2001-03-15 2003-09-09 Málmpróteinasatálmar
IS6943A IS6943A (is) 2001-03-15 2003-09-09 Málmpróteinasatálmar
IS6946A IS6946A (is) 2001-03-15 2003-09-10 Málmpróteinasatálmar
IS6944A IS6944A (is) 2001-03-15 2003-09-10 Málmpróteinasatálmar
NO20034025A NO20034025L (no) 2001-03-15 2003-09-11 Metalloproteinaseinhibitorer
NO20034044A NO20034044L (no) 2001-03-15 2003-09-12 Metallproteinase-inhibitorer
NO20034045A NO327114B1 (no) 2001-03-15 2003-09-12 Metallproteinaseinhibitorer, farmasoytiske sammensetninger som omfatter slike, og anvendelser derav.
NO20034042A NO326087B1 (no) 2001-03-15 2003-09-12 Metallproteinaseinhibitorer, farmasoytiske sammensetninger inneholdende slike samt anvendelser derav
HK04102796A HK1059932A1 (en) 2001-03-15 2004-04-21 Metalloproteinase inhibitors
HK06112181.8A HK1091492A1 (en) 2001-03-15 2004-04-21 Hydantoin derivatives as mmp inhibitors
HK04102888.7A HK1060121A1 (en) 2001-03-15 2004-04-23 Metalloproteinase inhibitors
CY20061101477T CY1107525T1 (el) 2001-03-15 2006-10-13 Αναστολεiς μεταλλοπρωτεϊνασης
US11/928,040 US7625934B2 (en) 2001-03-15 2007-10-30 Metalloproteinase inhibitors
US12/114,901 US7666892B2 (en) 2001-03-15 2008-05-05 Metalloproteinase inhibitors
US12/115,785 US7754750B2 (en) 2001-03-15 2008-05-06 Metalloproteinase inhibitors
JP2009256358A JP5140058B2 (ja) 2001-03-15 2009-11-09 メタロプロテイナーゼ阻害剤
US12/693,852 US8153673B2 (en) 2001-03-15 2010-01-26 Metalloproteinase inhibitors
US12/830,763 US20110003853A1 (en) 2001-03-15 2010-07-06 Metalloproteinase Inhibitors

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JP (4) JP2004527515A (ja)
KR (4) KR100879905B1 (ja)
CN (5) CN1962641B (ja)
AR (2) AR035695A1 (ja)
AT (3) ATE333454T1 (ja)
AU (2) AU2002237626B2 (ja)
BR (3) BR0207983A (ja)
CA (3) CA2440473C (ja)
CY (1) CY1107525T1 (ja)
CZ (3) CZ20032497A3 (ja)
DE (3) DE60238794D1 (ja)
DK (1) DK1370556T3 (ja)
EE (3) EE05431B1 (ja)
ES (3) ES2357138T3 (ja)
HK (3) HK1059932A1 (ja)
HU (3) HUP0400327A3 (ja)
IL (5) IL157652A0 (ja)
IS (3) IS6943A (ja)
MX (3) MXPA03008191A (ja)
MY (2) MY136141A (ja)
NO (3) NO326087B1 (ja)
NZ (3) NZ528107A (ja)
PL (3) PL364707A1 (ja)
PT (1) PT1370556E (ja)
RU (3) RU2293729C2 (ja)
SE (1) SE0100902D0 (ja)
SI (1) SI1370556T1 (ja)
SK (3) SK287834B6 (ja)
UA (3) UA78502C2 (ja)
WO (3) WO2002074751A1 (ja)
ZA (4) ZA200306731B (ja)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0100902D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
SE0100903D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
DE60234028D1 (de) 2001-05-25 2009-11-26 Bristol Myers Squibb Co Hydantion-derivate als hemmer von matrix-metalloproteinasen
SE0103710D0 (sv) * 2001-11-07 2001-11-07 Astrazeneca Ab Compounds
DE10221018A1 (de) * 2002-05-11 2003-11-27 Boehringer Ingelheim Pharma Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie
SE0202539D0 (sv) * 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
SE0202693D0 (sv) * 2002-09-11 2002-09-11 Astrazeneca Ab Compounds
GB0221246D0 (en) * 2002-09-13 2002-10-23 Astrazeneca Ab Compounds
WO2004033632A2 (en) * 2002-10-04 2004-04-22 Bristol-Myers Squibb Company Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme (tace)
JP4866610B2 (ja) 2003-08-18 2012-02-01 富士フイルムファインケミカルズ株式会社 ピリジルテトラヒドロピリジン類およびピリジルピペリジン類
WO2005090316A1 (en) * 2004-03-12 2005-09-29 Wyeth HYDANTOINS HAVING RNase MODULATORY ACTIVITY
SE0401762D0 (sv) * 2004-07-05 2004-07-05 Astrazeneca Ab Novel compounds
US7648992B2 (en) * 2004-07-05 2010-01-19 Astrazeneca Ab Hydantoin derivatives for the treatment of obstructive airway diseases
SE0401763D0 (sv) * 2004-07-05 2004-07-05 Astrazeneca Ab Compounds
US20080187508A1 (en) * 2004-09-08 2008-08-07 Boys Town National Research Hospital Treatment of Golmerular Basement Membrane Disease Involving Matrix Metalloproteinase-12
WO2006034279A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as therapeutic agents
AU2005329423A1 (en) 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
CN101084207A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途
TW200626154A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
CN101083982A (zh) * 2004-09-20 2007-12-05 泽农医药公司 用于治疗硬脂酰CoA去饱和酶介导的疾病的杂环衍生物
BRPI0515478A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos e seu uso como mediadores de estearoil-coa-desaturase
TW200626155A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
GB0427403D0 (en) * 2004-12-15 2005-01-19 Astrazeneca Ab Novel compounds I
SE0403086D0 (sv) * 2004-12-17 2004-12-17 Astrazeneca Ab Compounds
SE0403085D0 (sv) * 2004-12-17 2004-12-17 Astrazeneca Ab Novel componds
MX2007011378A (es) * 2005-03-16 2008-03-18 Sensus Metering Systems Inc Metodo, sistema, aparato y producto de programa de computadora para determinar la ubicacion fisica de un sensor.
BRPI0611187A2 (pt) 2005-06-03 2010-08-24 Xenon Pharmaceuticals Inc derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
EP1968961A2 (en) 2005-12-21 2008-09-17 Decode Genetics EHF Biaryl nitrogen heterocycle inhibitors of lta4h for treating inflammation
PE20071240A1 (es) 2006-01-17 2008-01-14 Schering Corp Compuestos derivados de hidantoina para el tratamiento de trastornos inflamatorios
TW200800954A (en) * 2006-03-16 2008-01-01 Astrazeneca Ab Novel crystal modifications
TW200740769A (en) * 2006-03-16 2007-11-01 Astrazeneca Ab Novel process
CA2649926C (en) * 2006-05-12 2013-07-23 Sca Hygiene Products Ab Elastic laminate and a method for producing an elastic laminate
MX2008014154A (es) * 2006-05-12 2008-11-18 Sca Hygiene Prod Ab Articulo absorbente del tipo de calzoncillos y un metodo para producir articulos absorbentes de tipo de calzoncillos.
WO2008053199A1 (en) * 2006-10-30 2008-05-08 Astrazeneca Ab Combination therapy for the treatment of respiratory diseases
TW200831488A (en) * 2006-11-29 2008-08-01 Astrazeneca Ab Novel compounds
GB0702456D0 (en) 2007-02-08 2007-03-21 Astrazeneca Ab New combination
WO2009007747A2 (en) * 2007-07-11 2009-01-15 Astrazeneca Ab Hydantoin derivatives used as mmp12 inhibitors
BRPI0722259A2 (pt) 2007-11-14 2014-04-08 Sca Hygiene Prod Ab Método para produção de um vestuário absorvente, e vestuário absorvente produzido de acordo com o método
BRPI0722260A2 (pt) 2007-11-14 2014-04-01 Sca Hygiene Prod Ab Método de produção de um vestuário absorvente, e um vestuário absorvente produzido de acordo com o método
FR2927330B1 (fr) * 2008-02-07 2010-02-19 Sanofi Aventis Derives de 5,6-bisaryl-2-pyridine-carboxamide, leur preparation et leur application en therapeutique comme antagonistes des recepteurs a l'urotensine ii
AU2009241365B2 (en) 2008-04-28 2015-01-22 Revalesio Corporation Compositions and methods for treating multiple sclerosis
FR2944524B1 (fr) * 2009-04-17 2012-11-30 Ipsen Pharma Sas Derives d'imidazolidine-2,4-dione et leur utilisation comme medicament
PL2433940T3 (pl) 2009-04-28 2015-03-31 Chugai Pharmaceutical Co Ltd Pochodna spiroimidazolonu
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
WO2011054734A1 (de) * 2009-11-06 2011-05-12 Basf Se Eisen- und manganhaltiger heterogenkatalysator und verfahren zur herstellung von olefinen durch umsetzung von kohlenmonoxid mit wasserstoff
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
WO2011073662A1 (en) 2009-12-17 2011-06-23 Astrazeneca Ab Combination of a benzoxazinone and a further agent for treating respiratory diseases
US20110202284A1 (en) * 2010-02-10 2011-08-18 Mcreynolds Cristopher Novel groups of biomarkers for diagnosing alzheimer's disease
AU2011261375B2 (en) 2010-06-04 2016-09-22 Albany Molecular Research, Inc. Glycine transporter-1 inhibitors, methods of making them, and uses thereof
GB201021992D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab Compound
GB201021979D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab New compound
CN103958480B (zh) * 2012-09-04 2016-04-06 上海恒瑞医药有限公司 咪唑啉类衍生物、其制备方法及其在医药上的应用
CN104854106B (zh) 2012-12-10 2017-07-04 中外制药株式会社 乙内酰脲衍生物
HUE050907T2 (hu) * 2013-11-13 2021-01-28 Hankkija Oy Gyantasavakat tartalmazó takarmány-kiegészítõ
ES2686353T3 (es) * 2013-12-31 2018-10-17 Ipsen Pharma S.A.S. Nuevos derivados de imidazolidino-2,4-diona
EP2907512A1 (en) 2014-02-14 2015-08-19 Commissariat A L'energie Atomique Et Aux Energies Alternatives Inhibitors of MMP-12 as antiviral Agents
CN106572994B (zh) 2014-06-09 2020-09-18 中外制药株式会社 含有乙内酰脲衍生物的药物组合物
PL3209655T3 (pl) 2014-10-24 2020-12-28 Landos Biopharma, Inc. Leczenie oparte na białku 2 podobnym do syntetazy lantioniny C
JO3501B1 (ar) 2014-12-22 2020-07-05 Servier Lab مشتقات 5-{(بيبرازين - 1-يل)-3-أوكسو - بروبيل}- إيميدازوليدين-2، 4 - دايون كمثبطات ل adamts لمعالجة هشاشة العظام)
JP6934012B2 (ja) * 2016-09-23 2021-09-08 科研製薬株式会社 (r)‐5‐(3,4‐ジフルオロフェニル)‐5‐[(3‐メチル‐2‐オキソピリジン‐1(2h)‐イル)メチル]イミダゾリジン‐2,4‐ジオンの製造方法およびその製造のための中間体
WO2021011720A2 (en) * 2019-07-18 2021-01-21 Avidence Therapeutics, Inc. Anti-osteoarthritis compounds and related compositions and methods
US11673884B2 (en) 2019-11-14 2023-06-13 Foresee Pharmaceuticals Co., Inc. Matrix metalloproteinase (MMP) inhibitors and methods of use thereof
CA3135502C (en) 2019-12-20 2024-01-09 Josep Bassaganya-Riera Lanthionine c-like protein 2 ligands, cells prepared therewith, and therapies using same
US20230255943A1 (en) 2020-06-26 2023-08-17 The University Of Birmingham Mmp-9 and mmp-12 inhibition for treating spinal cord injury or related injury to neurological tissue
CN115720578A (zh) * 2020-07-09 2023-02-28 深圳信立泰药业股份有限公司 并三环类衍生物、其制备方法及其在医药上的应用
CN112574193B (zh) * 2020-12-31 2022-05-17 南京医科大学 一类口服gsnor抑制剂及其药物用途

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2327890A (en) * 1940-04-17 1943-08-24 Parke Davis & Co Substituted phenoxyalkyl ethers
US2745875A (en) 1953-06-30 1956-05-15 Hoechst Ag Preparation of nu-acylamino-phenylpropane diols
US3452040A (en) 1966-01-05 1969-06-24 American Home Prod 5,5-disubstituted hydantoins
US3529019A (en) * 1968-04-23 1970-09-15 Colgate Palmolive Co Alkylaryloxy alanines
CS152617B1 (ja) 1970-12-29 1974-02-22
CS151744B1 (ja) 1971-01-19 1973-11-19
US3849574A (en) * 1971-05-24 1974-11-19 Colgate Palmolive Co Alpha-substituted-beta-arylthioalkyl amino-acids,for increasing heart rate
US4315031A (en) 1977-09-01 1982-02-09 Science Union Et Cie Thiosubstituted amino acids
GB1601310A (en) 1978-05-23 1981-10-28 Lilly Industries Ltd Aryl hydantoins
JPS6172762A (ja) 1984-09-17 1986-04-14 Kanegafuchi Chem Ind Co Ltd 光学活性ヒダントイン類の製造法
JPS61212292A (ja) * 1985-03-19 1986-09-20 Mitsui Toatsu Chem Inc D−α−アミノ酸の製造方法
CA1325222C (en) 1985-08-23 1993-12-14 Lederle (Japan), Ltd. Process for producing 4-biphenylylacetic acid
GB8618559D0 (en) 1986-07-30 1986-09-10 Genetics Int Inc Rhodococcus bacterium
JPH0279879A (ja) 1988-09-17 1990-03-20 Canon Inc 画像形成装置
US4983771A (en) * 1989-09-18 1991-01-08 Hexcel Corporation Method for resolution of D,L-alpha-phenethylamine with D(-)mandelic acid
NL9000386A (nl) 1990-02-16 1991-09-16 Stamicarbon Werkwijze voor de bereiding van optisch aktief aminozuuramide.
DK161690D0 (da) 1990-07-05 1990-07-05 Novo Nordisk As Fremgangsmaade til fremstilling af enantiomere forbindelser
IL99957A0 (en) 1990-11-13 1992-08-18 Merck & Co Inc Piperidinylcamphorsulfonyl oxytocin antagonists and pharmaceutical compositions containing them
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5308853A (en) 1991-12-20 1994-05-03 Warner-Lambert Company Substituted-5-methylidene hydantoins with AT1 receptor antagonist properties
US5246943A (en) * 1992-05-19 1993-09-21 Warner-Lambert Company Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties
NL9201230A (nl) 1992-07-09 1994-02-01 Dsm Nv Werkwijze voor de bereiding van optisch aktief methionineamide.
EP0640594A1 (en) 1993-08-23 1995-03-01 Fujirebio Inc. Hydantoin derivative as metalloprotease inhibitor
JPH07105549A (ja) 1993-09-30 1995-04-21 Canon Inc 光学的情報記録再生方法及び光学的情報記録再生装置
WO1995014025A1 (en) 1993-11-16 1995-05-26 Merck & Co., Inc. Piperidinylcamphorsulfonyl oxytocin antagonists
ATE183184T1 (de) 1994-01-31 1999-08-15 Pfizer Neuroprotektive chroman verbindungen
EP0709375B1 (en) 1994-10-25 2005-05-18 AstraZeneca AB Therapeutic heterocycles
ZA96211B (en) 1995-01-12 1996-07-26 Teva Pharma Compositions containing and methods of using 1- aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
US5863949A (en) 1995-03-08 1999-01-26 Pfizer Inc Arylsulfonylamino hydroxamic acid derivatives
US6166041A (en) 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
ES2172690T3 (es) * 1995-11-22 2002-10-01 Darwin Discovery Ltd Compuestos de mercaptoalquilpeptidil con un sustituyente de imidazol y su utilizacion como inhibidores de metaloproteinasas de matriz (mmp) y/o del factor de necrosis tumoral (tnf).
GB9616643D0 (en) 1996-08-08 1996-09-25 Chiroscience Ltd Compounds
US5919790A (en) * 1996-10-11 1999-07-06 Warner-Lambert Company Hydroxamate inhibitors of interleukin-1β converting enzyme
AU4812697A (en) * 1996-10-22 1998-05-15 Pharmacia & Upjohn Company Alpha-amino sulfonyl hydroxamic acids as matrix metalloproteinase inhibitors
HUP0003362A3 (en) 1997-05-06 2001-04-28 Novo Nordisk As Piperidine derivatives and pharmaceutical compositions containing them
DK0877019T3 (da) 1997-05-09 2002-04-08 Hoechst Ag Substituerede diaminocarboxylsyrer
KR20010014020A (ko) 1997-06-21 2001-02-26 로셰 디아그노스틱스 게엠베하 항전이성 및 항종양성 활성을 갖는 바르비투르산 유도체
DE19726427A1 (de) 1997-06-23 1998-12-24 Boehringer Mannheim Gmbh Pyrimidin-2,4,6-trion-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
KR100419353B1 (ko) * 1997-07-31 2004-02-19 아보트 러보러터리즈 N-하이드록시포름아미드 유도체 및 이를 포함하는 매트릭스 메탈로프로테이나제 억제용 조성물
TW514634B (en) 1997-10-14 2002-12-21 Lilly Co Eli Process to make chiral compounds
CN1283183A (zh) * 1997-11-12 2001-02-07 达尔文发现有限公司 具有mmp和tnf抑制活性的异羟肟酸和羧酸衍生物
RU2208609C2 (ru) 1998-02-04 2003-07-20 Новартис Аг Сульфониламинопроизводные, которые ингибируют разлагающие матрикс металлопротеиназы
US6329418B1 (en) 1998-04-14 2001-12-11 The Procter & Gamble Company Substituted pyrrolidine hydroxamate metalloprotease inhibitors
CA2330095A1 (en) 1998-05-14 1999-11-18 Dupont Pharmaceuticals Company Substituted aryl hydroxamic acids as metalloproteinase inhibitors
JP2002516904A (ja) 1998-06-03 2002-06-11 ジーピーアイ ニル ホールディングス インコーポレイテッド N−複素環式カルボン酸またはカルボン酸等配電子体のn−結合スルホンアミド
EP1087937A1 (en) 1998-06-17 2001-04-04 Du Pont Pharmaceuticals Company Cyclic hydroxamic acids as metalloproteinase inhibitors
FR2782082B3 (fr) * 1998-08-05 2000-09-22 Sanofi Sa Formes cristallines de (r)-(+)-n-[[3-[1-benzoyl-3-(3,4- dichlorophenyl)piperidin-3-yl]prop-1-yl]-4-phenylpiperidin-4 -yl]-n-methylacetamide (osanetant) et procede pour la preparation dudit compose
US6339101B1 (en) 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
JP2000127349A (ja) * 1998-08-21 2000-05-09 Komori Corp 凹版印刷機
EP1107953A1 (en) 1998-08-29 2001-06-20 British Biotech Pharmaceuticals Limited Hydroxamic acid derivatives as proteinase inhibitors
GB9919776D0 (en) 1998-08-31 1999-10-27 Zeneca Ltd Compoujnds
ATE238236T1 (de) 1998-10-07 2003-05-15 Yazaki Corp Sol-gel verfahren unter verwendung poröser formen
US6114361A (en) * 1998-11-05 2000-09-05 Pfizer Inc. 5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives
EA200100675A1 (ru) 1998-12-18 2001-12-24 Аксис Фармасьютикалз, Инк. Ингибиторы протеазы
CA2356689A1 (en) 1998-12-31 2000-07-13 Michael J. Janusz 1-carboxymethyl-2-oxo-azepan derivatives useful as selective inhibitors of mmp-12
US6340691B1 (en) * 1999-01-27 2002-01-22 American Cyanamid Company Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors
KR100440643B1 (ko) 1999-01-28 2004-07-21 쥬가이 세이야쿠 가부시키가이샤 치환 페네틸아민 유도체
US6294694B1 (en) 1999-06-04 2001-09-25 Wisconsin Alumni Research Foundation Matrix metalloproteinase inhibitors and method of using same
GB9916562D0 (en) * 1999-07-14 1999-09-15 Pharmacia & Upjohn Spa 3-Arylsulfonyl-2-(substituted-methyl) propanoic acid derivatives as matrix metalloproteinase inhibitora
US20020006920A1 (en) 1999-07-22 2002-01-17 Robinson Ralph Pelton Arylsulfonylamino hydroxamic acid derivatives
US6266453B1 (en) 1999-07-26 2001-07-24 Computerized Medical Systems, Inc. Automated image fusion/alignment system and method
DK1078923T3 (da) 1999-08-02 2006-07-10 Hoffmann La Roche Fremgangsmåde til fremstilling af benzothiophenderivater
ES2249270T3 (es) 1999-08-12 2006-04-01 Pharmacia Italia S.P.A. Derivados de 3(5)-aminopirazol, procedimiento para su preparacion y su uso como agentes antitumorales.
JP3710964B2 (ja) 1999-08-26 2005-10-26 富士通株式会社 ディスプレイデバイスのレイアウト設計方法
SE9904044D0 (sv) 1999-11-09 1999-11-09 Astra Ab Compounds
US6525202B2 (en) 2000-07-17 2003-02-25 Wyeth Cyclic amine phenyl beta-3 adrenergic receptor agonists
US7335673B2 (en) 2000-08-11 2008-02-26 Kaken Pharmaceutical Co., Ltd. 2,3-Diphenylpropionic acid derivatives or their salts, medicines or cell adhesion inhibitors containing the same, and their usage
US20020065219A1 (en) 2000-08-15 2002-05-30 Naidu B. Narasimhulu Water soluble thiazolyl peptide derivatives
US20020091107A1 (en) * 2000-09-08 2002-07-11 Madar David J. Oxazolidinone antibacterial agents
WO2002020515A1 (en) 2000-09-08 2002-03-14 Abbott Laboratories Oxazolidinone antibacterial agents
EP1191024A1 (en) 2000-09-22 2002-03-27 Harald Tschesche Thiadiazines and their use as inhibitors of metalloproteinases
SE0100903D0 (sv) 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
BR0208105A (pt) 2001-03-15 2004-03-09 Astrazeneca Ab Inibidores de metaloproteinase
SE0100902D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
DE60234028D1 (de) 2001-05-25 2009-11-26 Bristol Myers Squibb Co Hydantion-derivate als hemmer von matrix-metalloproteinasen
GB0114004D0 (en) 2001-06-08 2001-08-01 Glaxo Group Ltd Chemical compounds
SE0103710D0 (sv) * 2001-11-07 2001-11-07 Astrazeneca Ab Compounds
EP1550725A4 (en) 2002-06-05 2010-08-25 Kaneka Corp PROCESS FOR PRODUCING OPTICALLY ACTIVE alpha-METHYLCYSTEINE DERIVATIVE
SE0202539D0 (sv) 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
SE0202693D0 (sv) 2002-09-11 2002-09-11 Astrazeneca Ab Compounds
SE0202692D0 (sv) 2002-09-11 2002-09-11 Astrazeneca Ab Compounds
GB0221250D0 (en) 2002-09-13 2002-10-23 Astrazeneca Ab Compounds
GB0221246D0 (en) 2002-09-13 2002-10-23 Astrazeneca Ab Compounds
US6890913B2 (en) * 2003-02-26 2005-05-10 Food Industry Research And Development Institute Chitosans
US20040266832A1 (en) * 2003-06-26 2004-12-30 Li Zheng J. Crystal forms of 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl pyridine
TWI220073B (en) 2003-07-24 2004-08-01 Au Optronics Corp Method for manufacturing polysilicon film
SE0401762D0 (sv) 2004-07-05 2004-07-05 Astrazeneca Ab Novel compounds
US7648992B2 (en) 2004-07-05 2010-01-19 Astrazeneca Ab Hydantoin derivatives for the treatment of obstructive airway diseases
SE0401763D0 (sv) 2004-07-05 2004-07-05 Astrazeneca Ab Compounds
SE0403086D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Compounds
SE0403085D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Novel componds
TW200740769A (en) * 2006-03-16 2007-11-01 Astrazeneca Ab Novel process
TW200800954A (en) 2006-03-16 2008-01-01 Astrazeneca Ab Novel crystal modifications
TW200831488A (en) 2006-11-29 2008-08-01 Astrazeneca Ab Novel compounds

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