RS53422B - Substituted carbamoylmethylamino acetic acid derivatives as novel nep inhibitors - Google Patents

Substituted carbamoylmethylamino acetic acid derivatives as novel nep inhibitors

Info

Publication number
RS53422B
RS53422B RS20140355A RSP20140355A RS53422B RS 53422 B RS53422 B RS 53422B RS 20140355 A RS20140355 A RS 20140355A RS P20140355 A RSP20140355 A RS P20140355A RS 53422 B RS53422 B RS 53422B
Authority
RS
Serbia
Prior art keywords
alkyl
halo
hydroxy
acid
alkoxy
Prior art date
Application number
RS20140355A
Other languages
English (en)
Serbian (sr)
Inventor
Yuki Iwaki
Toshio Kawanami
Gary Michael Ksander
Muneto Mogi
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of RS53422B publication Critical patent/RS53422B/en

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
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    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms

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  • Diabetes (AREA)
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  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Communicable Diseases (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
RS20140355A 2009-11-20 2010-11-18 Substituted carbamoylmethylamino acetic acid derivatives as novel nep inhibitors RS53422B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26313709P 2009-11-20 2009-11-20
US35991410P 2010-06-30 2010-06-30
PCT/EP2010/067781 WO2011061271A1 (en) 2009-11-20 2010-11-18 Substituted carbamoylmethylamino acetic acid derivatives as novel nep inhibitors

Publications (1)

Publication Number Publication Date
RS53422B true RS53422B (en) 2014-12-31

Family

ID=43431937

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20140355A RS53422B (en) 2009-11-20 2010-11-18 Substituted carbamoylmethylamino acetic acid derivatives as novel nep inhibitors

Country Status (37)

Country Link
US (4) US8222286B2 (enEXAMPLES)
EP (2) EP2501683B1 (enEXAMPLES)
JP (2) JP5543609B2 (enEXAMPLES)
KR (1) KR101460421B1 (enEXAMPLES)
CN (1) CN102666493B (enEXAMPLES)
AR (1) AR079061A1 (enEXAMPLES)
AU (1) AU2010320930B2 (enEXAMPLES)
BR (1) BR112012011977A2 (enEXAMPLES)
CA (1) CA2780150C (enEXAMPLES)
CL (1) CL2012001298A1 (enEXAMPLES)
CO (1) CO6540001A2 (enEXAMPLES)
CR (1) CR20120237A (enEXAMPLES)
DK (1) DK2501683T3 (enEXAMPLES)
EA (1) EA021479B1 (enEXAMPLES)
EC (1) ECSP12011978A (enEXAMPLES)
ES (2) ES2598961T3 (enEXAMPLES)
GT (1) GT201200153A (enEXAMPLES)
HN (1) HN2012001037A (enEXAMPLES)
HR (1) HRP20140691T1 (enEXAMPLES)
IL (1) IL219314A0 (enEXAMPLES)
IN (1) IN2012DN02465A (enEXAMPLES)
JO (1) JO2967B1 (enEXAMPLES)
MA (1) MA33886B1 (enEXAMPLES)
MX (1) MX2012005813A (enEXAMPLES)
MY (1) MY158299A (enEXAMPLES)
NZ (1) NZ599136A (enEXAMPLES)
PE (1) PE20121311A1 (enEXAMPLES)
PH (1) PH12012500519A1 (enEXAMPLES)
PL (1) PL2501683T3 (enEXAMPLES)
PT (1) PT2501683E (enEXAMPLES)
RS (1) RS53422B (enEXAMPLES)
SI (1) SI2501683T1 (enEXAMPLES)
TN (1) TN2012000125A1 (enEXAMPLES)
TW (1) TWI481598B (enEXAMPLES)
UY (1) UY33044A (enEXAMPLES)
WO (1) WO2011061271A1 (enEXAMPLES)
ZA (1) ZA201202018B (enEXAMPLES)

Families Citing this family (34)

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MY156270A (en) 2009-05-28 2016-01-29 Novartis Ag Substituted aminopropionic derivatives as neprilysin inhibitors
WO2010136474A2 (en) 2009-05-28 2010-12-02 Novartis Ag Substituted aminobutyric derivatives as neprilysin inhibitors
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
US8993631B2 (en) * 2010-11-16 2015-03-31 Novartis Ag Method of treating contrast-induced nephropathy
MX354476B (es) 2010-12-15 2018-03-07 Theravance Inc Inhibidores de neprilisina.
SG190432A1 (en) 2010-12-15 2013-07-31 Theravance Inc Neprilysin inhibitors
US8449890B2 (en) 2011-02-17 2013-05-28 Theravance, Inc. Neprilysin inhibitors
EP2675795B1 (en) 2011-02-17 2016-04-20 Theravance Biopharma R&D IP, LLC Substituted aminobutyric derivatives as neprilysin inhibitors
ES2642883T3 (es) 2011-05-31 2017-11-20 Theravance Biopharma R&D Ip, Llc Inhibidores de neprilisina
WO2012166390A1 (en) 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors
ES2653215T3 (es) 2011-05-31 2018-02-06 Theravance Biopharma R&D Ip, Llc Inhibidores de neprilisina
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
JP6088047B2 (ja) 2012-05-31 2017-03-01 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー 一酸化窒素ドナーであるネプリライシン阻害剤
ES2710932T3 (es) 2012-06-08 2019-04-29 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina
EP3199517B1 (en) 2012-06-08 2018-09-12 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
US9126956B2 (en) 2012-08-08 2015-09-08 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
HUE038248T2 (hu) * 2013-02-14 2018-10-29 Novartis Ag Helyettesített biszfenil-bután-foszfonsav származékok, mint NEP (semleges endopeptidáz) inhibitorok
US9102635B2 (en) * 2013-02-14 2015-08-11 Novartis Ag Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy
LT2964616T (lt) 2013-03-05 2017-07-25 Theravance Biopharma R&D Ip, Llc Neprilizino inhibitoriai
PE20160991A1 (es) 2013-07-25 2016-10-15 Novartis Ag Bioconjugados de polipeptidos de apelina sintetica
UY35670A (es) 2013-07-25 2015-02-27 Novartis Ag Polipéptidos cíclicos para el tratamiento de insuficiencia cardíaca
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