ATE219942T1 - Therapeutische pulverformulierung zur pulmonaren anwendung, welche kristallines insulin enthält - Google Patents

Therapeutische pulverformulierung zur pulmonaren anwendung, welche kristallines insulin enthält

Info

Publication number
ATE219942T1
ATE219942T1 AT98907915T AT98907915T ATE219942T1 AT E219942 T1 ATE219942 T1 AT E219942T1 AT 98907915 T AT98907915 T AT 98907915T AT 98907915 T AT98907915 T AT 98907915T AT E219942 T1 ATE219942 T1 AT E219942T1
Authority
AT
Austria
Prior art keywords
powder formulation
drying
containing crystalline
use containing
crystalline insulin
Prior art date
Application number
AT98907915T
Other languages
English (en)
Inventor
Steen Jensen
Philip Hansen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE219942T1 publication Critical patent/ATE219942T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AT98907915T 1997-03-20 1998-03-20 Therapeutische pulverformulierung zur pulmonaren anwendung, welche kristallines insulin enthält ATE219942T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK31997 1997-03-20
PCT/DK1998/000108 WO1998042368A1 (en) 1997-03-20 1998-03-20 Therapeutic powder formulation for pulmonary administration, containing crystalline insulin

Publications (1)

Publication Number Publication Date
ATE219942T1 true ATE219942T1 (de) 2002-07-15

Family

ID=8092222

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98907915T ATE219942T1 (de) 1997-03-20 1998-03-20 Therapeutische pulverformulierung zur pulmonaren anwendung, welche kristallines insulin enthält

Country Status (6)

Country Link
EP (1) EP0971729B1 (de)
JP (1) JP2001518916A (de)
AT (1) ATE219942T1 (de)
AU (1) AU6611998A (de)
DE (1) DE69806362T2 (de)
WO (1) WO1998042368A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2311436A1 (de) 1998-04-27 2011-04-20 Altus Pharmaceuticals Inc. Stabilisierte Protein-Kristalle, diese enthaltende Formulierungen und ihre Herstellungsverfahren
AU758108B2 (en) * 1998-10-16 2003-03-13 Novo Nordisk A/S Insulin preparations for pulmonary delivery containing menthol
US6211144B1 (en) 1998-10-16 2001-04-03 Novo Nordisk A/S Stable concentrated insulin preparations for pulmonary delivery
US6635617B1 (en) 1998-10-16 2003-10-21 Novo Nordisk A/S Insulin preparations for pulmonary delivery containing menthol
ATE277630T1 (de) * 1998-10-16 2004-10-15 Novo Nordisk As Stabile konzentrierte insulin präparationen zur pulmonaren verabreichung
US6350432B1 (en) * 1999-03-19 2002-02-26 Generex Pharmaceuticals Incorporated Pressurized container having an aerosolized pharmaceutical composition
CA2370302A1 (en) * 1999-04-27 2000-11-02 Benjamin Lee Hughes Insulin crystals for pulmonary administration
WO2001000675A1 (en) * 1999-06-29 2001-01-04 Eli Lilly And Company Protamine-free insoluble acylated insulin compositions
EP1196445A1 (de) * 1999-06-29 2002-04-17 Eli Lilly And Company Insulinkristalle zur verabreichung über die lunge
US20040265238A1 (en) * 2003-06-27 2004-12-30 Imtiaz Chaudry Inhalable formulations for treating pulmonary hypertension and methods of using same
EP2107069B1 (de) 2003-08-05 2013-01-16 Novo Nordisk A/S Neuartige Insulinderivate
JP2006199589A (ja) * 2003-09-03 2006-08-03 Ltt Bio-Pharma Co Ltd 生理活性タンパク質またはペプチドを含有するナノ粒子およびその製造方法、ならびに当該ナノ粒子からなる外用剤
EP1711220A1 (de) 2004-01-16 2006-10-18 Biodel, Inc. Sublinguale arzneimittelabgabevorrichtung
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
PT1969004E (pt) 2005-12-28 2011-11-25 Novo Nordisk As Composições que compreendem uma insulina acilada e zinco e método para criar tais composições
JP5552046B2 (ja) * 2007-06-13 2014-07-16 ノボ・ノルデイスク・エー／エス インスリン誘導体を含有する薬学的製剤
EP2352513B1 (de) 2008-10-30 2016-09-14 Novo Nordisk A/S Behandlung des diabetes mit verabreichung des insulins weniger als einmal pro tag
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
RU2013123515A (ru) 2010-10-27 2014-12-10 Ново Нордиск А/С Лечение сахарного диабета с помощью инъекций инсулина, вводимых с различными интервалами
US10137172B2 (en) 2013-04-30 2018-11-27 Novo Nordisk A/S Administration regime
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2933946A1 (de) * 1979-08-22 1981-03-12 Hoechst Ag, 6000 Frankfurt Insulinkristallsuspension und verfahren zu ihrer herstellung.
IS1796B (is) * 1993-06-24 2001-12-31 Ab Astra Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
US5597893A (en) * 1994-10-31 1997-01-28 Eli Lilly And Company Preparation of stable insulin analog crystals
SE9404468D0 (sv) * 1994-12-22 1994-12-22 Astra Ab Powder formulations

Also Published As

Publication number Publication date
EP0971729A1 (de) 2000-01-19
WO1998042368A1 (en) 1998-10-01
DE69806362T2 (de) 2003-01-30
DE69806362D1 (de) 2002-08-08
AU6611998A (en) 1998-10-20
EP0971729B1 (de) 2002-07-03
JP2001518916A (ja) 2001-10-16

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Legal Events

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