ATE326451T1 - Chinazolin derivate und therapeutische verwendungen davon - Google Patents
Chinazolin derivate und therapeutische verwendungen davonInfo
- Publication number
- ATE326451T1 ATE326451T1 AT99938565T AT99938565T ATE326451T1 AT E326451 T1 ATE326451 T1 AT E326451T1 AT 99938565 T AT99938565 T AT 99938565T AT 99938565 T AT99938565 T AT 99938565T AT E326451 T1 ATE326451 T1 AT E326451T1
- Authority
- AT
- Austria
- Prior art keywords
- therapeutic uses
- quinazoline derivatives
- chymase
- quianazoline
- exacerbation
- Prior art date
Links
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical class N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 102000003858 Chymases Human genes 0.000 abstract 2
- 108090000227 Chymases Proteins 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 230000005713 exacerbation Effects 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000008728 vascular permeability Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/60—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23563398 | 1998-08-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE326451T1 true ATE326451T1 (de) | 2006-06-15 |
Family
ID=16988920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99938565T ATE326451T1 (de) | 1998-08-21 | 1999-08-20 | Chinazolin derivate und therapeutische verwendungen davon |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6867214B1 (de) |
| EP (1) | EP1114035B1 (de) |
| JP (1) | JP2002523404A (de) |
| KR (1) | KR20010089168A (de) |
| CN (1) | CN1216872C (de) |
| AT (1) | ATE326451T1 (de) |
| AU (1) | AU772771B2 (de) |
| CA (1) | CA2341357A1 (de) |
| DE (1) | DE69931378T2 (de) |
| ES (1) | ES2259476T3 (de) |
| HU (1) | HUP0103387A3 (de) |
| WO (1) | WO2000010982A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU784467B2 (en) | 1999-11-01 | 2006-04-06 | Daiichi Asubio Pharma Co., Ltd. | Inhibitors against vascular lipid deposition containing chymase-inhibiting substances |
| HUP0201287A3 (en) * | 2000-02-22 | 2003-02-28 | Daiichi Asubio Pharma Co Ltd | Preventive or therapeutic drugs for various eosinphilia-related diseases containing quinazoline derivative chymase inhibitors as the active ingredient |
| CA2368382A1 (en) * | 2000-02-22 | 2001-08-30 | Suntory Limited | Medicament for prevention and treatment of dermatitis having chymase inhibitor as effective ingredient |
| EP1192949A4 (de) * | 2000-02-22 | 2005-11-09 | Daiichi Suntory Pharma Co Ltd | Azneimittel mit chymaseinhibitoren als wirksames mittel, zur vorbeugung oder behandlung von fibrosis |
| US7071220B2 (en) | 2000-09-18 | 2006-07-04 | Toa Eiyo Ltd. | N-substituted benzothiophenesulfonamide derivatives |
| AU2001288053A1 (en) * | 2000-09-18 | 2002-03-26 | Toa Eiyo Ltd. | N-substituted benzothiophenesulfonamide derivatives |
| JPWO2005000825A1 (ja) * | 2003-06-27 | 2006-08-03 | 住友製薬株式会社 | チアゾールイミン類およびオキサゾールイミン類 |
| US7423155B2 (en) | 2003-11-14 | 2008-09-09 | 3M Innovative Properties Company | N-sulfonyldicarboximide containing tethering compounds |
| US7544756B2 (en) | 2005-09-30 | 2009-06-09 | 3M Innovative Properties Company | Crosslinked polymers with amine binding groups |
| BRPI0712721A2 (pt) * | 2006-05-31 | 2012-11-20 | Asubio Pharma Co Ltd | composto de anel de 7 membros e mÉtodo de produÇço e aplicaÇço farmacÊutica do mesmo |
| US9371307B2 (en) | 2011-09-12 | 2016-06-21 | The Johns Hopkins University | Serine protease inhibitors |
| US11840543B2 (en) | 2017-05-24 | 2023-12-12 | The University Of Queensland | Compounds and uses |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE913473A1 (en) | 1990-10-15 | 1992-04-22 | Fujisawa Pharmaceutical Co | Quinazoline derivatives and their preparation |
| JP2982454B2 (ja) * | 1991-12-20 | 1999-11-22 | 王子製紙株式会社 | 感熱記録体 |
| WO1996004248A1 (en) * | 1994-07-29 | 1996-02-15 | Suntory Limited | Imidazolidine derivative and use thereof |
| EP0795548B1 (de) | 1995-09-28 | 2002-07-03 | Suntory Limited | Chinazozin derivate und deren verwendung |
| JP4073489B2 (ja) * | 1996-05-24 | 2008-04-09 | ニューロサーチ・アクティーゼルスカブ | 酸性基を有するフエニル誘導体、その製造方法及びそれをクロライドチャンネル遮断剤として使用する方法 |
-
1999
- 1999-08-20 ES ES99938565T patent/ES2259476T3/es not_active Expired - Lifetime
- 1999-08-20 US US09/763,213 patent/US6867214B1/en not_active Expired - Fee Related
- 1999-08-20 AU AU53037/99A patent/AU772771B2/en not_active Ceased
- 1999-08-20 CN CN998111910A patent/CN1216872C/zh not_active Expired - Fee Related
- 1999-08-20 CA CA002341357A patent/CA2341357A1/en not_active Abandoned
- 1999-08-20 EP EP99938565A patent/EP1114035B1/de not_active Expired - Lifetime
- 1999-08-20 DE DE69931378T patent/DE69931378T2/de not_active Expired - Lifetime
- 1999-08-20 JP JP2000566256A patent/JP2002523404A/ja active Pending
- 1999-08-20 KR KR1020017002168A patent/KR20010089168A/ko not_active Ceased
- 1999-08-20 AT AT99938565T patent/ATE326451T1/de not_active IP Right Cessation
- 1999-08-20 WO PCT/JP1999/004503 patent/WO2000010982A1/en not_active Ceased
- 1999-08-20 HU HU0103387A patent/HUP0103387A3/hu unknown
-
2005
- 2005-03-08 US US11/073,654 patent/US7169951B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2259476T3 (es) | 2006-10-01 |
| KR20010089168A (ko) | 2001-09-29 |
| HUP0103387A2 (hu) | 2002-04-29 |
| AU5303799A (en) | 2000-03-14 |
| HUP0103387A3 (en) | 2002-07-29 |
| US6867214B1 (en) | 2005-03-15 |
| CN1216872C (zh) | 2005-08-31 |
| CN1319096A (zh) | 2001-10-24 |
| US7169951B2 (en) | 2007-01-30 |
| JP2002523404A (ja) | 2002-07-30 |
| CA2341357A1 (en) | 2000-03-02 |
| DE69931378T2 (de) | 2006-11-02 |
| DE69931378D1 (de) | 2006-06-22 |
| US20050148608A1 (en) | 2005-07-07 |
| AU772771B2 (en) | 2004-05-06 |
| EP1114035A1 (de) | 2001-07-11 |
| WO2000010982A1 (en) | 2000-03-02 |
| EP1114035B1 (de) | 2006-05-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |