BRPI0407591A - inibidores de transcriptase reversa de não-nucleosìdeo - Google Patents

inibidores de transcriptase reversa de não-nucleosìdeo

Info

Publication number
BRPI0407591A
BRPI0407591A BRPI0407591-9A BRPI0407591A BRPI0407591A BR PI0407591 A BRPI0407591 A BR PI0407591A BR PI0407591 A BRPI0407591 A BR PI0407591A BR PI0407591 A BRPI0407591 A BR PI0407591A
Authority
BR
Brazil
Prior art keywords
reverse transcriptase
formula
transcriptase inhibitors
nucleoside reverse
hiv
Prior art date
Application number
BRPI0407591-9A
Other languages
English (en)
Inventor
James Patrick Dunn
Taraneh Mirzadegan
Steven Swallow
Joan Heather Hogg
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0407591A publication Critical patent/BRPI0407591A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"INIBIDORES DE TRANSCRIPTASE REVERSA DE NãO-NUCLEOSìDEO". A presente invenção refere-se aos novos derivados de pirazol da fórmula (I) em que R¬ 1¬ a R¬ 4¬ são como definidos no sumário e sais farmaceuticamente aceitáveis e solvatos dos mesmos, métodos para inibir ou modular transcriptase reversa de Vírus da lmunodeficiência Humana (HIV) com os compostos da fórmula (I) e composições farmacêuticas da fórmula (I) misturadas com pelo menos um solvente, veículo ou excipiente. Os compostos são úteis para tratar distúrbios em que HIV e vírus geneticamente relacionado estão implicados (fórmula I).
BRPI0407591-9A 2003-02-18 2004-02-17 inibidores de transcriptase reversa de não-nucleosìdeo BRPI0407591A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44797403P 2003-02-18 2003-02-18
PCT/EP2004/001477 WO2004074257A1 (en) 2003-02-18 2004-02-17 Non-nucleoside reverse transcriptase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0407591A true BRPI0407591A (pt) 2006-02-14

Family

ID=32908518

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0407591-9A BRPI0407591A (pt) 2003-02-18 2004-02-17 inibidores de transcriptase reversa de não-nucleosìdeo

Country Status (17)

Country Link
US (1) US7241794B2 (pt)
EP (1) EP1597235B1 (pt)
JP (1) JP4608480B2 (pt)
KR (1) KR100776093B1 (pt)
CN (1) CN100389109C (pt)
AR (1) AR043195A1 (pt)
AT (1) ATE370124T1 (pt)
BR (1) BRPI0407591A (pt)
CA (1) CA2515151C (pt)
CL (1) CL2004000270A1 (pt)
DE (1) DE602004008227T2 (pt)
ES (1) ES2291854T3 (pt)
MX (1) MXPA05008748A (pt)
PL (1) PL378556A1 (pt)
RU (1) RU2305680C2 (pt)
TW (1) TW200423930A (pt)
WO (1) WO2004074257A1 (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1622876A1 (en) * 2003-05-07 2006-02-08 Pfizer Products Inc. Cannabinoid receptor ligands and uses thereof
EP1798226A4 (en) 2004-08-04 2009-06-17 Taisho Pharmaceutical Co Ltd TRAIZOL DERIVATIVE
UA87884C2 (uk) * 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
RU2409570C2 (ru) 2006-02-03 2011-01-20 Тайсо Фармасьютикал Ко., Лтд. Производные триазола
EP1988081B1 (en) 2006-02-06 2012-10-17 Taisho Pharmaceutical Co., Ltd Binding inhibitor of sphingosine-1-phosphate
RU2451677C2 (ru) * 2006-02-14 2012-05-27 Ихара Кемикал Индастри Ко., Лтд. Способ получения соединения 5-алкокси-4-гидроксиметилпиразола
CL2007002105A1 (es) * 2006-07-21 2008-02-22 Hoffmann La Roche Compuestos derivados de 2-[3-(3-cianofenoxi)(fenoxi o fenilsulfanil)]-n-fenil acetamida, inhibidores de la transcriptasa inversa del vih; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar u
DK2057125T3 (da) * 2006-08-16 2011-05-16 Hoffmann La Roche Ikke-nucleosid revers transkriptase-inhibitorer
EP2142520A1 (en) 2007-03-29 2010-01-13 F. Hoffmann-Roche AG Non-nucleoside reverse transcriptase inhibitors
PL2177512T3 (pl) 2007-08-01 2012-09-28 Taisho Pharmaceutical Co Ltd Inhibitor wiązania S1P1
RU2495878C2 (ru) * 2007-12-21 2013-10-20 Ф.Хоффманн-Ля Рош Аг Гетероциклические антивирусные соединения
DE102008015033A1 (de) * 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung
CN102971308B (zh) 2010-03-30 2015-02-04 默克加拿大有限公司 非核苷类逆转录酶抑制剂
ES2565193T3 (es) 2010-07-15 2016-04-01 Sumitomo Dainippon Pharma Co., Ltd. Compuesto de pirazol
EP2508511A1 (en) 2011-04-07 2012-10-10 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses
WO2013134562A1 (en) 2012-03-09 2013-09-12 Inception 2, Inc. Triazolone compounds and uses thereof
BR112014031896A2 (pt) 2012-06-20 2017-06-27 Univ Vanderbilt composto, composição farmacêutica, e, método para o tratamento de um distúrbio
MX2014014911A (es) 2012-06-20 2015-05-15 Univ Vanderbilt Análogos de alcoxi pirazol bicíclico sustituido como moduladores alostéricos de receptores de mglur5.
JO3470B1 (ar) 2012-10-08 2020-07-05 Merck Sharp & Dohme مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv
CA2894281C (en) 2012-12-20 2021-04-20 Inception 2, Inc. Triazolone compounds and uses thereof
EP3041826A4 (en) 2013-09-06 2017-02-15 Inception 2, Inc. Triazolone compounds and uses thereof
RU2693622C2 (ru) 2014-04-01 2019-07-03 Мерк Шарп И Доум Корп. Пролекарственные средства ингибиторов обратной транскриптазы вич
MX2017003518A (es) 2014-09-17 2017-07-28 Ironwood Pharmaceuticals Inc Estimuladores de guanilato ciclasa soluble (sgc).
US20170298055A1 (en) 2014-09-17 2017-10-19 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
JP2018510155A (ja) * 2015-03-19 2018-04-12 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ 殺菌・殺カビ性ピラゾール
EP3478665A1 (en) * 2016-06-29 2019-05-08 Esteve Pharmaceuticals, S.A. Pyrazole derivatives having activity against pain
CN110818636A (zh) * 2019-11-29 2020-02-21 河北科技大学 一种化合物或其盐及其应用和合成方法
CN115677585B (zh) * 2022-10-31 2024-03-19 上海群力化工有限公司 一种甲醛吡唑衍生物的合成工艺

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100387157B1 (ko) 1994-09-26 2003-09-29 시오노기세이야쿠가부시키가이샤 이미다졸유도체
DE19734664A1 (de) * 1997-08-11 1999-02-18 Bayer Ag (Hetero)Aryloxypyrazole
GB0016787D0 (en) * 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy
US20030008841A1 (en) * 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
GB0024795D0 (en) * 2000-10-10 2000-11-22 Hoffmann La Roche Pyrazole derivatives for the treatment of viral diseases
GB0028484D0 (en) * 2000-11-22 2001-01-10 Hoffmann La Roche Imidazolone derivatives for the treatment of viral diseases
AU2002242926B2 (en) * 2001-04-10 2007-10-11 Pfizer Inc. Pyrazole derivatives for treating HIV
GB0113524D0 (en) * 2001-06-04 2001-07-25 Hoffmann La Roche Pyrazole derivatives

Also Published As

Publication number Publication date
US20040192666A1 (en) 2004-09-30
RU2305680C2 (ru) 2007-09-10
US7241794B2 (en) 2007-07-10
MXPA05008748A (es) 2005-09-20
AR043195A1 (es) 2005-07-20
PL378556A1 (pl) 2006-05-02
CL2004000270A1 (es) 2005-02-04
ATE370124T1 (de) 2007-09-15
WO2004074257A1 (en) 2004-09-02
ES2291854T3 (es) 2008-03-01
CN1751028A (zh) 2006-03-22
EP1597235A1 (en) 2005-11-23
JP2006515339A (ja) 2006-05-25
CA2515151A1 (en) 2004-09-02
KR20050105471A (ko) 2005-11-04
DE602004008227T2 (de) 2008-05-15
JP4608480B2 (ja) 2011-01-12
EP1597235B1 (en) 2007-08-15
DE602004008227D1 (de) 2007-09-27
RU2005128832A (ru) 2006-04-27
AU2004213134A1 (en) 2004-09-02
CA2515151C (en) 2010-11-30
KR100776093B1 (ko) 2007-11-15
TW200423930A (en) 2004-11-16
CN100389109C (zh) 2008-05-21

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.