CY1106134T1 - Συνθεση πepιεχουσα εναν ανταγωνιστη υποδοχεα αγγειοτενσινης ιι και ενα διουρητικο και η χρηση της για την θepαπεια της υπερτασης - Google Patents

Συνθεση πepιεχουσα εναν ανταγωνιστη υποδοχεα αγγειοτενσινης ιι και ενα διουρητικο και η χρηση της για την θepαπεια της υπερτασης

Info

Publication number
CY1106134T1
CY1106134T1 CY20061101069T CY061101069T CY1106134T1 CY 1106134 T1 CY1106134 T1 CY 1106134T1 CY 20061101069 T CY20061101069 T CY 20061101069T CY 061101069 T CY061101069 T CY 061101069T CY 1106134 T1 CY1106134 T1 CY 1106134T1
Authority
CY
Cyprus
Prior art keywords
angiotensin
hypertension
treatment
receptor antagonist
diuretic
Prior art date
Application number
CY20061101069T
Other languages
English (en)
Inventor
Toshio Sada
Makoto Mizuno
Original Assignee
Sankyo Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26604360&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1106134(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sankyo Company Limited filed Critical Sankyo Company Limited
Publication of CY1106134T1 publication Critical patent/CY1106134T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Μια φαρμακευτική σύνθεση περιέχουσα ένα ανταγωνιστή υποδοχέα αγγειοτενσίνης II επιλεγμένο από την ομάδα αποτελούμενη από μία ένωση η οποία έχει ένα γενικό τύπο (I) φαρμακολογικά αποδεκτά άλατα της, φαρμακολογικά αποδεκτούς εστέρες της και φαρμακολογικά αποδεκτά άλατα των έν λόγω εστέρων της, και ένα ή περισσότερα διουρητικά(Επιδράσεις). Η φαρμακευτική σύνθεση της παρούσας εφεύρεσης έχει μία εξαίρετη υποτασική επίδραση και χαμηλή τοξικότητα και επομένως είναι χρήσιμη σαν ένα φάρμακο για τη πρόληψη ή τη θεραπεία της υπέρτασης ή καρδιακών παθήσεων.
CY20061101069T 2000-11-21 2006-07-31 Συνθεση πepιεχουσα εναν ανταγωνιστη υποδοχεα αγγειοτενσινης ιι και ενα διουρητικο και η χρηση της για την θepαπεια της υπερτασης CY1106134T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000354327 2000-11-21
JP2001164009 2001-05-31
PCT/JP2001/010095 WO2002041890A1 (fr) 2000-11-21 2001-11-19 Compositions medicinales

Publications (1)

Publication Number Publication Date
CY1106134T1 true CY1106134T1 (el) 2011-06-08

Family

ID=26604360

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061101069T CY1106134T1 (el) 2000-11-21 2006-07-31 Συνθεση πepιεχουσα εναν ανταγωνιστη υποδοχεα αγγειοτενσινης ιι και ενα διουρητικο και η χρηση της για την θepαπεια της υπερτασης

Country Status (24)

Country Link
US (2) US6878703B2 (el)
EP (2) EP1336407B1 (el)
KR (1) KR100656716B1 (el)
CN (1) CN1265788C (el)
AT (1) ATE324890T1 (el)
AU (2) AU1432402A (el)
BR (1) BR0115516A (el)
CA (1) CA2429260A1 (el)
CY (1) CY1106134T1 (el)
CZ (1) CZ20031367A3 (el)
DE (1) DE60119368T2 (el)
DK (1) DK1336407T3 (el)
ES (1) ES2262689T3 (el)
HK (1) HK1054692A1 (el)
HU (1) HUP0400553A3 (el)
IL (2) IL155965A0 (el)
MX (1) MXPA03004463A (el)
NO (1) NO332938B1 (el)
NZ (1) NZ525913A (el)
PL (1) PL207252B1 (el)
PT (1) PT1336407E (el)
SK (1) SK5992003A3 (el)
TW (1) TWI262076B (el)
WO (1) WO2002041890A1 (el)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3045174A1 (en) * 2003-01-31 2016-07-20 Daiichi Sankyo Company, Limited Medicine for prevention of and treatment for arteriosclerosis and hypertension
US20040198789A1 (en) * 2003-02-28 2004-10-07 Recordati Ireland Limited Lercanidipine/ARB/diuretic therapeutic combinations
AU2004270162B2 (en) 2003-08-28 2010-05-13 Nicox S.A. Nitrosated ad nitrosylated diuretic compouds, compositions and methods of use
US20070054948A1 (en) * 2004-09-02 2007-03-08 Lilach Hedvati Purification of olmesartan medoxomil
CN1976926A (zh) * 2004-09-02 2007-06-06 特瓦制药工业有限公司 奥美沙坦酯的制备
KR100953878B1 (ko) * 2004-09-02 2010-04-22 테바 파마슈티컬 인더스트리즈 리미티드 올메살탄 메독소밀의 정제
CA2597460A1 (en) 2005-02-24 2006-08-31 Nitromed, Inc. Nitric oxide enhancing diuretic compounds, compositions and methods of use
WO2006123765A1 (ja) * 2005-05-20 2006-11-23 Daiichi Sankyo Company, Limited フィルムコーティング製剤
TWI367756B (en) * 2005-05-20 2012-07-11 Sankyo Co A film-coated drug product comprising dextrose
WO2007047838A2 (en) * 2005-10-20 2007-04-26 Dr. Reddy's Laboratories Ltd. Process for preparing olmesartan medoxomil
US8077769B2 (en) * 2006-03-28 2011-12-13 Sony Corporation Method of reducing computations in transform and scaling processes in a digital video encoder using a threshold-based approach
EP1891952B1 (en) * 2006-05-04 2011-10-05 LEK Pharmaceuticals d.d. Pharmaceutical composition of olmesartan medoxomil
US20100143470A1 (en) * 2006-10-30 2010-06-10 Hanall Pharmaceutical Company, Ltd Controlled release pharmaceutical composition containing thiazides and angiotensin-ii-receptor blockers
EP2253318B1 (en) 2008-03-13 2014-08-06 Daiichi Sankyo Company, Limited Improvement of dissolvability of preparation containing olmesartan medoxomil
US20100008956A1 (en) * 2008-07-08 2010-01-14 Jie Du Composition and combinations of carboxylic acid losartan in dosage forms
DE102008059206A1 (de) 2008-11-27 2010-06-10 Bayer Schering Pharma Aktiengesellschaft Pharmazeutische Darreichungsform enthaltend Nifedipin oder Nisoldipin und einen Angiotensin-II Antagonisten und/oder ein Diuretikum
WO2010075347A2 (en) 2008-12-23 2010-07-01 Takeda Pharmaceutical Company Limited Methods of treating hypertension with at least one angiotensin ii receptor blocker and chlorthalidone
IT1400311B1 (it) 2010-05-10 2013-05-24 Menarini Int Operations Lu Sa Associazione di inibitori della xantina ossidasi e antagonisti del recettore dell'angiotensina ii e loro uso.
EP3807898A1 (en) 2018-06-14 2021-04-21 AstraZeneca UK Limited Methods for treatment of hypertension with an angiotensin ii receptor blocker pharmaceutical composition

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3254076A (en) 1966-05-31 Sulfamyl hydro
US3009911A (en) 1961-11-21 Derivatives of j
US2783241A (en) 1957-02-26 S-acylimino-x-substituted-az-i
US3025292A (en) * 1962-03-13 Reduction of i
US2976289A (en) 1961-03-21 X-tetrahydro -
US3108097A (en) * 1963-10-22 Ehnojs
US2554816A (en) 1950-04-04 1951-05-29 American Cyanamid Co Heterocyclic sulfonamides and methods of preparation thereof
GB795174A (en) 1954-10-13 1958-05-21 Upjohn Co Heterocyclic sulphonamides
US2835702A (en) 1956-05-02 1958-05-20 Merck & Co Inc Benzene 1, 3 disulfonamides possessing diuretic properties
US2980679A (en) 1957-04-04 1961-04-18 Omikron Gagliardi Societa Di F Process for preparing heterocyclic sulfonamides
US3055904A (en) 1957-11-04 1962-09-25 Geigy Chem Corp New isoindoline derivatives
GB851287A (en) 1958-07-10 1960-10-12 British Drug Houses Ltd 5-chlorotoluene-2:4-disulphonamide and alkali metal salts thereof
US3058882A (en) * 1959-12-28 1962-10-16 Hoechst Ag N'-substituted-3-carboxy-6-halo-sulfanilamide and derivatives thereof
US3255241A (en) 1961-01-19 1966-06-07 Merck & Co Inc (2-alkylidene acyl)phenoxy-and (2-alkylidene acyl)phenylmercaptocarboxylic acids
GB979994A (en) * 1961-07-28 1965-01-06 May & Baker Ltd Isoindolinone derivatives
US3265573A (en) 1962-07-27 1966-08-09 Squibb & Sons Inc Benzothiadiazinesulfonamide-1, 1-dioxide composition
BE639386A (el) * 1962-10-30
DE1278443C2 (de) 1963-11-30 1975-07-24 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 2,4-disulfonamid-1-chlorbenzolen
US3163645A (en) 1964-09-25 1964-12-29 Ciba Geigy Corp Derivatives of 3, 4-dihydro-2-h-[1, 2, 4]-benzothiadiazine-1, 1-dioxides
DE1270544B (de) * 1965-06-19 1968-06-20 Beiersdorf Ag 4-Chlor-5-sulfamylsalicylsaeure-(2', 6'-dimethyl)-anilid und dessen Alkali- oder Ammonium-Salze sowie Verfahren zu deren Herstellung
US3360518A (en) * 1966-01-03 1967-12-26 Wallace & Tiernan Inc Tetrahydro-halo-sulfamyl quinazolinones
US3634583A (en) * 1969-07-24 1972-01-11 Leo Pharm Prod Ltd Pharmaceutical composition for the treatment of oedematous conditions and hypertension
BE757001A (fr) 1969-10-10 1971-03-16 Cerpha Derives heterocycliques d'acides phenoxy acetique et leur preparation
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
EP0733366B1 (en) * 1988-01-07 1998-04-01 E.I. Du Pont De Nemours And Company Pharmaceutical compositions comprising angiotensin II receptor blocking imidazoles and diuretics
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
EP0400835A1 (en) * 1989-05-15 1990-12-05 Merck & Co. Inc. Substituted benzimidazoles as angiotensin II antagonists
US5656650A (en) * 1990-12-14 1997-08-12 Smithkline Beecham Corp. Angiotensin II receptor blocking compositions
FI112942B3 (fi) * 1991-02-21 2012-03-13 Daiichi Sankyo Co Ltd Menetelmä kohonneen verenpaineen hoitoon ja ennaltaehkäisyyn käyttökelpoisten 4'-(1H-imidatsol-1-yylimetyyli)-1,1' -bifenyylijohdannaisten valmistamiseksi
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
US5310928A (en) * 1991-11-18 1994-05-10 E. I. Du Pont De Nemours And Company Process for preparing biphenyltetrazole compounds
US5264447A (en) * 1992-09-01 1993-11-23 Merck & Co., Inc. Angiotensin II antagonist

Also Published As

Publication number Publication date
AU1432402A (en) 2002-06-03
HUP0400553A3 (en) 2010-03-29
IL155965A0 (en) 2003-12-23
NO20032261L (no) 2003-07-09
EP1595540A1 (en) 2005-11-16
WO2002041890A1 (fr) 2002-05-30
TWI262076B (en) 2006-09-21
US20050113367A1 (en) 2005-05-26
IL155965A (en) 2008-08-07
DE60119368D1 (de) 2006-06-08
SK5992003A3 (en) 2003-11-04
EP1336407A1 (en) 2003-08-20
PL361093A1 (en) 2004-09-20
CN1265788C (zh) 2006-07-26
US20040002529A1 (en) 2004-01-01
HUP0400553A2 (hu) 2004-06-28
EP1336407A4 (en) 2004-07-14
KR20030096235A (ko) 2003-12-24
KR100656716B1 (ko) 2006-12-13
CZ20031367A3 (cs) 2003-10-15
NZ525913A (en) 2004-05-28
ES2262689T3 (es) 2006-12-01
AU2002214324B2 (en) 2004-07-29
ATE324890T1 (de) 2006-06-15
MXPA03004463A (es) 2003-08-19
EP1336407B1 (en) 2006-05-03
HK1054692A1 (en) 2003-12-12
US6878703B2 (en) 2005-04-12
NO20032261D0 (no) 2003-05-20
DK1336407T3 (da) 2006-09-04
DE60119368T2 (de) 2007-05-03
PL207252B1 (pl) 2010-11-30
CN1486182A (zh) 2004-03-31
NO332938B1 (no) 2013-02-04
CA2429260A1 (en) 2002-05-30
BR0115516A (pt) 2004-02-03
PT1336407E (pt) 2006-07-31

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