DE602004008227D1 - Inhibitoren dernicht-nukleosid-inhibitoren der reversen transkriptase - Google Patents

Inhibitoren dernicht-nukleosid-inhibitoren der reversen transkriptase

Info

Publication number
DE602004008227D1
DE602004008227D1 DE602004008227T DE602004008227T DE602004008227D1 DE 602004008227 D1 DE602004008227 D1 DE 602004008227D1 DE 602004008227 T DE602004008227 T DE 602004008227T DE 602004008227 T DE602004008227 T DE 602004008227T DE 602004008227 D1 DE602004008227 D1 DE 602004008227D1
Authority
DE
Germany
Prior art keywords
inhibitors
reverse transcriptase
nucleoside
nucleoside inhibitors
transcriptase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004008227T
Other languages
English (en)
Other versions
DE602004008227T2 (de
Inventor
James Patrick Dunn
Joan Heather Hogg
Taraneh Mirzadegan
Steven Swallow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE602004008227D1 publication Critical patent/DE602004008227D1/de
Application granted granted Critical
Publication of DE602004008227T2 publication Critical patent/DE602004008227T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE602004008227T 2003-02-18 2004-02-17 Inhibitoren dernicht-nukleosid-inhibitoren der reversen transkriptase Expired - Lifetime DE602004008227T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44797403P 2003-02-18 2003-02-18
US447974P 2003-02-18
PCT/EP2004/001477 WO2004074257A1 (en) 2003-02-18 2004-02-17 Non-nucleoside reverse transcriptase inhibitors

Publications (2)

Publication Number Publication Date
DE602004008227D1 true DE602004008227D1 (de) 2007-09-27
DE602004008227T2 DE602004008227T2 (de) 2008-05-15

Family

ID=32908518

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004008227T Expired - Lifetime DE602004008227T2 (de) 2003-02-18 2004-02-17 Inhibitoren dernicht-nukleosid-inhibitoren der reversen transkriptase

Country Status (17)

Country Link
US (1) US7241794B2 (de)
EP (1) EP1597235B1 (de)
JP (1) JP4608480B2 (de)
KR (1) KR100776093B1 (de)
CN (1) CN100389109C (de)
AR (1) AR043195A1 (de)
AT (1) ATE370124T1 (de)
BR (1) BRPI0407591A (de)
CA (1) CA2515151C (de)
CL (1) CL2004000270A1 (de)
DE (1) DE602004008227T2 (de)
ES (1) ES2291854T3 (de)
MX (1) MXPA05008748A (de)
PL (1) PL378556A1 (de)
RU (1) RU2305680C2 (de)
TW (1) TW200423930A (de)
WO (1) WO2004074257A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05011922A (es) * 2003-05-07 2006-02-17 Pfizer Prod Inc Ligandos del receptor de cannabinoides y sus usos.
CN1993333B (zh) 2004-08-04 2012-08-01 大正制药株式会社 三唑衍生物
UA87884C2 (uk) * 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
US8022091B2 (en) 2006-02-03 2011-09-20 Taisho Pharmaceutical Co., Ltd. Triazole derivative
EP1988081B1 (de) * 2006-02-06 2012-10-17 Taisho Pharmaceutical Co., Ltd Bindungsinhibitor von sphingosin-1-phosphat
US7812175B2 (en) * 2006-02-14 2010-10-12 Ihara Chemical Industry Co., Ltd. Process for production of 5-alkoxy-4-hydroxymethylpyrazole compound
CL2007002105A1 (es) * 2006-07-21 2008-02-22 Hoffmann La Roche Compuestos derivados de 2-[3-(3-cianofenoxi)(fenoxi o fenilsulfanil)]-n-fenil acetamida, inhibidores de la transcriptasa inversa del vih; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar u
AU2007286345B2 (en) * 2006-08-16 2012-03-08 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
JP2010522706A (ja) 2007-03-29 2010-07-08 エフ．ホフマン−ラ ロシュ アーゲー 非ヌクレオシド逆転写酵素阻害剤
WO2009017219A1 (ja) 2007-08-01 2009-02-05 Taisho Pharmaceutical Co., Ltd. Ｓ１ｐ1結合阻害物質
MX2010006397A (es) * 2007-12-21 2010-07-05 Hoffmann La Roche Compuestos heterociclicos antivirales.
DE102008015033A1 (de) * 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung
EA024804B1 (ru) * 2010-03-30 2016-10-31 Мерк Кэнэда Инк. Ненуклеозидные ингибиторы обратной транскриптазы, композиции, их содержащие, и их применение
KR101891838B1 (ko) 2010-07-15 2018-09-28 다이닛본 스미토모 세이야꾸 가부시끼가이샤 피라졸 화합물
EP2508511A1 (de) 2011-04-07 2012-10-10 Laboratoire Biodim Inhibitoren der Virenreplikation, Verfahren zu deren Herstellung und deren therapeutische Verwendung
WO2013134562A1 (en) 2012-03-09 2013-09-12 Inception 2, Inc. Triazolone compounds and uses thereof
MX2014014911A (es) 2012-06-20 2015-05-15 Univ Vanderbilt Análogos de alcoxi pirazol bicíclico sustituido como moduladores alostéricos de receptores de mglur5.
CN104736156A (zh) 2012-06-20 2015-06-24 范德比尔特大学 作为mglur5受体变构调节剂的取代的双环烷氧基吡唑类似物
JO3470B1 (ar) 2012-10-08 2020-07-05 Merck Sharp & Dohme مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv
WO2014099503A1 (en) 2012-12-20 2014-06-26 Inception 2, Inc. Triazolone compounds and uses thereof
PE20160880A1 (es) 2013-09-06 2016-09-22 Inception 2 Inc Compuestos de triazolona y usos de los mismos
EP3125894B1 (de) 2014-04-01 2020-09-09 Merck Sharp & Dohme Corp. Prodrugs von hiv-umkehrtranskriptasehemmern
WO2016044445A2 (en) 2014-09-17 2016-03-24 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
JP2017527604A (ja) 2014-09-17 2017-09-21 アイアンウッド ファーマシューティカルズ インコーポレイテッド ｓＧＣ刺激剤
CN107428694A (zh) * 2015-03-19 2017-12-01 杜邦公司 杀真菌吡唑
WO2018001973A1 (en) * 2016-06-29 2018-01-04 Laboratorios Del Dr. Esteve S.A. Pyrazole derivatives having activity against pain
CN110818636A (zh) * 2019-11-29 2020-02-21 河北科技大学 一种化合物或其盐及其应用和合成方法
CN115677585B (zh) * 2022-10-31 2024-03-19 上海群力化工有限公司 一种甲醛吡唑衍生物的合成工艺

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9509024A (pt) 1994-09-26 1997-09-30 Shionogi & Co Derivados de imidazol
DE19734664A1 (de) * 1997-08-11 1999-02-18 Bayer Ag (Hetero)Aryloxypyrazole
GB0016787D0 (en) * 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy
US20030008841A1 (en) * 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
GB0024795D0 (en) * 2000-10-10 2000-11-22 Hoffmann La Roche Pyrazole derivatives for the treatment of viral diseases
GB0028484D0 (en) * 2000-11-22 2001-01-10 Hoffmann La Roche Imidazolone derivatives for the treatment of viral diseases
CZ305099B6 (cs) * 2001-04-10 2015-05-06 Pfizer Inc. Derivát pyrazolu, způsoby a meziprodukty pro výrobu, farmaceutická kompozice s jeho obsahem a jeho lékařské aplikace, zejména k léčení infekcí HIV
GB0113524D0 (en) * 2001-06-04 2001-07-25 Hoffmann La Roche Pyrazole derivatives

Also Published As

Publication number Publication date
EP1597235B1 (de) 2007-08-15
CN1751028A (zh) 2006-03-22
JP4608480B2 (ja) 2011-01-12
PL378556A1 (pl) 2006-05-02
DE602004008227T2 (de) 2008-05-15
ATE370124T1 (de) 2007-09-15
KR100776093B1 (ko) 2007-11-15
US7241794B2 (en) 2007-07-10
ES2291854T3 (es) 2008-03-01
CA2515151A1 (en) 2004-09-02
CA2515151C (en) 2010-11-30
KR20050105471A (ko) 2005-11-04
US20040192666A1 (en) 2004-09-30
RU2305680C2 (ru) 2007-09-10
JP2006515339A (ja) 2006-05-25
CL2004000270A1 (es) 2005-02-04
BRPI0407591A (pt) 2006-02-14
CN100389109C (zh) 2008-05-21
EP1597235A1 (de) 2005-11-23
WO2004074257A1 (en) 2004-09-02
MXPA05008748A (es) 2005-09-20
TW200423930A (en) 2004-11-16
AR043195A1 (es) 2005-07-20
AU2004213134A1 (en) 2004-09-02
RU2005128832A (ru) 2006-04-27

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Legal Events

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