ATE61574T1 - N-((2,6-disubstituierte)-phenyl>-harnstoff und - carbamat-inhibitoren der acyl-coenzym a:cholesterol-acyltransferase. - Google Patents
N-((2,6-disubstituierte)-phenyl>-harnstoff und - carbamat-inhibitoren der acyl-coenzym a:cholesterol-acyltransferase.Info
- Publication number
- ATE61574T1 ATE61574T1 AT88110575T AT88110575T ATE61574T1 AT E61574 T1 ATE61574 T1 AT E61574T1 AT 88110575 T AT88110575 T AT 88110575T AT 88110575 T AT88110575 T AT 88110575T AT E61574 T1 ATE61574 T1 AT E61574T1
- Authority
- AT
- Austria
- Prior art keywords
- acyl
- urea
- coenzyme
- disubstituted
- phenyl
- Prior art date
Links
- 239000004202 carbamide Substances 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102100030817 Liver carboxylesterase 1 Human genes 0.000 title 1
- 101710181187 Liver carboxylesterase 1 Proteins 0.000 title 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical class NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical class NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000001494 Sterol O-Acyltransferase Human genes 0.000 abstract 1
- 108010054082 Sterol O-acyltransferase Proteins 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000031891 intestinal absorption Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003558 thiocarbamic acid derivatives Chemical class 0.000 abstract 1
- 150000003672 ureas Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6906687A | 1987-07-02 | 1987-07-02 | |
| EP88110575A EP0297610B1 (de) | 1987-07-02 | 1988-07-01 | N-[(2,6-disubstituierte)-Phenyl]-Harnstoff und -Carbamat-Inhibitoren der Acyl-Coenzym A:Cholesterol-Acyltransferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE61574T1 true ATE61574T1 (de) | 1991-03-15 |
Family
ID=22086518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88110575T ATE61574T1 (de) | 1987-07-02 | 1988-07-01 | N-((2,6-disubstituierte)-phenyl>-harnstoff und - carbamat-inhibitoren der acyl-coenzym a:cholesterol-acyltransferase. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0297610B1 (de) |
| JP (1) | JPH0193569A (de) |
| AT (1) | ATE61574T1 (de) |
| DE (1) | DE3861988D1 (de) |
| ES (1) | ES2037768T3 (de) |
| GR (1) | GR3001602T3 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5290814A (en) * | 1988-11-21 | 1994-03-01 | Burroughs Wellcome Co. | Anti-atherosclerotic diaryl compounds |
| GB8827152D0 (en) * | 1988-11-21 | 1988-12-29 | Wellcome Found | Anti-atherosclerotic diaryl compounds |
| JPH0395153A (ja) * | 1989-06-15 | 1991-04-19 | Mitsubishi Kasei Corp | ジフェニル尿素誘導体 |
| CA2022346A1 (en) * | 1989-08-04 | 1991-02-05 | Mitsubishi Chemical Corporation | 1-phenylalkyl-3-phenylurea derivatives |
| AU6659090A (en) * | 1989-11-16 | 1991-06-13 | Warner-Lambert Company | Acat inhibitors |
| AU7440691A (en) * | 1990-03-12 | 1991-10-10 | Yamanouchi Pharmaceutical Co., Ltd. | Monourea derivative and its salt |
| WO1991015464A1 (en) * | 1990-04-11 | 1991-10-17 | Warner-Lambert Company | Amide ester acat inhibitors |
| HUT64318A (en) * | 1990-07-25 | 1993-12-28 | Teijin Ltd | Process for production benzodpyrane derivativs and pharmaceutical preparations containing these compounds as effective substance |
| JP3095413B2 (ja) * | 1990-12-28 | 2000-10-03 | 帝人株式会社 | ベンゾオキサ縮合環化合物 |
| IL100915A (en) * | 1991-02-19 | 1996-03-31 | Erba Carlo Spa | Disubstituted ureas and thioureas their preparation and pharmaceutical compositions containing them |
| US5420164A (en) * | 1991-04-04 | 1995-05-30 | Yoshitomi Pharmaceutical Industries, Ltd. | Cycloalkylurea compounds |
| HUT62558A (en) * | 1991-07-01 | 1993-05-28 | Sandoz Ag | Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same |
| US5254589A (en) * | 1991-10-15 | 1993-10-19 | Warner-Lambert Company | Sulfonyl urea and carbamate ACAT inhibitors |
| US6001860A (en) * | 1992-05-28 | 1999-12-14 | Pfizer Inc. | N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT) |
| US6133326A (en) | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
| WO1997001533A1 (en) * | 1995-06-27 | 1997-01-16 | The Green Cross Corporation | Thiocarbamic acid derivatives |
| BR0107954A (pt) | 2000-02-02 | 2002-10-22 | Warner Lambert Co | Inibidores duplos de sìntese de éster de colesterol e éster de cera para distúrbios de glândula sebácea |
| JP2005154298A (ja) * | 2003-11-21 | 2005-06-16 | Idemitsu Kosan Co Ltd | 第三級カルボン酸 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT191903B (de) * | 1955-02-24 | 1957-09-25 | Cilag Ag | Verfahren zur Herstellung neuer Harnstoffderivate und ihrer Salze |
| DE1102722B (de) * | 1959-04-18 | 1961-03-23 | Thomae Gmbh Dr K | Verfahren zur Herstellung von substituierten Harnstoffen |
| GB1112760A (en) * | 1965-05-03 | 1968-05-08 | Armour & Co | Aliphatic halophenyl ureas and their use in germicidal compositions |
| CH456570A (de) * | 1965-11-18 | 1968-07-31 | Geigy Ag J R | Verfahren zur Herstellung von neuen substituierten Harnstoffderivaten |
| CA961052A (en) * | 1967-01-12 | 1975-01-14 | Max Schellenbaum | N-2-ethylhexyl-n'-aryl ureas and preparation containing them |
| IT1064762B (it) * | 1976-04-14 | 1985-02-25 | Snam Progetti | Processo per la preparazione di ureiani aromatici |
| JPH0140026B2 (de) * | 1978-07-03 | 1989-08-24 | Amerikan Hoomu Purodakutsu Corp | |
| US4473579A (en) * | 1982-01-26 | 1984-09-25 | American Cyanamid Company | Antiatherosclerotic tetrasubstituted ureas and thioureas |
| JP2533331B2 (ja) * | 1986-08-26 | 1996-09-11 | 住友化学工業株式会社 | カ―バメイト誘導体およびそれを有効成分とする農園芸用殺菌剤 |
-
1988
- 1988-07-01 DE DE8888110575T patent/DE3861988D1/de not_active Expired - Fee Related
- 1988-07-01 JP JP63162744A patent/JPH0193569A/ja active Pending
- 1988-07-01 AT AT88110575T patent/ATE61574T1/de active
- 1988-07-01 ES ES198888110575T patent/ES2037768T3/es not_active Expired - Lifetime
- 1988-07-01 EP EP88110575A patent/EP0297610B1/de not_active Expired - Lifetime
-
1991
- 1991-03-14 GR GR91400230T patent/GR3001602T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3001602T3 (en) | 1992-11-23 |
| EP0297610A1 (de) | 1989-01-04 |
| EP0297610B1 (de) | 1991-03-13 |
| JPH0193569A (ja) | 1989-04-12 |
| DE3861988D1 (en) | 1991-04-18 |
| ES2037768T3 (es) | 1993-07-01 |
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