WO1992022653A1
(en)
|
1991-06-14 |
1992-12-23 |
Genentech, Inc. |
Method for making humanized antibodies
|
US6800738B1
(en)
|
1991-06-14 |
2004-10-05 |
Genentech, Inc. |
Method for making humanized antibodies
|
US6417168B1
(en)
|
1998-03-04 |
2002-07-09 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods of treating tumors
|
EP1745799B1
(en)
|
1998-03-04 |
2015-09-02 |
The Trustees of The University of Pennsylvania |
Compositions and methods of treating tumors
|
US6706721B1
(en)
|
1998-04-29 |
2004-03-16 |
Osi Pharmaceuticals, Inc. |
N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
|
WO2000074634A2
(en)
|
1999-06-03 |
2000-12-14 |
Au Jessie L S |
Methods and compositions for modulating cell proliferation and cell death
|
GB9925958D0
(en)
*
|
1999-11-02 |
1999-12-29 |
Bundred Nigel J |
Therapeutic use
|
US7087613B2
(en)
|
1999-11-11 |
2006-08-08 |
Osi Pharmaceuticals, Inc. |
Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
|
UA74803C2
(uk)
|
1999-11-11 |
2006-02-15 |
Осі Фармасьютікалз, Інк. |
Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
|
AU9500201A
(en)
*
|
2000-08-09 |
2002-02-18 |
Imclone Systems Inc |
Treatment of hyperproliferative diseases with epidermal growth factor receptor antagonists
|
AU2002239486A1
(en)
*
|
2000-12-08 |
2002-06-18 |
Uab Research Foundation |
Combination radiation therapy and chemotherapy in conjuction with administration of growth factor receptor antibody
|
CU22979A1
(es)
*
|
2000-12-08 |
2004-09-09 |
Centro Inmunologia Molecular |
Combinación inmunoterapéutica para el tratamiento de tumores que sobre-expresan receptores con actividad quinasa en residuos de tirosina
|
US7081454B2
(en)
|
2001-03-28 |
2006-07-25 |
Bristol-Myers Squibb Co. |
Tyrosine kinase inhibitors
|
JP2005526506A
(ja)
|
2002-03-04 |
2005-09-08 |
イムクローン システムズ インコーポレイティド |
Kdrに特異的なヒト抗体及びその利用
|
DE60318561T2
(de)
*
|
2002-04-02 |
2009-01-08 |
Nerviano Medical Sciences S.R.L., Nerviano |
Kombinierte tumortherapie auf der basis von distamycin-acryloyl derivaten und radiotherapie
|
KR101086533B1
(ko)
|
2002-05-24 |
2011-11-23 |
쉐링 코포레이션 |
중화 사람 항-igfr 항체, 이를 제조하는 방법 및 이를 포함하는 조성물
|
US7638605B2
(en)
|
2003-05-01 |
2009-12-29 |
ImClone, LLC |
Fully human antibodies directed against the human insulin-like growth factor-1 receptor
|
WO2005001053A2
(en)
|
2003-06-09 |
2005-01-06 |
Samuel Waksal |
Method of inhibiting receptor tyrosine kinases with an extracellular antagonist and an intracellular antagonist
|
US7312215B2
(en)
|
2003-07-29 |
2007-12-25 |
Bristol-Myers Squibb Company |
Benzimidazole C-2 heterocycles as kinase inhibitors
|
MXPA06001634A
(es)
|
2003-08-13 |
2006-04-28 |
Pfizer Prod Inc |
Anticuerpos humanos modificados igf-1r.
|
EP1694850B1
(en)
|
2003-11-12 |
2011-06-29 |
Schering Corporation |
Plasmid system for multigene expression
|
TW200526684A
(en)
|
2003-11-21 |
2005-08-16 |
Schering Corp |
Anti-IGFR1 antibody therapeutic combinations
|
EP1735348B1
(en)
|
2004-03-19 |
2012-06-20 |
Imclone LLC |
Human anti-epidermal growth factor receptor antibody
|
AU2005249206A1
(en)
|
2004-06-03 |
2005-12-15 |
F. Hoffmann-La Roche Ag |
Treatment with cisplatin and an EGFR-inhibitor
|
PT1828249E
(pt)
|
2004-12-03 |
2011-02-25 |
Schering Corp |
Biomarcadores para a pré-selecção de pacientes para terapêutica anti-igf1r
|
MY146381A
(en)
|
2004-12-22 |
2012-08-15 |
Amgen Inc |
Compositions and methods relating relating to anti-igf-1 receptor antibodies
|
ES2452115T3
(es)
|
2005-06-17 |
2014-03-31 |
Imclone Llc |
Un anticuerpo anti-PDGFRalfa para su uso en el tratamiento de cáncer de huesos metastásico
|
WO2007035744A1
(en)
|
2005-09-20 |
2007-03-29 |
Osi Pharmaceuticals, Inc. |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
EP3770174A1
(en)
|
2005-10-11 |
2021-01-27 |
Amgen Research (Munich) GmbH |
Compositions comprising cross-species-specific antibodies and uses thereof
|
TW200812615A
(en)
|
2006-03-22 |
2008-03-16 |
Hoffmann La Roche |
Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
|
MX2009001715A
(es)
|
2006-08-21 |
2009-02-25 |
Hoffmann La Roche |
Terapia tumoral con un anticuerpo anti-vegf.
|
SG178789A1
(en)
|
2007-02-16 |
2012-03-29 |
Merrimack Pharmaceuticals Inc |
Antibodies against erbb3 and uses thereof
|
PL2155788T3
(pl)
*
|
2007-04-03 |
2013-02-28 |
Amgen Res Munich Gmbh |
Swoiste międzygatunkowe bispecyficzne czynniki wiążące
|
WO2009030368A1
(en)
|
2007-09-05 |
2009-03-12 |
F. Hoffmann-La Roche Ag |
Combination therapy with type i and type ii anti-cd20 antibodies
|
US20090098118A1
(en)
|
2007-10-15 |
2009-04-16 |
Thomas Friess |
Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent
|
AR071891A1
(es)
|
2008-05-30 |
2010-07-21 |
Imclone Llc |
Anticuerpos humanos anti-flt3 (receptor tirosina cinasa 3 tipo fms humano)
|
BRPI0917871A2
(pt)
|
2008-08-15 |
2017-06-20 |
Merrimack Pharmaceuticals Inc |
agente terapêutico anti-erbb3 para uso em terapia de um tumor, métodos para predizer responsividade de um tumor de um agente terapêutco anti-erbb3, para selecionar terapia anti-erbb3 para um paciente, para predizer a resposta de células ao tratamento com um agente terapêutico, para identificar um biomarcador, e para evitar administração de uma droga para câncer anti-erbb3, e, kit para predizer a resposta das células ao tratamento com um agente terapêutico
|
US20120189641A1
(en)
|
2009-02-25 |
2012-07-26 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
EP2400990A2
(en)
|
2009-02-26 |
2012-01-04 |
OSI Pharmaceuticals, LLC |
In situ methods for monitoring the emt status of tumor cells in vivo
|
US20120064072A1
(en)
|
2009-03-18 |
2012-03-15 |
Maryland Franklin |
Combination Cancer Therapy Comprising Administration of an EGFR Inhibitor and an IGF-1R Inhibitor
|
RU2504553C2
(ru)
|
2009-03-20 |
2014-01-20 |
Дженентек, Инк. |
Антитела к her
|
AR075982A1
(es)
|
2009-03-31 |
2011-05-11 |
Roche Glycart Ag |
Terapia de combinacion de un anticuerpo afucosilado y una o mas de las citoquinas seleccionadas de gm- csf humano, m -csf humano y/o il-3 humano y composicion
|
EP2236139A1
(en)
|
2009-03-31 |
2010-10-06 |
F. Hoffmann-La Roche AG |
Combination therapy of erlotinib with an anti-IGF-1R antibody, which does not inhibit binding of insulin to the insulin receptor
|
TWI409079B
(zh)
|
2009-08-14 |
2013-09-21 |
Roche Glycart Ag |
非典型岩藻醣化cd20抗體與苯達莫斯汀(bendamustine)之組合療法
|
JP2013501741A
(ja)
|
2009-08-14 |
2013-01-17 |
ロシュ グリクアート アーゲー |
アフコシル化cd20抗体とフルダラビン及び/又はミトキサントロンの併用療法
|
AR078161A1
(es)
|
2009-09-11 |
2011-10-19 |
Hoffmann La Roche |
Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento.
|
US20110275644A1
(en)
|
2010-03-03 |
2011-11-10 |
Buck Elizabeth A |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
WO2011109584A2
(en)
|
2010-03-03 |
2011-09-09 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
KR101798679B1
(ko)
|
2010-03-11 |
2017-11-16 |
메리맥 파마슈티컬즈, 인크. |
3중 음성 및 기저형 유방암 치료 시의 erbb3 저해제의 용도
|
KR101620661B1
(ko)
|
2010-04-27 |
2016-05-12 |
로슈 글리카트 아게 |
어푸코실화된 CD20 항체와 mTOR 억제제의 복합 요법
|
AR082693A1
(es)
|
2010-08-17 |
2012-12-26 |
Roche Glycart Ag |
Terapia de combinacion de un anticuerpo anti-cd20 afucosilado con un anticuerpo anti-vegf
|
TW201302793A
(zh)
|
2010-09-03 |
2013-01-16 |
Glaxo Group Ltd |
新穎之抗原結合蛋白
|
CA2819436A1
(en)
|
2010-12-16 |
2012-06-21 |
Roche Glycart Ag |
Combination therapy of an afucosylated cd20 antibody with a mdm2 inhibitor
|
WO2012106556A2
(en)
|
2011-02-02 |
2012-08-09 |
Amgen Inc. |
Methods and compositons relating to inhibition of igf-1r
|
US20120214830A1
(en)
|
2011-02-22 |
2012-08-23 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma
|
WO2012129145A1
(en)
|
2011-03-18 |
2012-09-27 |
OSI Pharmaceuticals, LLC |
Nscle combination therapy
|
MX2013011706A
(es)
|
2011-04-07 |
2014-04-25 |
Amgen Inc |
Proteinas novedosas de enlace a antigeno.
|
US9896730B2
(en)
|
2011-04-25 |
2018-02-20 |
OSI Pharmaceuticals, LLC |
Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment
|
WO2013071056A2
(en)
|
2011-11-11 |
2013-05-16 |
Duke University |
Combination drug therapy for the treatment of solid tumors
|
US20130302274A1
(en)
|
2011-11-25 |
2013-11-14 |
Roche Glycart Ag |
Combination therapy
|
CN104136464A
(zh)
*
|
2012-02-23 |
2014-11-05 |
U3制药有限公司 |
用于调节放射敏感性的her3抑制剂
|
AR090263A1
(es)
|
2012-03-08 |
2014-10-29 |
Hoffmann La Roche |
Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
KR102158467B1
(ko)
|
2012-09-07 |
2020-09-25 |
제넨테크, 인크. |
Ii형 항-cd20 항체와 선택적 bcl-2 억제제와의 병용 치료요법
|
AR094403A1
(es)
|
2013-01-11 |
2015-07-29 |
Hoffmann La Roche |
Terapia de combinación de anticuerpos anti-her3
|
EP3087394A2
(en)
|
2013-12-27 |
2016-11-02 |
Merrimack Pharmaceuticals, Inc. |
Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies
|
JP2017516458A
(ja)
|
2014-03-24 |
2017-06-22 |
ジェネンテック, インコーポレイテッド |
c−met拮抗剤による癌治療及びc−met拮抗剤のHGF発現との相関
|
US10184006B2
(en)
|
2015-06-04 |
2019-01-22 |
Merrimack Pharmaceuticals, Inc. |
Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors
|
CN113607945A
(zh)
|
2015-07-07 |
2021-11-05 |
豪夫迈·罗氏有限公司 |
抗HER2抗体-药物缀合物和Bcl-2抑制剂的组合疗法
|
US20180371551A1
(en)
|
2015-12-03 |
2018-12-27 |
Agios Pharmaceuticals, Inc. |
Mat2a inhibitors for treating mtap null cancer
|
EP3405194A1
(en)
|
2016-01-18 |
2018-11-28 |
Institut National de la Sante et de la Recherche Medicale (INSERM) |
The use of a temporary inhibitor of p53 for preventing or reducing cancer relapse
|
CN109415441B
(zh)
|
2016-05-24 |
2023-04-07 |
英斯梅德股份有限公司 |
抗体及其制备方法
|
EP3658584A1
(en)
|
2017-07-26 |
2020-06-03 |
H. Hoffnabb-La Roche Ag |
Combination therapy with a bet inhibitor, a bcl-2 inhibitor and an anti-cd20 antibody
|
EP3658188A1
(en)
|
2017-07-26 |
2020-06-03 |
H. Hoffnabb-La Roche Ag |
Combination therapy with a bet inhibitor and a bcl-2 inhibitor
|
TW201920282A
(zh)
*
|
2017-09-29 |
2019-06-01 |
中國大陸商上海藥明生物技術有限公司 |
抗egfr和pd-1的雙特異性抗體
|
WO2019201882A1
(en)
|
2018-04-18 |
2019-10-24 |
F. Hoffmann-La Roche Ag |
Combination therapy with a bet inhibitor and a proteasome inhibitor
|
WO2020234445A1
(en)
|
2019-05-23 |
2020-11-26 |
F. Hoffmann-La Roche Ag |
Combination therapy with a bet inhibitor and a bcl-2 inhibitor
|
WO2021155006A1
(en)
|
2020-01-31 |
2021-08-05 |
Les Laboratoires Servier Sas |
Inhibitors of cyclin-dependent kinases and uses thereof
|