MX2013003227A - Nuevos analogos de piperazina con grupos heteroarilo sustituidos como antivirales de la influenza de espectro amplio. - Google Patents

Nuevos analogos de piperazina con grupos heteroarilo sustituidos como antivirales de la influenza de espectro amplio.

Info

Publication number
MX2013003227A
MX2013003227A MX2013003227A MX2013003227A MX2013003227A MX 2013003227 A MX2013003227 A MX 2013003227A MX 2013003227 A MX2013003227 A MX 2013003227A MX 2013003227 A MX2013003227 A MX 2013003227A MX 2013003227 A MX2013003227 A MX 2013003227A
Authority
MX
Mexico
Prior art keywords
broad
substituted heteroaryl
heteroaryl groups
novel piperazine
spectrum influenza
Prior art date
Application number
MX2013003227A
Other languages
English (en)
Inventor
David R Langley
Annapurna Pendri
Samuel Gerritz
Weixu Zhai
Guo Li
Christopher W Cianci
Bradley C Pearce
Shuhao Shi
Shirong Zhu
Sean Kim
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2013003227A publication Critical patent/MX2013003227A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

La presente invención se refiere a un compuesto de la siguiente Fórmula (I), que incluye las sales farmacéuticamente aceptables del mismo: en donde Het es un heterociclo de 5 o 6 miebros con -N, -O, o -s adyacente al substituyente -Ar o adyacente al punto de fijación para el substituyente -Ar; Ar es arilo o heteroarilo; R es CH3, -CH2-F, -CHF2 o -CH=CH2; V es -H, -CH3 o =0; W es -NO2, -Cl, -Br, -CH2OH, o -CN; X es -Cl, -Br, -F, -CH3, -OCH3, o -CN; Y es -CH o -N; y Z es -CH o -N. Este compuesto es útil en las composiciones para la prevención y el tratamiento del virus de la influenza.
MX2013003227A 2010-09-28 2011-09-23 Nuevos analogos de piperazina con grupos heteroarilo sustituidos como antivirales de la influenza de espectro amplio. MX2013003227A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38718610P 2010-09-28 2010-09-28
PCT/US2011/052965 WO2012044531A1 (en) 2010-09-28 2011-09-23 Novel piperazine analogs with substituted heteroaryl groups as broad-spectrum influenza antivirals

Publications (1)

Publication Number Publication Date
MX2013003227A true MX2013003227A (es) 2013-05-31

Family

ID=44759794

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013003227A MX2013003227A (es) 2010-09-28 2011-09-23 Nuevos analogos de piperazina con grupos heteroarilo sustituidos como antivirales de la influenza de espectro amplio.

Country Status (10)

Country Link
US (1) US20120245176A1 (es)
EP (1) EP2621920B1 (es)
JP (1) JP2013542201A (es)
CN (1) CN103209977A (es)
BR (1) BR112013007651A2 (es)
CA (1) CA2812935A1 (es)
EA (1) EA201390476A1 (es)
ES (1) ES2564257T3 (es)
MX (1) MX2013003227A (es)
WO (1) WO2012044531A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101369584B1 (ko) * 2011-04-19 2014-03-06 일양약품주식회사 페닐-이속사졸 유도체 및 그의 제조방법
CN102432555A (zh) * 2011-09-09 2012-05-02 中国科学院广州生物医药与健康研究院 1,2,3-三氮唑-4（5）羧酰胺类化合物及其应用
US9676734B2 (en) 2012-05-18 2017-06-13 Vironova Influenza Ab Compounds and methods
US9359310B2 (en) 2012-05-18 2016-06-07 Vironova Influenza Ab Methanethione compounds having antiviral activity
CN104447625B (zh) * 2013-09-16 2016-08-17 中国科学院广州生物医药与健康研究院 苯甲酰胺类化合物或其药学上可接受的盐及其应用
WO2015196086A1 (en) * 2014-06-20 2015-12-23 The University of Montana, Missoula, MT NOVEL INHIBITORS OF SYSTEM Xc(-)
CN107056762B (zh) * 2016-12-22 2020-08-28 四川百利药业有限责任公司 一种用作抗流感病毒的双羰基类似物
WO2021204924A1 (en) 2020-04-09 2021-10-14 Vironova Medical Ab Compounds for use in the treatment of hypercytokinemia
WO2021204923A1 (en) 2020-04-09 2021-10-14 Vironova Medical Ab Antiviral agents
CN114507220B (zh) * 2022-03-08 2023-01-10 中国医学科学院医药生物技术研究所 一种取代4-苯基-5-位官能团化的1,2,4-三唑类衍生物及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0010783A (pt) 1999-05-21 2002-04-09 Biovitrum Ab Novos compostos, seu uso e preparação
EP1396487B1 (en) * 2001-06-15 2008-12-10 Astellas Pharma Inc. Phenylpyridine carbonyl piperazine derivative
ATE323702T1 (de) 2002-08-06 2006-05-15 Astrazeneca Ab Kondensierte pyridine und pyrimidine mit tie2 (tek) aktivität
US7273882B2 (en) 2005-06-21 2007-09-25 Bristol-Myers Squibb Company Aminoacetamide acyl guanidines as β-secretase inhibitors
US8106077B2 (en) 2006-05-24 2012-01-31 Eli Lilly And Company Compounds and methods for modulating FXR
US8207205B2 (en) * 2008-04-21 2012-06-26 Institute For Oneworld Health Compounds, compositions and methods comprising oxadiazole derivatives
US9212177B2 (en) * 2009-08-05 2015-12-15 Versitech Limited Antiviral compounds and methods of making and using thereof
RU2012104214A (ru) * 2009-08-05 2013-09-10 Верситек Лимитед Противовирусные соединения и способы их получения и применения

Also Published As

Publication number Publication date
EP2621920B1 (en) 2016-01-27
CN103209977A (zh) 2013-07-17
WO2012044531A8 (en) 2012-08-09
US20120245176A1 (en) 2012-09-27
ES2564257T3 (es) 2016-03-21
EA201390476A1 (ru) 2013-08-30
BR112013007651A2 (pt) 2019-09-24
JP2013542201A (ja) 2013-11-21
WO2012044531A1 (en) 2012-04-05
EP2621920A1 (en) 2013-08-07
CA2812935A1 (en) 2012-04-05

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