RU2402569C2 - Человеческие антитела к рецептору эпидермального фактора роста - Google Patents

Человеческие антитела к рецептору эпидермального фактора роста Download PDF

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RU2402569C2
RU2402569C2 RU2006137060/13A RU2006137060A RU2402569C2 RU 2402569 C2 RU2402569 C2 RU 2402569C2 RU 2006137060/13 A RU2006137060/13 A RU 2006137060/13A RU 2006137060 A RU2006137060 A RU 2006137060A RU 2402569 C2 RU2402569 C2 RU 2402569C2
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egfr
antibody
seq
antibodies
tumor
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RU2006137060A (ru
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Меллин ЛИ (US)
Меллин ЛИ
Женпин ЖУ (US)
Женпин ЖУ
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Имклоун Элэлси
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
RU2006137060/13A 2004-03-19 2005-03-21 Человеческие антитела к рецептору эпидермального фактора роста RU2402569C2 (ru)

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US55455504P 2004-03-19 2004-03-19
US60/554,555 2004-03-19
US62426404P 2004-11-02 2004-11-02
US60/624,264 2004-11-02

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RU2006137060A RU2006137060A (ru) 2008-04-27
RU2402569C2 true RU2402569C2 (ru) 2010-10-27

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US (1) US7598350B2 (OSRAM)
EP (2) EP1735348B1 (OSRAM)
JP (1) JP4734319B2 (OSRAM)
CN (1) CN103007279B (OSRAM)
AU (1) AU2005224267B2 (OSRAM)
CA (1) CA2560305C (OSRAM)
CY (2) CY1113037T1 (OSRAM)
DK (1) DK1735348T3 (OSRAM)
ES (1) ES2387809T3 (OSRAM)
HU (1) HUS000495I2 (OSRAM)
LT (1) LTC1735348I2 (OSRAM)
LU (1) LU93093I2 (OSRAM)
MX (1) MXPA06010715A (OSRAM)
NL (1) NL300819I2 (OSRAM)
PL (1) PL1735348T3 (OSRAM)
PT (1) PT1735348E (OSRAM)
RU (1) RU2402569C2 (OSRAM)
WO (1) WO2005090407A1 (OSRAM)

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RU2663721C1 (ru) * 2015-03-05 2018-08-08 Бейджинг Беттермаб Биотекнолоджи Ко., Лтд Моноклональные антитела к человеческому il-17 и их применение
RU2687209C1 (ru) * 2013-12-20 2019-05-07 Интервет Интернэшнл Б.В. Собачьи антитела с модифицированными последовательностями ch2-ch3
RU2747457C2 (ru) * 2014-07-24 2021-05-05 Блубёрд Био, Инк. Химерные антигенные рецепторы к bcma
RU2801209C2 (ru) * 2013-12-20 2023-08-03 Интервет Интернэшнл Б.В. Собачьи антитела с модифицированными последовательностями ch2-ch3

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