RU2013123515A - Лечение сахарного диабета с помощью инъекций инсулина, вводимых с различными интервалами - Google Patents

Info

Publication number

RU2013123515A

RU2013123515A RU2013123515/15A RU2013123515A RU2013123515A RU 2013123515 A RU2013123515 A RU 2013123515A RU 2013123515/15 A RU2013123515/15 A RU 2013123515/15A RU 2013123515 A RU2013123515 A RU 2013123515A RU 2013123515 A RU2013123515 A RU 2013123515A

Authority

RU

Russia

Prior art keywords

insulin

chain

intervals

cooh

derivative

Prior art date

2010-10-27

Links

• Espacenet
• Global Dossier
• Discuss

• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims abstract 76
• 102000004877 Insulin Human genes 0.000 title claims abstract 26
• 108090001061 Insulin Proteins 0.000 title claims abstract 26
• 229940125396 insulin Drugs 0.000 title claims abstract 25
• 206010012601 diabetes mellitus Diseases 0.000 title claims 3
• 239000007924 injection Substances 0.000 title 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 37
• 239000004026 insulin derivative Substances 0.000 claims abstract 19
• 125000000729 N-terminal amino-acid group Chemical group 0.000 claims abstract 10
• 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 6
• 230000002035 prolonged effect Effects 0.000 claims abstract 5
• 201000010099 disease Diseases 0.000 claims abstract 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 4
• 125000003368 amide group Chemical group 0.000 claims abstract 3
• 101000976075 Homo sapiens Insulin Proteins 0.000 claims 25
• PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 claims 25
• VEVRNHHLCPGNDU-MUGJNUQGSA-O desmosine Chemical compound OC(=O)[C@@H](N)CCCC[N+]1=CC(CC[C@H](N)C(O)=O)=C(CCC[C@H](N)C(O)=O)C(CC[C@H](N)C(O)=O)=C1 VEVRNHHLCPGNDU-MUGJNUQGSA-O 0.000 claims 23
• 125000000539 amino acid group Chemical group 0.000 claims 12
• VILAVOFMIJHSJA-UHFFFAOYSA-N dicarbon monoxide Chemical compound [C]=C=O VILAVOFMIJHSJA-UHFFFAOYSA-N 0.000 claims 4
• 125000001183 hydrocarbyl group Chemical group 0.000 claims 4
• 125000003277 amino group Chemical group 0.000 claims 2
• 125000004432 carbon atom Chemical group C* 0.000 claims 2
• -1 carboxyethyl Chemical group 0.000 claims 2
• 230000007935 neutral effect Effects 0.000 claims 2
• 206010006895 Cachexia Diseases 0.000 claims 1
• 208000002705 Glucose Intolerance Diseases 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
• 208000008589 Obesity Diseases 0.000 claims 1
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
• 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
• 229940127003 anti-diabetic drug Drugs 0.000 claims 1
• 239000003472 antidiabetic agent Substances 0.000 claims 1
• 230000036528 appetite Effects 0.000 claims 1
• 235000019789 appetite Nutrition 0.000 claims 1
• 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 claims 1
• 230000009286 beneficial effect Effects 0.000 claims 1
• 239000011230 binding agent Substances 0.000 claims 1
• 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000001747 exhibiting effect Effects 0.000 claims 1
• 201000001421 hyperglycemia Diseases 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 235000020824 obesity Nutrition 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 201000009104 prediabetes syndrome Diseases 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1