ES8706673A1 - Un procedimiento para la preparacion de derivados de 1,4-dihidro-4-oxonaftiridina y sus sales - Google Patents
Un procedimiento para la preparacion de derivados de 1,4-dihidro-4-oxonaftiridina y sus salesInfo
- Publication number
- ES8706673A1 ES8706673A1 ES551538A ES551538A ES8706673A1 ES 8706673 A1 ES8706673 A1 ES 8706673A1 ES 551538 A ES551538 A ES 551538A ES 551538 A ES551538 A ES 551538A ES 8706673 A1 ES8706673 A1 ES 8706673A1
- Authority
- ES
- Spain
- Prior art keywords
- unsubstituted
- naphthyridines
- group
- salts
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
METODO DE OBTENER DERIVADOS DE 1,4-DIHIDRO-4-OXONAFTIRIDINA Y SUS SALES. CONSISTE EN SOMETER UN COMPUESTO DE FORMULA (II) O UNA SAL DEL MISMO, DONDE R ELEVADO A 1A ES UN GRUPO PROTECTOR DE CARBOXI, A UNA REACCION DE CIERRE DE ANILLO, A TEMPERATURA COMPRENDIDA ENTRE 20 Y 160GC, Y SI SE DESEA, SEPARAR EL GRUPO PROTECTOR CARBOXI, PARA OBTENER DERIVADOS DE 1,4-DIHIDRO-4-OXONAFTIRIDINA DE FORMULA (I) DONDE R ELEVADO A 1 ES UN ATOMO DE HIDROGENO O UN GRUPO PROTECTOR DE CARBOXI; R ELEVADO A 2 ES UN GRUPO ARILO SUSTITUIDO O NO SUSTITUIDO; Y R ELEVADO A 3 ES UN ATOMO DE HIDROGENO O UN GRUPO AMINO CICLICO SUSTITUIDO O NO SUSTITUIDO. TIENEN APLICACIONES FARMACEUTICAS POR SU ACTIVIDAD ANTIBACTERIANA. *FORMULA*
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP59084963A JPS60228479A (ja) | 1984-04-26 | 1984-04-26 | 1,4−ジヒドロ−4−オキソナフチリジン誘導体およびその塩 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8706673A1 true ES8706673A1 (es) | 1987-07-01 |
ES551538A0 ES551538A0 (es) | 1987-07-01 |
Family
ID=13845280
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES542584A Expired ES8700256A1 (es) | 1984-04-26 | 1985-04-25 | Un derivado de 1,4-dihidro-4-oxonaftiridina |
ES551538A Expired ES8706673A1 (es) | 1984-04-26 | 1986-01-31 | Un procedimiento para la preparacion de derivados de 1,4-dihidro-4-oxonaftiridina y sus sales |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES542584A Expired ES8700256A1 (es) | 1984-04-26 | 1985-04-25 | Un derivado de 1,4-dihidro-4-oxonaftiridina |
Country Status (30)
Country | Link |
---|---|
JP (1) | JPS60228479A (es) |
KR (1) | KR870001693B1 (es) |
AR (1) | AR241911A1 (es) |
AT (2) | AT389698B (es) |
AU (2) | AU565087B2 (es) |
BE (1) | BE902279A (es) |
CH (1) | CH673458A5 (es) |
CS (1) | CS250684B2 (es) |
DD (1) | DD238795A5 (es) |
DE (2) | DE3514076A1 (es) |
DK (1) | DK165877C (es) |
EG (1) | EG17339A (es) |
ES (2) | ES8700256A1 (es) |
FI (1) | FI80453C (es) |
FR (2) | FR2563521B1 (es) |
GB (2) | GB2158825B (es) |
HU (2) | HU197571B (es) |
ID (1) | ID21142A (es) |
IL (1) | IL75021A (es) |
IT (1) | IT1209953B (es) |
LU (1) | LU85871A1 (es) |
NL (2) | NL187314C (es) |
NO (1) | NO162238C (es) |
NZ (1) | NZ211895A (es) |
PH (3) | PH22801A (es) |
PL (1) | PL147392B1 (es) |
PT (1) | PT80349B (es) |
RO (2) | RO95509B (es) |
SE (2) | SE463102B (es) |
ZA (1) | ZA853102B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6172753A (ja) * | 1984-09-18 | 1986-04-14 | Dainippon Pharmaceut Co Ltd | ピリジルケトン誘導体 |
AU576657B2 (en) * | 1985-01-23 | 1988-09-01 | Toyama Chemical Co. Ltd. | Naphthyridine and pyridine derivatives |
AT392789B (de) * | 1985-01-23 | 1991-06-10 | Toyama Chemical Co Ltd | Verfahren zur herstellung von 1-substituierten aryl-1,4-dihydro-4-oxonaphthyridinderivaten |
DE3525108A1 (de) * | 1985-06-07 | 1986-12-11 | Bayer Ag, 5090 Leverkusen | Antibakteriell wirksame chinoloncarbonsaeureester |
IL79189A (en) * | 1985-06-26 | 1990-07-12 | Daiichi Seiyaku Co | Quinoline and/or naphthyridine-4-oxo-3-carboxylic acid derivatives,process for their preparation and pharmaceutical compositions comprising them |
US4962112A (en) * | 1987-08-04 | 1990-10-09 | Abbott Laboratories | 7-(2-methyl-4-aminopyrrolidinyl)naphthryidine and quinoline compounds |
IE62600B1 (en) * | 1987-08-04 | 1995-02-22 | Abbott Lab | Naphtyridine antianaerobic compounds |
US4859776A (en) * | 1988-03-11 | 1989-08-22 | Abbott Laboratories | (S)-7-(3-aminopyrrolidin-1-yl)-1-(ortho, para-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid and method for its preparation |
JP2844079B2 (ja) * | 1988-05-23 | 1999-01-06 | 塩野義製薬株式会社 | ピリドンカルボン酸系抗菌剤 |
DE3934082A1 (de) * | 1989-10-12 | 1991-04-18 | Bayer Ag | Chinoloncarbonsaeurederivate, verfahren zu ihrer herstellung sowie ihre verwendung als antivirale mittel |
CA2100242A1 (en) * | 1991-01-14 | 1992-07-15 | Soon K. Moon | Quinolone compounds and processes for preparation thereof |
FR2692577B1 (fr) * | 1992-05-26 | 1996-02-02 | Bouchara Sa | Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant. |
KR940014395A (ko) * | 1992-12-09 | 1994-07-18 | 강박광 | 신규한 퀴놀론 유도체 및 그의 제조방법 |
KR0148277B1 (ko) * | 1993-01-18 | 1998-11-02 | 채영복 | 신규한 플루오르퀴놀론계 유도체 및 그의 제조방법 |
WO1994025464A1 (en) * | 1993-04-24 | 1994-11-10 | Korea Research Institute Of Chemical Technology | Novel quinolone carboxylic acid derivatives and process for preparing the same |
KR950018003A (ko) * | 1993-12-09 | 1995-07-22 | 스미스클라인 비참 피엘씨 | 신규한 퀴놀론 유도체 및 그의 제조 방법 |
EP0787720B1 (en) * | 1994-10-20 | 2003-07-16 | Wakunaga Seiyaku Kabushiki Kaisha | Pyridonecarboxylate derivative or salt thereof and antibacterial containing the same as active ingredient |
ATE269320T1 (de) | 1996-04-19 | 2004-07-15 | Wakunaga Pharma Co Ltd | Neue pyridoncarbonsäure-derivate oder salze dieser derivate und antibakterielle mittel, die diese als aktiven wirkstoff enthalten |
EP0935600A1 (de) * | 1996-10-30 | 1999-08-18 | Bayer Ag | Verfahren zur herstellung von naphthyridinverbindungen und neue zwischenprodukte |
DE19713506A1 (de) | 1997-04-01 | 1998-10-08 | Bayer Ag | Verfahren zur Herstellung von 2,6-Dichlor-5-fluornicotinonitril und die chemische Verbindung 3-Cyano-2-hydroxy-5-fluorpyrid-6-on-mononatriumsalz sowie dessen Tautomere |
EP2275141A1 (en) | 1999-03-17 | 2011-01-19 | Daiichi Pharmaceutical Co., Ltd. | Tastemasked pharmaceutical compositions |
US6441182B1 (en) | 1999-06-10 | 2002-08-27 | Bayer Aktiengesellschaft | Method for the production of 2,6-dichloro-5-fluoro-nicotinic acid and coarse and particularly pure 2,6-dichloro-5-fluoro-nicotinic acid |
EP1219618A4 (en) | 1999-09-02 | 2002-09-18 | Wakunaga Pharma Co Ltd | QUINOLINECARBOXYLIC ACID DERIVATIVE OR ITS SALT |
WO2002018345A1 (en) * | 2000-08-29 | 2002-03-07 | Chiron Corporation | Quinoline antibacterial compounds and methods of use thereof |
KR100981351B1 (ko) * | 2003-10-29 | 2010-09-10 | 주식회사 엘지생명과학 | 7-클로로-1-사이클로프로필-6-플루오로-4-옥소-1,4-디하이드로-1,8-나프티리딘-3-카복실산의 제조방법 |
CN101792443A (zh) * | 2010-03-09 | 2010-08-04 | 北京欧凯纳斯科技有限公司 | 氟代喹诺酮衍生物及其制备方法和用途 |
JOP20190045A1 (ar) | 2016-09-14 | 2019-03-14 | Bayer Ag | مركبات أميد حمض 1- أريل-نفثيريدين-3-كربوكسيليك مستبدلة في الموضع 7 واستخدامها. |
CN114369092A (zh) * | 2021-12-20 | 2022-04-19 | 赤峰万泽药业股份有限公司 | 甲苯磺酸妥舒沙星及其制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2125310A1 (en) * | 1971-05-21 | 1972-11-30 | Sterling Drug Inc , New York, NY (V St A) | 1-alkyl-1,4-dihydro-4-oxo-1,8-naphtyridine 3-carboxylic acids antibac |
AR223983A1 (es) * | 1978-08-25 | 1981-10-15 | Dainippon Pharmaceutical Co | Un procedimiento para-preparar derivados de acido 6-halogeno-4-oxo-7-(1-piperazinil)-1,8-naftiridin-3-carboxilico |
DE3033157A1 (de) * | 1980-09-03 | 1982-04-01 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
US4382937A (en) * | 1981-02-27 | 1983-05-10 | Dainippon Pharmaceutical Co., Ltd. | Naphthyridine derivatives and their use as anti-bacterials |
IE55898B1 (en) * | 1982-09-09 | 1991-02-14 | Warner Lambert Co | Antibacterial agents |
NZ210847A (en) * | 1984-01-26 | 1988-02-29 | Abbott Lab | Naphthyridine and pyridopyrimidine derivatives and pharmaceutical compositions |
IL74064A (en) * | 1984-01-26 | 1988-09-30 | Abbott Lab | 1,7-disubstituted-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid derivatives and antibacterial compositions containing them |
AU576657B2 (en) * | 1985-01-23 | 1988-09-01 | Toyama Chemical Co. Ltd. | Naphthyridine and pyridine derivatives |
DE3525108A1 (de) * | 1985-06-07 | 1986-12-11 | Bayer Ag, 5090 Leverkusen | Antibakteriell wirksame chinoloncarbonsaeureester |
-
1984
- 1984-04-26 JP JP59084963A patent/JPS60228479A/ja active Granted
-
1985
- 1985-04-18 DE DE19853514076 patent/DE3514076A1/de active Granted
- 1985-04-18 DE DE3546658A patent/DE3546658C2/de not_active Expired - Lifetime
- 1985-04-23 NL NLAANVRAGE8501172,A patent/NL187314C/xx not_active IP Right Cessation
- 1985-04-23 PH PH32174A patent/PH22801A/en unknown
- 1985-04-23 GB GB08510297A patent/GB2158825B/en not_active Expired
- 1985-04-24 AU AU41650/85A patent/AU565087B2/en not_active Expired
- 1985-04-24 AT AT0122485A patent/AT389698B/de not_active IP Right Cessation
- 1985-04-24 DD DD85275518A patent/DD238795A5/de unknown
- 1985-04-24 IL IL7502185A patent/IL75021A/en not_active IP Right Cessation
- 1985-04-24 RO RO126286A patent/RO95509B/ro unknown
- 1985-04-24 EG EG261/85A patent/EG17339A/xx active
- 1985-04-24 RO RO118517A patent/RO91871B/ro unknown
- 1985-04-24 NZ NZ211895A patent/NZ211895A/xx unknown
- 1985-04-24 NO NO851643A patent/NO162238C/no not_active IP Right Cessation
- 1985-04-24 PT PT80349A patent/PT80349B/pt unknown
- 1985-04-25 CS CS853035A patent/CS250684B2/cs not_active IP Right Cessation
- 1985-04-25 AR AR85300190A patent/AR241911A1/es active
- 1985-04-25 KR KR1019850002822A patent/KR870001693B1/ko not_active IP Right Cessation
- 1985-04-25 ID IDP980525A patent/ID21142A/id unknown
- 1985-04-25 DK DK185685A patent/DK165877C/da not_active IP Right Cessation
- 1985-04-25 SE SE8502017A patent/SE463102B/sv not_active IP Right Cessation
- 1985-04-25 ZA ZA853102A patent/ZA853102B/xx unknown
- 1985-04-25 FR FR858506327A patent/FR2563521B1/fr not_active Expired
- 1985-04-25 ES ES542584A patent/ES8700256A1/es not_active Expired
- 1985-04-25 HU HU873675A patent/HU197571B/hu unknown
- 1985-04-25 FI FI851637A patent/FI80453C/fi not_active IP Right Cessation
- 1985-04-25 CH CH1798/85A patent/CH673458A5/de not_active IP Right Cessation
- 1985-04-25 BE BE0/214909A patent/BE902279A/fr not_active IP Right Cessation
- 1985-04-25 HU HU851599A patent/HU194226B/hu unknown
- 1985-04-26 IT IT8548002A patent/IT1209953B/it active
- 1985-04-26 LU LU85871A patent/LU85871A1/en unknown
- 1985-04-26 PL PL1985253108A patent/PL147392B1/pl unknown
-
1986
- 1986-01-31 ES ES551538A patent/ES8706673A1/es not_active Expired
-
1987
- 1987-07-17 GB GB8716897A patent/GB2191776B/en not_active Expired - Lifetime
- 1987-10-20 PH PH35958A patent/PH25046A/en unknown
- 1987-10-20 PH PH35960A patent/PH25228A/en unknown
- 1987-11-25 AU AU81804/87A patent/AU612993B2/en not_active Expired
-
1988
- 1988-06-30 FR FR888808836A patent/FR2614620B1/fr not_active Expired - Lifetime
- 1988-10-31 AT AT0267888A patent/AT390258B/de not_active IP Right Cessation
- 1988-12-20 SE SE8804586A patent/SE501412C2/sv not_active IP Right Cessation
-
1991
- 1991-04-15 NL NL9100648A patent/NL9100648A/nl not_active Application Discontinuation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8706673A1 (es) | Un procedimiento para la preparacion de derivados de 1,4-dihidro-4-oxonaftiridina y sus sales | |
IL148516A (en) | Retroviral protease inhibiting compound | |
MY102277A (en) | Quinoline compounds | |
UA7228A1 (uk) | Спосіб одержання похідних n-(4-індолілпіперідиноалкіл )бензімідазолону або їх солей з кислотами | |
ES2001794A6 (es) | Un procedimiento para la preparacion de derivados de quinolina | |
DE3661913D1 (en) | Derivatives of 2,3-dihydro-benzofurane, processes for their preparation and pharmaceutical compositions containing them | |
FI860073A0 (fi) | 6,7-disubstituerade 1-cyklopropyl-1,4-dihydro-4-oxo-1,8-naftyridin-3-karboxylsyror. | |
ES8706139A1 (es) | Procedimiento para la fabricacion de nuevos derivados de la cumarina | |
IL69292A (en) | Muramyl peptides substituted by 1,2-diacylated-sn-glycero-3-hydroxyphosphoryl,their manufacture and pharmaceutical compositions containing them | |
AP8800109A0 (en) | "Heterocyclic insecticides". | |
FI860426A (fi) | Primycinkomponenter samt foerfarande foer avskiljning av antibiotkomplex. | |
ES8504203A1 (es) | Un procedimiento para preparar derivados de penem. | |
AU1630288A (en) | Substituted compounds, processes for their preparation and uses thereof | |
GR3001784T3 (en) | Amino compounds and fungicides containing them | |
ES2001701A6 (es) | Un metodo para preparar compuesto de benzoilurea | |
ES8708132A1 (es) | Procedimiento para preparar n-fenil-4-fenil-1-piperazincarboxamidinas y compuestos afines como agentes anti-arritmicos | |
SE8703701L (sv) | Kemiska foreningar | |
DE3587915D1 (de) | Verfahren zur Herstellung von Cephalosporinen. | |
ZA853017B (en) | Antibacterial compounds | |
ES8202336A1 (es) | Procedimiento para la preparacion de derivados de aminotia- zolina | |
ES8605530A1 (es) | Procedimiento para la obtencion de triazolil-tionofosfatos | |
ES2000281A6 (es) | Procedimiento para la obtencion de 6-arialquenilpiradizinonas |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20070430 |