EP1097165A4 - Novel inhibitors of angiogenesis and tumor growth - Google Patents

Novel inhibitors of angiogenesis and tumor growth

Info

Publication number
EP1097165A4
EP1097165A4 EP99935517A EP99935517A EP1097165A4 EP 1097165 A4 EP1097165 A4 EP 1097165A4 EP 99935517 A EP99935517 A EP 99935517A EP 99935517 A EP99935517 A EP 99935517A EP 1097165 A4 EP1097165 A4 EP 1097165A4
Authority
EP
European Patent Office
Prior art keywords
angiogenesis
tumor growth
novel inhibitors
inhibitors
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99935517A
Other languages
German (de)
French (fr)
Other versions
EP1097165A1 (en
Inventor
Parkash S Gill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP1097165A1 publication Critical patent/EP1097165A1/en
Publication of EP1097165A4 publication Critical patent/EP1097165A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
EP99935517A 1998-07-13 1999-07-12 Novel inhibitors of angiogenesis and tumor growth Withdrawn EP1097165A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9264798P 1998-07-13 1998-07-13
US92647P 1998-07-13
PCT/US1999/015772 WO2000002902A1 (en) 1998-07-13 1999-07-12 Novel inhibitors of angiogenesis and tumor growth

Publications (2)

Publication Number Publication Date
EP1097165A1 EP1097165A1 (en) 2001-05-09
EP1097165A4 true EP1097165A4 (en) 2001-09-12

Family

ID=22234332

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99935517A Withdrawn EP1097165A4 (en) 1998-07-13 1999-07-12 Novel inhibitors of angiogenesis and tumor growth

Country Status (6)

Country Link
US (3) US6500431B1 (en)
EP (1) EP1097165A4 (en)
JP (1) JP2002530273A (en)
AU (1) AU772778B2 (en)
CA (1) CA2337438A1 (en)
WO (1) WO2000002902A1 (en)

Families Citing this family (35)

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WO2001055198A2 (en) * 2000-01-26 2001-08-02 Memorec Medical Molecular Research Cologne Stoffel Gmbh Dermo- and gastro-specific sphingolipid activator
GB0010630D0 (en) * 2000-05-04 2000-06-21 Univ Wales Medicine Sequence
DK1605965T3 (en) * 2003-03-26 2013-04-15 Evotec Internat Gmbh Use of saposin-related proteins for the prevention and treatment of obesity, diabetes and / or metabolic syndrome
US7834147B2 (en) * 2003-04-28 2010-11-16 Childrens Hospital Medical Center Saposin C-DOPS: a novel anti-tumor agent
NZ549787A (en) 2004-03-12 2010-05-28 Vasgene Therapeutics Inc Antibodies binding to EphB4 for inhibiting angiogenesis and tumor growth
US7973134B2 (en) * 2004-07-07 2011-07-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways
WO2006034455A2 (en) 2004-09-23 2006-03-30 Vasgene Therapeutics, Inc. Polipeptide compounds for inhibiting angiogenesis and tumor growth
US7935790B2 (en) * 2004-10-04 2011-05-03 Cell Singaling Technology, Inc. Reagents for the detection of protein phosphorylation in T-cell receptor signaling pathways
US7807789B2 (en) * 2004-12-21 2010-10-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in EGFR-signaling pathways
US20090099340A1 (en) * 2007-10-12 2009-04-16 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
US20100151495A9 (en) * 2005-08-31 2010-06-17 Cell Signaling Technolgy, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
WO2007027906A2 (en) * 2005-08-31 2007-03-08 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in leukemia signaling pathways
NZ599035A (en) 2006-01-12 2013-12-20 Alexion Pharma Inc Antibodies to ox-2/cd200 and uses thereof
WO2007127335A2 (en) * 2006-04-27 2007-11-08 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in atm and atr kinase signaling pathways
US7939636B2 (en) * 2006-08-11 2011-05-10 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in c-Src signaling pathways
US20090258442A1 (en) * 2006-08-31 2009-10-15 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
ES2415666T3 (en) 2007-02-01 2013-07-26 Acceleron Pharma, Inc. Pharmaceutical compositions comprising Activin-ActRIIa antagonists for use in the prevention or treatment of breast cancer metastases or bone loss related to breast cancer
EP1972639A3 (en) 2007-03-07 2008-12-03 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
EP1975184A3 (en) 2007-03-26 2008-11-26 Cell Signaling Technology, Inc. Serine or threonine phosphorylation sites
US20080238709A1 (en) * 2007-03-28 2008-10-02 Faramarz Vaziri One-way communication apparatus with dynamic key generation
EP1983003A3 (en) 2007-04-19 2009-03-11 Peter Hornbeck Tyrosine phosphorylation sites and antibodies specific for them
US7977462B2 (en) 2007-04-19 2011-07-12 Cell Signaling Technology, Inc. Tyrosine phosphorylation sites
EP1983002A3 (en) 2007-04-19 2009-03-11 Peter Hornbeck Tyrosine phosphorylation sites and antibodies specific for them
US20090053831A1 (en) 2007-05-01 2009-02-26 Cell Signaling Technology, Inc. Tyrosine phosphorylation sites
WO2009002931A2 (en) * 2007-06-22 2008-12-31 Children's Medical Center Corporation Methods and uses thereof of prosaposin
AU2013203640B2 (en) * 2007-06-22 2017-04-13 Children's Medical Center Corporation Methods and uses thereof of prosaposin
US7960343B2 (en) 2007-09-18 2011-06-14 Acceleron Pharma Inc. Activin-ActRIIa antagonists and uses for decreasing or inhibiting FSH secretion
EP2062920A3 (en) 2007-11-21 2009-06-17 Peter Hornbeck Protein phosphorylation by basophilic serine/threonine kinases in insulin signalling pathways
US20090220991A1 (en) * 2008-02-29 2009-09-03 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in leukemia signaling pathways
EP3366695B1 (en) * 2009-12-17 2021-07-07 Children's Medical Center Corporation Saposin-a derived peptides and uses thereof
EP2793921B1 (en) 2011-12-22 2019-04-24 Children's Medical Center Corporation Saposin-a derived peptides and uses thereof
WO2013149219A2 (en) 2012-03-30 2013-10-03 Sorrento Therapeutics Inc. Fully human antibodies that bind to vegfr2
US9921224B2 (en) 2013-03-14 2018-03-20 Children's Medical Center Corporation Use of CD36 to identify cancer subjects for treatment
CN106659764B (en) 2014-03-26 2021-11-02 儿童医学中心公司 Cyclic sphingolipid activator protein propeptide and uses thereof
EP4026849A1 (en) 2016-09-26 2022-07-13 Ensemble Group Holdings Methods of assessing and treating cancer in subjects having dysregulated lymphatic systems using a combination of vegfr-3 and pd-1 or pd-l1 inhibitors

Citations (11)

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Publication number Priority date Publication date Assignee Title
WO1991009871A1 (en) * 1989-12-22 1991-07-11 Seragen Incorporated Hybrid molecules having translocation region and cell-binding region
WO1993019777A1 (en) * 1992-03-30 1993-10-14 Immunex Corporation Fusion proteins comprising tumor necrosis factor receptor
WO1994006476A1 (en) * 1992-09-15 1994-03-31 Immunex Corporation Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists
WO1995003821A1 (en) * 1993-07-30 1995-02-09 The Regents Of The University Of California Prosaposin and cytokine-derived peptides as therapeutic agents
WO1996012802A1 (en) * 1989-10-31 1996-05-02 Ophidian Pharmaceuticals, Inc. Vaccine and antitoxin for treatment and prevention of c. difficile disease
WO1997005252A2 (en) * 1995-07-26 1997-02-13 Nps Pharmaceuticals, Inc. Chimeric receptors and methods for identifying compounds active at metabotropic glutamate receptors and the use of such compounds in the treatment of neurological disorders and diseases
WO1997025620A1 (en) * 1996-01-11 1997-07-17 The Penn State Research Foundation A method and use of polypeptide in sperm-egg binding to enhance or decrease fertility
WO1997031108A1 (en) * 1996-02-20 1997-08-28 Association Pour Le Developpement De La Recherche En Genetique Moleculaire (Aderegem) Modified nuclear glucocorticoid receptor, fusion protein, and dna fragments coding for said receptor and said fusion protein
WO1998033810A2 (en) * 1997-01-30 1998-08-06 University Of Virginia Patent Foundation Cysteine-depleted peptides recognized by a3-restricted cytotoxic lymphocytes, and uses therefor
WO1999012559A1 (en) * 1997-09-09 1999-03-18 The Regents Of The University Of California Inhibition of apoptotis using prosaposin receptor agonists
WO1999016889A1 (en) * 1997-10-01 1999-04-08 G.D. Searle & Co. Fusion proteins comprising an angiostatin moiety and their use in anti-tumor treatment

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CA2101942C (en) * 1991-02-08 2001-01-30 Richard T. Dean Technetium-99m labeled polypeptides for imaging
US5639876A (en) * 1991-02-12 1997-06-17 Heska Corporation Nucleic acid molecules encoding novel parasitic helminth proteins
US5571787A (en) 1993-07-30 1996-11-05 Myelos Corporation Prosaposin as a neurotrophic factor
US5716614A (en) * 1994-08-05 1998-02-10 Molecular/Structural Biotechnologies, Inc. Method for delivering active agents to mammalian brains in a complex with eicosapentaenoic acid or docosahexaenoic acid-conjugated polycationic carrier
US6403782B1 (en) * 1995-06-22 2002-06-11 President And Fellows Of Harvard College Nucleic acid encoding eotaxin
WO1997026483A1 (en) 1996-01-17 1997-07-24 Dialight Corporation An led illuminated lamp assembly

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996012802A1 (en) * 1989-10-31 1996-05-02 Ophidian Pharmaceuticals, Inc. Vaccine and antitoxin for treatment and prevention of c. difficile disease
WO1991009871A1 (en) * 1989-12-22 1991-07-11 Seragen Incorporated Hybrid molecules having translocation region and cell-binding region
WO1993019777A1 (en) * 1992-03-30 1993-10-14 Immunex Corporation Fusion proteins comprising tumor necrosis factor receptor
WO1994006476A1 (en) * 1992-09-15 1994-03-31 Immunex Corporation Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists
WO1995003821A1 (en) * 1993-07-30 1995-02-09 The Regents Of The University Of California Prosaposin and cytokine-derived peptides as therapeutic agents
WO1997005252A2 (en) * 1995-07-26 1997-02-13 Nps Pharmaceuticals, Inc. Chimeric receptors and methods for identifying compounds active at metabotropic glutamate receptors and the use of such compounds in the treatment of neurological disorders and diseases
WO1997025620A1 (en) * 1996-01-11 1997-07-17 The Penn State Research Foundation A method and use of polypeptide in sperm-egg binding to enhance or decrease fertility
WO1997031108A1 (en) * 1996-02-20 1997-08-28 Association Pour Le Developpement De La Recherche En Genetique Moleculaire (Aderegem) Modified nuclear glucocorticoid receptor, fusion protein, and dna fragments coding for said receptor and said fusion protein
WO1998033810A2 (en) * 1997-01-30 1998-08-06 University Of Virginia Patent Foundation Cysteine-depleted peptides recognized by a3-restricted cytotoxic lymphocytes, and uses therefor
WO1999012559A1 (en) * 1997-09-09 1999-03-18 The Regents Of The University Of California Inhibition of apoptotis using prosaposin receptor agonists
WO1999016889A1 (en) * 1997-10-01 1999-04-08 G.D. Searle & Co. Fusion proteins comprising an angiostatin moiety and their use in anti-tumor treatment

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LIEPINSH E A: "SAPOSIN FOLD REVEALED BY THE NMR STRUCTURE OF NK-LYSIN", NATURE STRUCTURAL BIOLOGY,US,NEW YORK, NY, vol. 4, no. 10, October 1997 (1997-10-01), pages 793 - 795, XP000867792, ISSN: 1072-8368 *
PONTING C P ET AL: "Swaposins: circular permutations within genes encoding saposin homologues", TIBS TRENDS IN BIOCHEMICAL SCIENCES,ELSEVIER PUBLICATION, CAMBRIDGE,EN, vol. 20, no. 5, May 1995 (1995-05-01), pages 179 - 180, XP004222261, ISSN: 0968-0004 *
See also references of WO0002902A1 *
WONG ET AL: "Pseudomonas aeruginosa outer membrane protien OprF as an expression vector for foreign epitopes: the effects of positioning and length on the antigenicity of the epitope.", GENE, vol. 158, 1995, pages 55 - 60, XP004206660 *

Also Published As

Publication number Publication date
US20080242840A1 (en) 2008-10-02
AU772778B2 (en) 2004-05-06
JP2002530273A (en) 2002-09-17
WO2000002902A9 (en) 2000-07-20
CA2337438A1 (en) 2000-01-20
US6500431B1 (en) 2002-12-31
WO2000002902A1 (en) 2000-01-20
EP1097165A1 (en) 2001-05-09
AU5097999A (en) 2000-02-01
US7341730B1 (en) 2008-03-11

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