PT926131E - Processo para a producao de derivados de aminoalcool e sua transformacao posterior em (1r,4s)-4-(2-amino-6-cloro-5-formamido-4-pirimidinil)-amino)-2-ciclopenteno-1-metanol - Google Patents

Processo para a producao de derivados de aminoalcool e sua transformacao posterior em (1r,4s)-4-(2-amino-6-cloro-5-formamido-4-pirimidinil)-amino)-2-ciclopenteno-1-metanol

Info

Publication number
PT926131E
PT926131E PT98122293T PT98122293T PT926131E PT 926131 E PT926131 E PT 926131E PT 98122293 T PT98122293 T PT 98122293T PT 98122293 T PT98122293 T PT 98122293T PT 926131 E PT926131 E PT 926131E
Authority
PT
Portugal
Prior art keywords
vii
amino
cyclopentene
cor
racemic
Prior art date
Application number
PT98122293T
Other languages
English (en)
Inventor
Walter Brieden
Jean-Paul Roduit
Michael Petersen
Christine Bernegger-Egli
Josef Schroer
Eva Maria Urban
Katja Berchtold
Holger Breitbach
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of PT926131E publication Critical patent/PT926131E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/23—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
PT98122293T 1997-11-27 1998-11-24 Processo para a producao de derivados de aminoalcool e sua transformacao posterior em (1r,4s)-4-(2-amino-6-cloro-5-formamido-4-pirimidinil)-amino)-2-ciclopenteno-1-metanol PT926131E (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CH273997 1997-11-27
CH278197 1997-12-03
CH13398 1998-01-21
CH72398 1998-03-27
EP98118895 1998-10-07

Publications (1)

Publication Number Publication Date
PT926131E true PT926131E (pt) 2004-06-30

Family

ID=27508776

Family Applications (4)

Application Number Title Priority Date Filing Date
PT04027540T PT1508565E (pt) 1997-11-27 1998-11-24 Processo para a produção de aminoálcoois com actividade óptica
PT06002571T PT1657243E (pt) 1997-11-27 1998-11-24 Processo para a produção de aminoálcoois
PT98122293T PT926131E (pt) 1997-11-27 1998-11-24 Processo para a producao de derivados de aminoalcool e sua transformacao posterior em (1r,4s)-4-(2-amino-6-cloro-5-formamido-4-pirimidinil)-amino)-2-ciclopenteno-1-metanol
PT04002913T PT1418170E (pt) 1997-11-27 1998-11-24 Processo para a preparacao de aminoalcoois opticamente activos por meio de separacao do racemato

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PT04027540T PT1508565E (pt) 1997-11-27 1998-11-24 Processo para a produção de aminoálcoois com actividade óptica
PT06002571T PT1657243E (pt) 1997-11-27 1998-11-24 Processo para a produção de aminoálcoois

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT04002913T PT1418170E (pt) 1997-11-27 1998-11-24 Processo para a preparacao de aminoalcoois opticamente activos por meio de separacao do racemato

Country Status (18)

Country Link
US (5) US6723868B1 (pt)
EP (5) EP1508565B1 (pt)
JP (4) JP4372873B2 (pt)
KR (4) KR100615370B1 (pt)
CN (4) CN1259306C (pt)
AT (4) ATE259345T1 (pt)
CA (4) CA2254693C (pt)
CZ (4) CZ298913B6 (pt)
DE (4) DE59814270D1 (pt)
DK (3) DK0926131T3 (pt)
ES (3) ES2312906T3 (pt)
HK (2) HK1070050A1 (pt)
HU (3) HU226473B1 (pt)
IL (5) IL127277A (pt)
NO (4) NO318697B1 (pt)
PL (2) PL200436B1 (pt)
PT (4) PT1508565E (pt)
SK (4) SK284596B6 (pt)

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MXPA04002694A (es) * 2001-09-25 2004-06-18 Hoffmann La Roche Proceso enzimatico para preparacion del acido 2-amino-3-(2-amino-fenilsulfanil)-propionico sustituido.
KR100684772B1 (ko) 2004-12-08 2007-02-22 주식회사농심 찹쌀을 이용한 푸딩 촉감의 식품 및 그의 제조 방법.
US8805134B1 (en) 2012-02-17 2014-08-12 Soraa Laser Diode, Inc. Methods and apparatus for photonic integration in non-polar and semi-polar oriented wave-guided optical devices
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US8945066B2 (en) 2009-11-06 2015-02-03 Crisi Medical Systems, Inc. Medication injection site and data collection system
CN102603652A (zh) * 2011-12-27 2012-07-25 河南师范大学 5-甲酰基嘧啶碳环核苷及制备方法
CN102719512B (zh) * 2012-06-21 2014-06-11 浙江工业大学 一种r-2-（4-羟基苯氧基）丙酸酯的制备方法
CN104098478B (zh) * 2013-04-08 2017-05-17 安徽贝克联合制药有限公司 一种氨基醇的拆分方法
WO2016067182A2 (en) * 2014-10-27 2016-05-06 Granules India Limited Process for the preparation of amino alcohol derivatives or salts thereof
CN104974051A (zh) * 2015-06-30 2015-10-14 苏州开元民生科技股份有限公司 (1S,4R)-cis-4-氨基-2-环戊烯-1-甲醇盐酸盐的合成方法
CN106220515A (zh) * 2016-08-12 2016-12-14 郸城巨鑫生物科技有限公司 一种(1r,4s)‑1‑氨基‑4‑羟甲基‑2‑环戊烯盐酸盐的合成方法
JP2019532959A (ja) * 2016-10-06 2019-11-14 ヤンセン ファーマシューティカ エヌ．ベー． Ｂｔｋ阻害剤を調製するための方法および中間体
US11421843B2 (en) 2018-12-21 2022-08-23 Kyocera Sld Laser, Inc. Fiber-delivered laser-induced dynamic light system
US11239637B2 (en) 2018-12-21 2022-02-01 Kyocera Sld Laser, Inc. Fiber delivered laser induced white light system
CN109735582B (zh) * 2018-12-24 2022-06-21 浙江工业大学 一种脂肪酶催化在线合成环己醇类β-氨基醇衍生物的方法
US11884202B2 (en) 2019-01-18 2024-01-30 Kyocera Sld Laser, Inc. Laser-based fiber-coupled white light system
US12000552B2 (en) 2019-01-18 2024-06-04 Kyocera Sld Laser, Inc. Laser-based fiber-coupled white light system for a vehicle
CN116730856B (zh) * 2023-06-19 2024-06-07 浙江竹子制药有限公司 一种氨甲环酸的合成方法

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Also Published As

Publication number Publication date
EP1508565A1 (de) 2005-02-23
KR100615370B1 (ko) 2007-04-26
PL329989A1 (en) 1999-06-07
EP0926131B1 (de) 2004-02-11
HU9802758D0 (en) 1999-01-28
US20060211862A1 (en) 2006-09-21
CZ298102B6 (cs) 2007-06-20
DK1418170T3 (da) 2006-10-09
CA2254693A1 (en) 1999-05-27
CN1277807C (zh) 2006-10-04
US6723868B1 (en) 2004-04-20
EP1657243B1 (de) 2010-08-18
NO327575B1 (no) 2009-08-17
DK0926131T3 (da) 2004-05-24
US7358073B2 (en) 2008-04-15
PT1657243E (pt) 2010-11-08
US20040142436A1 (en) 2004-07-22
KR20060013697A (ko) 2006-02-13
CN1323057C (zh) 2007-06-27
NO985511D0 (no) 1998-11-26
SK284596B6 (sk) 2005-07-01
EP1418170A2 (de) 2004-05-12
NO20044368L (no) 1999-05-28
EP1508565B1 (de) 2008-08-13
PT1508565E (pt) 2008-11-24
DE59813589D1 (de) 2006-07-20
KR100584638B1 (ko) 2006-05-30
NO318697B1 (no) 2005-04-25
KR100672268B1 (ko) 2007-01-24
ES2215264T3 (es) 2004-10-01
CA2591818A1 (en) 1999-05-27
US7338945B2 (en) 2008-03-04
JP2009221215A (ja) 2009-10-01
US20070123545A1 (en) 2007-05-31
JP2009227684A (ja) 2009-10-08
KR20060013698A (ko) 2006-02-13
CZ298144B6 (cs) 2007-07-04
PL200436B1 (pl) 2009-01-30
DK1657243T3 (da) 2010-11-22
DE59810751D1 (de) 2004-03-18
HU226475B1 (en) 2009-01-28
IL142623A (en) 2004-08-31
JPH11228510A (ja) 1999-08-24
CN1259306C (zh) 2006-06-14
ATE259345T1 (de) 2004-02-15
EP1982985A3 (de) 2008-11-05
DE59814466D1 (de) 2010-09-30
HU0700624D0 (en) 2007-11-28
HUP9802758A3 (en) 2000-09-28
JP2009227685A (ja) 2009-10-08
US20020010360A1 (en) 2002-01-24
NO20044369L (no) 1999-05-28
NO326251B1 (no) 2008-10-27
KR20060015690A (ko) 2006-02-17
CN1550553A (zh) 2004-12-01
NO20044370L (no) 1999-05-28
ATE478073T1 (de) 2010-09-15
CZ298913B6 (cs) 2008-03-12
ATE328863T1 (de) 2006-06-15
IL160787A0 (en) 2004-08-31
IL142622A (en) 2004-08-31
IL127277A (en) 2004-08-31
SK161598A3 (en) 2000-03-13
CZ299083B6 (cs) 2008-04-16
SK284416B6 (sk) 2005-03-04
DE59814270D1 (de) 2008-09-25
US6448402B2 (en) 2002-09-10
KR19990045530A (ko) 1999-06-25
CA2591566C (en) 2010-12-14
CA2254693C (en) 2009-06-30
EP0926131A3 (de) 2000-03-22
PL207859B1 (pl) 2011-02-28
CA2591571A1 (en) 1999-05-27
HU226473B1 (en) 2008-12-29
HK1070050A1 (en) 2005-06-10
ES2312906T3 (es) 2009-03-01
EP1418170B1 (de) 2006-06-07
KR100648030B1 (ko) 2006-11-23
CA2591818C (en) 2010-08-03
SK284594B6 (sk) 2005-07-01
CZ381798A3 (cs) 1999-06-16
EP1418170A3 (de) 2004-05-19
JP4372873B2 (ja) 2009-11-25
EP1982985A2 (de) 2008-10-22
HUP9802758A2 (hu) 2000-03-28
CA2591566A1 (en) 1999-05-27
HU225895B1 (en) 2007-12-28
US7229981B2 (en) 2007-06-12
ATE404689T1 (de) 2008-08-15
PT1418170E (pt) 2006-10-31
HU0700623D0 (en) 2007-11-28
EP1657243A1 (de) 2006-05-17
CN1218795A (zh) 1999-06-09
ES2270192T3 (es) 2007-04-01
HK1070103A1 (en) 2005-06-10
CN1550500A (zh) 2004-12-01
NO985511L (no) 1999-05-28
IL127277A0 (en) 1999-09-22
SK284595B6 (sk) 2005-07-01
CN1550490A (zh) 2004-12-01
EP0926131A2 (de) 1999-06-30
IL160787A (en) 2011-02-28

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