BR9812793A - Antagonistas do receptor de trombina - Google Patents
Antagonistas do receptor de trombinaInfo
- Publication number
- BR9812793A BR9812793A BR9812793-4A BR9812793A BR9812793A BR 9812793 A BR9812793 A BR 9812793A BR 9812793 A BR9812793 A BR 9812793A BR 9812793 A BR9812793 A BR 9812793A
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- BR
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- Prior art keywords
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Abstract
Patente de Invenção: <B>"ANTAGONISTAS DO RECEPTOR DE TROMBINA"<D>. Tricíclicos heterocíclicos-substituídos da fórmula (l) ou um sal farmaceuticamente aceitável dos mesmos em que: a linha pontilhada simples representa uma ligação dupla opcional; a linha pontilhada dupla representa uma ligação simples opcional; n é 0-2; Q e cicloaquila opcionalmente substituída, heterocicloalquila, arila ou heteroarila; Het é um grupo aromático mono-, bi- ou tricíclico opcionalmente substituído; B é -(CH~ 2~ )~ n3~ -em que n~ 3~ é 0-5, -CH~ 2~ -O-, -CH~ 2~ S-, -CH~ 2~ -NR^ 6^ -, -C(O)-NR^ 6^ C(O)-, (a) alquenila opcionalmente substituída ou alquinila opcionalmente substituída; X é -O- ou - NR^ 6^ -quando a linha pontilhada dupla representa uma ligação simples ou X é -OH ou NHR^ 20^- quando a ligação está ausente; Y é =O, =S, (H,H), (H, OH) ou (H, C~ 1~ -C~ 6~ alcóxi) quando a linha pontilhada dupla representa uma ligação simples ou, quando a ligação está ausente, Y é =O, (H, H), (H, OH), (H, SH) ou (H, C~ 1~ -C~ 6~ alcóxi); R^ 15^ está ausente quando a linha pontilhada dupla representa uma ligação dupla e é H, -NR^ 18^ R^ 19^ ou -OR^ 17^ quando a ligação está ausente; ou Y é (A) ou (B) e R^ 15^ é H ou C~ 1~ -C~ 6~ alquila; são divulgados, bem como composições farmacêuticas contendo os mesmos e um método de tratamento de doenças associadas com trombose, aterosclerose, restenose, hipertensão, angina pectoris, arritmia, insuficiência cardíaca e câncer através da administração dos referidos compostos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97797997A | 1997-11-25 | 1997-11-25 | |
| PCT/US1998/024523 WO1999026943A1 (en) | 1997-11-25 | 1998-11-23 | Thrombin receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9812793A true BR9812793A (pt) | 2000-10-17 |
Family
ID=25525702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9812793-4A BR9812793A (pt) | 1997-11-25 | 1998-11-23 | Antagonistas do receptor de trombina |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP1036072B1 (pt) |
| JP (2) | JP3449620B2 (pt) |
| KR (1) | KR100393492B1 (pt) |
| CN (2) | CN1290265A (pt) |
| AR (1) | AR017189A1 (pt) |
| AT (1) | ATE266025T1 (pt) |
| AU (1) | AU747204B2 (pt) |
| BR (1) | BR9812793A (pt) |
| CA (1) | CA2309352C (pt) |
| CO (1) | CO4990946A1 (pt) |
| CZ (1) | CZ298578B6 (pt) |
| DE (1) | DE69823694T2 (pt) |
| DK (1) | DK1036072T3 (pt) |
| ES (1) | ES2219919T3 (pt) |
| HK (1) | HK1031726A1 (pt) |
| HU (1) | HUP0100607A3 (pt) |
| ID (1) | ID24726A (pt) |
| IL (1) | IL135797A (pt) |
| MY (1) | MY140887A (pt) |
| NO (1) | NO322022B1 (pt) |
| NZ (1) | NZ504218A (pt) |
| PE (1) | PE133799A1 (pt) |
| PL (1) | PL195027B1 (pt) |
| PT (1) | PT1036072E (pt) |
| RU (1) | RU2204557C2 (pt) |
| SA (1) | SA99190972B1 (pt) |
| SK (1) | SK285153B6 (pt) |
| TR (1) | TR200001480T2 (pt) |
| TW (1) | TWI236476B (pt) |
| WO (1) | WO1999026943A1 (pt) |
| ZA (1) | ZA9810685B (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000229961A (ja) | 1998-12-11 | 2000-08-22 | Sagami Chem Res Center | ヒドロナフト［２，３−ｃ］フラン誘導体およびその製造方法 |
| EP1219607B1 (en) * | 1999-09-02 | 2011-04-06 | Shionogi & Co., Ltd. | Integrase inhibitors containing aromatic heterocycle derivatives |
| EP2301930B1 (en) * | 2000-06-15 | 2016-01-06 | Merck Sharp & Dohme Corp. | Derivatives of hexahydrobenzofuranone useful for the treatment of (inter alia) auto-immune or inflammatory disorders |
| US7235567B2 (en) | 2000-06-15 | 2007-06-26 | Schering Corporation | Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist |
| SI1294714T1 (sl) * | 2000-06-15 | 2007-12-31 | Schering Corp | Antagonisti trobinskega receptorja |
| CN1243735C (zh) | 2001-04-19 | 2006-03-01 | 卫材株式会社 | 2－亚氨基吡咯烷衍生物 |
| AR039570A1 (es) | 2002-04-16 | 2005-02-23 | Schering Corp | Antagonistas de los receptores de trombina |
| EP2444393A1 (en) | 2003-02-19 | 2012-04-25 | Eisai R&D Management Co., Ltd. | Methods for producing cyclic benzamidine derivatives |
| JPWO2005108370A1 (ja) | 2004-04-16 | 2008-03-21 | 味の素株式会社 | ベンゼン化合物 |
| US7442712B2 (en) * | 2004-05-28 | 2008-10-28 | Schering Corporation | Constrained himbacine analogs as thrombin receptor antagonists |
| MX2007004197A (es) * | 2004-10-08 | 2007-06-15 | Schering Corp | Antagonistas del receptor de trombina. |
| AR052871A1 (es) * | 2005-01-14 | 2007-04-11 | Schering Corp | Una sintesis exo-selectiva de analogos de himbacina |
| CA2594741A1 (en) * | 2005-01-14 | 2006-07-20 | Schering Corporation | Synthesis of himbacine analogs |
| ATE458726T1 (de) * | 2005-01-14 | 2010-03-15 | Schering Corp | Exo- und diastereoselektive synthese von himbacin-analoga |
| TWI367112B (en) * | 2006-06-30 | 2012-07-01 | Schering Corp | Immediate-release tablet formulations of a thrombin receptor antagonist |
| EP2069326B1 (en) | 2006-10-04 | 2015-03-18 | Merck Sharp & Dohme Corp. | Bicyclic and tricyclic derivatives as thrombin receptor antagonists |
| WO2011128420A1 (de) | 2010-04-16 | 2011-10-20 | Sanofi | Pyridyl-vinyl-pyrazolo-chinoline als par1-inhibitoren |
| PL2558465T3 (pl) | 2010-04-16 | 2015-05-29 | Sanofi Sa | Trycykliczne pirydylo-winylo-pirole jako inhibitory receptora aktywowanego proteazą 1 (PAR1) |
| CN108658910B (zh) * | 2017-03-29 | 2020-11-03 | 北京新领先医药科技发展有限公司 | 一种沃拉帕沙中间体1-α的制备方法 |
| CN113387947B (zh) * | 2021-07-12 | 2022-07-01 | 中国科学院成都生物研究所 | 调节雌激素受体合成活性的吡唑并吡啶衍生物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL106197A (en) * | 1992-07-30 | 1999-11-30 | Cor Therapeutics Inc | Agagonists for the rhombin receptors and pharmaceutical preparations containing them |
-
1998
- 1998-11-23 TR TR2000/01480T patent/TR200001480T2/xx unknown
- 1998-11-23 PT PT98958039T patent/PT1036072E/pt unknown
- 1998-11-23 WO PCT/US1998/024523 patent/WO1999026943A1/en active IP Right Grant
- 1998-11-23 PE PE1998001140A patent/PE133799A1/es not_active Application Discontinuation
- 1998-11-23 CN CN98813307A patent/CN1290265A/zh active Pending
- 1998-11-23 TW TW087119396A patent/TWI236476B/zh not_active IP Right Cessation
- 1998-11-23 DE DE69823694T patent/DE69823694T2/de not_active Expired - Lifetime
- 1998-11-23 CO CO98068933A patent/CO4990946A1/es unknown
- 1998-11-23 SK SK759-2000A patent/SK285153B6/sk not_active IP Right Cessation
- 1998-11-23 ES ES98958039T patent/ES2219919T3/es not_active Expired - Lifetime
- 1998-11-23 KR KR10-2000-7005679A patent/KR100393492B1/ko not_active IP Right Cessation
- 1998-11-23 ID IDW20000993A patent/ID24726A/id unknown
- 1998-11-23 DK DK98958039T patent/DK1036072T3/da active
- 1998-11-23 AT AT98958039T patent/ATE266025T1/de not_active IP Right Cessation
- 1998-11-23 CN CNA2008100835852A patent/CN101274929A/zh active Pending
- 1998-11-23 RU RU2000116548/04A patent/RU2204557C2/ru not_active IP Right Cessation
- 1998-11-23 AU AU14158/99A patent/AU747204B2/en not_active Ceased
- 1998-11-23 IL IL13579798A patent/IL135797A/xx not_active IP Right Cessation
- 1998-11-23 JP JP2000522101A patent/JP3449620B2/ja not_active Expired - Fee Related
- 1998-11-23 ZA ZA9810685A patent/ZA9810685B/xx unknown
- 1998-11-23 AR ARP980105935A patent/AR017189A1/es active IP Right Grant
- 1998-11-23 NZ NZ504218A patent/NZ504218A/en unknown
- 1998-11-23 CZ CZ20001856A patent/CZ298578B6/cs not_active IP Right Cessation
- 1998-11-23 HU HU0100607A patent/HUP0100607A3/hu unknown
- 1998-11-23 EP EP98958039A patent/EP1036072B1/en not_active Expired - Lifetime
- 1998-11-23 CA CA002309352A patent/CA2309352C/en not_active Expired - Fee Related
- 1998-11-23 BR BR9812793-4A patent/BR9812793A/pt not_active Application Discontinuation
- 1998-11-23 PL PL98341114A patent/PL195027B1/pl not_active IP Right Cessation
- 1998-11-24 MY MYPI98005330A patent/MY140887A/en unknown
-
1999
- 1999-01-10 SA SA99190972A patent/SA99190972B1/ar unknown
-
2000
- 2000-05-24 NO NO20002659A patent/NO322022B1/no not_active IP Right Cessation
-
2001
- 2001-03-16 HK HK01101899A patent/HK1031726A1/xx not_active IP Right Cessation
-
2002
- 2002-10-29 JP JP2002315015A patent/JP2003128670A/ja not_active Withdrawn
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08H | Application fees: decision cancelled [chapter 8.8 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1771 DE 20041214 POR TER SIDO APRESENTADA PAPELETA DE ESCLARECIMENTO. |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |