DK1036072T3 - Thrombinreceptorantagonister - Google Patents
ThrombinreceptorantagonisterInfo
- Publication number
- DK1036072T3 DK1036072T3 DK98958039T DK98958039T DK1036072T3 DK 1036072 T3 DK1036072 T3 DK 1036072T3 DK 98958039 T DK98958039 T DK 98958039T DK 98958039 T DK98958039 T DK 98958039T DK 1036072 T3 DK1036072 T3 DK 1036072T3
- Authority
- DK
- Denmark
- Prior art keywords
- receptor antagonists
- thrombin receptor
- thrombin
- antagonists
- receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97797997A | 1997-11-25 | 1997-11-25 | |
| PCT/US1998/024523 WO1999026943A1 (en) | 1997-11-25 | 1998-11-23 | Thrombin receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1036072T3 true DK1036072T3 (da) | 2004-09-06 |
Family
ID=25525702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98958039T DK1036072T3 (da) | 1997-11-25 | 1998-11-23 | Thrombinreceptorantagonister |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP1036072B1 (da) |
| JP (2) | JP3449620B2 (da) |
| KR (1) | KR100393492B1 (da) |
| CN (2) | CN1290265A (da) |
| AR (1) | AR017189A1 (da) |
| AT (1) | ATE266025T1 (da) |
| AU (1) | AU747204B2 (da) |
| BR (1) | BR9812793A (da) |
| CA (1) | CA2309352C (da) |
| CO (1) | CO4990946A1 (da) |
| CZ (1) | CZ298578B6 (da) |
| DE (1) | DE69823694T2 (da) |
| DK (1) | DK1036072T3 (da) |
| ES (1) | ES2219919T3 (da) |
| HK (1) | HK1031726A1 (da) |
| HU (1) | HUP0100607A3 (da) |
| ID (1) | ID24726A (da) |
| IL (1) | IL135797A (da) |
| MY (1) | MY140887A (da) |
| NO (1) | NO322022B1 (da) |
| NZ (1) | NZ504218A (da) |
| PE (1) | PE133799A1 (da) |
| PL (1) | PL195027B1 (da) |
| PT (1) | PT1036072E (da) |
| RU (1) | RU2204557C2 (da) |
| SA (1) | SA99190972B1 (da) |
| SK (1) | SK285153B6 (da) |
| TR (1) | TR200001480T2 (da) |
| TW (1) | TWI236476B (da) |
| WO (1) | WO1999026943A1 (da) |
| ZA (1) | ZA9810685B (da) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000229961A (ja) | 1998-12-11 | 2000-08-22 | Sagami Chem Res Center | ヒドロナフト［２，３−ｃ］フラン誘導体およびその製造方法 |
| AU6731100A (en) | 1999-09-02 | 2001-04-10 | Shionogi & Co., Ltd. | Integrase inhibitors containing aromatic heterocycle derivatives |
| SK287026B6 (sk) * | 2000-06-15 | 2009-10-07 | Schering Corporation | Nor-seko-himbacínové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie |
| EP1764366A3 (en) * | 2000-06-15 | 2007-10-03 | Schering Corporation | Thrombin receptor antagonists |
| US7235567B2 (en) | 2000-06-15 | 2007-06-26 | Schering Corporation | Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist |
| HUP0400467A3 (en) | 2001-04-19 | 2012-08-28 | Eisai R & D Man Co | 2-iminopyrrolidine derivatives, pharmaceutical compositions containing them and their use |
| EP1982984B1 (en) | 2002-04-16 | 2013-02-13 | Merck Sharp & Dohme Corp. | Manufacture of tricyclic thrombin receptor antagonists and pharmaceutical compositions comprising them |
| CN100439336C (zh) | 2003-02-19 | 2008-12-03 | 卫材R&D管理有限公司 | 制备环状苯甲脒衍生物的方法 |
| JPWO2005108370A1 (ja) * | 2004-04-16 | 2008-03-21 | 味の素株式会社 | ベンゼン化合物 |
| US7442712B2 (en) * | 2004-05-28 | 2008-10-28 | Schering Corporation | Constrained himbacine analogs as thrombin receptor antagonists |
| AU2005294490A1 (en) * | 2004-10-08 | 2006-04-20 | Schering Corporation | Thrombin receptor antagonists |
| US7605275B2 (en) * | 2005-01-14 | 2009-10-20 | Schering Corporation | Exo- and diastereo- selective syntheses of himbacine analogs |
| DE602006020414D1 (en) * | 2005-01-14 | 2011-04-14 | Schering Corp | Synthese von himbacinanaloga |
| CN101137636A (zh) * | 2005-01-14 | 2008-03-05 | 先灵公司 | Himbacine类似物的外型选择性合成 |
| TWI367112B (en) * | 2006-06-30 | 2012-07-01 | Schering Corp | Immediate-release tablet formulations of a thrombin receptor antagonist |
| CN101541782A (zh) | 2006-10-04 | 2009-09-23 | 先灵公司 | 作为凝血酶受体拮抗剂的二环和三环衍生物 |
| PL2558465T3 (pl) | 2010-04-16 | 2015-05-29 | Sanofi Sa | Trycykliczne pirydylo-winylo-pirole jako inhibitory receptora aktywowanego proteazą 1 (PAR1) |
| EP2558462B1 (de) | 2010-04-16 | 2014-10-22 | Sanofi | Pyridyl-vinyl-pyrazolo-chinoline als par1-inhibitoren |
| CN108658910B (zh) * | 2017-03-29 | 2020-11-03 | 北京新领先医药科技发展有限公司 | 一种沃拉帕沙中间体1-α的制备方法 |
| CN113387947B (zh) * | 2021-07-12 | 2022-07-01 | 中国科学院成都生物研究所 | 调节雌激素受体合成活性的吡唑并吡啶衍生物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL106197A (en) * | 1992-07-30 | 1999-11-30 | Cor Therapeutics Inc | Agagonists for the rhombin receptors and pharmaceutical preparations containing them |
-
1998
- 1998-11-23 CN CN98813307A patent/CN1290265A/zh active Pending
- 1998-11-23 CZ CZ20001856A patent/CZ298578B6/cs not_active IP Right Cessation
- 1998-11-23 HU HU0100607A patent/HUP0100607A3/hu unknown
- 1998-11-23 ZA ZA9810685A patent/ZA9810685B/xx unknown
- 1998-11-23 IL IL13579798A patent/IL135797A/xx not_active IP Right Cessation
- 1998-11-23 WO PCT/US1998/024523 patent/WO1999026943A1/en active IP Right Grant
- 1998-11-23 DK DK98958039T patent/DK1036072T3/da active
- 1998-11-23 CA CA002309352A patent/CA2309352C/en not_active Expired - Fee Related
- 1998-11-23 CO CO98068933A patent/CO4990946A1/es unknown
- 1998-11-23 AR ARP980105935A patent/AR017189A1/es active IP Right Grant
- 1998-11-23 EP EP98958039A patent/EP1036072B1/en not_active Expired - Lifetime
- 1998-11-23 SK SK759-2000A patent/SK285153B6/sk not_active IP Right Cessation
- 1998-11-23 AT AT98958039T patent/ATE266025T1/de not_active IP Right Cessation
- 1998-11-23 PL PL98341114A patent/PL195027B1/pl not_active IP Right Cessation
- 1998-11-23 PE PE1998001140A patent/PE133799A1/es not_active Application Discontinuation
- 1998-11-23 ES ES98958039T patent/ES2219919T3/es not_active Expired - Lifetime
- 1998-11-23 PT PT98958039T patent/PT1036072E/pt unknown
- 1998-11-23 TW TW087119396A patent/TWI236476B/zh not_active IP Right Cessation
- 1998-11-23 BR BR9812793-4A patent/BR9812793A/pt not_active Application Discontinuation
- 1998-11-23 RU RU2000116548/04A patent/RU2204557C2/ru not_active IP Right Cessation
- 1998-11-23 NZ NZ504218A patent/NZ504218A/en unknown
- 1998-11-23 AU AU14158/99A patent/AU747204B2/en not_active Ceased
- 1998-11-23 TR TR2000/01480T patent/TR200001480T2/xx unknown
- 1998-11-23 JP JP2000522101A patent/JP3449620B2/ja not_active Expired - Fee Related
- 1998-11-23 DE DE69823694T patent/DE69823694T2/de not_active Expired - Lifetime
- 1998-11-23 KR KR10-2000-7005679A patent/KR100393492B1/ko not_active IP Right Cessation
- 1998-11-23 ID IDW20000993A patent/ID24726A/id unknown
- 1998-11-23 CN CNA2008100835852A patent/CN101274929A/zh active Pending
- 1998-11-24 MY MYPI98005330A patent/MY140887A/en unknown
-
1999
- 1999-01-10 SA SA99190972A patent/SA99190972B1/ar unknown
-
2000
- 2000-05-24 NO NO20002659A patent/NO322022B1/no not_active IP Right Cessation
-
2001
- 2001-03-16 HK HK01101899A patent/HK1031726A1/xx not_active IP Right Cessation
-
2002
- 2002-10-29 JP JP2002315015A patent/JP2003128670A/ja not_active Withdrawn
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69812096D1 (de) | Neuropeptid y rezeptorantagonisten | |
| DE69833073D1 (de) | CCR-3-Rezeptor-Antagonisten | |
| DE69734833D1 (de) | Vitronektin rezeptor antagonisten | |
| DK1009732T3 (da) | 1-Amino-alkylcyclohexan NMDA receptor antagonister | |
| NO20012411D0 (no) | Pyrrolidin-derivater-CCR-3-reseptorantagonister | |
| NO20001100D0 (no) | IL-8 reseptorantagonister | |
| DE69921351D1 (de) | 4-aroyl-piperidin-ccr-3 rezeptor antagonisten iii | |
| NO993586D0 (no) | K-8 reseptor antagonister | |
| NO993350D0 (no) | Vitronectin-reseptor-antagonister | |
| DK1036072T3 (da) | Thrombinreceptorantagonister | |
| ID24162A (id) | Antagonis-antagonis reseptor vitronektin | |
| ID26223A (id) | Antagonis reseptor vitronektin | |
| NO20000542L (no) | Endothelin-antagonister | |
| DK0906294T3 (da) | Benzoxazinon-dopamin D4-receptor-antagonister | |
| DE69838874D1 (de) | Il-8 rezeptor-antagonisten | |
| ID28811A (id) | Antagonis reseptor vitronektin | |
| DE69831413D1 (de) | Il-8 rezeptor antagonisten | |
| DE69824837D1 (de) | Il-8-rezeptor-antagonisten | |
| ID22978A (id) | Antagonis reseptor endotelin | |
| DE69830671D1 (de) | Integrin-rezeptor-antagonisten | |
| DK0964867T3 (da) | Tachykininantagonister | |
| GB9702834D0 (en) | Fibrinogen receptor antagonists | |
| EP1001777A4 (en) | Fibrinogen Receptor Antagonists | |
| ZA986620B (en) | Fibrinogen receptor antagonist | |
| TR199601082A3 (tr) | Entegrin reseptör antagonistleri. |