DE69806362D1 - Therapeutische pulverformulierung zur pulmonaren anwendung, welche kristallines insulin enthält - Google Patents

Therapeutische pulverformulierung zur pulmonaren anwendung, welche kristallines insulin enthält

Info

Publication number
DE69806362D1
DE69806362D1 DE69806362T DE69806362T DE69806362D1 DE 69806362 D1 DE69806362 D1 DE 69806362D1 DE 69806362 T DE69806362 T DE 69806362T DE 69806362 T DE69806362 T DE 69806362T DE 69806362 D1 DE69806362 D1 DE 69806362D1
Authority
DE
Germany
Prior art keywords
drying
powder formula
contains crystalline
crystalline insulin
therapeutic powder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69806362T
Other languages
English (en)
Other versions
DE69806362T2 (de
Inventor
Steen Jensen
Philip Hansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of DE69806362D1 publication Critical patent/DE69806362D1/de
Application granted granted Critical
Publication of DE69806362T2 publication Critical patent/DE69806362T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
DE69806362T 1997-03-20 1998-03-20 Therapeutische pulverformulierung zur pulmonaren anwendung, welche kristallines insulin enthält Expired - Fee Related DE69806362T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK31997 1997-03-20
PCT/DK1998/000108 WO1998042368A1 (en) 1997-03-20 1998-03-20 Therapeutic powder formulation for pulmonary administration, containing crystalline insulin

Publications (2)

Publication Number Publication Date
DE69806362D1 true DE69806362D1 (de) 2002-08-08
DE69806362T2 DE69806362T2 (de) 2003-01-30

Family

ID=8092222

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69806362T Expired - Fee Related DE69806362T2 (de) 1997-03-20 1998-03-20 Therapeutische pulverformulierung zur pulmonaren anwendung, welche kristallines insulin enthält

Country Status (6)

Country Link
EP (1) EP0971729B1 (de)
JP (1) JP2001518916A (de)
AT (1) ATE219942T1 (de)
AU (1) AU6611998A (de)
DE (1) DE69806362T2 (de)
WO (1) WO1998042368A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2311436A1 (de) 1998-04-27 2011-04-20 Altus Pharmaceuticals Inc. Stabilisierte Protein-Kristalle, diese enthaltende Formulierungen und ihre Herstellungsverfahren
US6211144B1 (en) 1998-10-16 2001-04-03 Novo Nordisk A/S Stable concentrated insulin preparations for pulmonary delivery
ATE277630T1 (de) * 1998-10-16 2004-10-15 Novo Nordisk As Stabile konzentrierte insulin präparationen zur pulmonaren verabreichung
US6635617B1 (en) 1998-10-16 2003-10-21 Novo Nordisk A/S Insulin preparations for pulmonary delivery containing menthol
AU758108B2 (en) * 1998-10-16 2003-03-13 Novo Nordisk A/S Insulin preparations for pulmonary delivery containing menthol
US6350432B1 (en) * 1999-03-19 2002-02-26 Generex Pharmaceuticals Incorporated Pressurized container having an aerosolized pharmaceutical composition
EP1173482A1 (de) * 1999-04-27 2002-01-23 Eli Lilly And Company Insulinkristalle zur aufnahme über die lunge
EP1196446A1 (de) * 1999-06-29 2002-04-17 Eli Lilly And Company Protaminfreie, unlösliche zusammensetzungen von acyliertem insulin
EP1196445A1 (de) * 1999-06-29 2002-04-17 Eli Lilly And Company Insulinkristalle zur verabreichung über die lunge
US20040265238A1 (en) * 2003-06-27 2004-12-30 Imtiaz Chaudry Inhalable formulations for treating pulmonary hypertension and methods of using same
MXPA06001283A (es) 2003-08-05 2006-04-11 Novo Nordisk As Derivados de insulina novedosos.
JP2006199589A (ja) * 2003-09-03 2006-08-03 Ltt Bio-Pharma Co Ltd 生理活性タンパク質またはペプチドを含有するナノ粒子およびその製造方法、ならびに当該ナノ粒子からなる外用剤
JP4601627B2 (ja) 2004-01-16 2010-12-22 バイオデル， インコーポレイテッド 舌下薬物送達デバイス
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
WO2007074133A2 (en) 2005-12-28 2007-07-05 Novo Nordisk A/S Compositions comprising an acylated insulin and zinc and method of making the said compositions
ES2744384T3 (es) * 2007-06-13 2020-02-24 Novo Nordisk As Formulación farmacéutica que comprende un derivado de insulina
AU2009309623B9 (en) 2008-10-30 2014-10-02 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
RU2013123515A (ru) 2010-10-27 2014-12-10 Ново Нордиск А/С Лечение сахарного диабета с помощью инъекций инсулина, вводимых с различными интервалами
JP2016519127A (ja) 2013-04-30 2016-06-30 ノヴォ ノルディスク アー／エス 新規投与レジメン
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2933946A1 (de) * 1979-08-22 1981-03-12 Hoechst Ag, 6000 Frankfurt Insulinkristallsuspension und verfahren zu ihrer herstellung.
IS1796B (is) * 1993-06-24 2001-12-31 Ab Astra Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
US5597893A (en) * 1994-10-31 1997-01-28 Eli Lilly And Company Preparation of stable insulin analog crystals
SE9404468D0 (sv) * 1994-12-22 1994-12-22 Astra Ab Powder formulations

Also Published As

Publication number Publication date
EP0971729A1 (de) 2000-01-19
EP0971729B1 (de) 2002-07-03
JP2001518916A (ja) 2001-10-16
AU6611998A (en) 1998-10-20
WO1998042368A1 (en) 1998-10-01
DE69806362T2 (de) 2003-01-30
ATE219942T1 (de) 2002-07-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee