RU2012153675A - Соединения, пригодные в качестве ингибиторов atr киназы - Google Patents
Соединения, пригодные в качестве ингибиторов atr киназы Download PDFInfo
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- RU2012153675A RU2012153675A RU2012153675/04A RU2012153675A RU2012153675A RU 2012153675 A RU2012153675 A RU 2012153675A RU 2012153675/04 A RU2012153675/04 A RU 2012153675/04A RU 2012153675 A RU2012153675 A RU 2012153675A RU 2012153675 A RU2012153675 A RU 2012153675A
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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| US33386710P | 2010-05-12 | 2010-05-12 | |
| US61/333,867 | 2010-05-12 | ||
| US201161470585P | 2011-04-01 | 2011-04-01 | |
| US61/470,585 | 2011-04-01 | ||
| PCT/US2011/036246 WO2011143426A1 (en) | 2010-05-12 | 2011-05-12 | Compounds useful as inhibitors of atr kinase |
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| RU2012153675A true RU2012153675A (ru) | 2014-06-20 |
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| EP (1) | EP2569313A1 (OSRAM) |
| JP (1) | JP5836367B2 (OSRAM) |
| KR (1) | KR20130066633A (OSRAM) |
| CN (1) | CN103228651A (OSRAM) |
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| US8853217B2 (en) | 2011-09-30 | 2014-10-07 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| WO2013049719A1 (en) | 2011-09-30 | 2013-04-04 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| WO2013071094A1 (en) * | 2011-11-09 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| WO2013071085A1 (en) | 2011-11-09 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Pyrazine compounds useful as inhibitors of atr kinase |
| EP2776422A1 (en) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| WO2013071088A1 (en) | 2011-11-09 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| EP2776420A1 (en) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Pyrazine compounds useful as inhibitors of atr kinase |
| CN108478577A (zh) | 2012-04-05 | 2018-09-04 | 沃泰克斯药物股份有限公司 | 可用作atr激酶抑制剂的化合物及其组合疗法 |
| CN103373996A (zh) | 2012-04-20 | 2013-10-30 | 山东亨利医药科技有限责任公司 | 作为crth2受体拮抗剂的二并环衍生物 |
| US8999632B2 (en) | 2012-10-04 | 2015-04-07 | Vertex Pharmaceuticals Incorporated | Method for measuring ATR inhibition mediated increases in DNA damage |
| WO2014062604A1 (en) | 2012-10-16 | 2014-04-24 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| JP6096005B2 (ja) | 2013-02-26 | 2017-03-15 | リンテック株式会社 | シート剥離装置および剥離方法 |
-
2011
- 2011-05-12 CA CA2798763A patent/CA2798763A1/en not_active Abandoned
- 2011-05-12 SG SG2012083176A patent/SG185524A1/en unknown
- 2011-05-12 WO PCT/US2011/036246 patent/WO2011143426A1/en not_active Ceased
- 2011-05-12 NZ NZ603477A patent/NZ603477A/en not_active IP Right Cessation
- 2011-05-12 AU AU2011253025A patent/AU2011253025A1/en not_active Abandoned
- 2011-05-12 RU RU2012153675/04A patent/RU2012153675A/ru not_active Application Discontinuation
- 2011-05-12 EP EP11720956A patent/EP2569313A1/en not_active Withdrawn
- 2011-05-12 MX MX2012013081A patent/MX2012013081A/es active IP Right Grant
- 2011-05-12 US US13/106,476 patent/US9630956B2/en not_active Expired - Fee Related
- 2011-05-12 JP JP2013510300A patent/JP5836367B2/ja not_active Expired - Fee Related
- 2011-05-12 CN CN2011800303808A patent/CN103228651A/zh active Pending
- 2011-05-12 KR KR1020127032379A patent/KR20130066633A/ko not_active Withdrawn
-
2012
- 2012-11-07 ZA ZA2012/08373A patent/ZA201208373B/en unknown
- 2012-11-11 IL IL222968A patent/IL222968A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2569313A1 (en) | 2013-03-20 |
| JP2013526541A (ja) | 2013-06-24 |
| KR20130066633A (ko) | 2013-06-20 |
| CA2798763A1 (en) | 2011-11-17 |
| ZA201208373B (en) | 2014-01-29 |
| CN103228651A (zh) | 2013-07-31 |
| AU2011253025A1 (en) | 2012-11-29 |
| US9630956B2 (en) | 2017-04-25 |
| NZ603477A (en) | 2014-09-26 |
| MX2012013081A (es) | 2013-05-09 |
| IL222968A0 (en) | 2013-02-03 |
| SG185524A1 (en) | 2012-12-28 |
| US20120027874A1 (en) | 2012-02-02 |
| WO2011143426A1 (en) | 2011-11-17 |
| JP5836367B2 (ja) | 2015-12-24 |
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Legal Events
| Date | Code | Title | Description |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20150909 |