RU2756253C2 - Терапевтические композиции и способы против злокачественных опухолей с молекулами рнки, направленными против hsp47 - Google Patents

Терапевтические композиции и способы против злокачественных опухолей с молекулами рнки, направленными против hsp47 Download PDF

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RU2756253C2
RU2756253C2 RU2017126610A RU2017126610A RU2756253C2 RU 2756253 C2 RU2756253 C2 RU 2756253C2 RU 2017126610 A RU2017126610 A RU 2017126610A RU 2017126610 A RU2017126610 A RU 2017126610A RU 2756253 C2 RU2756253 C2 RU 2756253C2
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hsp47
sirna
cancer
directed against
molecules
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RU2017126610A
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RU2017126610A3 (enExample
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Венбин ИН
Акихиро ЙОНЕДА
Ясуаки ТАМУРА
Кендзироу МИНОМИ
Бхарат МАДЖЕТИ
Цзихуа ЛЮ
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Нитто Денко Корпорейшн
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RU2017126610A 2014-12-26 2015-12-28 Терапевтические композиции и способы против злокачественных опухолей с молекулами рнки, направленными против hsp47 RU2756253C2 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2014-266198 2014-12-26
JP2014266198 2014-12-26
US201562184195P 2015-06-24 2015-06-24
US62/184,195 2015-06-24
US201562266670P 2015-12-13 2015-12-13
US62/266,670 2015-12-13
PCT/US2015/067558 WO2016106403A2 (en) 2014-12-26 2015-12-28 Therapeutic compositions and methods for malignant tumors with rnai molecules targeted to hsp47 and p21

Publications (3)

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RU2017126610A RU2017126610A (ru) 2019-01-28
RU2017126610A3 RU2017126610A3 (enExample) 2019-07-17
RU2756253C2 true RU2756253C2 (ru) 2021-09-28

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RU2017126610A RU2756253C2 (ru) 2014-12-26 2015-12-28 Терапевтические композиции и способы против злокачественных опухолей с молекулами рнки, направленными против hsp47
RU2017126601A RU2017126601A (ru) 2014-12-26 2015-12-28 Способы и композиции для лечения злокачественных опухолей, ассоциированных с мутацией kras
RU2017126613A RU2719185C2 (ru) 2014-12-26 2015-12-28 Препараты, осуществляющие рнк-интерференцию, для модуляции гена gst-pi
RU2017126598A RU2017126598A (ru) 2014-12-26 2015-12-28 Рнк-агенты для модуляции гена gst-pi

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RU2017126601A RU2017126601A (ru) 2014-12-26 2015-12-28 Способы и композиции для лечения злокачественных опухолей, ассоциированных с мутацией kras
RU2017126613A RU2719185C2 (ru) 2014-12-26 2015-12-28 Препараты, осуществляющие рнк-интерференцию, для модуляции гена gst-pi
RU2017126598A RU2017126598A (ru) 2014-12-26 2015-12-28 Рнк-агенты для модуляции гена gst-pi

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US (14) US10264976B2 (enExample)
EP (9) EP3236969A4 (enExample)
JP (10) JP6793649B2 (enExample)
KR (4) KR20170093988A (enExample)
CN (7) CN107108686B (enExample)
AU (4) AU2015369598A1 (enExample)
BR (2) BR112017013597B1 (enExample)
CA (4) CA2972265A1 (enExample)
RU (4) RU2756253C2 (enExample)
WO (7) WO2016106402A1 (enExample)

Families Citing this family (36)

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Publication number Priority date Publication date Assignee Title
US10264976B2 (en) 2014-12-26 2019-04-23 The University Of Akron Biocompatible flavonoid compounds for organelle and cell imaging
US20180002702A1 (en) 2014-12-26 2018-01-04 Nitto Denko Corporation Methods and compositions for treating malignant tumors associated with kras mutation
US10792299B2 (en) 2014-12-26 2020-10-06 Nitto Denko Corporation Methods and compositions for treating malignant tumors associated with kras mutation
ES2789049T3 (es) * 2014-12-26 2020-10-23 Nitto Denko Corp Agentes de interferencia de ARN para modulación génica de GST-pi
US11045488B2 (en) 2014-12-26 2021-06-29 Nitto Denko Corporation RNA interference agents for GST-π gene modulation
CN107708739A (zh) 2015-06-24 2018-02-16 日东电工株式会社 可电离化合物、组合物及它们的用途
KR102740699B1 (ko) 2015-12-13 2024-12-09 닛토덴코 가부시키가이샤 높은 활성 및 감소한 오프 타겟을 위한 sirna 구조
JP7177439B2 (ja) 2016-05-10 2022-11-24 国立大学法人 東京医科歯科大学 炎症促進因子発現抑制剤、その有効成分のスクリーニング方法、該方法に有用な発現カセット、診断薬、及び診断方法
JP2019508379A (ja) * 2017-02-16 2019-03-28 日東電工株式会社 悪性腫瘍に対する治療方法及び治療用組成物
CN111386105B (zh) * 2017-11-06 2023-09-15 日东电工株式会社 用于递送生物活性分子的膜融合化合物
CA3082006A1 (en) * 2017-11-09 2019-05-16 National University Corporation Tokyo Medical And Dental University Inhibitor of the expression of cancer-promoting factors, screening method for active ingredient thereof, expression cassette useful in said method, diagnostic drug, and diagnosticmethod
CN109777798A (zh) * 2017-11-13 2019-05-21 深圳华大生命科学研究院 一种基于CRISPR技术治疗KRAS突变恶性肿瘤的sgRNA及其应用
JP6952594B2 (ja) * 2017-12-15 2021-10-20 洋司郎 新津 細胞増殖抑制剤及びそれを含むがんの治療若しくは予防用医薬組成物
CN108486011B (zh) * 2018-03-27 2020-05-05 山东大学 一种三联苯化合物、制备方法及其应用
JP7432929B2 (ja) * 2018-05-31 2024-02-19 コリア ユニバーシティ リサーチ アンド ビジネス ファウンデーション マイクロｒｎａの非正規標的を抑制するｒｎａ干渉誘導核酸およびその用途
WO2020009189A1 (ja) * 2018-07-05 2020-01-09 洋司郎 新津 Ｂｒａｆ阻害剤によるがん細胞の逆説的増殖を抑制する薬剤
EP3848050A4 (en) * 2018-08-22 2022-06-08 Nitto Denko Corporation DRUG USING AN HSP47 INHIBITOR TO INCREASE SENSITIVITY TO A CHEMOTHERAPY DRUG
CN112739381A (zh) * 2018-08-22 2021-04-30 日东电工株式会社 使用了hsp47的抑制物质的癌转移抑制
US11708575B2 (en) * 2018-11-16 2023-07-25 Nitto Denko Corporation RNA interference delivery formulation and methods for malignant tumors
JPWO2020116537A1 (ja) * 2018-12-05 2021-10-21 日東電工株式会社 がん処置用ＲＮＡｉ分子
EP3909588A4 (en) 2019-01-10 2023-01-04 Osaka University IMMUNO-STIMULATING COMPOSITION
US20220170022A1 (en) * 2019-03-28 2022-06-02 Nitto Denko Corporation Rnai molecule
JP2019116507A (ja) * 2019-04-25 2019-07-18 有限会社オービット Ｈｓｐ４７の発現促進剤、脱毛抑制方法、Ｈｓｐ４７の発現促進剤の製造方法及び飲食物の製造方法
EP3965781A2 (en) * 2019-07-02 2022-03-16 Argonaute Rna Limited Apolipoprotein b antagonist
JP7692829B2 (ja) * 2019-07-30 2025-06-16 塩野義製薬株式会社 Ｍｕｒｆ１を標的とする核酸医薬
US20230061751A1 (en) * 2020-01-17 2023-03-02 University Of Massachusetts Universal dynamic pharmacokinetic-modifying anchors
CN112280800B (zh) * 2020-10-19 2022-06-07 上海市东方医院（同济大学附属东方医院） 一种构建体及其在制备动物衰老细胞示踪和衰老细胞清除药物中的应用
EP4267741A2 (en) * 2020-12-28 2023-11-01 1E Therapeutics, Ltd. P21 mrna target areas for silencing
WO2022144883A2 (en) 2020-12-28 2022-07-07 1E Therapeutics, Ltd. P21 mrna targeting dnazymes
KR102732910B1 (ko) * 2021-12-29 2024-11-20 의료법인 명지의료재단 K-ras 특이적 활성화 T 세포를 포함하는 대장암의 예방 및 치료용 약제학적 조성물 및 이의 제조방법
KR102732911B1 (ko) * 2021-12-29 2024-11-20 의료법인 명지의료재단 K-ras 특이적 활성화 T 세포를 포함하는 유방암의 예방 및 치료용 약제학적 조성물 및 이의 제조방법
KR102732913B1 (ko) * 2021-12-29 2024-11-20 의료법인 명지의료재단 K-ras 특이적 활성화 T 세포를 포함하는 흑색종의 예방 및 치료용 약제학적 조성물 및 이의 제조방법
KR102732912B1 (ko) * 2021-12-29 2024-11-20 의료법인 명지의료재단 K-ras 특이적 활성화 T 세포를 포함하는 폐 선암종의 예방 및 치료용 약제학적 조성물 및 이의 제조방법
KR102732909B1 (ko) * 2021-12-29 2024-11-20 의료법인 명지의료재단 K-ras 특이적 활성화 T 세포를 포함하는 폐 유두상 선암종의 예방 및 치료용 약제학적 조성물 및 이의 제조방법
WO2023210713A1 (ja) * 2022-04-27 2023-11-02 国立大学法人京都大学 心外膜細胞再生促進剤および心外膜細胞の再生促進方法
TW202529777A (zh) * 2023-09-28 2025-08-01 日商日東電工股份有限公司 組合療法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013173307A1 (en) * 2012-05-16 2013-11-21 Neil Desai Multi-target modulation for treating fibrosis and inflammatory conditions
RU2505315C2 (ru) * 2008-07-30 2014-01-27 Нитто Денко Корпорейшн Носители лекарственных средств
US20140351961A1 (en) * 2011-08-31 2014-11-27 Alexzander A. Asea Compositions and methods for treatment of metastatic cancer

Family Cites Families (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR970005898B1 (ko) 1987-09-21 1997-04-21 젠- 프로우브 인코퍼레이티드 뉴클레오티드 프로브에 대한 비-뉴클레오티드 연결시약
US5204241A (en) 1990-10-22 1993-04-20 Oxi-Gene Inc. Glutathione-S-transferase mu as a measure of drug resistance
US5786336A (en) 1991-04-29 1998-07-28 Terrapin Technologies, Inc. Target-selective protocols based on mimics
US5658780A (en) 1992-12-07 1997-08-19 Ribozyme Pharmaceuticals, Inc. Rel a targeted ribozymes
EP0748382B1 (en) 1993-09-02 2002-11-06 Ribozyme Pharmaceuticals, Inc. Non-nucleotide containing enzymatic nucleic acid
JPH09504297A (ja) 1993-10-27 1997-04-28 リボザイム・ファーマシューティカルズ・インコーポレーテッド ２′−アミドおよび２′−ペプチド修飾オリゴヌクレオチド
DE69633722T2 (de) 1995-06-07 2005-11-03 TELIK, INC., Palo Alto Stoffwechseleffekt von bestimmten glutation analogen
US5968737A (en) * 1996-11-12 1999-10-19 The University Of Mississippi Method of identifying inhibitors of glutathione S-transferase (GST) gene expression
JPH10330249A (ja) * 1997-05-30 1998-12-15 Kureha Chem Ind Co Ltd レチノール化合物含有ｈｓｐ４７合成抑制剤
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
WO1999054346A1 (en) 1998-04-16 1999-10-28 Teijin Limited Glutathione derivatives and dosage forms thereof
GB9827152D0 (en) 1998-07-03 1999-02-03 Devgen Nv Characterisation of gene function using double stranded rna inhibition
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
AU1086501A (en) 1999-10-15 2001-04-30 Carnegie Institution Of Washington Rna interference pathway genes as tools for targeted genetic interference
GB9927444D0 (en) 1999-11-19 2000-01-19 Cancer Res Campaign Tech Inhibiting gene expression
US20070083945A1 (en) * 2000-03-10 2007-04-12 Byrum Joseph R Nucleic acid molecules and other molecules associated with plants
US20030144236A1 (en) 2000-03-29 2003-07-31 Weiss Robert H Novel specific inhibitor of the cyclin kinase inhibitor p21 (wafl/cip1)
IL154129A0 (en) 2000-07-28 2003-07-31 Compugen Inc Oligonucleotide library for detecting rna transcripts and splice variants that populate a transcriptome
BRPI0115814B8 (pt) 2000-12-01 2021-05-25 Europaeisches Laboratorium Fuer Molekularbiologie Embl moléculas de rna de filamento duplo, seu método de preparação e composição farmacêutica compreendendo as mesmas
EP1627061B1 (en) 2001-05-18 2009-08-12 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA)
US20030099974A1 (en) 2001-07-18 2003-05-29 Millennium Pharmaceuticals, Inc. Novel genes, compositions, kits and methods for identification, assessment, prevention, and therapy of breast cancer
US20040142325A1 (en) * 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
US20040029275A1 (en) * 2002-08-10 2004-02-12 David Brown Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
EP2314691A3 (en) * 2002-11-14 2012-01-18 Dharmacon, Inc. Fuctional and hyperfunctional siRNA
WO2004055165A2 (en) 2002-12-13 2004-07-01 St. Jude Children's Research Hospital Glutathione-s-transferase test for susceptibility to parkinson's
WO2004094636A1 (en) 2003-04-24 2004-11-04 Galapagos Genomics N.V. Effective sirna knock-down constructs
US20050142596A1 (en) 2003-11-14 2005-06-30 Krolewski Andrzej S. Methods of diagnosing renal and cardiovascular disease
AU2005222965B8 (en) 2004-03-15 2010-07-01 City Of Hope Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
AU2005243410B2 (en) 2004-05-14 2010-04-22 Rosetta Genomics Ltd. Micronas and uses thereof
MX2007002294A (es) * 2004-08-26 2007-10-19 Engeneic Molecular Delivery Pty Ltd Suministro de acidos nucleicos funcionales a celulas mamiferas via minicelulas intactas, derivadas bacterialmente.
EP2727583B1 (en) 2004-12-22 2021-11-17 Nitto Denko Corporation Drug carrier and drug carrier kit for inhibiting fibrosis
US9393315B2 (en) * 2011-06-08 2016-07-19 Nitto Denko Corporation Compounds for targeting drug delivery and enhancing siRNA activity
JP2008536874A (ja) 2005-04-15 2008-09-11 ボード オブ リージェンツ ザ ユニバーシティー オブ テキサス システム 中性脂質組成物によるｓｉＲＮＡの送達
WO2007072220A2 (en) * 2005-09-12 2007-06-28 Aurelium Biopharma Inc. Focused microarray and methods of diagnosing cancer
ES2324128A1 (es) * 2005-09-29 2009-07-30 Proyecto De Biomedicina Cima, S.L. Metodo para el diagnostico de carcinoma hepatocelular mediante el empleo de marcadores moleculares.
US20090220956A1 (en) 2005-10-25 2009-09-03 Dimitry Serge Antoine Nuyten Prediction of Local Recurrence of Breast Cancer
RU2448974C2 (ru) * 2005-11-01 2012-04-27 Элнилэм Фармасьютикалз, Инк. РНКи-ИНГИБИРОВАНИЕ РЕПЛИКАЦИИ ВИРУСА ГРИППА
KR20080086440A (ko) 2005-11-01 2008-09-25 알닐람 파마슈티칼스 인코포레이티드 인플루엔자 바이러스 복제의 ＲＮＡｉ 억제
WO2007051303A1 (en) 2005-11-02 2007-05-10 Protiva Biotherapeutics, Inc. MODIFIED siRNA MOLECULES AND USES THEREOF
ATE422162T1 (de) * 2005-11-17 2009-02-15 Childrens Medical Center Verfahren zur vorhersage und verhinderung der resistenz gegen taxoid-verbindungen
US7729737B2 (en) 2005-11-22 2010-06-01 Isense Corporation Method and apparatus for background current arrangements for a biosensor
ES2419106T3 (es) 2005-12-01 2013-08-19 Pronai Therapeutics, Inc. Formulación de liposomas anfóteros
US9572886B2 (en) * 2005-12-22 2017-02-21 Nitto Denko Corporation Agent for treating myelofibrosis
JP5342834B2 (ja) * 2008-09-05 2013-11-13 日東電工株式会社 骨髄線維症処置剤
WO2007130604A2 (en) * 2006-05-04 2007-11-15 Baylor Research Institute Anti-tumor activity of an oncolytic adenovirus-delivered oncogene sirna
CN101484588B (zh) 2006-05-11 2013-11-06 阿尔尼拉姆医药品有限公司 抑制pcsk9基因表达的组合物和方法
US8067390B2 (en) 2007-03-02 2011-11-29 The Board Of Regents Of The University Of Texas System Therapeutic targeting of interleukins using siRNA in neutral liposomes
TWI407971B (zh) 2007-03-30 2013-09-11 Nitto Denko Corp Cancer cells and tumor-related fibroblasts
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
EA201000085A1 (ru) * 2007-07-05 2010-10-29 Новартис Аг dsPHK, ПРЕДНАЗНАЧЕННАЯ ДЛЯ ЛЕЧЕНИЯ ВИРУСНОЙ ИНФЕКЦИИ
ES2873350T3 (es) * 2007-08-27 2021-11-03 1Globe Health Inst Llc Composiciones de ARN interferente asimétrico y usos de las mismas
WO2009033284A1 (en) * 2007-09-14 2009-03-19 Mcmaster University Inhibitors of collagen biosynthesis as anti-tumor agents
PT2268628E (pt) * 2008-03-06 2012-06-28 Rottapharm Spa Derivados de 2-aril e de 2-heteroaril 4h-1-benzopiran-4-ona- 6-amidino para o tratamento de artrite, cancro e dores relacionadas
EP2321414B1 (en) * 2008-07-25 2018-01-10 Alnylam Pharmaceuticals, Inc. Enhancement of sirna silencing activity using universal bases or mismatches in the sense strand
CN107028886A (zh) * 2009-11-04 2017-08-11 不列颠哥伦比亚大学 含有核酸的脂质粒子及相关的方法
KR101718534B1 (ko) 2009-12-09 2017-03-22 닛토덴코 가부시키가이샤 Ｈｓｐ４７ 발현의 조절
EP2539469A4 (en) 2010-02-24 2013-07-31 Bodysync Inc METHOD FOR DETERMINING GENE NUTRITIONAL INTERACTIONS
US20130004494A1 (en) 2010-03-12 2013-01-03 Ellen Heber-Katz Inhibition of P21 and Use Thereof for Inducing Tissue Regeneration
US8372819B2 (en) 2010-04-11 2013-02-12 Salk Institute For Biological Studies Methods and compositions for targeting skip
US8828944B2 (en) 2010-04-22 2014-09-09 Institut Gustave Roussy Compounds and uses thereof to induce an immunogenic cancer cell death in a subject
EP2566955A4 (en) 2010-05-06 2014-10-29 Stem Cell Medicine Ltd STEM CELL BANK FOR PERSONALIZED MEDICINE
JP5950428B2 (ja) * 2010-08-05 2016-07-13 日東電工株式会社 線維化組織から正常組織を再生するための組成物
WO2012044620A2 (en) * 2010-09-30 2012-04-05 Nitto Denko Corporation Modulation of timp1 and timp2 expression
CN110123830A (zh) 2010-11-09 2019-08-16 阿尔尼拉姆医药品有限公司 用于抑制Eg5和VEGF基因的表达的脂质配制的组合物和方法
US9011903B2 (en) * 2011-06-08 2015-04-21 Nitto Denko Corporation Cationic lipids for therapeutic agent delivery formulations
CN107043334B (zh) 2011-06-08 2020-06-16 日东电工株式会社 用于定向药物输送和增强siRNA活性的化合物
TWI658830B (zh) 2011-06-08 2019-05-11 日東電工股份有限公司 Ｈｓｐ47表現調控強化用類視色素脂質體
JP6023709B2 (ja) * 2011-06-21 2016-11-09 日東電工株式会社 アポトーシス誘導剤
CN102896619B (zh) * 2011-07-26 2015-04-22 苏州宝时得电动工具有限公司 动力工具及其操作方法
US9579338B2 (en) 2011-11-04 2017-02-28 Nitto Denko Corporation Method of producing lipid nanoparticles for drug delivery
CA2856117A1 (en) * 2011-11-17 2013-05-23 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Auto-recognizing therapeutic rna/dna chimeric nanoparticles (np)
US20140134158A1 (en) 2012-05-22 2014-05-15 Alberto Bardelli Kras mutations and resistance to anti-egfr treatment
EP2858974B9 (en) * 2012-06-08 2022-07-20 Nitto Denko Corporation Lipids for therapeutic agent delivery formulations
WO2013192364A1 (en) 2012-06-22 2013-12-27 The University Of Vermont And State Agricultural College Treatments of oxidative stress conditions
CN104684584A (zh) * 2012-07-02 2015-06-03 费卜卢斯坦丁公司 Gpbp-1的抑制及其治疗用途
WO2014022739A2 (en) 2012-08-03 2014-02-06 Alnylam Pharmaceuticals, Inc. Modified rnai agents
JP6340162B2 (ja) * 2012-12-20 2018-06-06 日東電工株式会社 アポトーシス誘導剤
EP3608308B1 (en) * 2013-03-08 2021-07-21 Novartis AG Lipids and lipid compositions for the delivery of active agents
CN103695421B (zh) 2013-12-09 2016-06-15 浙江大学 一种特异抑制p21基因表达的siRNA及其应用
CN113577290B (zh) * 2014-12-26 2023-10-24 日东电工株式会社 细胞死亡诱导试剂、细胞增殖抑制试剂及用于治疗由细胞增殖异常导致的疾病的医药组合物
US10792299B2 (en) * 2014-12-26 2020-10-06 Nitto Denko Corporation Methods and compositions for treating malignant tumors associated with kras mutation
US20180002702A1 (en) 2014-12-26 2018-01-04 Nitto Denko Corporation Methods and compositions for treating malignant tumors associated with kras mutation
US20160187319A1 (en) 2014-12-26 2016-06-30 Nitto Denko Corporation Cell death-inducing agent, cell growth-inhibiting agent, and pharmaceutical composition for treatment of disease caused by abnormal cell growth
US10264976B2 (en) * 2014-12-26 2019-04-23 The University Of Akron Biocompatible flavonoid compounds for organelle and cell imaging
KR102740699B1 (ko) * 2015-12-13 2024-12-09 닛토덴코 가부시키가이샤 높은 활성 및 감소한 오프 타겟을 위한 sirna 구조
JP6899201B2 (ja) 2016-06-23 2021-07-07 日東電工株式会社 細胞死誘導剤、細胞増殖抑制剤及び細胞の増殖異常に起因する疾患の治療用医薬組成物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2505315C2 (ru) * 2008-07-30 2014-01-27 Нитто Денко Корпорейшн Носители лекарственных средств
US20140351961A1 (en) * 2011-08-31 2014-11-27 Alexzander A. Asea Compositions and methods for treatment of metastatic cancer
WO2013173307A1 (en) * 2012-05-16 2013-11-21 Neil Desai Multi-target modulation for treating fibrosis and inflammatory conditions

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FENSKE D.B. et al. Liposomal nanomedicines: an emerging field. Toxicol Pathol. 2008 Jan; 36(1): 21-9. *
YAMAMOTO N. et al. Tumor-suppressive microRNA-29a inhibits cancer cell migration and invasion via targeting HSP47 in cervical squamous cell carcinoma. Int J Oncol. 2013 Dec; 43(6): 1855-63. *
ZHAO D. et al. Heat shock protein 47 regulated by miR-29a to enhance glioma tumor growth and invasion. J Neurooncol. 2014 May; 118(1): 39-47. *
ZHAO D. et al. Heat shock protein 47 regulated by miR-29a to enhance glioma tumor growth and invasion. J Neurooncol. 2014 May; 118(1): 39-47. FENSKE D.B. et al. Liposomal nanomedicines: an emerging field. Toxicol Pathol. 2008 Jan; 36(1): 21-9. YAMAMOTO N. et al. Tumor-suppressive microRNA-29a inhibits cancer cell migration and invasion via targeting HSP47 in cervical squamous cell carcinoma. Int J Oncol. 2013 Dec; 43(6): 1855-63. *

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EP3236974B9 (en) 2020-08-05
EP3236974A2 (en) 2017-11-01
CA2971881A1 (en) 2016-06-30
JP6865169B2 (ja) 2021-04-28
EP3236975A4 (en) 2018-09-12
US9695206B2 (en) 2017-07-04
WO2016106403A3 (en) 2016-08-18
JP7307137B2 (ja) 2023-07-11
US20160215286A1 (en) 2016-07-28
WO2016106400A3 (en) 2016-09-01
US20160186182A1 (en) 2016-06-30
EP3683309A1 (en) 2020-07-22
US20220087531A1 (en) 2022-03-24
US20160376296A1 (en) 2016-12-29
EP3236945A2 (en) 2017-11-01
CN108024961A (zh) 2018-05-11
CN107108686A (zh) 2017-08-29
RU2719185C2 (ru) 2020-04-17
JP2018512373A (ja) 2018-05-17
RU2017126613A3 (enExample) 2019-06-05

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