RU2015153061A - Замещенные связанные мостиковой связью мочевинные аналоги в качестве модуляторов сиртуина - Google Patents
Замещенные связанные мостиковой связью мочевинные аналоги в качестве модуляторов сиртуина Download PDFInfo
- Publication number
- RU2015153061A RU2015153061A RU2015153061A RU2015153061A RU2015153061A RU 2015153061 A RU2015153061 A RU 2015153061A RU 2015153061 A RU2015153061 A RU 2015153061A RU 2015153061 A RU2015153061 A RU 2015153061A RU 2015153061 A RU2015153061 A RU 2015153061A
- Authority
- RU
- Russia
- Prior art keywords
- compound
- membered saturated
- heterocycle
- salt
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361822758P | 2013-05-13 | 2013-05-13 | |
| US51822758 | 2013-05-13 | ||
| PCT/US2014/037767 WO2014186313A1 (en) | 2013-05-13 | 2014-05-13 | Substituted bridged urea analogs as sirtuin modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015153061A true RU2015153061A (ru) | 2017-06-15 |
| RU2015153061A3 RU2015153061A3 (enExample) | 2018-03-21 |
Family
ID=53264426
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015153061A RU2015153061A (ru) | 2013-05-13 | 2014-05-13 | Замещенные связанные мостиковой связью мочевинные аналоги в качестве модуляторов сиртуина |
| RU2017120859A RU2017120859A (ru) | 2013-05-13 | 2015-11-19 | Замещенные мостиковые аналоги мочевины в качестве модуляторов сиртуина |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017120859A RU2017120859A (ru) | 2013-05-13 | 2015-11-19 | Замещенные мостиковые аналоги мочевины в качестве модуляторов сиртуина |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US9765075B2 (enExample) |
| EP (2) | EP2997029B1 (enExample) |
| JP (2) | JP6376707B2 (enExample) |
| KR (2) | KR20160006215A (enExample) |
| CN (2) | CN105392788B (enExample) |
| AU (3) | AU2014265671B2 (enExample) |
| BR (2) | BR112015028613A2 (enExample) |
| CA (2) | CA2912683A1 (enExample) |
| ES (1) | ES2718550T3 (enExample) |
| RU (2) | RU2015153061A (enExample) |
| WO (1) | WO2014186313A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9624184B2 (en) * | 2013-04-04 | 2017-04-18 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| JP6376707B2 (ja) * | 2013-05-13 | 2018-08-22 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ | サーチュイン調節剤としての置換架橋尿素類似体 |
| JP2016079173A (ja) * | 2014-10-15 | 2016-05-16 | 日本合成化学工業株式会社 | 新規ピリジン系化合物、それを用いたアニオン硬化性化合物用硬化剤、硬化性組成物及び硬化物 |
| CN107207520A (zh) * | 2014-11-19 | 2017-09-26 | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 作为沉默调节蛋白调节剂的取代的桥环脲类似物 |
| WO2016095089A1 (en) * | 2014-12-15 | 2016-06-23 | Merck Sharp & Dohme Corp. | Erk inhibitors |
| WO2016095088A1 (en) * | 2014-12-15 | 2016-06-23 | Merck Sharp & Dohme Corp. | Erk inhibitors |
| US10364245B2 (en) | 2017-06-07 | 2019-07-30 | Chiesi Farmaceutici S.P.A. | Kinase inhibitors |
| CN111511723A (zh) * | 2017-08-21 | 2020-08-07 | 米可如比奥提克斯有限公司 | 用作抗菌剂的代谢稳定的n-酰基氨基噁二唑 |
| JP7156207B2 (ja) * | 2019-08-07 | 2022-10-19 | 株式会社島津製作所 | 糖ペプチド解析装置 |
| CN112759593A (zh) * | 2019-11-01 | 2021-05-07 | 北京伯汇生物技术有限公司 | 桥环并醛基吡啶衍生物及其应用 |
| CN112094362B (zh) * | 2020-09-29 | 2022-04-12 | 四川大学华西医院 | 烟酰胺核糖或单核苷酸类似物-大分子载体轭合物及制法和应用 |
| CN112645805A (zh) * | 2020-12-23 | 2021-04-13 | 北京理工大学 | 一种由温勒伯酰胺制备均苯三甲醛的方法 |
| CN115518062B (zh) * | 2022-09-02 | 2024-03-22 | 成都大学 | Phellopterin在制备用于治疗STAT信号通路介导的相关疾病药物中的用途 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4727064A (en) | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| DE4424484A1 (de) * | 1994-07-12 | 1996-01-18 | Bayer Ag | Azofarbstoffe, deren Herstellung und Verwendung |
| EP1781300A1 (en) * | 2004-07-16 | 2007-05-09 | ProteoSys AG | Muscarinic antagonists with parp and sir modulatng activity as agents for inflammatory diseases |
| AU2006204699B2 (en) * | 2005-01-13 | 2012-04-26 | Sirtris Pharmaceuticals, Inc. | Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders |
| WO2006094248A1 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | Aryl-substituted cyclic sirtuin modulators |
| WO2006094210A2 (en) * | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | Tetrahydroquinoxalinone sirtuin modulators |
| EP2805719A1 (en) | 2005-03-30 | 2014-11-26 | Glaxosmithkline LLC | Nicotinamide riboside and analogues thereof |
| ATE488232T1 (de) | 2006-09-04 | 2010-12-15 | Univ Dundee | P53 aktivierende benzoylharnstoff- und benzoylthioharnstoff-verbindungen |
| CN101952286A (zh) * | 2007-12-21 | 2011-01-19 | 阿斯利康(瑞典)有限公司 | 用于治疗和雄激素受体有关的病症的双环衍生物 |
| AU2009243006B2 (en) | 2008-05-01 | 2013-03-21 | Sirtris Pharmaceuticals, Inc. | Quinolines and related analogs as sirtuin modulators |
| CA2738794C (en) | 2008-09-29 | 2016-01-05 | Sirtris Pharmaceuticals, Inc. | Chromenone analogs as sirtuin modulators |
| EP2350051A4 (en) | 2008-10-29 | 2012-05-30 | Sirtris Pharmaceuticals Inc | PYRIDINE, BICYCLIC PYRIDINE AND ITS ANALOGS AS SIRTUINE MODULATORS |
| CN102388054B (zh) | 2008-12-19 | 2015-03-04 | 西特里斯药业公司 | 噻唑并吡啶沉默调节蛋白调节剂的化合物 |
| WO2011059839A1 (en) * | 2009-10-29 | 2011-05-19 | Sirtris Pharmaceuticals, Inc. | Bicyclic pyridines and analogs as sirtuin modulators |
| US20140288052A1 (en) | 2011-10-20 | 2014-09-25 | GlaxoSmithKline, LLC | Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators |
| WO2016081692A2 (en) | 2014-11-19 | 2016-05-26 | Glaxosmithkline Llc | Substituted bridged urea analogs as sirtuin modulators |
| JP6376707B2 (ja) | 2013-05-13 | 2018-08-22 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ | サーチュイン調節剤としての置換架橋尿素類似体 |
-
2014
- 2014-05-13 JP JP2016514017A patent/JP6376707B2/ja not_active Expired - Fee Related
- 2014-05-13 BR BR112015028613A patent/BR112015028613A2/pt not_active Application Discontinuation
- 2014-05-13 CN CN201480040001.7A patent/CN105392788B/zh not_active Expired - Fee Related
- 2014-05-13 ES ES14798509T patent/ES2718550T3/es active Active
- 2014-05-13 CA CA2912683A patent/CA2912683A1/en not_active Abandoned
- 2014-05-13 AU AU2014265671A patent/AU2014265671B2/en not_active Ceased
- 2014-05-13 KR KR1020157034916A patent/KR20160006215A/ko not_active Ceased
- 2014-05-13 RU RU2015153061A patent/RU2015153061A/ru unknown
- 2014-05-13 EP EP14798509.7A patent/EP2997029B1/en active Active
- 2014-05-13 WO PCT/US2014/037767 patent/WO2014186313A1/en not_active Ceased
- 2014-05-13 US US14/891,158 patent/US9765075B2/en not_active Expired - Fee Related
- 2014-11-19 US US14/547,861 patent/US9834558B2/en not_active Expired - Fee Related
-
2015
- 2015-11-19 RU RU2017120859A patent/RU2017120859A/ru unknown
- 2015-11-19 CA CA2975291A patent/CA2975291A1/en not_active Abandoned
- 2015-11-19 JP JP2017526877A patent/JP6833686B2/ja not_active Expired - Fee Related
- 2015-11-19 US US15/528,195 patent/US10590135B2/en active Active
- 2015-11-19 KR KR1020177016322A patent/KR20170084274A/ko not_active Withdrawn
- 2015-11-19 BR BR112017010592A patent/BR112017010592A2/pt not_active Application Discontinuation
- 2015-11-19 CN CN201580074601.XA patent/CN107207496A/zh active Pending
- 2015-11-19 EP EP15861618.5A patent/EP3221312A4/en not_active Withdrawn
- 2015-11-19 AU AU2015349912A patent/AU2015349912A1/en not_active Abandoned
-
2017
- 2017-06-20 AU AU2017204176A patent/AU2017204176B2/en not_active Ceased
- 2017-08-04 US US15/669,301 patent/US20180044338A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2012122065A (ru) | Бициклические пиридины и аналоги в качестве модуляторов сиртуина | |
| IL264541A (en) | History of sulfamolepyrolamide and their use as drugs for the treatment of jaundice b | |
| RU2014120180A (ru) | Замещенные бициклические аза-гетероциклы и аналоги в качестве модуляторов сиртуина | |
| JP2011519863A5 (enExample) | ||
| RU2011109190A (ru) | Бензоксазолы, бензтиазолы и родственные аналоги в качестве модуляторов сиртуина | |
| RU2015100901A (ru) | Производные эфира гетероарилкарбоновой кислоты | |
| JP2016518448A5 (enExample) | ||
| RU2011117159A (ru) | Аналоги хроменона в качестве модуляторов сиртуина | |
| JP2013531031A5 (enExample) | ||
| RU2018124993A (ru) | Ингибиторы репликации вируса гриппа, способы их применения и использование | |
| JP2013531029A5 (enExample) | ||
| JP2013510825A5 (enExample) | ||
| JP2013509442A5 (enExample) | ||
| RU2013146011A (ru) | Сульфонамидные соединения, обладающие антагонистической активностью в отношении trpm8 | |
| AR095192A1 (es) | Quinolina y quinazolinamidas como modulares de canales de sodio | |
| AR073993A1 (es) | Compuesto de pirazolilaminopiridina, composicion farmaceuticamente aceptable que lo comprende y su uso para preparar un medicamento util para tratar el cancer | |
| JP2018536648A5 (enExample) | ||
| RU2012127334A (ru) | Производные 5-замещенного хиназолинона, содержащие их композиции и способы их применения | |
| JP2012522729A5 (enExample) | ||
| RU2017132433A (ru) | Фторированные производные тетрагидронафтиридинилнонановой кислоты и их применение | |
| RU2013154733A (ru) | Производные бензоциклогептенуксусной кислоты | |
| RU2016129380A (ru) | Замещенные диаминопиримидильные соединения, их композиции и способы лечения с их участием | |
| AR098522A1 (es) | Compuesto de triazolo-piridina | |
| RU2016115934A (ru) | Конденсированное гетероциклическое соединение, способ его получения, его фармацевтическая композиция и применения | |
| EA201591775A1 (ru) | Замещенные ароматические соединения и связанный с ними способ лечения фиброза |