PL214718B1 - Tricykliczny antagonista receptora trombinowego, zawierajaca go kompozycja farmaceutyczna i jego zastosowanie - Google Patents

Tricykliczny antagonista receptora trombinowego, zawierajaca go kompozycja farmaceutyczna i jego zastosowanie

Info

Publication number
PL214718B1
PL214718B1 PL373332A PL37333203A PL214718B1 PL 214718 B1 PL214718 B1 PL 214718B1 PL 373332 A PL373332 A PL 373332A PL 37333203 A PL37333203 A PL 37333203A PL 214718 B1 PL214718 B1 PL 214718B1
Authority
PL
Poland
Prior art keywords
compound
alkyl
group
mmol
compounds
Prior art date
Application number
PL373332A
Other languages
English (en)
Polish (pl)
Other versions
PL373332A1 (en
Inventor
Samuel Chackalamannil
Martin C. Clasby
William J. Greenlee
Yuguang Wang
Yan Xia
Enrico P. Veltri
Mariappan Chelliah
Wenxue Wu
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29250954&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL214718(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of PL373332A1 publication Critical patent/PL373332A1/xx
Publication of PL214718B1 publication Critical patent/PL214718B1/pl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL373332A 2002-04-16 2003-04-14 Tricykliczny antagonista receptora trombinowego, zawierajaca go kompozycja farmaceutyczna i jego zastosowanie PL214718B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37307202P 2002-04-16 2002-04-16

Publications (2)

Publication Number Publication Date
PL373332A1 PL373332A1 (en) 2005-08-22
PL214718B1 true PL214718B1 (pl) 2013-09-30

Family

ID=29250954

Family Applications (1)

Application Number Title Priority Date Filing Date
PL373332A PL214718B1 (pl) 2002-04-16 2003-04-14 Tricykliczny antagonista receptora trombinowego, zawierajaca go kompozycja farmaceutyczna i jego zastosowanie

Country Status (34)

Country Link
US (3) US7304078B2 (zh)
EP (5) EP1860106B1 (zh)
JP (2) JP4558331B2 (zh)
KR (1) KR101026929B1 (zh)
CN (1) CN1659162B (zh)
AR (1) AR039570A1 (zh)
AT (3) ATE378330T1 (zh)
AU (1) AU2003221932B2 (zh)
BR (1) BRPI0309309B8 (zh)
CA (1) CA2482858C (zh)
CY (3) CY1107184T1 (zh)
DE (3) DE60331114D1 (zh)
DK (2) DK1495018T3 (zh)
EC (1) ECSP045368A (zh)
ES (3) ES2357876T3 (zh)
FR (1) FR15C0047I2 (zh)
HK (3) HK1070887A1 (zh)
IL (1) IL164585A (zh)
LT (1) LTC1495018I2 (zh)
LU (1) LU92759I2 (zh)
MX (1) MXPA04010308A (zh)
MY (1) MY144040A (zh)
NL (1) NL300746I2 (zh)
NO (2) NO330500B1 (zh)
NZ (2) NZ535880A (zh)
PE (1) PE20040412A1 (zh)
PL (1) PL214718B1 (zh)
PT (2) PT1495018E (zh)
RU (2) RU2329264C9 (zh)
SG (1) SG164279A1 (zh)
SI (2) SI1495018T1 (zh)
TW (1) TWI343919B (zh)
WO (1) WO2003089428A1 (zh)
ZA (1) ZA200408342B (zh)

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US7541471B2 (en) * 2005-01-14 2009-06-02 Schering Corporation Synthesis of himbacine analogs
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DK1848705T3 (da) * 2005-01-14 2010-06-14 Schering Corp EXO- og diastereoselektive synteser af himbacin-analoger
EP2399912B1 (en) * 2005-01-14 2015-02-25 Merck Sharp & Dohme Corp. An exo-selective synthesis of himbacine analogs
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TWI316937B (en) 2005-03-31 2009-11-11 Schering Corp Spirocyclic thrombin receptor antagonists
WO2007075808A2 (en) * 2005-12-20 2007-07-05 Schering Corporation Methods for preventing and/or treating a cell proliferative disorder
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CN101553484A (zh) * 2006-10-04 2009-10-07 先灵公司 以喜巴辛的被改质三环单位为基础的凝血酶受体拮抗剂
US20080194560A1 (en) * 2006-12-22 2008-08-14 Zhi Yun Wang Disintegration promoters in solid dose wet granulation formulations
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PL2240487T3 (pl) 2008-02-05 2012-05-31 Sanofi Sa Triazolopirydazyny jako inhibitory PAR1, ich otrzymywanie i zastosowanie jako leków
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US8148363B2 (en) 2008-05-19 2012-04-03 Schering Corporation Heterocyclic compounds as factor IXA inhibitors
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JP2012529431A (ja) 2009-06-08 2012-11-22 メルク・シャープ・アンド・ドーム・コーポレーション トロンビン受容体アンタゴニストおよびクロピドグレルの固定用量錠剤
US8609676B2 (en) 2009-08-04 2013-12-17 Merck Sharp & Dohme, Corp. 4, 5, 6-trisubstituted pyrimidine derivatives as factor IXa inhibitors
EP2558465B1 (de) 2010-04-16 2014-12-17 Sanofi Trizyklische pyridyl-vinyl-pyrrole als par1-inhibitoren
ES2527535T3 (es) 2010-04-16 2015-01-26 Sanofi Piridil-vinil-pirazolo-quinolinas como inhibidores de PAR1
KR101303348B1 (ko) 2010-06-25 2013-09-03 한국화학연구원 트롬빈 수용체 길항제인 ［6＋5］접합 바이사이클, 그의 제조방법 및 그를 포함하는 약제학적 조성물
US9340530B2 (en) 2012-03-06 2016-05-17 Merck Sharp & Dohme Corp. Preparation and use of bicyclic himbacine derivatives as PAR-1 receptor antagonists
WO2015013083A1 (en) * 2013-07-22 2015-01-29 Merck Sharp & Dohme Corp. Co-crystal of the par-1 receptor antagonist vorapaxar and aspirin
US20160200715A1 (en) * 2013-08-22 2016-07-14 Merck Sharp & Dohme Corp. Preparation and use of 7a-heterocycle substituted- 6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists
US9808473B2 (en) 2013-08-22 2017-11-07 Merck Sharp & Dohme Corp. Preparation and use of 3-pyridyl substituted-6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists
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FR3014693B1 (fr) 2013-12-16 2016-01-08 Pf Medicament Utilisation de la 3-(2-chloro-phenyl)-1-[4-(4-fluoro-benzyl)-piperazin-1-yl]-propenone pour la prevention et/ou le traitement des pathologies fonctionnelles pelvi-perineales
EP3131897B8 (en) 2014-04-16 2022-08-03 Merck Sharp & Dohme LLC Factor ixa inhibitors
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CN105985303B (zh) * 2015-02-13 2020-08-14 上海彩迩文生化科技有限公司 抗凝血剂的制备方法、中间体及其制备方法
CN106478608A (zh) * 2015-09-01 2017-03-08 博瑞生物医药（苏州）股份有限公司 沃拉帕沙的硫酸盐的结晶多晶型物
CN106749201A (zh) * 2015-11-25 2017-05-31 博瑞生物医药（苏州）股份有限公司 一种沃拉帕沙及其中间体的制备方法
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TR201601548A2 (tr) * 2016-02-05 2018-03-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Vorapaksar ve metoprololün bi̇r farmasöti̇k kompozi̇syonu
TW201738221A (zh) * 2016-04-22 2017-11-01 Jiangsu Tasly Diyi Pharmaceutical Co Ltd 新的喜巴辛類似物、其藥物組合物及其在醫藥中的應用
CN106236779A (zh) * 2016-08-22 2016-12-21 孔五 一种脐带血富血小板血浆prp的制备方法
FR3090317B1 (fr) 2018-12-19 2021-05-07 Cvasthera Utilisation d’un antagoniste de par-1 pour le traitement d’une maladie inflammatoire chronique intestinale
CN110407819B (zh) * 2019-08-02 2020-06-26 牡丹江医学院 一种作为预防外科手术并发症的凝血酶受体拮抗剂
US20210113536A1 (en) * 2019-10-21 2021-04-22 United States Government as Represented by the Department of Veteran Affairs Methods and compositions for detecting and treating venous thromboembolism
FR3109089B1 (fr) 2020-04-08 2023-04-14 Cvasthera Composition pharmaceutique pour le traitement des maladies inflammatoires intestinales
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US11845748B2 (en) 2021-03-18 2023-12-19 Janssen Pharmaceutica Nv Bicyclic pyridine N-oxide derivatives useful as a factor XIa inhibitors
US11919881B2 (en) 2021-03-18 2024-03-05 Janssen Pharmaceutica Nv Substituted pyridine N-oxide derivatives useful as a factor XIa inhibitors
US11814364B2 (en) 2021-03-18 2023-11-14 Janssen Pharmaceutica Nv Pyridine N-oxide derivatives useful as factor XIa inhibitors
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Also Published As

Publication number Publication date
LU92759I2 (en) 2015-08-31
CY2015029I2 (el) 2016-04-13
EP1495018B3 (en) 2011-03-16
KR20040099441A (ko) 2004-11-26
EP1982984A3 (en) 2008-10-29
NO2015016I1 (no) 2015-07-20
CA2482858A1 (en) 2003-10-30
EP1982984B1 (en) 2013-02-13
TW200404068A (en) 2004-03-16
ATE378330T1 (de) 2007-11-15
JP2010132710A (ja) 2010-06-17
NO2015016I2 (no) 2015-07-09
BRPI0309309B1 (pt) 2018-09-04
ZA200408342B (en) 2006-05-31
NL300746I1 (zh) 2016-01-21
EP2065384A1 (en) 2009-06-03
ES2357876T3 (es) 2011-05-03
CY1107184T1 (el) 2012-10-24
EP2062890B1 (en) 2011-01-05
RU2004133375A (ru) 2005-07-10
CY1111363T1 (el) 2015-08-05
NZ535880A (en) 2007-11-30
DE60331114D1 (de) 2010-03-11
IL164585A0 (en) 2005-12-18
IL164585A (en) 2010-11-30
CA2482858C (en) 2010-11-30
NZ575139A (en) 2010-08-27
CN1659162A (zh) 2005-08-24
EP1860106A1 (en) 2007-11-28
DK2065384T3 (da) 2011-05-02
NO330500B1 (no) 2011-05-02
PE20040412A1 (es) 2004-07-12
LTC1495018I2 (lt) 2017-04-10
US7713999B2 (en) 2010-05-11
FR15C0047I1 (zh) 2015-08-28
PL373332A1 (en) 2005-08-22
JP4558331B2 (ja) 2010-10-06
SG164279A1 (en) 2010-09-29
PT2065384E (pt) 2011-03-16
SI1495018T1 (sl) 2008-04-30
DK1495018T3 (da) 2008-02-18
ES2297150T7 (es) 2012-03-16
US7304078B2 (en) 2007-12-04
RU2329264C2 (ru) 2008-07-20
EP2062890A1 (en) 2009-05-27
FR15C0047I2 (fr) 2016-05-06
DE60317493T2 (de) 2008-09-18
AR039570A1 (es) 2005-02-23
RU2008106401A (ru) 2009-08-27
AU2003221932B2 (en) 2007-11-22
DE60317493T3 (de) 2018-07-12
HK1123302A1 (en) 2009-06-12
AU2003221932A1 (en) 2003-11-03
MXPA04010308A (es) 2005-02-03
BR0309309A (pt) 2005-02-15
US20030216437A1 (en) 2003-11-20
NL300746I2 (zh) 2016-01-21
WO2003089428A1 (en) 2003-10-30
EP1495018B1 (en) 2007-11-14
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ATE494284T1 (de) 2011-01-15
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HK1129893A1 (en) 2009-12-11
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US20070270439A1 (en) 2007-11-22
BRPI0309309B8 (pt) 2021-05-25
SI2065384T1 (sl) 2011-05-31
ATE455774T1 (de) 2010-02-15
NO20044963L (no) 2004-11-15
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