AR061727A1 - Sintesis de dietil [[ 5- ( 3-fluorofenil) -piridin -2il] metil] fosfonato - Google Patents

Sintesis de dietil [[ 5- ( 3-fluorofenil) -piridin -2il] metil] fosfonato

Info

Publication number
AR061727A1
AR061727A1 ARP070102893A ARP070102893A AR061727A1 AR 061727 A1 AR061727 A1 AR 061727A1 AR P070102893 A ARP070102893 A AR P070102893A AR P070102893 A ARP070102893 A AR P070102893A AR 061727 A1 AR061727 A1 AR 061727A1
Authority
AR
Argentina
Prior art keywords
phosphonate
dietile
piridin
fluorophenyl
synthesis
Prior art date
Application number
ARP070102893A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AR061727A1 publication Critical patent/AR061727A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)

Abstract

La presente revela un proceso para la preparacion de ésteres de fosfonato, los cuales son utiles como sustancias intermedias para la elaboracion de los análogos de la himbacina que, a su vez, son utiles como antagonistas del receptor de la trombina. La química ensenada en la presente puede ejemplificarse por medio del esquema (1).
ARP070102893A 2006-06-30 2007-06-28 Sintesis de dietil [[ 5- ( 3-fluorofenil) -piridin -2il] metil] fosfonato AR061727A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81786706P 2006-06-30 2006-06-30

Publications (1)

Publication Number Publication Date
AR061727A1 true AR061727A1 (es) 2008-09-17

Family

ID=38606711

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070102893A AR061727A1 (es) 2006-06-30 2007-06-28 Sintesis de dietil [[ 5- ( 3-fluorofenil) -piridin -2il] metil] fosfonato

Country Status (9)

Country Link
US (2) US7687631B2 (es)
EP (1) EP2046804B1 (es)
JP (2) JP5117493B2 (es)
CN (1) CN101511852B (es)
AR (1) AR061727A1 (es)
CA (1) CA2656265A1 (es)
MX (1) MX2009000157A (es)
WO (1) WO2008005348A1 (es)
ZA (2) ZA200900713B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ17621U1 (cs) * 2003-08-26 2007-06-25 Shire Holdings Ag Farmaceutický prostredek zahrnující slouceniny lanthanu
SG158884A1 (en) 2005-01-14 2010-02-26 Schering Corp An exo-selective synthesis of himbacine analogs
AR061727A1 (es) * 2006-06-30 2008-09-17 Schering Corp Sintesis de dietil [[ 5- ( 3-fluorofenil) -piridin -2il] metil] fosfonato
US7842725B2 (en) 2008-07-24 2010-11-30 Ecolab USA, Inc. Foaming alcohol compositions with selected dimethicone surfactants
AT515117B1 (de) * 2014-04-15 2015-06-15 Dietmar Dr Sonnleitner Zahnimplantatsystem
CN105330689B (zh) * 2014-08-08 2018-08-17 博瑞生物医药（苏州）股份有限公司 制备Himbacine类似物中间体的制备方法
CN105777681B (zh) * 2014-12-17 2019-03-01 博瑞生物医药（苏州）股份有限公司 喜巴辛类似物及其中间体的制备方法
CN105348241B (zh) * 2015-12-11 2017-09-05 南京华威医药科技开发有限公司 一种硫酸沃拉帕沙中间体的合成方法
US11247940B2 (en) 2016-10-26 2022-02-15 The Regents Of The University Of California Efficient integration of manufacturing of upcycled concrete product into power plants
CN106749138B (zh) * 2016-12-07 2019-08-16 扬子江药业集团四川海蓉药业有限公司 一种硫酸沃拉帕沙中间体醛的制备方法
CN108658910B (zh) * 2017-03-29 2020-11-03 北京新领先医药科技发展有限公司 一种沃拉帕沙中间体1-α的制备方法
US11230473B2 (en) * 2017-06-30 2022-01-25 The Regents Of The University Of California CO2 mineralization in produced and industrial effluent water by pH-swing carbonation
WO2019036386A1 (en) 2017-08-14 2019-02-21 The Regents Of The University Of California MITIGATION OF THE ALKALI-SILICA REACTION IN CONCRETE USING EASILY SOLUBLE CHEMICAL ADDITIVES
US11384029B2 (en) 2019-03-18 2022-07-12 The Regents Of The University Of California Formulations and processing of cementitious components to meet target strength and CO2 uptake criteria

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063847A (en) * 1997-11-25 2000-05-16 Schering Corporation Thrombin receptor antagonists
ATE368659T1 (de) * 2000-06-15 2007-08-15 Schering Corp Thrombinrezeptorantagonisten
US7235567B2 (en) * 2000-06-15 2007-06-26 Schering Corporation Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
US20040192753A1 (en) * 2000-06-15 2004-09-30 Samuel Chackalamannil Methods of use of thrombin receptor antagonists
PL371948A1 (en) * 2001-10-18 2005-07-11 Schering Corporation Himbacine analogues as thrombin receptor antagonists
EP1860106B1 (en) * 2002-04-16 2010-01-20 Schering Corporation Tricyclic thrombin receptor antagonists
DE602005009355D1 (de) * 2004-05-28 2008-10-09 Schering Corp Gehinderte himbacinanaloga als thrombinrezeptorantagonisten
US7541471B2 (en) * 2005-01-14 2009-06-02 Schering Corporation Synthesis of himbacine analogs
ES2374379T3 (es) * 2005-01-14 2012-02-16 Schering Corporation Síntesis exo y diastereoselectiva de análogos de himbacina.
AR061727A1 (es) * 2006-06-30 2008-09-17 Schering Corp Sintesis de dietil [[ 5- ( 3-fluorofenil) -piridin -2il] metil] fosfonato

Also Published As

Publication number Publication date
US8329905B2 (en) 2012-12-11
MX2009000157A (es) 2009-01-23
JP2009542676A (ja) 2009-12-03
US20080004449A1 (en) 2008-01-03
ZA200900713B (en) 2010-09-29
JP2012197307A (ja) 2012-10-18
WO2008005348A1 (en) 2008-01-10
US7687631B2 (en) 2010-03-30
ZA201003436B (en) 2011-08-31
EP2046804A1 (en) 2009-04-15
CN101511852B (zh) 2012-10-03
JP5117493B2 (ja) 2013-01-16
CA2656265A1 (en) 2008-01-10
EP2046804B1 (en) 2015-07-15
CN101511852A (zh) 2009-08-19
US20100137597A1 (en) 2010-06-03

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