RU2230556C2 - Препаративные формы гидрокодона с контролируемым высвобождением - Google Patents

Препаративные формы гидрокодона с контролируемым высвобождением Download PDF

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RU2230556C2
RU2230556C2 RU2002113921/15A RU2002113921A RU2230556C2 RU 2230556 C2 RU2230556 C2 RU 2230556C2 RU 2002113921/15 A RU2002113921/15 A RU 2002113921/15A RU 2002113921 A RU2002113921 A RU 2002113921A RU 2230556 C2 RU2230556 C2 RU 2230556C2
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Russia
Prior art keywords
dosage form
hydrocodone
max
provides
hours
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RU2002113921/15A
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English (en)
Russian (ru)
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RU2002113921A (ru
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Бенджамин ОШЛАК (US)
Бенджамин Ошлак
Хуа-Пин ХУАНГ (US)
Хуа-Пин Хуанг
Альфред П. ТОНЕЛЛИ (US)
Альфред П. ТОНЕЛЛИ
Джон МАССЕЛИНК (US)
Джон МАССЕЛИНК
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Эро-Селтик, С.А.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
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    • A61K9/1605—Excipients; Inactive ingredients
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    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
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    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/282—Organic compounds, e.g. fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
RU2002113921/15A 1999-10-29 2000-10-30 Препаративные формы гидрокодона с контролируемым высвобождением RU2230556C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16254199P 1999-10-29 1999-10-29
US60/162,541 1999-10-29

Publications (2)

Publication Number Publication Date
RU2002113921A RU2002113921A (ru) 2004-01-10
RU2230556C2 true RU2230556C2 (ru) 2004-06-20

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RU2002113921/15A RU2230556C2 (ru) 1999-10-29 2000-10-30 Препаративные формы гидрокодона с контролируемым высвобождением

Country Status (21)

Country Link
US (12) US7943174B2 (pt)
EP (5) EP2305218A1 (pt)
JP (6) JP4806507B2 (pt)
KR (8) KR20080015955A (pt)
CN (3) CN107213128A (pt)
AT (1) ATE526950T1 (pt)
AU (2) AU764453B2 (pt)
BR (1) BRPI0015284B8 (pt)
CA (1) CA2389235C (pt)
CY (1) CY1112260T1 (pt)
DK (1) DK1623703T3 (pt)
ES (1) ES2374717T3 (pt)
HK (2) HK1054698A1 (pt)
HU (1) HU230828B1 (pt)
IL (4) IL149352A0 (pt)
MX (1) MXPA02004293A (pt)
NO (1) NO333380B1 (pt)
NZ (1) NZ529928A (pt)
PT (1) PT1623703E (pt)
RU (1) RU2230556C2 (pt)
WO (1) WO2001032148A1 (pt)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA017435B1 (ru) * 2004-08-31 2012-12-28 Эро-Селтик С.А. Мультичастицы, способ получения мультичастиц и их применения
RU2477995C2 (ru) * 2007-07-20 2013-03-27 Эбботт Гмбх Унд Ко.Кг Составы неопиоидных и ограниченных опиоидных аналгетиков
RU2609412C2 (ru) * 2011-01-11 2017-02-01 Сигничер Терапьютикс, Инк. Композиции, содержащие расщепляемое ферментами пролекарство оксикодона

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EP2263658A1 (en) 2000-10-30 2010-12-22 Euro-Celtique S.A. Controlled release hydrocodone formulations
CN100356907C (zh) * 2001-06-08 2007-12-26 恩德制药公司 利用丙烯酸酯聚合物的控释剂型和其制备方法
CA2452871C (en) 2001-07-06 2011-10-04 Endo Pharmaceuticals, Inc. Oxymorphone controlled release formulations
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SK286107B6 (sk) * 2002-04-12 2008-03-05 Zentiva, A. S. Analgeticky účinný perorálny liečivý prípravok s kontrolovaným uvoľňovaním opioidnej účinnej látky a spôsob jeho prípravy
EP1551402A4 (en) * 2002-09-23 2009-05-27 Verion Inc PHARMACEUTICAL COMPOSITIONS NOT INDUCING ABUSE
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JP4997109B2 (ja) 2004-09-01 2012-08-08 ユーロ−セルティーク エス．エイ． 用量比例的な定常状態ｃａｖｅおよび定常状態ａｕｃ、ならびに、用量比例よりも小さい単回投与ｃｍａｘを有するオピオイド投薬形態物
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