ATE61574T1 - N-((2,6-disubstituierte)-phenyl>-harnstoff und - carbamat-inhibitoren der acyl-coenzym a:cholesterol-acyltransferase. - Google Patents

N-((2,6-disubstituierte)-phenyl>-harnstoff und - carbamat-inhibitoren der acyl-coenzym a:cholesterol-acyltransferase.

Info

Publication number
ATE61574T1
ATE61574T1 AT88110575T AT88110575T ATE61574T1 AT E61574 T1 ATE61574 T1 AT E61574T1 AT 88110575 T AT88110575 T AT 88110575T AT 88110575 T AT88110575 T AT 88110575T AT E61574 T1 ATE61574 T1 AT E61574T1
Authority
AT
Austria
Prior art keywords
acyl
urea
coenzyme
disubstituted
phenyl
Prior art date
Application number
AT88110575T
Other languages
English (en)
Inventor
William Howard Roark
Bruce David Roth
Bharat Kalidas Trivedi
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE61574T1 publication Critical patent/ATE61574T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT88110575T 1987-07-02 1988-07-01 N-((2,6-disubstituierte)-phenyl>-harnstoff und - carbamat-inhibitoren der acyl-coenzym a:cholesterol-acyltransferase. ATE61574T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6906687A 1987-07-02 1987-07-02
EP88110575A EP0297610B1 (de) 1987-07-02 1988-07-01 N-[(2,6-disubstituierte)-Phenyl]-Harnstoff und -Carbamat-Inhibitoren der Acyl-Coenzym A:Cholesterol-Acyltransferase

Publications (1)

Publication Number Publication Date
ATE61574T1 true ATE61574T1 (de) 1991-03-15

Family

ID=22086518

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88110575T ATE61574T1 (de) 1987-07-02 1988-07-01 N-((2,6-disubstituierte)-phenyl>-harnstoff und - carbamat-inhibitoren der acyl-coenzym a:cholesterol-acyltransferase.

Country Status (6)

Country Link
EP (1) EP0297610B1 (de)
JP (1) JPH0193569A (de)
AT (1) ATE61574T1 (de)
DE (1) DE3861988D1 (de)
ES (1) ES2037768T3 (de)
GR (1) GR3001602T3 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8827152D0 (en) * 1988-11-21 1988-12-29 Wellcome Found Anti-atherosclerotic diaryl compounds
US5290814A (en) * 1988-11-21 1994-03-01 Burroughs Wellcome Co. Anti-atherosclerotic diaryl compounds
JPH0395153A (ja) * 1989-06-15 1991-04-19 Mitsubishi Kasei Corp ジフェニル尿素誘導体
AU629376B2 (en) * 1989-08-04 1992-10-01 Mitsubishi Chemical Corporation 1-phenylalkyl-3-phenylurea derivatives
AU6659090A (en) * 1989-11-16 1991-06-13 Warner-Lambert Company Acat inhibitors
WO1991013871A1 (en) * 1990-03-12 1991-09-19 Yamanouchi Pharmaceutical Co., Ltd. Monourea derivative and its salt
AU7745991A (en) * 1990-04-11 1991-10-30 Warner-Lambert Company Amide ester acat inhibitors
HUT64318A (en) * 1990-07-25 1993-12-28 Teijin Ltd Process for production benzodpyrane derivativs and pharmaceutical preparations containing these compounds as effective substance
ES2145743T3 (es) * 1990-12-28 2000-07-16 Teijin Ltd Compuesto de anillo condensado benzoxa, su produccion y composicion farmaceutica que lo contiene.
IL100915A (en) * 1991-02-19 1996-03-31 Erba Carlo Spa Double-transformed urea and theories, their preparation and pharmaceutical preparations containing them
US5420164A (en) * 1991-04-04 1995-05-30 Yoshitomi Pharmaceutical Industries, Ltd. Cycloalkylurea compounds
HUT62558A (en) * 1991-07-01 1993-05-28 Sandoz Ag Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same
US5254589A (en) * 1991-10-15 1993-10-19 Warner-Lambert Company Sulfonyl urea and carbamate ACAT inhibitors
KR950701621A (ko) * 1992-05-28 1995-04-28 알렌 제이. 스피겔 아실 조효소a : 콜레스테롤 아실 전이효소(acat)의 억제제로서 신규한 n- 아릴 및 n- 헤테로아릴우레아 유도체(new n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a : cholesterol acyl transferase(acat)
US6133326A (en) 1994-08-31 2000-10-17 Pfizer Inc Compositions and methods for decreasing sebum production
WO1997001533A1 (fr) * 1995-06-27 1997-01-16 The Green Cross Corporation Derives d'acide thiocarbamique
CA2398219A1 (en) 2000-02-02 2001-08-09 Warner-Lambert Company Dual inhibitors of cholesterol ester and wax ester synthesis for sebaceous gland disorders
JP2005154298A (ja) * 2003-11-21 2005-06-16 Idemitsu Kosan Co Ltd 第三級カルボン酸

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT191903B (de) * 1955-02-24 1957-09-25 Cilag Ag Verfahren zur Herstellung neuer Harnstoffderivate und ihrer Salze
DE1102722B (de) * 1959-04-18 1961-03-23 Thomae Gmbh Dr K Verfahren zur Herstellung von substituierten Harnstoffen
GB1112760A (en) * 1965-05-03 1968-05-08 Armour & Co Aliphatic halophenyl ureas and their use in germicidal compositions
CH456570A (de) * 1965-11-18 1968-07-31 Geigy Ag J R Verfahren zur Herstellung von neuen substituierten Harnstoffderivaten
CA961052A (en) * 1967-01-12 1975-01-14 Max Schellenbaum N-2-ethylhexyl-n'-aryl ureas and preparation containing them
IT1064762B (it) * 1976-04-14 1985-02-25 Snam Progetti Processo per la preparazione di ureiani aromatici
WO1980000151A1 (en) * 1978-07-03 1980-02-07 American Home Prod N-(3-alkylaminopropyl)-n'-phenylureas
US4473579A (en) * 1982-01-26 1984-09-25 American Cyanamid Company Antiatherosclerotic tetrasubstituted ureas and thioureas
JP2533331B2 (ja) * 1986-08-26 1996-09-11 住友化学工業株式会社 カ―バメイト誘導体およびそれを有効成分とする農園芸用殺菌剤

Also Published As

Publication number Publication date
DE3861988D1 (en) 1991-04-18
GR3001602T3 (en) 1992-11-23
EP0297610A1 (de) 1989-01-04
ES2037768T3 (es) 1993-07-01
JPH0193569A (ja) 1989-04-12
EP0297610B1 (de) 1991-03-13

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