HUP0103837A2 - Pulmonáris beadásra alkalmas, száraz por formájú hatóanyag és eljárás az előállítására - Google Patents

Pulmonáris beadásra alkalmas, száraz por formájú hatóanyag és eljárás az előállítására

Info

Publication number
HUP0103837A2
HUP0103837A2 HU0103837A HUP0103837A HUP0103837A2 HU P0103837 A2 HUP0103837 A2 HU P0103837A2 HU 0103837 A HU0103837 A HU 0103837A HU P0103837 A HUP0103837 A HU P0103837A HU P0103837 A2 HUP0103837 A2 HU P0103837A2
Authority
HU
Hungary
Prior art keywords
dry powder
preparation
active agent
pulmonary delivery
powder active
Prior art date
Application number
HU0103837A
Other languages
English (en)
Inventor
Andrew Clark
Mei-Chang Kuo
Cecily Lalor
Original Assignee
Inhale Therapeutic Systems, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inhale Therapeutic Systems, Inc. filed Critical Inhale Therapeutic Systems, Inc.
Publication of HUP0103837A2 publication Critical patent/HUP0103837A2/hu
Publication of HUP0103837A3 publication Critical patent/HUP0103837A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

A jelen találmány részecskekészítményre és egy aktív anyag betegemberek tüdejébe való bejuttatásának módszerére vonatkozik. Az aktívanyagkészítmény száraz porállagú és (i) alacsony a nedvességelnyelőképessége és (ii) a higroszkopikus növekedéssel szemben ellenálló,különösen stimulált tüdőkörülmények között. A találmány kiterjed ahatóanyag előállítási eljárására is. Ó
HU0103837A 1998-09-14 1999-09-13 Dry powder active agent pulmonary delivery and process for its preparation HUP0103837A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10016398P 1998-09-14 1998-09-14

Publications (2)

Publication Number Publication Date
HUP0103837A2 true HUP0103837A2 (hu) 2002-05-29
HUP0103837A3 HUP0103837A3 (en) 2002-11-28

Family

ID=22278404

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0103837A HUP0103837A3 (en) 1998-09-14 1999-09-13 Dry powder active agent pulmonary delivery and process for its preparation

Country Status (44)

Country Link
EP (1) EP1117442A1 (hu)
JP (1) JP2002524535A (hu)
KR (1) KR20010075063A (hu)
CN (1) CN1317977A (hu)
AP (1) AP1374A (hu)
AR (1) AR022090A1 (hu)
AU (1) AU753014B2 (hu)
BG (1) BG105430A (hu)
BR (1) BR9913722A (hu)
CA (1) CA2343920A1 (hu)
CO (1) CO5130023A1 (hu)
CZ (1) CZ2001829A3 (hu)
DZ (1) DZ2892A1 (hu)
EA (1) EA003476B1 (hu)
EE (1) EE200100151A (hu)
GE (1) GEP20043257B (hu)
GT (1) GT199900156A (hu)
HK (1) HK1042231A1 (hu)
HN (1) HN1999000159A (hu)
HR (1) HRP20010189A2 (hu)
HU (1) HUP0103837A3 (hu)
ID (1) ID28845A (hu)
IL (2) IL141562A0 (hu)
IS (1) IS5878A (hu)
LT (1) LT4897B (hu)
LV (1) LV12658B (hu)
MA (1) MA25590A1 (hu)
MY (1) MY129282A (hu)
NO (1) NO20011251L (hu)
NZ (1) NZ510168A (hu)
OA (1) OA11781A (hu)
PA (1) PA8481901A1 (hu)
PE (1) PE20001061A1 (hu)
PL (1) PL195574B1 (hu)
SA (1) SA99200718B1 (hu)
SK (1) SK3442001A3 (hu)
TN (1) TNSN99173A1 (hu)
TR (1) TR200101182T2 (hu)
TW (1) TWI226248B (hu)
UA (1) UA76085C2 (hu)
UY (1) UY25711A1 (hu)
WO (1) WO2000015262A1 (hu)
YU (1) YU24201A (hu)
ZA (1) ZA200101995B (hu)

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AU782916B2 (en) 1999-06-09 2005-09-08 Robert E. Sievers Supercritical fluid-assisted nebulization and bubble drying
US6475468B2 (en) * 2001-02-15 2002-11-05 Aeropharm Technology Incorporated Modulated release particles for aerosol delivery
CA2446904A1 (en) * 2001-05-24 2003-04-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
EG24184A (en) 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
US7759506B2 (en) 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
NZ564486A (en) 2002-02-25 2009-03-31 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
WO2004004798A2 (en) * 2002-07-03 2004-01-15 The Brigham And Women's Hospital, Inc. Central airway administration for systemic delivery of therapeutics
MXPA05006802A (es) * 2002-12-19 2005-09-08 Pharmacia Corp Formulacion no higroscopica que comprende un farmaco higroscopico.
DE10338403A1 (de) * 2003-08-18 2005-03-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverformulierung, enthaltend den CGRP-Antagonisten 1-[N2-[3,5-Dibrom-N-[[4-(3,4-dihydro-2(1H)-oxochinazolin-3-yl]-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyrindinyl)-piperazin, Verfahren zu dessen Herstellung sowie dessen Verwendung als Inhalativum
GB0327723D0 (en) * 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
JP2007534693A (ja) 2004-04-23 2007-11-29 サイデックス・インコーポレイテッド スルホアルキルエーテルシクロデキストリンを含有するｄｐｉ製剤
US8030350B2 (en) 2005-02-24 2011-10-04 Diffusion Pharmaceuticals Llc Trans carotenoids, their synthesis, formulation and uses
JPWO2006095788A1 (ja) * 2005-03-09 2008-08-14 小野薬品工業株式会社 粒子およびその粒子を含有する製剤
US7629331B2 (en) 2005-10-26 2009-12-08 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
PT2581078E (pt) 2005-10-26 2015-03-10 Cydex Pharmaceuticals Inc Composições de éter sulfoalquílico de ciclodextrina e métodos para a sua preparação
WO2008021451A2 (en) * 2006-08-14 2008-02-21 Aktiv-Dry Llc Human-powered dry powder inhaler and dry powder inhaler compositions
JP5315056B2 (ja) * 2006-10-25 2013-10-16 大日本住友製薬株式会社 固結抑制粒状製剤
EP1925295A1 (de) * 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Stabile Pulverformulierung enthaltend ein Anticholinergikum
JP2010524855A (ja) 2007-04-13 2010-07-22 ディフュージョン・ファーマシューティカルズ・エルエルシー 末梢血管疾患の前処置としての、及びその処置における双極性トランスカロテノイドの使用
AU2008319225B2 (en) 2007-10-31 2016-09-29 Diffusion Pharmaceuticals Llc A new class of therapeutics that enhance small molecule diffusion
CN105770882A (zh) 2009-05-20 2016-07-20 Aeras全球Tb疫苗基金会 稳定的经喷雾干燥的免疫原性的病毒组合物
KR101875843B1 (ko) 2009-06-22 2018-07-06 디퓨젼 파마슈티컬즈 엘엘씨 확산 촉진 화합물 및 그 화합물 단독 또는 혈전 용해제와 합쳐진 화합물의 용도
CN103124498A (zh) 2010-06-02 2013-05-29 扩散药品有限公司 双极性反式类胡萝卜素的口服制剂
CN104394846B (zh) * 2012-05-03 2018-10-19 爱尔兰詹森科学公司 用于治疗上呼吸道感染的聚肌苷酸-聚胞苷酸（聚(i:c)）配制品
WO2014074797A1 (en) * 2012-11-09 2014-05-15 Civitas Therapeutics, Inc. Ultra low density pulmonary powders
US20180043585A9 (en) * 2013-09-20 2018-02-15 Virginia Commonwealth University Delivery of particles using hygroscopic excipients
WO2016067252A1 (en) 2014-10-31 2016-05-06 Glaxosmithkline Intellectual Property Development Limited Powder formulation
EP3432929A4 (en) 2016-03-24 2019-11-27 Diffusion Pharmaceuticals LLC USE OF BIPOLAR TRANSCAROTINOIDS WITH CHEMOTHERAPY AND RADIOTHERAPY FOR THE TREATMENT OF CANCER

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US3155573A (en) * 1958-05-06 1964-11-03 Benger Lab Ltd Inhalant composition and method of making same
EP0611567B1 (en) * 1992-06-12 2002-08-28 Teijin Limited Ultrafine powder for inhalation and production thereof
US6524557B1 (en) * 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
WO1998031346A1 (en) * 1997-01-16 1998-07-23 Massachusetts Institute Of Technology Preparation of particles for inhalation
US6086376A (en) * 1998-01-30 2000-07-11 Rtp Pharma Inc. Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant

Also Published As

Publication number Publication date
AR022090A1 (es) 2002-09-04
KR20010075063A (ko) 2001-08-09
EA200100300A1 (ru) 2001-10-22
AU6039799A (en) 2000-04-03
AP1374A (en) 2005-02-28
SA99200718B1 (ar) 2006-11-04
MA25590A1 (fr) 2002-12-31
CO5130023A1 (es) 2002-02-27
MY129282A (en) 2007-03-30
YU24201A (sh) 2003-08-29
LT2001021A (en) 2001-11-26
BG105430A (en) 2001-12-29
TR200101182T2 (tr) 2001-09-21
GEP20043257B (en) 2004-06-25
CZ2001829A3 (cs) 2001-09-12
CA2343920A1 (en) 2000-03-23
CN1317977A (zh) 2001-10-17
AP2001002093A0 (en) 2001-03-31
EE200100151A (et) 2002-06-17
IL141562A0 (en) 2002-03-10
ID28845A (id) 2001-07-05
DZ2892A1 (fr) 2003-12-15
PL195574B1 (pl) 2007-10-31
PL346768A1 (en) 2002-02-25
AU753014B2 (en) 2002-10-03
PA8481901A1 (es) 2002-04-25
TWI226248B (en) 2005-01-11
HUP0103837A3 (en) 2002-11-28
LV12658A (lv) 2001-05-20
TNSN99173A1 (fr) 2005-11-10
JP2002524535A (ja) 2002-08-06
HRP20010189A2 (en) 2005-04-30
EP1117442A1 (en) 2001-07-25
IL141562A (en) 2007-07-24
LV12658B (lv) 2001-09-20
BR9913722A (pt) 2001-05-29
UY25711A1 (es) 1999-11-17
UA76085C2 (en) 2006-07-17
NO20011251L (no) 2001-04-17
ZA200101995B (en) 2002-03-11
NO20011251D0 (no) 2001-03-13
IS5878A (is) 2001-03-05
OA11781A (en) 2005-07-26
NZ510168A (en) 2003-09-26
SK3442001A3 (en) 2001-11-06
GT199900156A (es) 2001-03-07
PE20001061A1 (es) 2000-10-08
LT4897B (lt) 2002-02-25
HN1999000159A (es) 1999-11-11
EA003476B1 (ru) 2003-06-26
WO2000015262A1 (en) 2000-03-23
HK1042231A1 (zh) 2002-08-09

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