TR200001480T2 - Trombin reseptör antagonistleri - Google Patents

Trombin reseptör antagonistleri

Info

Publication number
TR200001480T2
TR200001480T2 TR2000/01480T TR200001480T TR200001480T2 TR 200001480 T2 TR200001480 T2 TR 200001480T2 TR 2000/01480 T TR2000/01480 T TR 2000/01480T TR 200001480 T TR200001480 T TR 200001480T TR 200001480 T2 TR200001480 T2 TR 200001480T2
Authority
TR
Turkey
Prior art keywords
bond
line represents
dotted line
double
single bond
Prior art date
Application number
TR2000/01480T
Other languages
English (en)
Inventor
Chackalamannil Samuel
Asberom Theodros
Xia Yan
Doller Dar�O
C. Clasby Mart�N
F. Czarniecki M�Chael
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of TR200001480T2 publication Critical patent/TR200001480T2/tr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)

Abstract

Formül (I) heterosiklik-degistirilmis trisiklikler veya bunlarin farmasötik olarak kabul edilebilen tuzu , ki burada tekli kesikli çizgi opsiyonel bir çift bagi temsil eder; çift kesiklik çizgi opsiyonel bir tekli bagi temsil eder; n 0-2'dir;Q opsiyonel olarak degistirilmis sikloalkil, heterosikloalkil, aril veya heteroarildir; het opsiyonel olarak degistirilmis bir mono-,bi-veya trisiklikheteroaromatik gruptur; B n 3'ün -0-5 oldugu-(CH2)n3-,CH2-O-,CH2-S-, -CH2-NR6-,-C(O)NR6-,NR6C(O)-,(a), opsiyonel olarak degistirilmis alkenil veya opsiyonel olarak degistirilmis alkinildir; X, çift kesikli çizgi tekli bir bagi temsil ettiginde -O- veya-NR6-dir veya X bag olmadiginda-OH veya-NHR20'dir; Y ÇIft kesik çizgi tekli bir bagi temsil ettiginde =O,=S,(H,H),(H,OH) VEYA (H,C1-C6 alkoksi)'dir veya bag olmadiginda Y=O,(H,H),(H,OH),(H,SH) veya (H,C1-C6 alkoksi)'dir; çift kesikli çizgi tekli bir bagi temsil ettiginde R15 yoktur ve bag olmadiginda H,-NR18R19 DEVAMI VAR
TR2000/01480T 1997-11-25 1998-11-23 Trombin reseptör antagonistleri TR200001480T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97797997A 1997-11-25 1997-11-25

Publications (1)

Publication Number Publication Date
TR200001480T2 true TR200001480T2 (tr) 2000-09-21

Family

ID=25525702

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/01480T TR200001480T2 (tr) 1997-11-25 1998-11-23 Trombin reseptör antagonistleri

Country Status (31)

Country Link
EP (1) EP1036072B1 (tr)
JP (2) JP3449620B2 (tr)
KR (1) KR100393492B1 (tr)
CN (2) CN1290265A (tr)
AR (1) AR017189A1 (tr)
AT (1) ATE266025T1 (tr)
AU (1) AU747204B2 (tr)
BR (1) BR9812793A (tr)
CA (1) CA2309352C (tr)
CO (1) CO4990946A1 (tr)
CZ (1) CZ298578B6 (tr)
DE (1) DE69823694T2 (tr)
DK (1) DK1036072T3 (tr)
ES (1) ES2219919T3 (tr)
HK (1) HK1031726A1 (tr)
HU (1) HUP0100607A3 (tr)
ID (1) ID24726A (tr)
IL (1) IL135797A (tr)
MY (1) MY140887A (tr)
NO (1) NO322022B1 (tr)
NZ (1) NZ504218A (tr)
PE (1) PE133799A1 (tr)
PL (1) PL195027B1 (tr)
PT (1) PT1036072E (tr)
RU (1) RU2204557C2 (tr)
SA (1) SA99190972B1 (tr)
SK (1) SK285153B6 (tr)
TR (1) TR200001480T2 (tr)
TW (1) TWI236476B (tr)
WO (1) WO1999026943A1 (tr)
ZA (1) ZA9810685B (tr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000229961A (ja) 1998-12-11 2000-08-22 Sagami Chem Res Center ヒドロナフト［２，３−ｃ］フラン誘導体およびその製造方法
AU6731100A (en) * 1999-09-02 2001-04-10 Shionogi & Co., Ltd. Integrase inhibitors containing aromatic heterocycle derivatives
EP1764366A3 (en) * 2000-06-15 2007-10-03 Schering Corporation Thrombin receptor antagonists
US7235567B2 (en) 2000-06-15 2007-06-26 Schering Corporation Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
US6645987B2 (en) * 2000-06-15 2003-11-11 Schering Corporation Nor-seco himbacine derivatives useful as thrombin receptor antagonists
NZ528820A (en) 2001-04-19 2007-01-26 Eisai Co Ltd 2-iminopyrrolidine derivatives
PT1495018E (pt) * 2002-04-16 2008-02-19 Schering Corp Antagonistas tricíclicos de receptores de trombina
EP2444393A1 (en) 2003-02-19 2012-04-25 Eisai R&D Management Co., Ltd. Methods for producing cyclic benzamidine derivatives
WO2005108370A1 (ja) * 2004-04-16 2005-11-17 Ajinomoto Co., Inc. ベンゼン化合物
CA2567981C (en) * 2004-05-28 2010-08-31 Schering Corporation Constrained himbacine analogs as thrombin receptor antagonists
MX2007004197A (es) * 2004-10-08 2007-06-15 Schering Corp Antagonistas del receptor de trombina.
US7772276B2 (en) 2005-01-14 2010-08-10 Schering Corporation Exo-selective synthesis of himbacine analogs
EP1853592B1 (en) * 2005-01-14 2011-03-02 Schering Corporation Synthesis of himbacine analogs
PT1848705E (pt) * 2005-01-14 2010-05-10 Schering Corp Sínteses exo- e diastereo-selectivas de análogos da himbacina
TWI367112B (en) * 2006-06-30 2012-07-01 Schering Corp Immediate-release tablet formulations of a thrombin receptor antagonist
JP2010505842A (ja) 2006-10-04 2010-02-25 シェーリング コーポレイション トロンビン受容体拮抗薬としての二環式誘導体および三環式誘導体
ES2532902T3 (es) 2010-04-16 2015-04-01 Sanofi Piridil-vinil-pirroles tricíclicos como inhibidores de PAR1
ES2527535T3 (es) 2010-04-16 2015-01-26 Sanofi Piridil-vinil-pirazolo-quinolinas como inhibidores de PAR1
CN108658910B (zh) * 2017-03-29 2020-11-03 北京新领先医药科技发展有限公司 一种沃拉帕沙中间体1-α的制备方法
CN113387947B (zh) * 2021-07-12 2022-07-01 中国科学院成都生物研究所 调节雌激素受体合成活性的吡唑并吡啶衍生物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL106197A (en) * 1992-07-30 1999-11-30 Cor Therapeutics Inc Agagonists for the rhombin receptors and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
CA2309352C (en) 2005-01-25
ATE266025T1 (de) 2004-05-15
ZA9810685B (en) 1999-12-23
CA2309352A1 (en) 1999-06-03
RU2204557C2 (ru) 2003-05-20
PL341114A1 (en) 2001-03-26
NO20002659L (no) 2000-07-24
HUP0100607A3 (en) 2002-06-28
CO4990946A1 (es) 2000-12-26
BR9812793A (pt) 2000-10-17
EP1036072B1 (en) 2004-05-06
JP3449620B2 (ja) 2003-09-22
CN101274929A (zh) 2008-10-01
NO20002659D0 (no) 2000-05-24
SK285153B6 (sk) 2006-07-07
AR017189A1 (es) 2001-08-22
CN1290265A (zh) 2001-04-04
DK1036072T3 (da) 2004-09-06
IL135797A0 (en) 2001-05-20
PL195027B1 (pl) 2007-08-31
NZ504218A (en) 2002-04-26
CZ298578B6 (cs) 2007-11-14
AU1415899A (en) 1999-06-15
DE69823694D1 (de) 2004-06-09
NO322022B1 (no) 2006-08-07
SK7592000A3 (en) 2001-02-12
PT1036072E (pt) 2004-08-31
KR20010032439A (ko) 2001-04-25
AU747204B2 (en) 2002-05-09
CZ20001856A3 (cs) 2000-10-11
MY140887A (en) 2010-01-29
JP2003128670A (ja) 2003-05-08
KR100393492B1 (ko) 2003-08-02
TWI236476B (en) 2005-07-21
HUP0100607A2 (hu) 2002-05-29
HK1031726A1 (en) 2001-06-22
JP2001524479A (ja) 2001-12-04
PE133799A1 (es) 2000-01-10
DE69823694T2 (de) 2005-04-21
ES2219919T3 (es) 2004-12-01
IL135797A (en) 2003-09-17
WO1999026943A1 (en) 1999-06-03
SA99190972B1 (ar) 2006-07-30
ID24726A (id) 2000-08-03
EP1036072A1 (en) 2000-09-20

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