DE69012116D1 - Antihyperlipidemische und antiartherosklerotische harnstoffverbindungen. - Google Patents

Antihyperlipidemische und antiartherosklerotische harnstoffverbindungen.

Info

Publication number
DE69012116D1
DE69012116D1 DE69012116T DE69012116T DE69012116D1 DE 69012116 D1 DE69012116 D1 DE 69012116D1 DE 69012116 T DE69012116 T DE 69012116T DE 69012116 T DE69012116 T DE 69012116T DE 69012116 D1 DE69012116 D1 DE 69012116D1
Authority
DE
Germany
Prior art keywords
antiartherosclerotic
antihyperlipidemic
urea compounds
cholesterol
thiourea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69012116T
Other languages
English (en)
Other versions
DE69012116T2 (de
Inventor
Bharat Trivedi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of DE69012116D1 publication Critical patent/DE69012116D1/de
Publication of DE69012116T2 publication Critical patent/DE69012116T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
DE69012116T 1989-06-01 1990-05-31 Antihyperlipidemische und antiartherosklerotische harnstoffverbindungen. Expired - Fee Related DE69012116T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/359,830 US5015644A (en) 1987-06-02 1989-06-01 Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds
PCT/US1990/003055 WO1990015048A1 (en) 1989-06-01 1990-05-31 Antihyperlipidemic and antiatherosclerotic urea compounds

Publications (2)

Publication Number Publication Date
DE69012116D1 true DE69012116D1 (de) 1994-10-06
DE69012116T2 DE69012116T2 (de) 1994-12-22

Family

ID=23415467

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69012116T Expired - Fee Related DE69012116T2 (de) 1989-06-01 1990-05-31 Antihyperlipidemische und antiartherosklerotische harnstoffverbindungen.

Country Status (12)

Country Link
US (1) US5015644A (de)
EP (1) EP0474733B1 (de)
JP (1) JP2799242B2 (de)
AT (1) ATE110713T1 (de)
AU (1) AU5675990A (de)
CA (1) CA2054209C (de)
DE (1) DE69012116T2 (de)
DK (1) DK0474733T3 (de)
IE (1) IE64603B1 (de)
PT (1) PT94231A (de)
WO (1) WO1990015048A1 (de)
ZA (1) ZA904231B (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5290814A (en) * 1988-11-21 1994-03-01 Burroughs Wellcome Co. Anti-atherosclerotic diaryl compounds
IL100915A (en) * 1991-02-19 1996-03-31 Erba Carlo Spa Double-transformed urea and theories, their preparation and pharmaceutical preparations containing them
FR2679555B1 (fr) * 1991-07-25 1993-11-19 Fabre Medicament Pierre Nouveaux derives de l'uree, leur preparation et leur application en therapeutique.
RU94046149A (ru) * 1992-05-28 1996-11-27 Пфайзер Инк. (US) Новые n-арил и n-гетероарил производные мочевины как ингибиторы ацил кофермента а:холестерин ацил трансферазы (асат) фармацевтическая композиция, способ ингибирования (асат)
IL110151A (en) * 1993-06-30 1998-10-30 Sankyo Co Amid and urea histories and pharmaceutical preparations containing them
US5362744A (en) * 1993-11-22 1994-11-08 Warner-Lambert Company Tetrazole-substituted urea acat inhibitors
US5441984A (en) * 1994-01-06 1995-08-15 Eli Lilly And Company Urea, thiourea and guanidine derivatives
US5461049A (en) * 1994-05-27 1995-10-24 Warner-Lambert Company Amide tetrazole ACAT inhibitors
US6133326A (en) 1994-08-31 2000-10-17 Pfizer Inc Compositions and methods for decreasing sebum production
EP0742208A1 (de) * 1995-05-05 1996-11-13 Grelan Pharmaceutical Co., Ltd. 2-Ureido-benzamid-Derivate
WO1997042155A1 (en) * 1996-05-06 1997-11-13 Eli Lilly And Company Anti-viral compounds
PT806408E (pt) * 1996-05-06 2001-04-30 Lilly Co Eli Compostos anti-virais
US6156924A (en) * 1996-05-06 2000-12-05 Eli Lilly And Company Anti-viral compounds
WO1997041846A1 (en) * 1996-05-06 1997-11-13 Eli Lilly And Company Anti-viral compounds
PT811599E (pt) * 1996-05-06 2001-06-29 Lilly Co Eli Compostos anti-virais
US6127422A (en) * 1996-05-06 2000-10-03 Eli Lilly And Company Anti-viral method
US6103923A (en) * 1996-05-06 2000-08-15 Eli Lilly And Company Anti-viral compounds
US6096917A (en) * 1997-05-02 2000-08-01 Eli Lilly And Company Anti-viral compounds
PL341291A1 (en) * 1997-12-16 2001-04-09 Warner Lambert Co 1-substituted derivatives of 1-aminomethyl-ccycloalkanes (gabapentin analogues), their production and application of them in treating neurological disorders
US6605623B1 (en) 1998-12-18 2003-08-12 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
WO2001017953A1 (en) * 1999-09-08 2001-03-15 Guilford Pharmaceuticals Inc. Non-peptidic cyclophilin binding compounds and their use
YU57502A (sh) 2000-02-02 2006-01-16 Warner-Lambert Company Dvojni inhibitori sinteze estara holesterola i estara voska kod poremećaja lojne žlezde
US6175034B1 (en) 2000-04-10 2001-01-16 Eli Lilly And Company Anti-viral compounds
GB2368579A (en) * 2000-10-31 2002-05-08 Parke Davis & Co Ltd Azole pharmaceutical agents
US6656971B2 (en) 2001-01-25 2003-12-02 Guilford Pharmaceuticals Inc. Trisubstituted carbocyclic cyclophilin binding compounds and their use
US20040072903A1 (en) * 2001-05-08 2004-04-15 Auerbach Bruce Jeffrey Carboxyalkylether-acat inhibitors combinations
US7173151B2 (en) * 2003-02-27 2007-02-06 Sanofi-Aventisdeutschand Gmbh Cycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals
KR101494067B1 (ko) 2004-03-05 2015-02-16 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 부작용을 최소화하면서 과지질혈증 및 과콜레스테롤혈증과 연관된 질환 또는 질병의 치료 방법
CA2636324C (en) * 2006-01-06 2012-03-20 Sepracor Inc. Cycloalkylamines as monoamine reuptake inhibitors
BRPI0716952A2 (pt) * 2006-09-15 2013-10-29 Reviva Pharmaceuticals Inc Composto, métodos para tratar e/ou prevenir obesidade ou indicação co-mórbida relacionada à obesidade, e para sintetizar derivado de cicloalquilmetilamina
US8604244B2 (en) 2010-07-02 2013-12-10 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives
TW200831497A (en) * 2006-10-12 2008-08-01 Epix Delaware Inc Carboxamide compounds and their use
JP2010513534A (ja) * 2006-12-21 2010-04-30 エージェリオン ファーマシューティカルズ， インコーポレイテッド Ｍｔｐインヒビターおよびコレステロール吸収インヒビターを含む組み合わせを用いて肥満症を処置する方法
CA2708364A1 (en) 2007-12-11 2009-06-18 Efrat Ben-Zeev Carboxamide compounds and their use as chemokine receptor agonists
EP2341924A4 (de) 2008-10-02 2013-01-23 David Gladstone Inst Verfahren zur behandlung von hepatitis-c-virusinfektionen
NZ630828A (en) 2012-03-22 2016-10-28 Univ Michigan Compounds and methods for treating aberrant adrenocartical cell disorders
NZ723940A (en) 2014-02-03 2017-12-22 Quadriga Biosciences Inc Beta-substituted beta-amino acids and analogs as chemotherapeutic agents
BR112016017993A2 (pt) 2014-02-03 2017-08-08 Quadriga Biosciences Inc Gama-aminoácidos beta-substituídos e análogos como agentes quimioterapêuticos
MX2017003916A (es) * 2014-09-26 2017-06-30 Millendo Therapeutics Inc Forma de medicamento solido de clorhidrato de n-(2,6 bis (1 metiletil)fenil)-n'-((1-(4-(dimetilamino)fenil)ciclopentil) metil)urea y composiciones, metodos y kits relacionados con la misma.
WO2016164476A2 (en) 2015-04-06 2016-10-13 Millendo Therapeutics, Inc. Combination therapy for treating disorders associated with excess cortisol production
WO2017024009A1 (en) 2015-08-03 2017-02-09 Quadriga Biosciences, Inc. Beta-substituted beta-amino acids and analogs as chemotherapeutic agents and uses thereof
CN112441941B (zh) * 2020-12-03 2022-08-02 浙江荣耀生物科技股份有限公司 一种1-(4-氨基苯基)环戊基甲腈的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3852343A (en) * 1970-07-22 1974-12-03 Labofina Sa A process for the production of benzene carboxylic acids from ethyl substituted benzens
EP0049538A3 (de) * 1979-07-14 1982-10-13 Bayer Ag Verwendung von Thioharnstoffderivaten als Arzneimittel bei der Behandlung von Fettstoffwechselstörungen
DE2945530A1 (de) * 1979-11-10 1981-06-04 Chemische Werke Hüls AG, 4370 Marl Harnstoffe mit cyclischen substituenten, ihre herstellung und verwendung als herbizide
US4410697A (en) * 1980-01-25 1983-10-18 Reanal Finomvegyszergyar Process for the preparation of N-aryl-N'-(mono- or di substituted)-urea derivatives
US4397868A (en) * 1982-01-26 1983-08-09 American Cyanamid Company Method of treating atherosclerosis with trisubstituted ureas
US4623662A (en) * 1985-05-23 1986-11-18 American Cyanamid Company Antiatherosclerotic ureas and thioureas
US4387105A (en) * 1982-01-26 1983-06-07 American Cyanamid Company Methods of treating atherosclerosis with dialkylureas and dialkylthioureas
IE61716B1 (en) * 1987-06-02 1994-11-30 Warner Lambert Co Antihyperlipidemic and antiatherosclerotic urea compounds

Also Published As

Publication number Publication date
EP0474733A1 (de) 1992-03-18
ZA904231B (en) 1992-02-26
DK0474733T3 (da) 1994-11-21
CA2054209A1 (en) 1990-12-02
AU5675990A (en) 1991-01-07
IE901983A1 (en) 1991-01-02
IE901983L (en) 1990-12-01
JPH04505617A (ja) 1992-10-01
DE69012116T2 (de) 1994-12-22
CA2054209C (en) 2002-01-15
JP2799242B2 (ja) 1998-09-17
US5015644A (en) 1991-05-14
IE64603B1 (en) 1995-08-23
WO1990015048A1 (en) 1990-12-13
EP0474733B1 (de) 1994-08-31
ATE110713T1 (de) 1994-09-15
PT94231A (pt) 1991-02-08

Similar Documents

Publication Publication Date Title
DE69012116D1 (de) Antihyperlipidemische und antiartherosklerotische harnstoffverbindungen.
DE68906940T2 (de) Antihyperlipidemische und antiatherosclerotische Verbindungen und Zusammensetzungen.
IE881380L (en) Antiatherosclerotic ureas
ES2060682T3 (es) N-((fenil(2,6-disubstituido))-n'-aril)ureas como agentes antihipercolesterolemicos y antiateroscleroticos.
BR8703425A (pt) Conjunto para o amortecimento de vibracoes
BR8806948A (pt) Conjunto para o amortecimento de vibracoes
FI880796A0 (fi) Maettade fettsyreamider som inhibitorer av acyl-coa:kolesterol-acyltransferaser.
ES2056992T3 (es) N-((fenil(2,6-disubstituido))-n'-diarilalquil)ureas como agentes antihiperlipidemicos y antiateroscleroticos.
ES2037768T3 (es) Procedimiento para preparar n-(fenil(2,6-disustituido))-ureas y carbamatos inhibidores de acil-coa: colesterol acil-transferasa.
ATE158288T1 (de) Antiatherosklerotische und antithrombotische 1- benzopyran-4-on- und 2-amino-1,3-benzoxazin-4-on- derivate
FI915093A0 (fi) Sackarinderivat anvaendbara som inhibitorer foer proteolytiskt enzym och deras framstaellning.
BR8904423A (pt) Catalisador e processo para o tratamento de gas contendo compostos de enxofre
NO174708C (no) Substituerte arylureaforbindelser som sötningsmidler med höy styrke.
IT9021645A0 (it) Procedimento per il trattamento di torbide di raffineria
ES2088128T3 (es) Aminosulfonilureas inhibidoras de acat.
NO934721D0 (no) Hemmere av HIV-protease som er nyttige for behandling av AIDS
NO883063L (no) Fremgangsmaate, anordning og sett for maaling av vevplasminogenaktivator-aktivitet.
IT8420682A0 (it) Procedimento per il trattamento di articoli di maglieria.
DK0386487T3 (da) N-(Substitueret aryl)-N-(substitueret alkoxy)-urinstoffer og -thiourinstoffer som antihypercholesterolæmiske og antiatherosclerotiske midler
NO904336D0 (no) Fremgangsmaate for fremstilling av piperazinoner for anvendelse som svoveldioksyd-absorberende midler.
ES546542A0 (es) Procedimiento para la inmovilizacion de celulas de bacillus subtilis
FI883135A (fi) Homocyklostatin och cyklostatin innehaollande polypeptider som antihypertensiva medel.
ES2176187T3 (es) Polimorfos de mupirocina cristalina.
ES557132A0 (es) Procedimiento para la obtencion de isocianatos piperidinicos.
NO166515C (no) Fremgangsmaate for fremstilling av et spiselig produkt sometterligner hummerkjoett.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee