BR0011863A - Conjugados de fitosterol ou fitostanol com ácido ascórbico e uso destes no tratamento ou prevenção de doença cardiovascular - Google Patents

Conjugados de fitosterol ou fitostanol com ácido ascórbico e uso destes no tratamento ou prevenção de doença cardiovascular

Info

Publication number
BR0011863A
BR0011863A BR0011863-0A BR0011863A BR0011863A BR 0011863 A BR0011863 A BR 0011863A BR 0011863 A BR0011863 A BR 0011863A BR 0011863 A BR0011863 A BR 0011863A
Authority
BR
Brazil
Prior art keywords
phytosterol
phytostanol
ascorbic acid
cardiovascular disease
conjugates
Prior art date
Application number
BR0011863-0A
Other languages
English (en)
Inventor
James P Kutney
Yangbing Ding
Honming Chen
Duanjie Hou
Radka K Milanova
Original Assignee
Forbes Medi Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forbes Medi Tech Inc filed Critical Forbes Medi Tech Inc
Publication of BR0011863A publication Critical patent/BR0011863A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"CONJUGADOS DE FITOSTEROL OU FITOSTANOL COM áCIDO ASCóRBICO E USO DESTES NO TRATAMENTO OU PREVENçãO DE DOENçA CARDIOVASCULAR". A presente invenção refere-se a novos derivados de fitosterol e/ou fitostanol, incluindo sais destes, os quais são representados pelas fórmulas: (I), (II), (III), em que R é uma metade fitosterol ou fitostanol, R~ 2~ é derivado de ácido ascórbico e R~ 3~ é hidrogênio ou qualquer metal, metal alcalino terroso ou metal alcalino. Esses derivados são eficazes no tratamento e prevenção de doença cardiovascular e suas condições latentes, incluindo aterosclerose e hiperlipidemia.
BR0011863-0A 1999-06-23 2000-06-20 Conjugados de fitosterol ou fitostanol com ácido ascórbico e uso destes no tratamento ou prevenção de doença cardiovascular BR0011863A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33990399A 1999-06-23 1999-06-23
PCT/CA2000/000730 WO2001000653A1 (en) 1999-06-23 2000-06-20 Conjugates of phytosterol or phytostanol with ascorbic acid and use thereof in treating or preventing cardiovascular disease

Publications (1)

Publication Number Publication Date
BR0011863A true BR0011863A (pt) 2003-10-14

Family

ID=23331117

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011863-0A BR0011863A (pt) 1999-06-23 2000-06-20 Conjugados de fitosterol ou fitostanol com ácido ascórbico e uso destes no tratamento ou prevenção de doença cardiovascular

Country Status (20)

Country Link
US (1) US20020156051A1 (pt)
EP (2) EP1189924B1 (pt)
JP (1) JP2003522124A (pt)
KR (1) KR100711861B1 (pt)
CN (1) CN1237071C (pt)
AT (1) ATE273992T1 (pt)
AU (1) AU5383700A (pt)
BR (1) BR0011863A (pt)
CA (1) CA2377492A1 (pt)
DE (1) DE60013130T2 (pt)
DK (1) DK1189924T3 (pt)
ES (1) ES2226856T3 (pt)
HK (1) HK1049342B (pt)
NO (1) NO323774B1 (pt)
NZ (1) NZ516349A (pt)
PT (1) PT1189924E (pt)
RU (1) RU2002101483A (pt)
SI (1) SI1189924T1 (pt)
WO (1) WO2001000653A1 (pt)
ZA (1) ZA200110483B (pt)

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KR20020026053A (ko) * 2000-09-30 2002-04-06 노승권 음료용 식물성 스테롤의 분산방법 및 이를 함유하는 음료
DE60125220T2 (de) * 2000-10-25 2007-04-12 Forbes Medi-Tech Inc., Vancouver Verbindungen,die ein phytosterol- und/oder ein phytostanolteil und ascorbinsäure enthalten und deren verwendung als gewichtsregulatoren
KR100396211B1 (ko) * 2000-10-31 2003-09-17 (주)유진사이언스 천연물로 구성된 수용성 식물성 스테롤 유도체 및 이의염과 이들의 제조방법
WO2003009854A1 (en) * 2001-07-20 2003-02-06 Lonza Ag Lipid lowering composition comprising carnitine and phytosterol
CN1558766A (zh) * 2001-09-26 2004-12-29 福布斯梅迪泰克公司 降低体内胆固醇酯转移蛋白介导的胆固醇酯在高密度脂蛋白(hdl)和低密度脂蛋白(ldl)之间转移的方法
WO2003063605A1 (en) * 2002-02-01 2003-08-07 Eugene Science Inc. Chewing gum composition containing plant sterol for decrease of flood cholesterol levels and prevention of periodontal disease
CA2478931A1 (en) * 2002-03-14 2003-09-18 Tatjana Lukic A method of treating diabetes mellitus including conditions associated with diabetes mellitus and complications of diabetes mellitus
EP1653814A4 (en) * 2002-03-20 2009-03-04 Eugene Science Inc PLANT STARCH NUTRITIONAL AGENT AND METHOD FOR THE PRODUCTION THEREOF
US20050118203A1 (en) * 2002-03-20 2005-06-02 Won-Tae Yoon Mixing powder of plant sterol and emulsifier, and method for preparing the same
US20030232797A1 (en) * 2002-06-06 2003-12-18 Forbes Medi-Tech Inc. Novel derivatives of androstane and androstene with ascorbic acid and use thereof in treating or preventing various conditions, diseases, and disorders
AU2003241478A1 (en) * 2002-06-10 2003-12-22 Elan Pharma International, Ltd. Nanoparticulate sterol formulations and sterol combinations
US7306819B2 (en) 2002-06-12 2007-12-11 The Coca-Cola Company Beverages containing plant sterols
SI1549159T1 (sl) 2002-06-12 2009-04-30 Coca Cola Co Napitki, ki vsebujejo rastlinske sterole
US20040001874A1 (en) * 2002-06-24 2004-01-01 Vital Living, Inc. Safe and effective nutritional supplement formulations and associated regimens adapted to prevent and/or treat targeted diseases or medical or health conditions, and related methods
KR20050084572A (ko) * 2002-09-25 2005-08-26 포비스 메디-테크 인코포레이티드 스테롤 및/또는 스탄올 및 특정한 종류의 항염증제를포함하는 유도체, 및 심혈관 질환을 치료 또는 예방하는이들의 용도
CN100352889C (zh) * 2002-11-22 2007-12-05 日本水产株式会社 高氧化稳定性的含有双键有机物的组合物
KR20060052792A (ko) * 2003-07-09 2006-05-19 포비스 메디-테크 인코포레이티드 신규 화합물 및 스테롤 및/또는 스탄올 및 콜레스테롤생합성 억제제를 포함하는 조성물 및 다양한 질병 및증상을 치료 또는 예방하기 위한 이들의 용도
WO2005042692A2 (en) * 2003-10-31 2005-05-12 Forbes Medi-Tech Inc. A method of inhibiting the expression of genes which mediate cellular cholesterol influx in animal cells and inhibiting the production of proteins resulting from the expression of such genes using cholesterol absorption inhibitors
GB0329667D0 (en) * 2003-12-22 2004-01-28 King S College London Core 2 GlcNAc-T inhibitor
GB0513881D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors III
US20080182801A1 (en) * 2003-12-22 2008-07-31 Btg International Limited Core 2 glcnac-t inhibitors
PT1732605T (pt) * 2004-03-29 2019-07-12 Wyeth Llc Suplementos nutricionais multivitamínicos e minerais
US20050234025A1 (en) * 2004-04-20 2005-10-20 Forbes Medi-Tech Inc. Compositions comprising one or more policosanols and/or policosanoic acids combined with sterol and/or steroid based ascorbic acid derivatives, and uses thereof
WO2006063219A2 (en) * 2004-12-09 2006-06-15 Pro-Health, Inc. Product and method for oral administration of nutraceuticals
GB0512726D0 (en) * 2005-06-22 2005-07-27 Btg Int Ltd Multiple sclerosis therapy and diagnosis
GB0513883D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Diagnosis of Atherosclerosis
GB0513888D0 (en) 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors II
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Also Published As

Publication number Publication date
CN1370180A (zh) 2002-09-18
ATE273992T1 (de) 2004-09-15
HK1049342A1 (en) 2003-05-09
PT1189924E (pt) 2004-12-31
ZA200110483B (en) 2003-06-20
EP1420026A3 (en) 2004-12-15
EP1189924B1 (en) 2004-08-18
CA2377492A1 (en) 2001-01-04
DK1189924T3 (da) 2004-12-20
NO20016294D0 (no) 2001-12-20
SI1189924T1 (en) 2005-02-28
EP1420026A2 (en) 2004-05-19
US20020156051A1 (en) 2002-10-24
KR20020028907A (ko) 2002-04-17
KR100711861B1 (ko) 2007-04-25
NO323774B1 (no) 2007-07-02
NZ516349A (en) 2004-03-26
DE60013130T2 (de) 2005-01-05
CN1237071C (zh) 2006-01-18
NO20016294L (no) 2002-02-22
RU2002101483A (ru) 2003-09-20
WO2001000653A1 (en) 2001-01-04
EP1189924A1 (en) 2002-03-27
ES2226856T3 (es) 2005-04-01
AU5383700A (en) 2001-01-31
HK1049342B (zh) 2006-04-07
DE60013130D1 (de) 2004-09-23
JP2003522124A (ja) 2003-07-22

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 9A. E 10A. ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2077 DE 26/10/2010.