RU1826971C - Способ получени производных аденозина или их солей - Google Patents

Способ получени производных аденозина или их солей

Info

Publication number
RU1826971C
RU1826971C SU884613189A SU4613189A RU1826971C RU 1826971 C RU1826971 C RU 1826971C SU 884613189 A SU884613189 A SU 884613189A SU 4613189 A SU4613189 A SU 4613189A RU 1826971 C RU1826971 C RU 1826971C
Authority
RU
Russia
Prior art keywords
synthesis
salts
adenosine derivatives
adenosine
reagent
Prior art date
Application number
SU884613189A
Other languages
English (en)
Russian (ru)
Inventor
Эванс Брайан
Original Assignee
Глэксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глэксо Груп Лимитед filed Critical Глэксо Груп Лимитед
Application granted granted Critical
Publication of RU1826971C publication Critical patent/RU1826971C/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SU884613189A 1987-12-23 1988-12-22 Способ получени производных аденозина или их солей RU1826971C (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878729994A GB8729994D0 (en) 1987-12-23 1987-12-23 Chemical compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
SU925010893A Division RU2060996C1 (ru) 1987-12-23 1992-02-24 Производные аденозина

Publications (1)

Publication Number Publication Date
RU1826971C true RU1826971C (ru) 1993-07-07

Family

ID=10628947

Family Applications (2)

Application Number Title Priority Date Filing Date
SU884613189A RU1826971C (ru) 1987-12-23 1988-12-22 Способ получени производных аденозина или их солей
SU925010893A RU2060996C1 (ru) 1987-12-23 1992-02-24 Производные аденозина

Family Applications After (1)

Application Number Title Priority Date Filing Date
SU925010893A RU2060996C1 (ru) 1987-12-23 1992-02-24 Производные аденозина

Country Status (35)

Country Link
US (1) US5032583A (https=)
EP (1) EP0322242B1 (https=)
JP (1) JP2736088B2 (https=)
KR (1) KR890009967A (https=)
CN (1) CN1024198C (https=)
AT (1) ATA315488A (https=)
AU (2) AU612747B2 (https=)
BE (1) BE1002167A5 (https=)
CA (1) CA1320195C (https=)
CH (1) CH677495A5 (https=)
CZ (1) CZ403991A3 (https=)
DE (2) DE3856154T2 (https=)
DK (1) DK170894B1 (https=)
ES (1) ES2012927A6 (https=)
FI (1) FI90429C (https=)
FR (1) FR2629715B1 (https=)
GB (2) GB8729994D0 (https=)
GR (1) GR1000307B (https=)
HU (1) HU203364B (https=)
IE (1) IE61302B1 (https=)
IL (1) IL88765A (https=)
IT (1) IT1224840B (https=)
LU (1) LU87414A1 (https=)
MX (1) MX14331A (https=)
NL (1) NL8803140A (https=)
NO (1) NO171506C (https=)
NZ (1) NZ227485A (https=)
PH (1) PH25932A (https=)
PL (1) PL158800B1 (https=)
PT (1) PT89328B (https=)
RU (2) RU1826971C (https=)
SE (1) SE8804609L (https=)
SG (1) SG44701A1 (https=)
YU (1) YU234188A (https=)
ZA (1) ZA889593B (https=)

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GB2226027B (en) * 1988-12-13 1992-05-20 Sandoz Ltd Adenosine derivatives,their production and use
FR2665362B1 (fr) * 1990-08-03 1994-12-09 Cepbepe Substance contenant, comme principe actif, une adenosine substitutee en n6 et son application.
US5561134A (en) * 1990-09-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
SG80526A1 (en) * 1990-09-25 2001-05-22 Rhone Poulenc Rorer Int Compounds having antihypertensive and anti- ischemic properies
GB9111580D0 (en) * 1991-05-30 1991-07-24 Wellcome Found Nucleoside derivative
DK62692D0 (https=) * 1992-05-14 1992-05-14 Novo Nordisk As
US5672588A (en) * 1992-05-20 1997-09-30 Novo Nordisk A/S Purine derivatives
US5443836A (en) * 1993-03-15 1995-08-22 Gensia, Inc. Methods for protecting tissues and organs from ischemic damage
AU2546195A (en) * 1994-05-10 1995-11-29 Novartis Ag Adenosine derivatives
GB9421133D0 (en) * 1994-10-20 1994-12-07 Glaxo Group Ltd Medicaments
AU2022497A (en) * 1996-03-13 1997-10-01 Novo Nordisk A/S A method of treating disorders related to cytokines in mammals
WO1997033591A1 (en) * 1996-03-13 1997-09-18 Novo Nordisk A/S A method of treating disorders related to cytokines in mammals
US6376472B1 (en) * 1996-07-08 2002-04-23 Aventis Pharmaceuticals, Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
YU76100A (sh) 1998-06-02 2003-12-31 Osi Pharmaceuticals Inc. Pirolo(2,3-d) pirimidin preparati i njihova primena
US6686366B1 (en) 1998-06-02 2004-02-03 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6878716B1 (en) 1998-06-02 2005-04-12 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptor and uses thereof
US6784165B1 (en) * 1999-11-23 2004-08-31 Aderis Pharmaceuticals, Inc. Treatment of heart rhythm disturbances with N6-substituted-5′-(N-substituted) carboxamidoadenosines
US6680322B2 (en) 1999-12-02 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6664252B2 (en) 1999-12-02 2003-12-16 Osi Pharmaceuticals, Inc. 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
US7160890B2 (en) 1999-12-02 2007-01-09 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6294522B1 (en) * 1999-12-03 2001-09-25 Cv Therapeutics, Inc. N6 heterocyclic 8-modified adenosine derivatives
GB9930077D0 (en) * 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments
GB9930083D0 (en) * 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6673802B2 (en) 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
GB0106867D0 (en) 2001-03-20 2001-05-09 Glaxo Group Ltd Process
EP1258247A1 (en) * 2001-05-14 2002-11-20 Aventis Pharma Deutschland GmbH Adenosine analogues for the treatment of insulin resistance syndrome and diabetes
AU2002360436A1 (en) 2001-11-30 2003-06-17 Osi Pharmaceuticals, Inc. 2-aryl pyrrologpyrimidines for a1 and a3 receptors
CN1620294A (zh) 2001-12-20 2005-05-25 Osi药物公司 嘧啶a2b选择性拮抗剂化合物,它们的合成及用途
CN101973998A (zh) 2001-12-20 2011-02-16 Osi药物公司 吡咯并嘧啶A2b选择性拮抗剂化合物
MXPA05011428A (es) * 2003-04-24 2006-05-31 Aderis Pharmaceuticals Inc Metodo de tratamiento de fibrilacion atrial o trepidacion auricular.
TWI494102B (zh) * 2003-05-02 2015-08-01 Japan Tobacco Inc 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合
US20050118262A1 (en) * 2003-09-17 2005-06-02 Jack Aurora Controlled release formulation
EA015683B1 (ru) * 2005-11-30 2011-10-31 Инотек Фармасьютикалз Корпорейшн Производные пурина и способы их применения
CN101712709A (zh) * 2008-10-06 2010-05-26 中国医学科学院药物研究所 三乙酰基-3-羟基苯基腺苷及其调血脂的用途
AU2010288864A1 (en) 2009-08-31 2012-04-19 Lonza Ltd Process for the preparation of (1S,4R)-2-oxa-3-azabicyclo[2,2.1]hept-5-enes
TWI677489B (zh) 2014-06-20 2019-11-21 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成

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DE2052596A1 (de) * 1970-10-27 1972-05-04 Boehringer Mannheim Gmbh, 6800 Mannheim Neuartige Verwendung von N(6)-substituierten Adenosin-Derivaten
NL7203984A (https=) * 1971-04-10 1972-10-12
BE788958A (fr) * 1971-09-18 1973-03-19 Schering Ag Derives d'adenosine et leur procede de preparation
DE2148838A1 (de) * 1971-09-30 1973-04-05 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
DE2157036A1 (de) * 1971-11-17 1973-05-24 Boehringer Mannheim Gmbh Neue heterocyclisch substituierte nebularin-derivate und verfahren zu deren herstellung
DE2244328A1 (de) * 1972-09-09 1974-03-21 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
DE2338705A1 (de) * 1973-07-31 1975-02-13 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
DE2338963A1 (de) * 1973-08-01 1975-02-13 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
DE2426682A1 (de) * 1974-06-01 1975-12-11 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
AU579412B2 (en) * 1984-10-26 1988-11-24 Warner-Lambert Company N` - substituted adenosines
ZA857998B (en) * 1984-10-26 1986-05-28 Warner Lambert Co N6-substituted adenosines

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Патент GB № 1416423, кл. С 07 D 473/34, А 61 К 31/52, 1975. *

Also Published As

Publication number Publication date
CN1035295A (zh) 1989-09-06
SG44701A1 (en) 1997-12-19
LU87414A1 (fr) 1989-07-07
FR2629715A1 (fr) 1989-10-13
GB2212498A (en) 1989-07-26
GB8829983D0 (en) 1989-02-15
SE8804609D0 (sv) 1988-12-21
DK713488D0 (da) 1988-12-21
YU234188A (en) 1990-12-31
NO171506B (no) 1992-12-14
FR2629715B1 (fr) 1993-09-03
AU612747B2 (en) 1991-07-18
IT1224840B (it) 1990-10-24
HK1009650A1 (en) 1999-06-04
EP0322242A3 (en) 1990-04-18
AU2740188A (en) 1989-06-29
HUT48903A (en) 1989-07-28
ES2012927A6 (es) 1990-04-16
PL276697A1 (en) 1990-02-19
KR890009967A (ko) 1989-08-05
JPH01203400A (ja) 1989-08-16
CA1320195C (en) 1993-07-13
DE3843609A1 (de) 1989-07-06
IL88765A (en) 1993-04-04
NO171506C (no) 1993-03-24
DK170894B1 (da) 1996-03-04
EP0322242B1 (en) 1998-04-01
AU8589491A (en) 1991-12-12
GR1000307B (el) 1992-05-12
ZA889593B (en) 1989-09-27
NO885719D0 (no) 1988-12-22
US5032583A (en) 1991-07-16
EP0322242A2 (en) 1989-06-28
NO885719L (no) 1989-06-26
PT89328A (pt) 1989-12-29
DE3856154D1 (de) 1998-05-07
ATA315488A (de) 1994-02-15
NZ227485A (en) 1991-06-25
IE883845L (en) 1989-06-23
CH677495A5 (https=) 1991-05-31
PL158800B1 (en) 1992-10-30
HU203364B (en) 1991-07-29
GB2212498B (en) 1991-07-24
CN1024198C (zh) 1994-04-13
MX14331A (es) 1993-12-01
PH25932A (en) 1991-12-19
BE1002167A5 (fr) 1990-08-28
JP2736088B2 (ja) 1998-04-02
IT8848714A0 (it) 1988-12-23
RU2060996C1 (ru) 1996-05-27
IL88765A0 (en) 1989-07-31
PT89328B (pt) 1993-08-31
NL8803140A (nl) 1989-07-17
FI90429B (fi) 1993-10-29
GB8729994D0 (en) 1988-02-03
IE61302B1 (en) 1994-10-19
DE3856154T2 (de) 1998-08-27
SE8804609L (sv) 1989-06-24
FI90429C (fi) 1994-02-10
DK713488A (da) 1989-06-24
CZ403991A3 (en) 1993-04-14
FI885943L (fi) 1989-06-24

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