JP2011519863A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011519863A5 JP2011519863A5 JP2011507632A JP2011507632A JP2011519863A5 JP 2011519863 A5 JP2011519863 A5 JP 2011519863A5 JP 2011507632 A JP2011507632 A JP 2011507632A JP 2011507632 A JP2011507632 A JP 2011507632A JP 2011519863 A5 JP2011519863 A5 JP 2011519863A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- fluoro
- phenyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- GYZKKKIFYYBYSB-UHFFFAOYSA-N CC(Cc1c2)C=Cc1ncc2-c(cc1)nc2c1C=CCC2NC(c1ccccc1)=O Chemical compound CC(Cc1c2)C=Cc1ncc2-c(cc1)nc2c1C=CCC2NC(c1ccccc1)=O GYZKKKIFYYBYSB-UHFFFAOYSA-N 0.000 description 1
- KMZSRRANCBLSIZ-UHFFFAOYSA-N COCC1C=CC(CNC(c(cccc2cc3)c2nc3-c2ccccc2)=O)=CC1 Chemical compound COCC1C=CC(CNC(c(cccc2cc3)c2nc3-c2ccccc2)=O)=CC1 KMZSRRANCBLSIZ-UHFFFAOYSA-N 0.000 description 1
- PUJQPIUTUFMOES-UHFFFAOYSA-N COc(cc1)ccc1S(Nc1cccc(nc2)c1nc2-c1ccncc1)(=O)=O Chemical compound COc(cc1)ccc1S(Nc1cccc(nc2)c1nc2-c1ccncc1)(=O)=O PUJQPIUTUFMOES-UHFFFAOYSA-N 0.000 description 1
- UOBCRIAKAHFLDZ-UHFFFAOYSA-N COc1ccc(CNC(C(CCC=C2C=C3)=C2N=C3c(cc2)ccc2OC)=O)cc1 Chemical compound COc1ccc(CNC(C(CCC=C2C=C3)=C2N=C3c(cc2)ccc2OC)=O)cc1 UOBCRIAKAHFLDZ-UHFFFAOYSA-N 0.000 description 1
- FBNHXCOGKZBJCL-UHFFFAOYSA-N O=C(c1ccccc1)Nc1cccc2ccc(-c3nc(cccc4)c4cc3)nc12 Chemical compound O=C(c1ccccc1)Nc1cccc2ccc(-c3nc(cccc4)c4cc3)nc12 FBNHXCOGKZBJCL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12611208P | 2008-05-01 | 2008-05-01 | |
| US61/126,112 | 2008-05-01 | ||
| PCT/US2009/042255 WO2009134973A1 (en) | 2008-05-01 | 2009-04-30 | Quenolines and related analogs as sirtuin modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011519863A JP2011519863A (ja) | 2011-07-14 |
| JP2011519863A5 true JP2011519863A5 (enExample) | 2012-06-21 |
| JP5425891B2 JP5425891B2 (ja) | 2014-02-26 |
Family
ID=41255415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011507632A Expired - Fee Related JP5425891B2 (ja) | 2008-05-01 | 2009-04-30 | サーチュイン調節薬としてのキノリンおよび関連する類似体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8685970B2 (enExample) |
| EP (1) | EP2273992B1 (enExample) |
| JP (1) | JP5425891B2 (enExample) |
| KR (1) | KR20110007235A (enExample) |
| CN (1) | CN102083438B (enExample) |
| AU (1) | AU2009243006B2 (enExample) |
| BR (1) | BRPI0912356A2 (enExample) |
| CA (1) | CA2723135A1 (enExample) |
| EA (1) | EA021938B1 (enExample) |
| ES (1) | ES2586459T3 (enExample) |
| IL (1) | IL208997A0 (enExample) |
| MX (1) | MX2010012010A (enExample) |
| SG (1) | SG190603A1 (enExample) |
| WO (1) | WO2009134973A1 (enExample) |
| ZA (1) | ZA201007677B (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009266889B2 (en) | 2008-07-03 | 2013-05-02 | Glaxosmithkline Llc | Benzimidazoles and related analogs as sirtuin modulators |
| CN102227420B (zh) * | 2008-09-29 | 2015-06-24 | 西特里斯药业公司 | 作为沉默调节蛋白调节剂的喹唑啉酮、喹诺酮和相关的类似物 |
| CA2752150A1 (en) * | 2009-02-11 | 2010-08-19 | Reaction Biology Corp. | Selective kinase inhibitors |
| CN102414180A (zh) * | 2009-03-02 | 2012-04-11 | 西特里斯药业公司 | 作为沉默调节蛋白调节剂的8-取代的喹啉及相关的类似物 |
| US9556201B2 (en) | 2009-10-29 | 2017-01-31 | Glaxosmithkline Llc | Bicyclic pyridines and analogs as sirtuin modulators |
| CN101723894B (zh) * | 2009-12-03 | 2011-12-28 | 南京大学 | N-喹啉酰胺类衍生物及其制法与用途 |
| US20120214803A1 (en) | 2011-02-18 | 2012-08-23 | Vifor (International) Ag | Novel Sulfonaminoquinoline Hepcidin Antagonists |
| WO2012122534A2 (en) | 2011-03-10 | 2012-09-13 | The Trustees Of Columbia University In The City Of New York | N-quinolin-benzensulfonamides and related compounds for the treatment of cancer, autoimmune disorders and inflammation |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| KR20150020228A (ko) * | 2012-05-31 | 2015-02-25 | 에프. 호프만-라 로슈 아게 | 아미노퀴나졸린 및 피리도피리미딘 유도체 |
| EP2882746B1 (en) | 2012-08-07 | 2016-12-07 | Merck Patent GmbH | Pyridopyrimidine derivatives as protein kinase inhibitors |
| WO2016081692A2 (en) * | 2014-11-19 | 2016-05-26 | Glaxosmithkline Llc | Substituted bridged urea analogs as sirtuin modulators |
| BR112015028613A2 (pt) | 2013-05-13 | 2017-07-25 | Glaxosmithkline Llc | análogos de uréia com ligações por pontes substituída como moduladores de sirtuína |
| WO2014201326A1 (en) | 2013-06-13 | 2014-12-18 | Monsanto Technology Llc | Acetyl-coa carboxylase modulators |
| WO2014201327A1 (en) * | 2013-06-13 | 2014-12-18 | Monsanto Technology Llc | Acetyl-coa carboxylase modulators |
| WO2015186068A1 (en) | 2014-06-02 | 2015-12-10 | Glaxosmithkline Intellectual Property (No.2) Limited | Preparation and use of crystalline beta-d-nicotinamide riboside |
| RU2016149767A (ru) | 2014-06-06 | 2018-07-16 | Глэксосмитклайн Интеллекчуал Проперти (Но.2) Лимитед | Аналоги никотинамидрибозида и фармацевтические композиции и их применение |
| US20200347038A1 (en) | 2014-08-29 | 2020-11-05 | Russell Dahl | Quinolines that modulate serca and their use for treating disease |
| WO2016032569A1 (en) * | 2014-08-29 | 2016-03-03 | Celladon Corporation | Quinolines and their use for treating endoplasmic reticulum stress-caused diseases |
| HRP20240644T1 (hr) | 2014-11-06 | 2024-08-02 | Bial-R&D Investments, S.A. | Supstituirani pirazolo(1,5-a)pirimidini i njihova uporaba u liječenju medicinskih poremećaja |
| US20170333435A1 (en) | 2014-11-06 | 2017-11-23 | Lysosomal Therapeutics Inc. | Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders |
| CA2966581A1 (en) | 2014-11-06 | 2016-05-12 | Lysosomal Therapeutics Inc. | Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders |
| US10045981B2 (en) | 2015-11-24 | 2018-08-14 | Jakpharm, Llc | Selective kinase inhibitors |
| US10383868B2 (en) * | 2015-11-28 | 2019-08-20 | Russell Dahl | Quinoline containing compounds and their use for treating endoplasmic reticulum stress-related diseases |
| ES2950348T3 (es) | 2015-12-09 | 2023-10-09 | Novartis Ag | Moduladores de receptores NMDA de tienopirimidinona y usos de los mismos |
| PL3386591T3 (pl) | 2015-12-09 | 2021-02-22 | Novartis Ag | Heteroaromatyczne modulatory receptorów nmda i ich zastosowania |
| SG11201808830YA (en) | 2016-04-06 | 2018-11-29 | Lysosomal Therapeutics Inc | Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| US11124516B2 (en) | 2016-04-06 | 2021-09-21 | BIAL-BioTech Investments, Inc. | Pyrrolo[1,2-A]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| JP7046827B2 (ja) | 2016-04-06 | 2022-04-04 | リソソーマル・セラピューティクス・インコーポレイテッド | イミダゾ［１，５－ａ］ピリミジニルカルボキサミド化合物および医学的障害の処置におけるその使用 |
| WO2017192931A1 (en) | 2016-05-05 | 2017-11-09 | Lysosomal Therapeutics Inc. | SUBSTITUTED IMDAZO[1,2-α]PYRIDINES, SUBSTITUTED IMIDAZO[1,2-α]PYRAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| WO2017192929A1 (en) * | 2016-05-05 | 2017-11-09 | Lysosomal Therapeutics Inc. | SUBSTITUTED PYRROLO[1,2-α]TRIAZINES AND RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| JP7164774B2 (ja) | 2016-05-05 | 2022-11-02 | ビアル－アール・アンド・ディ・インベストメンツ・ソシエダーデ・アノニマ | 置換イミダゾ［１，２－ｂ］ピリダジン、置換イミダゾ［１，５－ｂ］ピリダジン、関連化合物、および医学的障害の治療におけるその使用 |
| US10730868B2 (en) | 2016-07-14 | 2020-08-04 | Bristol-Myers Squibb Company | Bicyclic heteroaryl substituted compounds |
| CN109689664B (zh) | 2016-07-14 | 2022-04-15 | 百时美施贵宝公司 | 作为par4抑制剂的三环杂芳基取代的喹啉和氮杂喹啉化合物 |
| CN109689647B (zh) | 2016-07-14 | 2023-01-20 | 百时美施贵宝公司 | 二环杂芳基取代的化合物 |
| EP3558318B1 (en) | 2016-12-22 | 2023-12-20 | Novartis AG | Nmda receptor modulators and uses thereof |
| MX2020001793A (es) * | 2017-08-17 | 2020-07-22 | Ikena Oncology Inc | Inhibidores del receptor de hidrocarburos de arilo (ahr) y usos de los mismos. |
| WO2019057053A1 (zh) * | 2017-09-20 | 2019-03-28 | 北京加科思益新药研发有限公司 | 用作fgfr4抑制剂的稠环衍生物 |
| FI3749669T6 (fi) | 2018-02-06 | 2024-11-13 | Ideaya Biosciences Inc | AHR-modulaattoreita |
| RS64359B1 (sr) | 2018-08-03 | 2023-08-31 | Novartis Ag | Heteroaromatični modulatori nmda receptora i njihove upotrebe |
| CN113101295A (zh) * | 2020-03-20 | 2021-07-13 | 上海疆云医疗健康科技有限公司 | 二苯乙烯类似物在治疗糖尿病肾脏疾病中的用途 |
| US11730729B2 (en) | 2020-07-20 | 2023-08-22 | Neurodon Corporation | Quinolines that modulate SERCA and their use for treating disease |
| EP4291555A1 (en) * | 2021-02-09 | 2023-12-20 | Celgene Corporation | Sulfonamides and their use for treatment of helminthic infections and diseases |
| CN112939955B (zh) * | 2021-03-05 | 2022-10-21 | 朗捷睿(苏州)生物科技有限公司 | 一种8-(吡啶酰胺)取代香豆素类化合物及其制备方法和应用 |
| PT4426434T (pt) | 2021-11-02 | 2025-11-24 | Flare Therapeutics Inc | Agonistas inversos de pparg e suas utilizações |
| WO2024026423A1 (en) * | 2022-07-27 | 2024-02-01 | Black Diamond Therapeutics, Inc. | Substituted quinoline derivatives as pi3k inhibitors |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5838449B2 (ja) * | 1979-04-17 | 1983-08-23 | カネボウ株式会社 | 微粉末状絹フィプロインの製造法 |
| NZ212525A (en) * | 1985-06-24 | 1989-02-24 | Dfc New Zealand Ltd Formerly D | Nitrogen-containing heterocyclic compounds, and pharmaceutical compositions containing such |
| JP2002363169A (ja) | 2001-06-08 | 2002-12-18 | Fujiyakuhin Co Ltd | 抗腫瘍活性を有する複素環化合物 |
| JP2004043457A (ja) | 2002-05-22 | 2004-02-12 | Kyorin Pharmaceut Co Ltd | ２−置換キノリン−８−カルボン酸アミド誘導体 |
| FR2864535B1 (fr) * | 2003-12-24 | 2006-12-22 | Merck Sante Sas | Derives acides de quinoline et leurs applications en therapeutique |
| GB0428475D0 (en) | 2004-12-30 | 2005-02-02 | 4 Aza Bioscience Nv | Pyrido(3,2-D)pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders |
| WO2006094209A2 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | N-benzimidazolylalkyl-substituted amide sirtuin modulators |
| WO2006094248A1 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | Aryl-substituted cyclic sirtuin modulators |
| CA2600154A1 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | Fluorescence polarization assays for acetyltransferase/deacetylase activity |
| EP1853610A1 (en) * | 2005-03-03 | 2007-11-14 | Sirtris Pharmaceuticals, Inc. | N-phenyl benzamide derivatives as sirtuin modulators |
| WO2006094237A2 (en) * | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | Acridine and quinoline dervatives as sirtuin modulators |
| WO2006094210A2 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | Tetrahydroquinoxalinone sirtuin modulators |
| WO2006094233A1 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | N,n'-dicyclic isothiourea sirtuin modulators |
| WO2006094246A2 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | N-arylmethyl benzamide sirtuin modulators |
| WO2006105440A2 (en) | 2005-03-30 | 2006-10-05 | Sirtris Pharmaceuticals, Inc. | Nicotinamide riboside and analogues thereof |
| US20070014833A1 (en) | 2005-03-30 | 2007-01-18 | Sirtris Pharmaceuticals, Inc. | Treatment of eye disorders with sirtuin modulators |
| WO2006127987A2 (en) | 2005-05-25 | 2006-11-30 | Sirtris Pharmaceuticals, Inc. | Treatment of eye disorders with sirtuin modulators |
| JP2008543888A (ja) * | 2005-06-24 | 2008-12-04 | ギリアード サイエンシーズ， インコーポレイテッド | ピリド（３，２−ｄ）ピリミジン、およびＣ型肝炎を治療するのに有用な医薬組成物 |
| CN103055313A (zh) | 2005-07-07 | 2013-04-24 | 西特里斯药业公司 | 用于治疗或预防肥胖、胰岛素抵抗障碍和线粒体相关障碍的方法和相关组合物 |
| CA2618370A1 (en) | 2005-08-04 | 2007-02-15 | Sirtris Pharmaceuticals, Inc. | Oxazolopyridine derivatives as sirtuin modulators |
| US8093401B2 (en) | 2005-08-04 | 2012-01-10 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| US8088928B2 (en) | 2005-08-04 | 2012-01-03 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| US7855289B2 (en) | 2005-08-04 | 2010-12-21 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| AU2006339607A1 (en) | 2005-12-02 | 2007-09-13 | Sirtris Pharmaceuticals, Inc. | Modulators of Cdc2-like kinases (Clks) and methods of use thereof |
| ES2389111T3 (es) | 2005-12-02 | 2012-10-23 | Sirtris Pharmaceuticals, Inc. | Ensayos de espectrometría de masas para la actividad acetiltransferasa/desacetilasa |
| US20080021063A1 (en) * | 2006-07-18 | 2008-01-24 | Kazantsev Aleksey G | Compositions and methods for modulating sirtuin activity |
| WO2008027379A2 (en) | 2006-08-29 | 2008-03-06 | Sirtris Pharmaceuticals, Inc. | Indicators of sirtuin activity and methods of use thereof |
| US20080249103A1 (en) | 2006-11-15 | 2008-10-09 | Sirtris Pharmaceuticals, Inc. | Sirtuin polymorphisms and methods of use thereof |
| WO2008073451A2 (en) | 2006-12-11 | 2008-06-19 | Sirtris Pharmaceuticals, Inc. | Benzoimidazole derivatives as sirtuin (sir) modulating compounds |
| WO2008100423A1 (en) | 2007-02-09 | 2008-08-21 | Sirtris Pharmaceuticals, Inc. | Gut microsomal triglyceride transport protein inhibitors |
| WO2008100376A2 (en) | 2007-02-15 | 2008-08-21 | Sirtris Pharmaceuticals, Inc. | Truncation variants of sirt1 and methods of use thereof |
| WO2008115518A2 (en) | 2007-03-19 | 2008-09-25 | Sirtris Pharmaceuticals, Inc. | Biomarkers of sirtuin activity and methods of use thereof |
| CL2008001821A1 (es) | 2007-06-20 | 2009-03-13 | Sirtris Pharmaceuticals Inc | Compuestos derivados de imidazo[2,1-b]-tiazol; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de diabetes, sindrome metabolico, resistencia a la insulina, entre otras. |
| CL2008001822A1 (es) | 2007-06-20 | 2009-03-13 | Sirtris Pharmaceuticals Inc | Compuestos derivados de tiazolo[5,4-b]piridina; composicion farmaceutica que comprende a dichos compuestos; y uso del compuesto en el tratamiento de la resistencia a la insulina, sindrome metabolico, diabetes, entre otras. |
| WO2009058348A1 (en) | 2007-11-01 | 2009-05-07 | Sirtris Pharmaceuticals, Inc. | Amide derivatives as sirtuin modulators |
| CN101910184A (zh) | 2007-11-08 | 2010-12-08 | 西特里斯药业公司 | 可溶性噻唑并吡啶 |
| WO2009085226A2 (en) | 2007-12-21 | 2009-07-09 | Sirtris Pharmaceuticals, Inc. | Inhibitors of cdc2-like kinases (clks) and methods of use thereof |
| WO2009089011A2 (en) | 2008-01-08 | 2009-07-16 | Sirtris Pharmaceuticals, Inc. | Resveratrol formulations |
| US20110113498A1 (en) | 2008-05-15 | 2011-05-12 | Westphal Christoph H | Sirt1 polymorphic variants and methods of use thereof |
| MX2010012961A (es) | 2008-05-29 | 2011-03-03 | Sirtris Pharmaceuticals Inc Star | Imidazopiridina y analogos relacionados como moduladores de sirtuina. |
| AU2009266889B2 (en) | 2008-07-03 | 2013-05-02 | Glaxosmithkline Llc | Benzimidazoles and related analogs as sirtuin modulators |
| MX2011001702A (es) | 2008-08-12 | 2011-04-28 | Sirtris Pharmaceuticals Inc | Benzoxazoles, benzotiazoles y analogos relacionados como moduladores de sirtuina. |
| CN102227420B (zh) | 2008-09-29 | 2015-06-24 | 西特里斯药业公司 | 作为沉默调节蛋白调节剂的喹唑啉酮、喹诺酮和相关的类似物 |
| KR20110079763A (ko) | 2008-10-29 | 2011-07-07 | 서트리스 파마슈티컬즈, 인코포레이티드 | 시르투인 조절제로서의 피리딘, 비시클릭 피리딘 및 관련 유사체 |
| EP2373645A4 (en) | 2008-12-08 | 2012-05-02 | Sirtris Pharmaceuticals Inc | ISOINDOLINONE AND RELATED ANALOGUES AS SIRTUIN MODULATORS |
| WO2010077947A1 (en) | 2008-12-16 | 2010-07-08 | Sirtris Pharmaceuticals, Inc. | Phthalazinone and related analogs as sirtuin modulators |
| JP5628828B2 (ja) | 2008-12-19 | 2014-11-19 | サートリス ファーマシューティカルズ， インコーポレイテッド | チアゾロピリジンサーチュイン調節化合物 |
| WO2010088574A1 (en) | 2009-01-30 | 2010-08-05 | Sirtris Pharmaceuticals, Inc. | Azabenzimidazoles and related analogs as sirtuin modulators |
| CN102414180A (zh) | 2009-03-02 | 2012-04-11 | 西特里斯药业公司 | 作为沉默调节蛋白调节剂的8-取代的喹啉及相关的类似物 |
| WO2011116176A1 (en) | 2010-03-17 | 2011-09-22 | Sirtris Pharmaceuticals Inc. | 3-substitued imidazo (4, 5-b) pyridines and analogs as sirtuin modulators |
-
2009
- 2009-04-30 JP JP2011507632A patent/JP5425891B2/ja not_active Expired - Fee Related
- 2009-04-30 BR BRPI0912356A patent/BRPI0912356A2/pt not_active IP Right Cessation
- 2009-04-30 KR KR1020107026866A patent/KR20110007235A/ko not_active Ceased
- 2009-04-30 EP EP09739775.6A patent/EP2273992B1/en active Active
- 2009-04-30 US US12/990,339 patent/US8685970B2/en not_active Expired - Fee Related
- 2009-04-30 SG SG2013032677A patent/SG190603A1/en unknown
- 2009-04-30 EA EA201071263A patent/EA021938B1/ru not_active IP Right Cessation
- 2009-04-30 WO PCT/US2009/042255 patent/WO2009134973A1/en not_active Ceased
- 2009-04-30 AU AU2009243006A patent/AU2009243006B2/en not_active Ceased
- 2009-04-30 CA CA2723135A patent/CA2723135A1/en not_active Abandoned
- 2009-04-30 MX MX2010012010A patent/MX2010012010A/es not_active Application Discontinuation
- 2009-04-30 CN CN200980125767.4A patent/CN102083438B/zh not_active Expired - Fee Related
- 2009-04-30 ES ES09739775.6T patent/ES2586459T3/es active Active
-
2010
- 2010-10-27 ZA ZA2010/07677A patent/ZA201007677B/en unknown
- 2010-10-28 IL IL208997A patent/IL208997A0/en unknown