AR083873A1 - Derivados de acido amino-fenil-pentanoico sustituidos como inhibidores de nep - Google Patents

Derivados de acido amino-fenil-pentanoico sustituidos como inhibidores de nep

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Publication number
AR083873A1
AR083873A1 ARP110104250A ARP110104250A AR083873A1 AR 083873 A1 AR083873 A1 AR 083873A1 AR P110104250 A ARP110104250 A AR P110104250A AR P110104250 A ARP110104250 A AR P110104250A AR 083873 A1 AR083873 A1 AR 083873A1
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AR
Argentina
Prior art keywords
alkyl
phenyl
amino
acid derivatives
pentanoic acid
Prior art date
Application number
ARP110104250A
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English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR083873A1 publication Critical patent/AR083873A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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Abstract

Reivindicación 1: Un compuesto de la fórmula (1), en donde: X y X1 son independientemente OH, -O-alquilo C1-7, NRaRb, -NHS(O)2-alquilo C1-7 o -NHS(O)2-bencilo, en donde Ra y Rb, por cada presentación, son independientemente H o alquilo C1-7; R1 es H o alquilo C1-6; R2 por cada presentación, es independientemente alcoxilo C1-6, hidroxilo, halógeno, alquilo C1-6, ciano o halo-alquilo C1-6; A1 es un alquileno C1-4 lineal; R3 por cada presentación, es independientemente halógeno, hidroxilo, alcoxilo C1-7, halógeno, alquilo C1-7, o halo-alquilo C1-7; o n es un entero de 1 a 5; s es 0 o un entero de 1 a 4; o una sal farmacéuticamente aceptable del mismo.
ARP110104250A 2010-11-16 2011-11-14 Derivados de acido amino-fenil-pentanoico sustituidos como inhibidores de nep AR083873A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41416310P 2010-11-16 2010-11-16

Publications (1)

Publication Number Publication Date
AR083873A1 true AR083873A1 (es) 2013-03-27

Family

ID=45093705

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110104250A AR083873A1 (es) 2010-11-16 2011-11-14 Derivados de acido amino-fenil-pentanoico sustituidos como inhibidores de nep

Country Status (14)

Country Link
US (1) US8673974B2 (es)
EP (1) EP2640690A1 (es)
JP (1) JP5872575B2 (es)
KR (1) KR101951492B1 (es)
CN (1) CN103201257B (es)
AR (1) AR083873A1 (es)
AU (1) AU2011331294B2 (es)
BR (1) BR112013011580A2 (es)
CA (1) CA2817114A1 (es)
EA (1) EA021537B1 (es)
MX (1) MX2013005533A (es)
TW (1) TW201305089A (es)
UY (1) UY33731A (es)
WO (1) WO2012065956A1 (es)

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CN104557600B (zh) * 2015-01-26 2016-05-04 苏州明锐医药科技有限公司 沙库比曲的制备方法
AU2016219362B2 (en) 2015-02-11 2019-11-14 Theravance Biopharma R&D Ip, Llc (2S,4R)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-4-(ethoxyoxalylamino)-2-hydroxymethyl-2-methylpentanoic acid as neprilysin inhibitor
EP3259255B1 (en) 2015-02-19 2020-10-21 Theravance Biopharma R&D IP, LLC (2r,4r)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-hydroxy-4-[(5-methyloxazole-2-carbonyl)amino]pentanoic acid
SG11201807591VA (en) 2016-03-08 2018-10-30 Theravance Biopharma R&D Ip Llc Crystalline(2s,4r)-5-(5'-chloro-2'-fluoro-[1,1'-biphenyl]-4-yl)-2-(ethoxymethyl)-4-(3-hydroxyisoxazole-5-carboxamido)-2-methylpentanoic acid and uses thereof
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
UY38485A (es) 2018-11-27 2020-06-30 Novartis Ag Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación
US20230089867A1 (en) 2018-11-27 2023-03-23 Novartis Ag Cyclic pentamer compounds as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorder
EP3887388A1 (en) 2018-11-27 2021-10-06 Novartis AG Cyclic peptides as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorders
WO2023084449A1 (en) 2021-11-12 2023-05-19 Novartis Ag Diaminocyclopentylpyridine derivatives for the treatment of a disease or disorder

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CA2817114A1 (en) 2012-05-24
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EP2640690A1 (en) 2013-09-25
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