PL392311A1 - Kompozycja farmaceutyczna hamująca ekspresję lub aktywność antygenu, sposób diagnozowania, sposób oznaczania regresji, sposób leczenia choroby, sposób hamowania rozwoju raka, kwas nukleinowy, cząsteczka zrekombinowanego DNA lub RNA, komórka gospodarza, białko lub polipeptyd, fragment immunologiczny białka lub polipeptydu, czynnik, przeciwciało, produkt sprzęgania, zestaw do wykrywania ekspresji i zrekombinowana cząsteczka - Google Patents
Kompozycja farmaceutyczna hamująca ekspresję lub aktywność antygenu, sposób diagnozowania, sposób oznaczania regresji, sposób leczenia choroby, sposób hamowania rozwoju raka, kwas nukleinowy, cząsteczka zrekombinowanego DNA lub RNA, komórka gospodarza, białko lub polipeptyd, fragment immunologiczny białka lub polipeptydu, czynnik, przeciwciało, produkt sprzęgania, zestaw do wykrywania ekspresji i zrekombinowana cząsteczkaInfo
- Publication number
- PL392311A1 PL392311A1 PL392311A PL39231103A PL392311A1 PL 392311 A1 PL392311 A1 PL 392311A1 PL 392311 A PL392311 A PL 392311A PL 39231103 A PL39231103 A PL 39231103A PL 392311 A1 PL392311 A1 PL 392311A1
- Authority
- PL
- Poland
- Prior art keywords
- polypeptide
- protein
- particle
- expression
- recombined
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3023—Lung
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
- G01N33/5017—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Wood Science & Technology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10254601A DE10254601A1 (de) | 2002-11-22 | 2002-11-22 | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
PL392311A1 true PL392311A1 (pl) | 2010-11-22 |
PL219093B1 PL219093B1 (pl) | 2015-03-31 |
Family
ID=32240310
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL392311A PL219093B1 (pl) | 2002-11-22 | 2003-11-21 | Kompozycja farmaceutyczna, kompozycja farmaceutyczna do zastosowania w leczeniu, czynnik do zastosowania w sposobie diagnozowania choroby, czynnik do zastosowania w sposobie oznaczania regresji, przebiegu lub rozpoczęcia choroby, cytolityczne lub wydzielające cytokinę komórki T, komórka gospodarza lub jej wyciąg, komórki z ekspresją związanego z nowotworem antygenu, kwas nukleinowy, cząsteczka zrekombinowanego DNA lub RNA, komórka gospodarza, białko lub polipeptyd, przeciwciało, produkt sprzęgania i zestaw do wykrywania ekspresji |
PL392310A PL219043B1 (pl) | 2002-11-22 | 2003-11-21 | Kompozycja farmaceutyczna, kompozycja farmaceutyczna do zastosowania w leczeniu choroby, czynnik do zastosowania w sposobie diagnozowania, czynnik do zastosowania w sposobie oznaczania regresji, cytolityczne lub wydzielające cytokinę komórki T do zastosowania w sposobie leczenia, kwas nukleinowy, komórka gospodarza, polipeptyd, przeciwciało, produkt sprzęgania przeciwciała i zestaw do wykrywania ekspresji |
PL377240A PL219018B1 (pl) | 2002-11-22 | 2003-11-21 | Kompozycja farmaceutyczna, czynnik do zastosowania w sposobie diagnozowania choroby nowotworowej, czynnik do zastosowania w sposobie oznaczania regresji, przebiegu lub początku choroby nowotworowej, cytolityczne lub wydzielające cytokinę komórki T, kwas nukleinowy, komórka gospodarza, białko lub polipeptyd, przeciwciało, produkt sprzęgania przeciwciała i zestaw do wykrywania ekspresji antygenu |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL392310A PL219043B1 (pl) | 2002-11-22 | 2003-11-21 | Kompozycja farmaceutyczna, kompozycja farmaceutyczna do zastosowania w leczeniu choroby, czynnik do zastosowania w sposobie diagnozowania, czynnik do zastosowania w sposobie oznaczania regresji, cytolityczne lub wydzielające cytokinę komórki T do zastosowania w sposobie leczenia, kwas nukleinowy, komórka gospodarza, polipeptyd, przeciwciało, produkt sprzęgania przeciwciała i zestaw do wykrywania ekspresji |
PL377240A PL219018B1 (pl) | 2002-11-22 | 2003-11-21 | Kompozycja farmaceutyczna, czynnik do zastosowania w sposobie diagnozowania choroby nowotworowej, czynnik do zastosowania w sposobie oznaczania regresji, przebiegu lub początku choroby nowotworowej, cytolityczne lub wydzielające cytokinę komórki T, kwas nukleinowy, komórka gospodarza, białko lub polipeptyd, przeciwciało, produkt sprzęgania przeciwciała i zestaw do wykrywania ekspresji antygenu |
Country Status (21)
Country | Link |
---|---|
US (7) | US7527933B2 (pl) |
EP (27) | EP2400017A3 (pl) |
JP (7) | JP2006516190A (pl) |
KR (7) | KR101551621B1 (pl) |
CN (4) | CN1714150B (pl) |
AU (2) | AU2003282101B2 (pl) |
BR (1) | BR0316435A (pl) |
CA (2) | CA3000243C (pl) |
CY (1) | CY1117786T1 (pl) |
DE (1) | DE10254601A1 (pl) |
ES (2) | ES2675785T3 (pl) |
HK (1) | HK1165480A1 (pl) |
HU (1) | HUE027825T2 (pl) |
IL (7) | IL168168A (pl) |
MX (2) | MX344216B (pl) |
NZ (4) | NZ595896A (pl) |
PL (3) | PL219093B1 (pl) |
PT (1) | PT2400018T (pl) |
SG (3) | SG10201705641SA (pl) |
SI (1) | SI2400018T1 (pl) |
WO (1) | WO2004047863A2 (pl) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
DE10344799A1 (de) * | 2003-09-26 | 2005-04-14 | Ganymed Pharmaceuticals Ag | Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie |
US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
DE102004023187A1 (de) * | 2004-05-11 | 2005-12-01 | Ganymed Pharmaceuticals Ag | Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie |
DE102004024617A1 (de) * | 2004-05-18 | 2005-12-29 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
AU2011256897B2 (en) * | 2004-05-18 | 2013-09-19 | Astellas Pharma Inc. | Genetic products differentially expressed in tumors and the use thereof |
US7892755B2 (en) | 2004-08-30 | 2011-02-22 | Takeda Pharmaceutical Company Limited | Screening method |
US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
DE102005013846A1 (de) * | 2005-03-24 | 2006-10-05 | Ganymed Pharmaceuticals Ag | Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie |
AU2014208256B2 (en) * | 2005-11-24 | 2016-01-14 | Astellas Pharma Inc. | Monoclonal antibodies against claudin-18 for treatment of cancer |
AU2016202322B2 (en) * | 2005-11-24 | 2018-03-08 | Astellas Pharma Inc. | Monoclonal antibodies against claudin-18 for treatment of cancer |
EP1790664A1 (en) * | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against claudin-18 for treatment of cancer |
JP2009536313A (ja) | 2006-01-11 | 2009-10-08 | レインダンス テクノロジーズ, インコーポレイテッド | ナノリアクターの形成および制御において使用するマイクロ流体デバイスおよび方法 |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
US20080014589A1 (en) | 2006-05-11 | 2008-01-17 | Link Darren R | Microfluidic devices and methods of use thereof |
US9012390B2 (en) | 2006-08-07 | 2015-04-21 | Raindance Technologies, Inc. | Fluorocarbon emulsion stabilizing surfactants |
WO2008039941A2 (en) | 2006-09-27 | 2008-04-03 | The Government Of The Usa As Represented By The Secretary Of The Dpt. Of Health And Human Services | Scgb3a2 as a growth factor and anti-apoptotic agent |
WO2008043018A1 (en) * | 2006-10-04 | 2008-04-10 | Dana-Farber Cancer Institute, Inc. | Tumor immunity |
US7951781B2 (en) * | 2006-11-02 | 2011-05-31 | University Of Iowa Research Foundation | Methods and compositions related to PLUNC surfactant polypeptides |
US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
EP1997832A1 (en) * | 2007-05-29 | 2008-12-03 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against Claudin-18 for treatment of cancer |
EP2060583A1 (en) * | 2007-10-23 | 2009-05-20 | Ganymed Pharmaceuticals AG | Identification of tumor-associated markers for diagnosis and therapy |
US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
WO2010009365A1 (en) | 2008-07-18 | 2010-01-21 | Raindance Technologies, Inc. | Droplet libraries |
WO2010036652A1 (en) * | 2008-09-23 | 2010-04-01 | Thomas Jefferson University | Cancer vaccines against mucosal antigens and methods of making and using the same |
US8528589B2 (en) | 2009-03-23 | 2013-09-10 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
WO2011042564A1 (en) | 2009-10-09 | 2011-04-14 | Universite De Strasbourg | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
MX2012003198A (es) * | 2009-10-23 | 2012-06-12 | Millennium Pharm Inc | Moleculas de anticuerpo anti-gcc y composiciones y metodos relacionados. |
US10837883B2 (en) | 2009-12-23 | 2020-11-17 | Bio-Rad Laboratories, Inc. | Microfluidic systems and methods for reducing the exchange of molecules between droplets |
US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
WO2011100604A2 (en) | 2010-02-12 | 2011-08-18 | Raindance Technologies, Inc. | Digital analyte analysis |
AU2011229518B2 (en) * | 2010-03-16 | 2015-09-24 | Biontech Protein Therapeutics Gmbh | Tumor vaccination involving a humoral immune response against self-proteins |
US9562897B2 (en) | 2010-09-30 | 2017-02-07 | Raindance Technologies, Inc. | Sandwich assays in droplets |
US9364803B2 (en) | 2011-02-11 | 2016-06-14 | Raindance Technologies, Inc. | Methods for forming mixed droplets |
EP3736281A1 (en) | 2011-02-18 | 2020-11-11 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
WO2012139137A2 (en) | 2011-04-08 | 2012-10-11 | Tufts Medical Center, Inc. | Pepducin design and use |
US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
EP2714970B1 (en) | 2011-06-02 | 2017-04-19 | Raindance Technologies, Inc. | Enzyme quantification |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
CN102526703B (zh) * | 2012-01-18 | 2013-11-13 | 广东医学院司法鉴定中心 | 一种鼻咽癌相关易感基因yh1蛋白的制备方法及其应用 |
EP2823303A4 (en) | 2012-02-10 | 2015-09-30 | Raindance Technologies Inc | MOLECULAR DIAGNOSTIC SCREEN TYPE ASSAY |
SA113340502B1 (ar) | 2012-04-27 | 2015-09-17 | ميلينيوم فارماسيوتيكالز، انك | جزيئات أجسام مضادة لـ gcc وطرق لاستخدام هذه الجزيئات |
WO2013165748A1 (en) | 2012-04-30 | 2013-11-07 | Raindance Technologies, Inc | Digital analyte analysis |
WO2013167153A1 (en) | 2012-05-09 | 2013-11-14 | Ganymed Pharmaceuticals Ag | Antibodies useful in cancer diagnosis |
WO2013174404A1 (en) | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
US10093736B2 (en) | 2012-11-13 | 2018-10-09 | Biontech Ag | Agents for treatment of claudin expressing cancer diseases |
WO2014127785A1 (en) | 2013-02-20 | 2014-08-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
WO2014146672A1 (en) | 2013-03-18 | 2014-09-25 | Ganymed Pharmaceuticals Ag | Therapy involving antibodies against claudin 18.2 for treatment of cancer |
EP2986762B1 (en) | 2013-04-19 | 2019-11-06 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
US11193176B2 (en) | 2013-12-31 | 2021-12-07 | Bio-Rad Laboratories, Inc. | Method for detecting and quantifying latent retroviral RNA species |
CA2938467C (en) | 2014-02-13 | 2022-06-28 | Basf Se | Powder and granule, process for making such powder and granule, and use thereof |
WO2015124138A1 (de) * | 2014-02-20 | 2015-08-27 | Rheinische Friedrich-Wilhelms-Universität Bonn | Tumor-assoziierte antigene und genprodukte in der diagnose und therapie |
CN107750279A (zh) * | 2015-03-16 | 2018-03-02 | 个人基因组诊断公司 | 核酸分析系统和方法 |
WO2016165762A1 (en) * | 2015-04-15 | 2016-10-20 | Ganymed Pharmaceuticals Ag | Drug conjugates comprising antibodies against claudin 18.2 |
US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
CA3005029A1 (en) | 2015-11-13 | 2017-05-18 | Oasis Pharmaceuticals, LLC | Protease-activated receptor-2 modulators |
CN105463094B (zh) * | 2015-12-29 | 2018-09-07 | 北京泱深生物信息技术有限公司 | 直肠腺癌的诊治标记物 |
US11927591B2 (en) | 2016-08-02 | 2024-03-12 | Georgetown University | Methods of identifying novel proteins and antigens in cancer cells |
US10998178B2 (en) | 2017-08-28 | 2021-05-04 | Purdue Research Foundation | Systems and methods for sample analysis using swabs |
MX2020012607A (es) * | 2018-05-23 | 2021-01-29 | Pfizer | Anticuerpos especificos para gucy2c y sus usos. |
CN110862454B (zh) | 2018-08-27 | 2022-12-30 | 南京圣和药业股份有限公司 | 一种抗Claudin18_2抗体及其应用 |
CN113645996B (zh) | 2019-02-01 | 2024-04-02 | 新石生物制药有限公司 | 抗claudin 18抗体及其使用方法 |
WO2021111003A1 (en) | 2019-12-06 | 2021-06-10 | SOTIO a.s. | Humanized cldn18.2 antibodies |
AU2020410998A1 (en) | 2019-12-23 | 2022-06-16 | Sotio Biotech A.S. | Tumor-specific Claudin 18.2 antibodies |
MX2022014896A (es) * | 2020-05-25 | 2023-01-04 | Suzhou Transcenta Therapeutics Co Ltd | Anticuerpos anti-cldn18.2 y usos para diagnostico de los mismos. |
WO2022043974A1 (en) * | 2020-08-31 | 2022-03-03 | World Biotech Regenerative Medical Group Limited | Personalized immunogenic compositions and methods for producing and using same |
CN114181944B (zh) * | 2020-09-14 | 2023-10-03 | 中国科学院动物研究所 | 突变基因及构建短肢性侏儒症小型猪模型的方法和用途 |
WO2022122709A1 (en) | 2020-12-07 | 2022-06-16 | Sotio Biotech A.S. | Antibody-drug conjugates based on humanized cldn18.2 antibodies |
TW202237638A (zh) | 2020-12-09 | 2022-10-01 | 日商武田藥品工業股份有限公司 | 烏苷酸環化酶c(gcc)抗原結合劑之組成物及其使用方法 |
TW202237639A (zh) | 2020-12-09 | 2022-10-01 | 日商武田藥品工業股份有限公司 | 鳥苷酸環化酶c(gcc)抗原結合劑之組成物及其使用方法 |
CA3199830A1 (en) | 2020-12-23 | 2022-06-30 | Lukas BAMMERT | Tumor-specific claudin 18.2 antibody-drug conjugates |
Family Cites Families (245)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4475196A (en) | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
US5374548A (en) | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
MX9203291A (es) | 1985-06-26 | 1992-08-01 | Liposome Co Inc | Metodo para acoplamiento de liposomas. |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
US4954617A (en) | 1986-07-07 | 1990-09-04 | Trustees Of Dartmouth College | Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
US4881175A (en) | 1986-09-02 | 1989-11-14 | Genex Corporation | Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides |
JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・2・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
US5013653A (en) | 1987-03-20 | 1991-05-07 | Creative Biomolecules, Inc. | Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage |
US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
AU612370B2 (en) | 1987-05-21 | 1991-07-11 | Micromet Ag | Targeted multifunctional proteins |
US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
GB8809129D0 (en) | 1988-04-18 | 1988-05-18 | Celltech Ltd | Recombinant dna methods vectors and host cells |
US4956556A (en) | 1988-11-14 | 1990-09-11 | Siemens Analytical X-Ray Instruments, Inc. | Radiation scintillation detector |
US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
US6020145A (en) | 1989-06-30 | 2000-02-01 | Bristol-Myers Squibb Company | Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96 |
US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
WO1991009974A1 (en) | 1989-12-27 | 1991-07-11 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | Diagnostic probe for detecting human stomach cancer |
US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
GB9019812D0 (en) | 1990-09-11 | 1990-10-24 | Scotgen Ltd | Novel antibodies for treatment and prevention of infection in animals and man |
US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
GB9223377D0 (en) | 1992-11-04 | 1992-12-23 | Medarex Inc | Humanized antibodies to fc receptors for immunoglobulin on human mononuclear phagocytes |
FR2697752B1 (fr) | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
US5595756A (en) | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
US5589579A (en) * | 1994-07-19 | 1996-12-31 | Cytoclonal Pharmaceutics, Inc. | Gene sequence and probe for a marker of non-small cell lung carinoma |
WO2000053757A2 (en) | 1999-03-08 | 2000-09-14 | Genentech, Inc. | Promotion or inhibition of angiogenesis and cardiovascularization |
WO2000073454A1 (en) | 1999-06-02 | 2000-12-07 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
WO2000075316A1 (en) | 1999-06-02 | 2000-12-14 | Genentech, Inc. | Methods and compositions for inhibiting neoplastic cell growth |
US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
US5677139A (en) | 1995-04-21 | 1997-10-14 | President And Fellows Of Harvard College | In vitro differentiation of CD34+ progenitor cells into T lymphocytes |
UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
JP2001501447A (ja) * | 1996-01-11 | 2001-02-06 | コリクサ コーポレイション | 乳癌の処置および診断のための組成物および方法 |
US5939265A (en) * | 1996-11-05 | 1999-08-17 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the lung |
WO2000053756A2 (en) | 1999-03-08 | 2000-09-14 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
GB9704444D0 (en) * | 1997-03-04 | 1997-04-23 | Isis Innovation | Non-invasive prenatal diagnosis |
US7368531B2 (en) | 1997-03-07 | 2008-05-06 | Human Genome Sciences, Inc. | Human secreted proteins |
US7411051B2 (en) | 1997-03-07 | 2008-08-12 | Human Genome Sciences, Inc. | Antibodies to HDPPA04 polypeptide |
US20070224663A1 (en) | 1997-03-07 | 2007-09-27 | Human Genome Sciences, Inc. | Human Secreted Proteins |
WO2000012708A2 (en) | 1998-09-01 | 2000-03-09 | Genentech, Inc. | Further pro polypeptides and sequences thereof |
US20020127584A1 (en) | 1997-09-18 | 2002-09-12 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US20030073129A1 (en) | 1998-09-01 | 2003-04-17 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US20030022298A1 (en) | 1997-09-15 | 2003-01-30 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US20030166104A1 (en) | 1997-09-18 | 2003-09-04 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US20030166109A1 (en) | 1997-09-18 | 2003-09-04 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US20030027272A1 (en) | 1997-09-18 | 2003-02-06 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US20030008352A1 (en) | 1997-09-18 | 2003-01-09 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US20050196832A1 (en) | 1997-09-18 | 2005-09-08 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US7160985B2 (en) * | 1997-10-29 | 2007-01-09 | Genentech, Inc. | Pro180 polypeptide |
US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
US20030040471A1 (en) | 1998-04-29 | 2003-02-27 | Watson James D. | Compositions isolated from skin cells and methods for their use |
US20030022835A1 (en) | 1998-04-29 | 2003-01-30 | Genesis Research And Development Corporation Limited | Compositions isolated from skin cells and methods for their use |
US6852318B1 (en) * | 1998-05-08 | 2005-02-08 | The Regents Of The University Of California | Methods for detecting and inhibiting angiogenesis |
JP3428441B2 (ja) | 1998-05-15 | 2003-07-22 | エーザイ株式会社 | タイトジャンクション構成膜蛋白質クローディンファミリー |
WO1999060160A1 (en) * | 1998-05-21 | 1999-11-25 | Diadexus Llc | A novel method of diagnosing, monitoring, and staging lung cancer |
US7319008B2 (en) | 1998-06-02 | 2008-01-15 | Genentech, Inc. | Nucleic acid underexpressed in melanoma |
US7351543B2 (en) | 1998-06-02 | 2008-04-01 | Genentech, Inc. | Antibodies to a polypeptide encoded by a nucleic acid underexpressed in melanoma |
WO1999064452A1 (en) * | 1998-06-11 | 1999-12-16 | Smithkline Beecham Corporation | Gpr35a receptor |
US7339033B2 (en) | 1998-06-26 | 2008-03-04 | Genentech, Inc. | Pro1481 |
EP1092026A2 (en) * | 1998-07-02 | 2001-04-18 | Incyte Pharmaceuticals, Inc. | Neurotransmission associated proteins |
EP1104486A4 (en) | 1998-08-04 | 2002-07-17 | Diadexus Llc | NEW METHOD FOR DIAGNOSIS, FOLLOW-UP, AND IMAGE OF LUNG CANCER |
US7488796B2 (en) | 1998-09-01 | 2009-02-10 | Genentech, Inc. | PRO1269 polypeptides |
US20030054406A1 (en) | 1998-09-01 | 2003-03-20 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US20030082626A1 (en) | 1998-09-01 | 2003-05-01 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US20050181478A1 (en) | 1998-09-01 | 2005-08-18 | Baker Kevin P. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
IL141535A0 (en) | 1998-09-16 | 2002-03-10 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
CA2343001A1 (en) * | 1998-09-16 | 2000-03-23 | Zymogenetics, Inc. | Stomach polypeptide zsig28 |
US6355623B2 (en) * | 1998-09-24 | 2002-03-12 | Hopital-Sainte-Justine | Method of treating IBD/Crohn's disease and related conditions wherein drug metabolite levels in host blood cells determine subsequent dosage |
JP2004500011A (ja) | 1998-10-06 | 2004-01-08 | キュラゲン コーポレイション | 新規な分泌タンパク質、およびそれをコードするポリヌクレオチド |
US7399834B2 (en) | 1998-10-07 | 2008-07-15 | Genentech, Inc. | Anti-PRO1558 antibodies |
AU1450900A (en) * | 1998-10-21 | 2000-05-08 | Arch Development Corporation | Methods of treatment of type 2 diabetes |
JP2002530062A (ja) * | 1998-10-28 | 2002-09-17 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 12個のヒト分泌タンパク質 |
US20030009013A1 (en) | 1998-12-30 | 2003-01-09 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US7026449B2 (en) | 1999-01-05 | 2006-04-11 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US7507404B2 (en) | 1999-03-08 | 2009-03-24 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
PT1609863E (pt) | 1999-03-23 | 2009-01-02 | Genentech Inc | Polipéptidos segregados e transmembranares e ácidos nucleicos que os codificam |
JP2004507202A (ja) | 1999-03-31 | 2004-03-11 | キュラジェン コーポレイション | ポリペプチドをコードするオープンリーディングフレームを含む核酸;「orfx」 |
US20080286821A1 (en) | 1999-05-14 | 2008-11-20 | Eaton Dan L | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
ES2287020T3 (es) | 1999-06-02 | 2007-12-16 | Genentech, Inc. | Procedimiento y composiciones para inhibir el crecimiento de celulas neoplasicas. |
AU3246100A (en) | 1999-06-02 | 2000-12-28 | Genentech Inc. | Methods and compositions for inhibiting neoplastic cell growth |
ATE448246T1 (de) | 1999-06-15 | 2009-11-15 | Genentech Inc | Sekretierte und transmembran-polypeptide sowie nukleinsäuren zu deren kodierung |
AU2883700A (en) | 1999-06-23 | 2001-01-09 | Genentech Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
AU2883900A (en) | 1999-07-07 | 2001-01-30 | Genentech Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
EP1206536A2 (en) * | 1999-08-17 | 2002-05-22 | Sagami Chemical Research Center | HUMAN PROTEINS HAVING HYDROPHOBIC DOMAINS AND DNAs ENCODING THESE PROTEINS |
JP3951035B2 (ja) * | 1999-09-01 | 2007-08-01 | ジェネンテック・インコーポレーテッド | 分泌及び膜貫通ポリペプチドとそれをコードしている核酸 |
US7442776B2 (en) * | 1999-10-08 | 2008-10-28 | Young David S F | Cancerous disease modifying antibodies |
AU1205901A (en) * | 1999-10-14 | 2001-04-23 | Board Of Trustees Of The University Of Arkansas, The | Tumor antigen derived gene-16 (tadg-16): a novel extracellular serine protease and uses thereof |
EP1690872A3 (en) | 1999-12-01 | 2006-08-23 | Genentech, Inc. | Composition and methods for the diagnosis of tumours |
US6380362B1 (en) | 1999-12-23 | 2002-04-30 | Genesis Research & Development Corporation Ltd. | Polynucleotides, polypeptides expressed by the polynucleotides and methods for their use |
JP4280444B2 (ja) | 2000-01-06 | 2009-06-17 | ジェネンテック・インコーポレーテッド | 腫瘍性細胞成長阻害のための組成物及び方法 |
WO2001055326A2 (en) | 2000-01-31 | 2001-08-02 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
CA2392757A1 (en) | 2000-01-31 | 2001-08-02 | Human Genome Sciences Inc. | Nucleic acids, proteins, and antibodies |
EP1251863A4 (en) * | 2000-01-31 | 2005-03-02 | Human Genome Sciences Inc | 22 SEPARATE HUMAN PROTEINS |
US20030077808A1 (en) | 2000-01-31 | 2003-04-24 | Rosen Craig A. | Nucleic acids, proteins, and antibodies |
JP2003525599A (ja) * | 2000-02-17 | 2003-09-02 | ディアデクサス インコーポレーテッド | 肺癌特異的遺伝子による肺癌の診断、モニタリング、病期分類、イメージングおよび治療の方法 |
EP1261711A2 (en) * | 2000-02-22 | 2002-12-04 | Corixa Corporation | Compositions and methods for diagnosis and therapy of malignant mesothelioma |
AU6802801A (en) * | 2000-03-01 | 2001-09-24 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
WO2001070979A2 (en) | 2000-03-21 | 2001-09-27 | Millennium Pharmaceuticals, Inc. | Genes, compositions, kits, and method for identification, assessment, prevention and therapy of ovarian cancer |
US6436703B1 (en) * | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
CA2405557C (en) | 2000-04-12 | 2013-09-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
WO2001090357A1 (en) | 2000-05-24 | 2001-11-29 | Genesis Research & Development Corporation Limited | Compositions isolated from skin cells and methods for their use |
CA2412211A1 (en) * | 2000-06-23 | 2002-01-03 | Genetech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
AU2001271714A1 (en) * | 2000-06-30 | 2002-01-14 | Human Genome Sciences, Inc. | B7-like polynucleotides, polypeptides, and antibodies |
WO2002002621A2 (en) | 2000-06-30 | 2002-01-10 | Zymogenetics, Inc. | Mammalian secreted proteins |
EP1354040A2 (en) * | 2000-07-20 | 2003-10-22 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
IL154751A0 (en) | 2000-08-03 | 2003-10-31 | Humanized antibodies, recombination vectors, transgenic vectors and methods for the preparation of humanized antibodies from transgenic animals | |
ATE363531T1 (de) | 2000-08-15 | 2007-06-15 | Immunex Corp | Claudin polypeptide |
WO2002014500A2 (en) * | 2000-08-16 | 2002-02-21 | Chiron Corporation | Human genes and gene expression products |
US20030017468A1 (en) * | 2000-08-28 | 2003-01-23 | Sei-Yu Chen | Compositions and methods relating to lung specific genes |
JP2004509617A (ja) | 2000-09-08 | 2004-04-02 | シェーリング コーポレイション | 哺乳動物遺伝子;関連試薬および方法 |
WO2002022684A2 (en) * | 2000-09-15 | 2002-03-21 | Incyte Genomics, Inc. | Transporters and ion channels |
WO2002022885A1 (en) | 2000-09-18 | 2002-03-21 | Thomas Jefferson University | Compositions and methods for identifying and targeting stomach and esophageal cancer cells |
JP2004520821A (ja) * | 2000-10-26 | 2004-07-15 | ディアデクサス インコーポレーテッド | 肺特異的遺伝子およびタンパク質に関する組成物および方法 |
AU2002220265A1 (en) * | 2000-11-03 | 2002-05-15 | University Of Vermont And State Agricultural College | Compositions for inhibiting grb7 |
EP1916303B1 (en) | 2000-11-30 | 2013-02-27 | Medarex, Inc. | Nucleic acids encoding rearranged human immunoglobulin sequences from transgenic transchromosomal mice |
WO2002061087A2 (en) * | 2000-12-19 | 2002-08-08 | Lifespan Biosciences, Inc. | Antigenic peptides, such as for g protein-coupled receptors (gpcrs), antibodies thereto, and systems for identifying such antigenic peptides |
WO2002068579A2 (en) | 2001-01-10 | 2002-09-06 | Pe Corporation (Ny) | Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
EP1368499A2 (en) | 2001-01-29 | 2003-12-10 | Phase-1 Molecular Toxicology Inc. | Rat toxicologically relevant genes and uses thereof |
JP3948702B2 (ja) | 2001-02-14 | 2007-07-25 | 社団法人畜産技術協会 | ウシのClaudin−16欠損症タイプ2の遺伝子診断法 |
JP2004526441A (ja) * | 2001-02-26 | 2004-09-02 | アリーナ・フアーマシユーチカルズ・インコーポレーテツド | 内因性および非内因性型ヒトgタンパク質共役受容体 |
WO2002074237A2 (en) * | 2001-03-19 | 2002-09-26 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of kidney cancer |
US20030152939A1 (en) | 2001-04-09 | 2003-08-14 | Glennda Smithson | Novel secreted proteins and polynucleotides encoding them |
US20060084794A1 (en) | 2001-04-12 | 2006-04-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
JP2003000249A (ja) | 2001-05-10 | 2003-01-07 | Daiichi Fine Chemical Co Ltd | クローディンによるMT−MMPsを介したproMMP−2活性化 |
AU2002330714A1 (en) | 2001-05-30 | 2003-01-02 | Biomedical Center | In silico screening for phenotype-associated expressed sequences |
CA2448112A1 (en) * | 2001-06-05 | 2002-12-12 | Exelixis Inc. | Lces as modifiers of the p53 pathway and methods of use |
EP1493028A4 (en) | 2001-07-06 | 2006-06-14 | Genentech Inc | PHAGEN DISPLAY PRESENTED LIGANDS OF THE PDZ DOMAIN |
EP1443951A4 (en) | 2001-08-03 | 2006-05-03 | Arbor Vita Corp | MOLECULAR INTERACTIONS IN CELLS |
US7202335B2 (en) | 2001-12-06 | 2007-04-10 | Genentech, Inc. | PRO300 polypeptides |
US20040002587A1 (en) | 2002-02-20 | 2004-01-01 | Watkins Jeffry D. | Fc region variants |
CA2379661A1 (en) | 2002-03-28 | 2003-09-28 | Kursad Turksen | Paracellular drug delivery system |
WO2003101283A2 (en) | 2002-06-04 | 2003-12-11 | Incyte Corporation | Diagnostics markers for lung cancer |
EP2364996B1 (en) | 2002-09-27 | 2016-11-09 | Xencor Inc. | Optimized FC variants and methods for their generation |
WO2004029629A1 (en) | 2002-09-27 | 2004-04-08 | Janssen Pharmaceutica N.V. | N-11 truncated amyloid-beta nomoclonal antibodies, compositions, methods and uses |
RU2349340C2 (ru) | 2002-10-10 | 2009-03-20 | Мерк Патент Гмбх | Биспецифические антитела к erb-b и их применение для лечения опухолей |
PL218660B1 (pl) | 2002-10-17 | 2015-01-30 | Genmab As | Izolowane ludzkie przeciwciało monoklonalne wiążące ludzki CD20, związane z tym przeciwciałem transfektoma, komórka gospodarza, transgeniczne zwierzę lub roślina, kompozycja, immunokoniugat, cząsteczka bispecyficzna, wektor ekspresyjny, kompozycja farmaceutyczna, zastosowanie medyczne, zestaw oraz przeciwciało antyidiotypowe i jego zastosowanie |
EP1578365A4 (en) | 2002-11-14 | 2009-09-23 | Arbor Vita Corp | MOLECULAR INTERACTIONS IN NEURONS |
DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
EP1430902A1 (en) | 2002-12-20 | 2004-06-23 | Mondobiotech Laboratories Anstalt | Pharmaceutical composition of interferon gamma with molecular diagnostics for the improved treatment of asthma bronchiale |
ES2897506T3 (es) | 2003-01-09 | 2022-03-01 | Macrogenics Inc | Identificación y modificación de anticuerpos con regiones Fc variantes y métodos de utilización de los mismos |
US20050181375A1 (en) | 2003-01-10 | 2005-08-18 | Natasha Aziz | Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of metastatic cancer |
US7393531B2 (en) * | 2003-01-21 | 2008-07-01 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of MCSP |
US8048146B2 (en) | 2003-05-06 | 2011-11-01 | Abbott Laboratories | Endoprosthesis having foot extensions |
US7919089B2 (en) | 2003-05-31 | 2011-04-05 | Micromet Ag | Pharmaceutical composition comprising a bispecific antibody for EpCAM |
EP1629012B1 (en) | 2003-05-31 | 2018-11-28 | Amgen Research (Munich) GmbH | Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders |
US20060019256A1 (en) | 2003-06-09 | 2006-01-26 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
US20060240441A1 (en) | 2003-10-03 | 2006-10-26 | Bayer Pharmaceuticals Corporation | Gene expression profiles and methods of use |
AU2004283850C1 (en) | 2003-10-16 | 2011-11-03 | Amgen Research (Munich) Gmbh | Multispecific deimmunized CD3-binders |
DE10354601B3 (de) | 2003-11-21 | 2005-06-23 | Chiropro Gmbh | Gelenkprothese für Fingerglieder |
WO2005052182A2 (en) | 2003-11-26 | 2005-06-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | A method of analyzing plasma membrane protein content of cells |
WO2005061548A1 (en) | 2003-12-23 | 2005-07-07 | Nono Inc. | Polypeptides for modulating binding of trp channel proteins and trp-associated proteins. |
WO2005076939A2 (en) | 2004-02-09 | 2005-08-25 | University Of Kentucky Research Foundation | Assay and method for diagnosing and treating alzheimer’s disease |
AU2005216922A1 (en) | 2004-02-26 | 2005-09-09 | Icoria, Inc. | Diagnosis of hyperinsulinemia and type II diabetes and protection against same based on genes differentially expressed in muscle cells |
BRPI0509411A (pt) | 2004-04-16 | 2007-09-04 | Emisphere Tech Inc | método para tratar doença maligna, hipercalcemia de malignidade e metástases ósseas osteolìticas, sal de mesilato, composição e método de administração de agente ativo e bisfosfonato |
US20050255041A1 (en) | 2004-05-13 | 2005-11-17 | Arius Research, Inc. | Cancerous disease modifying antibodies |
DE102004024617A1 (de) | 2004-05-18 | 2005-12-29 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
DK1766412T3 (da) | 2004-05-21 | 2009-05-25 | Inst Systems Biology | Sammensætninger og fremgangsmåder til kvantificering af serumglycoproteiner |
WO2006023121A1 (en) | 2004-07-27 | 2006-03-02 | Ohio University | Diagnosis of hyperinsulinemia and type ii diabetes and protection against same based on genes differentially expressed in white adipose tissue (13) |
DE102004042822A1 (de) | 2004-08-31 | 2006-03-16 | Technische Universität Dresden | Verbindungen und Methoden zur Behandlung, Diagnose und Prognose bei Pankreaserkrankungen |
FR2876705B1 (fr) | 2004-10-19 | 2008-12-12 | Biomerieux Sa | Procede pour le diagnostic d'une intolerance a l'aspirine |
US20070072175A1 (en) | 2005-05-13 | 2007-03-29 | Biogen Idec Ma Inc. | Nucleotide array containing polynucleotide probes complementary to, or fragments of, cynomolgus monkey genes and the use thereof |
EP1910837B1 (en) | 2005-07-01 | 2012-03-14 | Arbor Vita Corporation | Methods and compositions for diagnosis and treatment of influenza |
CA2619577A1 (en) | 2005-08-15 | 2007-02-22 | Genentech, Inc. | Gene disruptions, compositions and methods relating thereto |
WO2007027867A2 (en) | 2005-08-31 | 2007-03-08 | Cell Signaling Technology, Inc. | Reagents for the detection of protein phosphorylation in carcinoma signaling pathways |
JP5384827B2 (ja) | 2005-09-08 | 2014-01-08 | 株式会社メディネット | 抗原提示細胞の活性化処理方法 |
WO2007035676A2 (en) | 2005-09-19 | 2007-03-29 | Veridex., Llc | Methods and materials for identifying the origin of a carcinoma of unknown primary origin |
DE102005046490A1 (de) | 2005-09-28 | 2007-03-29 | Johannes-Gutenberg-Universität Mainz | Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen |
EP1938104A2 (en) | 2005-10-17 | 2008-07-02 | Institute for Systems Biology | Tissue-and serum-derived glycoproteins and methods of their use |
EP1790664A1 (en) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against claudin-18 for treatment of cancer |
WO2007071426A1 (en) | 2005-12-21 | 2007-06-28 | Micromet Ag | Pharmaceutical compositions with resistance to soluble cea |
EP1981539B1 (en) | 2006-02-09 | 2014-07-23 | Amgen Research (Munich) GmbH | Treatment of metastatic breast cancer |
TWI388568B (zh) | 2006-02-10 | 2013-03-11 | Genentech Inc | 抗fgf19抗體及其使用方法 |
CA2647430A1 (en) | 2006-03-29 | 2007-10-11 | Genentech, Inc. | Diagnostics and treatments for tumors |
WO2008013948A2 (en) | 2006-07-27 | 2008-01-31 | Cell Signaling Technology, Inc. | Tyrosine phosphorylation sites |
EP2057465A4 (en) | 2006-08-09 | 2010-04-21 | Homestead Clinical Corp | SPECIFIC ORGAN PROTEINS AND METHODS OF USE |
WO2008021115A2 (en) | 2006-08-14 | 2008-02-21 | The Brigham And Women's Hospital, Inc. | Diagnostic tests using gene expression ratios |
US20100004253A1 (en) | 2006-09-19 | 2010-01-07 | Novartis Ag | Biomarkers of target modulation, efficacy, diagnosis and/or prognosis for raf inhibitors |
US20110150897A1 (en) | 2006-10-11 | 2011-06-23 | Meyer Thomas F | Influenza targets |
EP2097538A4 (en) | 2006-12-07 | 2011-11-30 | Switchgear Genomics | TRANSCRIPTION REAGULATION ELEMENTS OF BIOLOGICAL PATHS, TOOLS AND METHODS |
EP2104734A2 (en) | 2006-12-08 | 2009-09-30 | Asuragen, INC. | Mir-20 regulated genes and pathways as targets for therapeutic intervention |
MX2009008307A (es) | 2007-02-01 | 2009-08-25 | Veridex Llc | Metodos y materiales para identificar el origen de un carcinoma de origen primario desconocido. |
EP1970384A1 (en) | 2007-03-14 | 2008-09-17 | Ganymed Pharmaceuticals AG | Monoclonal antibodies for treatment of cancer |
US20090004213A1 (en) | 2007-03-26 | 2009-01-01 | Immatics Biotechnologies Gmbh | Combination therapy using active immunotherapy |
EP1983002A3 (en) | 2007-04-19 | 2009-03-11 | Peter Hornbeck | Tyrosine phosphorylation sites and antibodies specific for them |
EP1997832A1 (en) | 2007-05-29 | 2008-12-03 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against Claudin-18 for treatment of cancer |
US20090227533A1 (en) | 2007-06-08 | 2009-09-10 | Bader Andreas G | miR-34 Regulated Genes and Pathways as Targets for Therapeutic Intervention |
WO2008152822A1 (ja) | 2007-06-15 | 2008-12-18 | Medinet Co., Ltd. | 医薬 |
WO2009008992A2 (en) | 2007-07-06 | 2009-01-15 | Osi Pharmaceuticals Inc. | Combination anti-cancer therapy comprising an inhibitor of both mtorc1 and mt0rc2 |
WO2009015050A2 (en) | 2007-07-20 | 2009-01-29 | The Gov. Of The U.S.A. As Represented By The Secretary Of The Department Of Health & Human Services | Gene expression profile for predicting ovarian cancer patient survival |
WO2009035497A2 (en) | 2007-08-08 | 2009-03-19 | Savidge Tor C | Disease related cysteine modifications and uses thereof |
EP2036987A1 (en) | 2007-09-17 | 2009-03-18 | Siemens Healthcare Diagnostics GmbH | Molecular markers for tumor cell content in tissue samples |
WO2009038090A1 (ja) | 2007-09-19 | 2009-03-26 | Suntory Holdings Limited | セサミン類とアラキドン酸類を含有する組成物 |
AU2008309520A1 (en) | 2007-10-12 | 2009-04-16 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin | Method for opening tight junctions |
WO2009102367A2 (en) | 2007-11-19 | 2009-08-20 | The Regents Of The University Of Colorado | Tight junction protein modulators and uses thereof |
RU2509085C2 (ru) | 2008-01-28 | 2014-03-10 | Медиммун Лимитед | Стабилизированные антитела против ангиопоэтина-2 и их применение |
KR20110018930A (ko) | 2008-06-02 | 2011-02-24 | 엔에스에이비피 파운데이션, 인크. | 암 치료에서 예후적 및 예견적 마커의 확인 및 용도 |
WO2009155609A1 (en) | 2008-06-20 | 2009-12-23 | Oklahoma Medical Research Foundation | IMMUNOGENIC MEMAPSIN 2 β-SECRETASE PEPTIDES AND METHODS OF USE |
AU2009273540A1 (en) | 2008-07-25 | 2010-01-28 | Merck Patent Gmbh | Method of determination of receptor binding saturation effected by monoclonal antibodies |
US20110190380A1 (en) | 2008-10-23 | 2011-08-04 | Elena Feinstein | Methods for delivery of sirna to bone marrow cells and uses thereof |
CN101381524A (zh) | 2008-10-24 | 2009-03-11 | 南开大学 | 单层氧化石墨与水溶性高分子增强复合材料 |
PL2344539T3 (pl) | 2008-11-07 | 2015-07-31 | Amgen Res Munich Gmbh | Leczenie pediatrycznej ostrej białaczki limfoblastycznej |
US20110286916A1 (en) | 2008-11-20 | 2011-11-24 | Jose Miguel Aste-Amezaga | Generation and characterization of anti-notch antibodies for therapeutic and diagnostic use |
GB0904957D0 (en) | 2009-03-23 | 2009-05-06 | Univ Erasmus Medical Ct | Tumour gene profile |
WO2010120526A2 (en) | 2009-03-31 | 2010-10-21 | Emory University | Methods and systems for screening for and diagnosing dna methylation associated with autism spectrum disorders |
CN101584860A (zh) | 2009-04-27 | 2009-11-25 | 西安杰诺瓦生物科技有限公司 | 重组人Claudin18.2肿瘤疫苗及其制备方法 |
WO2010141093A2 (en) | 2009-06-04 | 2010-12-09 | The University Of Maryland, Baltimore | Co-signaling methods for treating cancers |
EP2483813A1 (en) | 2009-10-01 | 2012-08-08 | Chipdx LLC | System and method for classification of patients |
NZ734307A (en) | 2009-11-11 | 2020-05-29 | Ganymed Pharmaceuticals Ag | Antibodies specific for claudin 6 (cldn6) |
EP2507397A4 (en) | 2009-12-01 | 2013-05-01 | Compendia Bioscience Inc | CLASSIFICATION OF CANCERS |
WO2011090005A1 (ja) | 2010-01-19 | 2011-07-28 | 協和発酵キリン株式会社 | 大腸癌の治療用医薬および治療方法 |
EP2366709A1 (en) | 2010-03-16 | 2011-09-21 | BioNTech AG | Tumor vaccination involving a humoral immune response against self-proteins |
AU2011229518B2 (en) | 2010-03-16 | 2015-09-24 | Biontech Protein Therapeutics Gmbh | Tumor vaccination involving a humoral immune response against self-proteins |
US8945847B2 (en) | 2010-05-24 | 2015-02-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods and kits for ascertaining biosafety of an agent |
CA2801107A1 (en) | 2010-06-07 | 2011-12-15 | F. Hoffman-La Roche Ag | Gene expression markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment |
US20130157891A1 (en) | 2010-06-24 | 2013-06-20 | Xiao-Jun Li | Organ specific diagnostic panels and methods for identification of organ specific panel proteins |
WO2012070014A2 (en) | 2010-11-26 | 2012-05-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Identification of novel cell surface markers for pancreatic progenitor cells and definite endodermal cells |
AU2012206163B2 (en) | 2011-01-12 | 2013-11-14 | Morinaga Milk Industry Co., Ltd. | Method for screening for diet providing production of milk having immunoregulatory action |
DE102011005235B4 (de) | 2011-03-08 | 2017-05-24 | Sirs-Lab Gmbh | Verfahren zum Identifizieren einer Teilmenge von Polynucleotiden aus einer dem Humangenom entsprechenden Ausgangsmenge von Polynucleotiden zur in vitro Bestimmung eines Schweregrads der Wirtsantwort eines Patienten |
EP2833923A4 (en) | 2012-04-02 | 2016-02-24 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS |
WO2013167153A1 (en) | 2012-05-09 | 2013-11-14 | Ganymed Pharmaceuticals Ag | Antibodies useful in cancer diagnosis |
WO2013174404A1 (en) | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
WO2013174403A1 (en) | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
WO2014025199A2 (ko) | 2012-08-09 | 2014-02-13 | 주식회사 한독 | 스테필로코칼 엔테로톡신 유래의 초항원 변이체 및 이에 표적 특이적 폴리펩타이드가 연결된 융합단백질 및 그 용도 |
WO2014025198A2 (ko) | 2012-08-09 | 2014-02-13 | 주식회사 한독 | Lfa3 변이체 및 상기 변이체 또는 lfa3 cd2 결합영역과 이에 표적 특이적 폴리펩타이드가 연결된 융합단백질 및 그 용도 |
WO2014031859A2 (en) | 2012-08-24 | 2014-02-27 | University Of Utah Research Foundation | Compositions and methods relating to blood-based biomarkers of breast cancer |
US20140073524A1 (en) | 2012-09-07 | 2014-03-13 | Institute For Systems Biology | Markers and methods for detecting posttraumatic stress disorder (ptsd) |
US9856532B2 (en) | 2012-09-07 | 2018-01-02 | Institute For Systems Biology | Markers and methods for detecting posttraumatic stress disorder (PTSD) |
US10093736B2 (en) | 2012-11-13 | 2018-10-09 | Biontech Ag | Agents for treatment of claudin expressing cancer diseases |
WO2014127785A1 (en) | 2013-02-20 | 2014-08-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
WO2014146672A1 (en) * | 2013-03-18 | 2014-09-25 | Ganymed Pharmaceuticals Ag | Therapy involving antibodies against claudin 18.2 for treatment of cancer |
JP6241403B2 (ja) | 2014-10-24 | 2017-12-06 | 横浜ゴム株式会社 | リン酸変性ポリマー |
-
2002
- 2002-11-22 DE DE10254601A patent/DE10254601A1/de not_active Ceased
-
2003
- 2003-11-21 EP EP20110007328 patent/EP2400017A3/de not_active Withdrawn
- 2003-11-21 MX MX2012004983A patent/MX344216B/es unknown
- 2003-11-21 CN CN2003801037821A patent/CN1714150B/zh not_active Expired - Fee Related
- 2003-11-21 KR KR1020147025289A patent/KR101551621B1/ko active IP Right Grant
- 2003-11-21 SG SG10201705641SA patent/SG10201705641SA/en unknown
- 2003-11-21 CN CN2010102791184A patent/CN101966337A/zh active Pending
- 2003-11-21 BR BR0316435-7A patent/BR0316435A/pt not_active Application Discontinuation
- 2003-11-21 JP JP2004554414A patent/JP2006516190A/ja active Pending
- 2003-11-21 PT PT110073293T patent/PT2400018T/pt unknown
- 2003-11-21 EP EP11007315A patent/EP2400004A3/de not_active Withdrawn
- 2003-11-21 PL PL392311A patent/PL219093B1/pl unknown
- 2003-11-21 NZ NZ595896A patent/NZ595896A/xx not_active IP Right Cessation
- 2003-11-21 MX MXPA05005423A patent/MXPA05005423A/es active IP Right Grant
- 2003-11-21 EP EP11007329.3A patent/EP2400018B1/de not_active Expired - Lifetime
- 2003-11-21 KR KR1020057009252A patent/KR20050083962A/ko active Search and Examination
- 2003-11-21 EP EP11007323A patent/EP2400012A3/de not_active Withdrawn
- 2003-11-21 EP EP20110007320 patent/EP2400009A3/de not_active Withdrawn
- 2003-11-21 EP EP20110007317 patent/EP2400006A3/de not_active Ceased
- 2003-11-21 ES ES03773719.4T patent/ES2675785T3/es not_active Expired - Lifetime
- 2003-11-21 CN CN201310159717.6A patent/CN103381274B/zh not_active Expired - Fee Related
- 2003-11-21 EP EP11007307.9A patent/EP2399996B1/de not_active Expired - Lifetime
- 2003-11-21 EP EP11007312.9A patent/EP2400001B1/de not_active Expired - Lifetime
- 2003-11-21 EP EP11007310A patent/EP2399999A3/de not_active Withdrawn
- 2003-11-21 KR KR1020117028601A patent/KR101483736B1/ko active IP Right Grant
- 2003-11-21 EP EP20110007327 patent/EP2400016A3/de not_active Withdrawn
- 2003-11-21 SG SG2012077905A patent/SG2012077905A/en unknown
- 2003-11-21 SI SI200332486A patent/SI2400018T1/sl unknown
- 2003-11-21 EP EP03773719.4A patent/EP1563068B1/de not_active Expired - Lifetime
- 2003-11-21 ES ES11007329.3T patent/ES2583754T3/es not_active Expired - Lifetime
- 2003-11-21 CN CN201610244960.1A patent/CN106581694A/zh active Pending
- 2003-11-21 PL PL392310A patent/PL219043B1/pl unknown
- 2003-11-21 EP EP11007311A patent/EP2400000A3/de not_active Withdrawn
- 2003-11-21 EP EP11007314A patent/EP2400003A3/de not_active Withdrawn
- 2003-11-21 SG SG2008036014A patent/SG180019A1/en unknown
- 2003-11-21 EP EP20110007318 patent/EP2400007A3/de not_active Withdrawn
- 2003-11-21 EP EP20110007319 patent/EP2400008A3/de not_active Withdrawn
- 2003-11-21 WO PCT/EP2003/013091 patent/WO2004047863A2/de active Application Filing
- 2003-11-21 PL PL377240A patent/PL219018B1/pl unknown
- 2003-11-21 EP EP11007325A patent/EP2400014A3/de not_active Withdrawn
- 2003-11-21 KR KR1020137031249A patent/KR101604788B1/ko not_active IP Right Cessation
- 2003-11-21 EP EP18157559.8A patent/EP3348570A1/de not_active Ceased
- 2003-11-21 NZ NZ539649A patent/NZ539649A/en not_active IP Right Cessation
- 2003-11-21 CA CA3000243A patent/CA3000243C/en not_active Expired - Lifetime
- 2003-11-21 CA CA002505757A patent/CA2505757A1/en not_active Abandoned
- 2003-11-21 US US10/537,002 patent/US7527933B2/en not_active Expired - Lifetime
- 2003-11-21 EP EP11007306A patent/EP2399995A3/de not_active Withdrawn
- 2003-11-21 NZ NZ590225A patent/NZ590225A/en not_active IP Right Cessation
- 2003-11-21 NZ NZ578130A patent/NZ578130A/en not_active IP Right Cessation
- 2003-11-21 KR KR1020177006922A patent/KR20170031804A/ko active IP Right Grant
- 2003-11-21 EP EP11007330A patent/EP2400019A3/de not_active Withdrawn
- 2003-11-21 AU AU2003282101A patent/AU2003282101B2/en not_active Ceased
- 2003-11-21 KR KR1020157004401A patent/KR101718117B1/ko active Application Filing
- 2003-11-21 EP EP20110007322 patent/EP2400011A3/de not_active Withdrawn
- 2003-11-21 EP EP11007308A patent/EP2399997A3/de not_active Withdrawn
- 2003-11-21 HU HUE11007329A patent/HUE027825T2/en unknown
- 2003-11-21 EP EP11007324A patent/EP2400013A3/de not_active Withdrawn
- 2003-11-21 EP EP20110007326 patent/EP2400015A3/de not_active Withdrawn
- 2003-11-21 EP EP11007316A patent/EP2400005A3/de not_active Withdrawn
- 2003-11-21 KR KR1020127025528A patent/KR101507976B1/ko not_active IP Right Cessation
- 2003-11-21 EP EP11007313A patent/EP2400002A3/de not_active Withdrawn
- 2003-11-21 EP EP11007309A patent/EP2399998A3/de not_active Withdrawn
- 2003-11-21 EP EP20110007321 patent/EP2400010A3/de not_active Withdrawn
-
2005
- 2005-04-21 IL IL168168A patent/IL168168A/en active IP Right Grant
-
2008
- 2008-12-03 US US12/326,997 patent/US8088588B2/en not_active Expired - Fee Related
-
2009
- 2009-04-14 US US12/423,153 patent/US8586047B2/en not_active Expired - Fee Related
- 2009-10-01 IL IL201278A patent/IL201278A/en active IP Right Grant
-
2010
- 2010-02-17 JP JP2010032059A patent/JP5726422B2/ja not_active Expired - Lifetime
- 2010-06-10 AU AU2010202440A patent/AU2010202440B2/en not_active Ceased
-
2011
- 2011-01-07 JP JP2011001695A patent/JP5904478B2/ja not_active Expired - Fee Related
- 2011-11-15 US US13/296,620 patent/US8637012B2/en not_active Expired - Fee Related
-
2012
- 2012-06-19 HK HK12106007.4A patent/HK1165480A1/zh not_active IP Right Cessation
- 2012-10-16 JP JP2012228760A patent/JP2013046626A/ja active Pending
-
2013
- 2013-10-01 US US14/043,109 patent/US20140186338A1/en not_active Abandoned
-
2014
- 2014-03-04 IL IL231294A patent/IL231294A0/en unknown
- 2014-03-04 IL IL231296A patent/IL231296A0/en unknown
- 2014-03-04 IL IL231297A patent/IL231297A0/en unknown
- 2014-03-04 IL IL231298A patent/IL231298A0/en unknown
- 2014-03-04 IL IL231295A patent/IL231295A0/en unknown
- 2014-11-06 JP JP2014225894A patent/JP6182127B2/ja not_active Expired - Fee Related
-
2015
- 2015-08-07 US US14/821,411 patent/US20150337052A1/en not_active Abandoned
-
2016
- 2016-02-10 JP JP2016023703A patent/JP2016104800A/ja active Pending
- 2016-07-15 CY CY20161100686T patent/CY1117786T1/el unknown
-
2017
- 2017-07-14 US US15/650,092 patent/US10414824B2/en not_active Expired - Lifetime
- 2017-08-04 JP JP2017151213A patent/JP2017206551A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PL392311A1 (pl) | Kompozycja farmaceutyczna hamująca ekspresję lub aktywność antygenu, sposób diagnozowania, sposób oznaczania regresji, sposób leczenia choroby, sposób hamowania rozwoju raka, kwas nukleinowy, cząsteczka zrekombinowanego DNA lub RNA, komórka gospodarza, białko lub polipeptyd, fragment immunologiczny białka lub polipeptydu, czynnik, przeciwciało, produkt sprzęgania, zestaw do wykrywania ekspresji i zrekombinowana cząsteczka | |
ES2424269T3 (es) | Inmuno-PCR sándwich por desplazamiento | |
Downs et al. | Analysis of collagenase-cleavage of type II collagen using a neoepitope ELISA | |
JP4700626B2 (ja) | 分子上のエピトープの免疫検出のための試薬、キット及び方法 | |
JP2005504513A5 (pl) | ||
UA90082C2 (ru) | Выделенное моноклональное антитело человека, которое специфически связывается с cd25 человека и ингибирует связывание il-2 с cd25 | |
NZ513498A (en) | Monoclonal antibodies, antigens and diagnosis and therapy of malignant diseases | |
WO2004009622A3 (en) | Protein complexes of cellular networks underlying the development of cancer and other diseases | |
JP2008508861A5 (pl) | ||
WO2004024750A3 (en) | Cd44-binding ligands | |
US20220170935A1 (en) | Methods of classifying response to immunotherapy for cancer | |
IL177239A (en) | Invention of a biological marker based on an animal-tribal antibody and developmental infrastructure | |
WO2002062945A3 (en) | Compositions and methods relating to lung specific genes and proteins | |
WO2004051269A3 (en) | Ciz1 replication protein | |
WO2002040673A3 (en) | Compositions and methods relating to lung specific genes and proteins | |
EP1802972B1 (en) | Method of detecting cancer based on immune reaction to boris | |
WO2005017102A3 (en) | Compositions, splice variants and methods relating to ovarian specific nucleic acids and proteins | |
WO2004058986A3 (en) | Btl-ii nucleic acids, proteins, and antibodies | |
US20040023292A1 (en) | Method and reagent for the detection of proteins and peptides | |
WO2004013311A3 (en) | Compositions and methods relating to ovarian specific genes and proteins | |
WO2002064788A3 (en) | Compositions and methods relating to lung specific genes and proteins | |
WO2005090397A8 (de) | Hyphenspezifische zellwandproteine von candida | |
WO2001085989A3 (de) | Hyphenspezifische faktoren aus candida albicans | |
Zhang et al. | Research Progress on Quantification Methods of Drug Concentration of Monoclonal Antibodies | |
WO2003042370A3 (en) | New gene expressed in prostate cancer and methods of use |