ES2161955T3 - Benzofuranil-ureas sustituidas con heterociclilcarbonilo. - Google Patents
Benzofuranil-ureas sustituidas con heterociclilcarbonilo.Info
- Publication number
- ES2161955T3 ES2161955T3 ES96119046T ES96119046T ES2161955T3 ES 2161955 T3 ES2161955 T3 ES 2161955T3 ES 96119046 T ES96119046 T ES 96119046T ES 96119046 T ES96119046 T ES 96119046T ES 2161955 T3 ES2161955 T3 ES 2161955T3
- Authority
- ES
- Spain
- Prior art keywords
- ureas
- substituted
- heterociclilcarbonilo
- benzofuranil
- replaced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
Abstract
BENZOFURANILUREAS SUSTITUIDAS CON HETEROCICLILOCARBONILO DE FORMULA (I) SE PREPARAN MEDIANTE LA REACCION DE 3-AMINOBENZOFURANOS SUSTITUIDOS CON HETEROCICLILOCARBONILO CON ISOCIANATOS O ISOTIOCIANATOS ADECUADOS. LAS UREAS INSUSTITUIDAS SON TRANSFERIDAS EN UREAS SUSTITUIDAS MEDIANTE METODOS DE SUSTITUCION USUALES. LAS BENZOFURANILUREAS SUSTITUIDAS CON HETEROCICLILOCARBONILO SON UTILES COMO INGREDIENTES ACTIVOS EN MEDICAMENTOS PARTICULARMENTE PARA EL TRATAMIENTO DE PROCESOS INFLAMATORIOS AGUDOS Y CRONICOS. A, D, L, R{SUP,1}, R{SUP,2}, R{SUP,3}, R{SUB,4} SON COMO SE DEFINIA EN LAS APLICACIONES, R{SUP,4} SIENDO UN GRUPO HETEROCICLICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9525262.3A GB9525262D0 (en) | 1995-12-11 | 1995-12-11 | Heterocyclylcarbonyl substituted benzofuranyl-ureas |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2161955T3 true ES2161955T3 (es) | 2001-12-16 |
Family
ID=10785231
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96119046T Expired - Lifetime ES2161955T3 (es) | 1995-12-11 | 1996-11-28 | Benzofuranil-ureas sustituidas con heterociclilcarbonilo. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5922740A (es) |
EP (1) | EP0779291B1 (es) |
JP (1) | JPH09202785A (es) |
AT (1) | ATE206709T1 (es) |
CA (1) | CA2192281A1 (es) |
DE (1) | DE69615802T2 (es) |
DK (1) | DK0779291T3 (es) |
ES (1) | ES2161955T3 (es) |
GB (1) | GB9525262D0 (es) |
PT (1) | PT779291E (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9312853D0 (en) | 1993-06-22 | 1993-08-04 | Euro Celtique Sa | Chemical compounds |
US5922751A (en) | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
US5591776A (en) | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
US6166041A (en) | 1995-10-11 | 2000-12-26 | Euro-Celtique, S.A. | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma |
US6075016A (en) | 1996-04-10 | 2000-06-13 | Euro-Celtique S.A. | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity |
GB9614718D0 (en) * | 1996-07-12 | 1996-09-04 | Bayer Ag | 3-ureido-pyridofurans and -pyridothiophenes |
UY25338A1 (es) * | 1998-01-07 | 2001-08-27 | Smithkline Beecham Corp | Método para tratar copd |
GB2350110A (en) * | 1999-05-17 | 2000-11-22 | Bayer Ag | Pharmaceutically active benzofurans |
GB2350112A (en) * | 1999-05-17 | 2000-11-22 | Bayer Ag | Pharmaceutically active cycloalkyl ketones |
GB2350109A (en) | 1999-05-17 | 2000-11-22 | Bayer Ag | Pharmaceutically active benzofuranyl sulfonates |
GB2350111A (en) * | 1999-05-17 | 2000-11-22 | Bayer Ag | Oligohydroxyl substituted 3-urea-benzofuran and pyridofuran derivatives |
DE10064997A1 (de) | 2000-12-23 | 2002-06-27 | Merck Patent Gmbh | Benzoylpyridazine |
DE10150517A1 (de) * | 2001-10-12 | 2003-04-17 | Merck Patent Gmbh | Verwendung von Phosphodiesterase IV-Inhibitoren |
US7144885B2 (en) | 2002-02-22 | 2006-12-05 | Bayer Pharmaceuticals Corporation | Fused tricyclic heterocycles useful for treating hyper-proliferative disorders |
EP1478639A1 (en) * | 2002-02-22 | 2004-11-24 | Bayer Pharmaceuticals Corporation | Fused tricyclic heterocycles useful for treating hyper-proliferative disorders |
JP4206382B2 (ja) * | 2002-11-19 | 2009-01-07 | アキリオン ファーマシューティカルズ,インコーポレーテッド | 置換されたアリールチオウレアおよび関連化合物;ウイルス複製のインヒビター |
TW200600492A (en) * | 2004-05-18 | 2006-01-01 | Achillion Pharmaceuticals Inc | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication |
DE102005055354A1 (de) * | 2005-11-21 | 2007-10-31 | Merck Patent Gmbh | Substituierte 5-Phenyl-3,6-dihydro-2-oxo-6H-[1,3,4]thiadiazine |
DE102005055355A1 (de) * | 2005-11-21 | 2007-10-31 | Merck Patent Gmbh | 3,6-Dihydro-2-oxo-6H-[1,3,4]thiadiazinderivate |
CA2666469A1 (en) * | 2006-09-01 | 2008-03-06 | Bayer Healthcare Ag | Benzofuran and benzothiophene derivatives useful in the treatment of cancers of the central nervous system |
US8084612B2 (en) * | 2008-01-08 | 2011-12-27 | Purdue Pharma L.P. | Proline analogs as ligands for cannabinoid receptors |
US8883857B2 (en) | 2012-12-07 | 2014-11-11 | Baylor College Of Medicine | Small molecule xanthine oxidase inhibitors and methods of use |
BR112015032921B1 (pt) * | 2013-07-03 | 2022-06-14 | Karyopharm Therapeutics, Inc | Compostos de benzofuranila e benzoxazolila substituídos e utilizações dos mesmos |
US10822299B2 (en) | 2016-05-26 | 2020-11-03 | The Regents Of The University Of California | Compounds and methods for hematopoietic regeneration |
WO2019108800A1 (en) * | 2017-11-29 | 2019-06-06 | The Regents Of The University Of California | Compounds and methods for hematopoietic regeneration |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4745127A (en) * | 1983-10-31 | 1988-05-17 | Merck Frosst Canada, Inc. | Benzyl esters of benzofuran-2-carboxylic acids useful as inhibitors of leukotriene biosynthesis |
EP0146243A1 (en) * | 1983-10-31 | 1985-06-26 | Merck Frosst Canada Inc. | Lipoxygenase inhibitors |
NZ237566A (en) * | 1990-03-27 | 1994-03-25 | Smithkline Beecham Corp | Substituted amide and hydroxyamine derivatives and pharmaceutical compositions |
JPH07267961A (ja) * | 1994-03-30 | 1995-10-17 | Taisho Pharmaceut Co Ltd | ベンゾフロ[3,2−dピリミジン−4−オン誘導体 |
GB9504460D0 (en) * | 1995-03-06 | 1995-04-26 | Bayer Ag | N-(3-Benzofuranyl)urea-derivatives |
-
1995
- 1995-12-11 GB GBGB9525262.3A patent/GB9525262D0/en active Pending
-
1996
- 1996-11-28 AT AT96119046T patent/ATE206709T1/de not_active IP Right Cessation
- 1996-11-28 EP EP96119046A patent/EP0779291B1/en not_active Expired - Lifetime
- 1996-11-28 PT PT96119046T patent/PT779291E/pt unknown
- 1996-11-28 ES ES96119046T patent/ES2161955T3/es not_active Expired - Lifetime
- 1996-11-28 DE DE69615802T patent/DE69615802T2/de not_active Expired - Fee Related
- 1996-11-28 DK DK96119046T patent/DK0779291T3/da active
- 1996-12-04 US US08/760,612 patent/US5922740A/en not_active Expired - Fee Related
- 1996-12-06 CA CA002192281A patent/CA2192281A1/en not_active Abandoned
- 1996-12-06 JP JP8340388A patent/JPH09202785A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
PT779291E (pt) | 2002-02-28 |
DK0779291T3 (da) | 2002-01-21 |
CA2192281A1 (en) | 1997-06-12 |
DE69615802T2 (de) | 2002-04-04 |
EP0779291B1 (en) | 2001-10-10 |
EP0779291A1 (en) | 1997-06-18 |
US5922740A (en) | 1999-07-13 |
JPH09202785A (ja) | 1997-08-05 |
ATE206709T1 (de) | 2001-10-15 |
DE69615802D1 (de) | 2001-11-15 |
GB9525262D0 (en) | 1996-02-07 |
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