BRPI0513858A - compostos de benziltriazolona como inibidores não-nucleosìdeos da transcriptase reversa - Google Patents
compostos de benziltriazolona como inibidores não-nucleosìdeos da transcriptase reversaInfo
- Publication number
- BRPI0513858A BRPI0513858A BRPI0513858-2A BRPI0513858A BRPI0513858A BR PI0513858 A BRPI0513858 A BR PI0513858A BR PI0513858 A BRPI0513858 A BR PI0513858A BR PI0513858 A BRPI0513858 A BR PI0513858A
- Authority
- BR
- Brazil
- Prior art keywords
- benzyltriazolone
- compounds
- reverse transcriptase
- transcriptase inhibitors
- nucleoside reverse
- Prior art date
Links
- FBMUOYIIXNRNPN-UHFFFAOYSA-N 5-benzyltriazol-4-one Chemical class O=C1N=NN=C1CC1=CC=CC=C1 FBMUOYIIXNRNPN-UHFFFAOYSA-N 0.000 title abstract 2
- 229940042402 non-nucleoside reverse transcriptase inhibitor Drugs 0.000 title 1
- 239000002726 nonnucleoside reverse transcriptase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 102100034343 Integrase Human genes 0.000 abstract 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59131104P | 2004-07-27 | 2004-07-27 | |
US60/591,311 | 2004-07-27 | ||
PCT/EP2005/007893 WO2006010545A1 (en) | 2004-07-27 | 2005-07-20 | Benzyltriazolone compounds as non-nucleoside reverse transcriptase inhibitors |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0513858A true BRPI0513858A (pt) | 2008-05-20 |
BRPI0513858B1 BRPI0513858B1 (pt) | 2020-11-10 |
BRPI0513858B8 BRPI0513858B8 (pt) | 2021-05-25 |
Family
ID=35056908
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0513858A BRPI0513858B8 (pt) | 2004-07-27 | 2005-07-20 | compostos de benziltriazolona como inibidores não-nucleosídeos da transcriptase reversa, seu processo de preparação, seu uso e composição farmacêutica que os compreende |
Country Status (16)
Country | Link |
---|---|
US (1) | US7666891B2 (pt) |
EP (1) | EP1773790B1 (pt) |
JP (1) | JP4675959B2 (pt) |
CN (1) | CN1993332B (pt) |
AR (1) | AR050266A1 (pt) |
AU (1) | AU2005266530B2 (pt) |
BR (1) | BRPI0513858B8 (pt) |
CA (1) | CA2574308C (pt) |
ES (1) | ES2391461T3 (pt) |
IL (1) | IL180495A (pt) |
MX (1) | MX2007000788A (pt) |
NO (1) | NO338376B1 (pt) |
RU (1) | RU2394028C2 (pt) |
SG (1) | SG148179A1 (pt) |
TW (1) | TWI299334B (pt) |
WO (1) | WO2006010545A1 (pt) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR057455A1 (es) * | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
BRPI0617720A2 (pt) | 2005-10-19 | 2011-08-02 | Hoffmann La Roche | compostos inibidores de nnrt de fenil-acetamida, usos dos referidos compostos e composição farmacêutica que os contém |
CL2007002105A1 (es) * | 2006-07-21 | 2008-02-22 | Hoffmann La Roche | Compuestos derivados de 2-[3-(3-cianofenoxi)(fenoxi o fenilsulfanil)]-n-fenil acetamida, inhibidores de la transcriptasa inversa del vih; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar u |
WO2008019968A1 (en) * | 2006-08-16 | 2008-02-21 | F. Hoffmann-La Roche Ag | Non-nucleoside reverse transcriptase inhibitors |
TW200831085A (en) * | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Non-nucleoside reverse transcriptase inhibitors |
CA2682637A1 (en) * | 2007-03-29 | 2008-10-09 | F. Hoffmann-La Roche Ag | Non-nucleoside reverse transcriptase inhibitors |
BRPI0810496A2 (pt) * | 2007-04-09 | 2018-11-06 | Hoffmann La Roche | inibidores de transcriptase reversa de não-nucleosídeo |
CN101679320B (zh) * | 2007-05-30 | 2013-01-23 | 弗·哈夫曼-拉罗切有限公司 | 制备三唑酮的方法 |
EP2155692B1 (en) * | 2007-05-30 | 2015-06-17 | F. Hoffmann-La Roche AG | Non-nucleoside reverse transcriptase inhibitors |
MX2009013865A (es) * | 2007-06-22 | 2010-01-27 | Hoffmann La Roche | Urea y derivados carbamato como inhibidores no nucleosidicos de la transcriptasa inversa. |
MX2010006397A (es) | 2007-12-21 | 2010-07-05 | Hoffmann La Roche | Compuestos heterociclicos antivirales. |
US20090181068A1 (en) | 2008-01-14 | 2009-07-16 | Dunn Richard L | Low Viscosity Liquid Polymeric Delivery System |
CN101723909B (zh) * | 2008-10-29 | 2011-12-28 | 天津药物研究院 | 三唑酮类化合物、其制备方法和用途 |
CN101735023B (zh) * | 2008-11-24 | 2014-07-09 | 联化科技股份有限公司 | 一种3-溴-5-氯苯酚的制备方法 |
PT2501698T (pt) | 2009-11-18 | 2018-07-23 | Nat Res Council Canada | Monómeros fluorados, oligómeros e polímeros para utilização em dispositivos eletrónicos orgânicos |
CN102146022B (zh) * | 2010-02-05 | 2013-07-03 | 中国中化股份有限公司 | 3-氯-5-溴苯酚的制备方法 |
CN103025696B (zh) | 2010-07-15 | 2015-08-12 | 阿尔比马尔公司 | 用于制备4-溴代-2-甲氧基苯甲醛的方法 |
BR112015005997A8 (pt) * | 2012-09-26 | 2023-04-11 | Merck Sharp & Dohme | Composto |
PE20151521A1 (es) | 2012-12-20 | 2015-11-25 | Inception 2 Inc | Compuestos de triazolona y usos de los mismos |
MX2016002795A (es) | 2013-09-06 | 2016-05-26 | Inception 2 Inc | Compuestos de triazolona y usos de los mismos. |
GB2598624A (en) * | 2020-09-07 | 2022-03-09 | Lorico Aurelio | Use of triazole analogues for inhibition of a tripartite VOR protein complex in multicellular organisms |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3274185A (en) | 1963-10-08 | 1966-09-20 | S E Massengill Company | Phthalazine derivatives |
US3813384A (en) | 1972-01-17 | 1974-05-28 | Asta Werke Ag Chem Fab | Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof |
JP2593084B2 (ja) | 1986-12-19 | 1997-03-19 | メレルダウファーマスーティカルズ インコーポレーテッド | 5−アリールー3h−1,2,4−トリアゾールー3−オン類の神経変性障害の処置への用途 |
US5436252A (en) | 1986-12-19 | 1995-07-25 | Merrell Dow Pharmaceuticals Inc. | 5-aryl-3H-1,2,4-triazol-3-ones and their use in the treatment of neurodegenerative disorders |
JP2542880B2 (ja) | 1986-12-19 | 1996-10-09 | メレルダウファーマスーティカルズ インコーポレーテッド | 5−アリ―ル−3h−1,2,4,−トリアゾ―ル−3−オン類の抗痙攣剤としての用途 |
US4826990A (en) | 1987-09-30 | 1989-05-02 | American Home Products Corporation | 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents |
US5103014A (en) | 1987-09-30 | 1992-04-07 | American Home Products Corporation | Certain 3,3'-[[[(2-phenyl-4-thiazolyl)methoxy]phenyl]methylene]dithiobis-propanoic acid derivatives |
US4942236A (en) | 1987-09-30 | 1990-07-17 | American Home Products Corporation | 2-aryl substituted pyridyl-containing phenyl sulfonamido compounds as antiallergic and antiinflammatory agents |
US5331002A (en) | 1990-04-19 | 1994-07-19 | Merrell Dow Pharmaceuticals Inc. | 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enhancers |
US5922751A (en) | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
WO1997040017A2 (en) | 1996-04-19 | 1997-10-30 | Novo Nordisk A/S | Modulators of molecules with phosphotyrosine recognition units |
TW467902B (en) | 1996-07-31 | 2001-12-11 | Bristol Myers Squibb Co | Diphenyl heterocycles as potassium channel modulators |
US6367003B1 (en) * | 1998-03-04 | 2002-04-02 | Micron Technology, Inc. | Digital signal processor having enhanced utilization of multiply accumulate (MAC) stage and method |
IT1305313B1 (it) * | 1998-07-17 | 2001-05-04 | Colla Paolo | 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1. |
UA82048C2 (uk) * | 2000-11-10 | 2008-03-11 | Эли Лилли Энд Компани | Агоністи альфа-рецепторів, активованих проліфератором пероксисом |
WO2002040021A2 (en) * | 2000-11-17 | 2002-05-23 | Idenix (Cayman) Limited | Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines |
TW200505441A (en) * | 2003-03-24 | 2005-02-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitorsⅠ |
-
2005
- 2005-07-20 RU RU2007106928/04A patent/RU2394028C2/ru active
- 2005-07-20 MX MX2007000788A patent/MX2007000788A/es active IP Right Grant
- 2005-07-20 AU AU2005266530A patent/AU2005266530B2/en active Active
- 2005-07-20 ES ES05763730T patent/ES2391461T3/es active Active
- 2005-07-20 CN CN2005800255832A patent/CN1993332B/zh active Active
- 2005-07-20 WO PCT/EP2005/007893 patent/WO2006010545A1/en active Application Filing
- 2005-07-20 CA CA2574308A patent/CA2574308C/en active Active
- 2005-07-20 SG SG200808471-7A patent/SG148179A1/en unknown
- 2005-07-20 BR BRPI0513858A patent/BRPI0513858B8/pt active IP Right Grant
- 2005-07-20 EP EP05763730A patent/EP1773790B1/en active Active
- 2005-07-20 JP JP2007522983A patent/JP4675959B2/ja active Active
- 2005-07-25 AR ARP050103064A patent/AR050266A1/es not_active Application Discontinuation
- 2005-07-25 TW TW094125051A patent/TWI299334B/zh not_active IP Right Cessation
- 2005-07-27 US US11/190,478 patent/US7666891B2/en active Active
-
2007
- 2007-01-02 IL IL180495A patent/IL180495A/en active IP Right Grant
- 2007-01-15 NO NO20070258A patent/NO338376B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
AR050266A1 (es) | 2006-10-11 |
TW200616979A (en) | 2006-06-01 |
EP1773790A1 (en) | 2007-04-18 |
RU2394028C2 (ru) | 2010-07-10 |
BRPI0513858B1 (pt) | 2020-11-10 |
IL180495A0 (en) | 2007-06-03 |
CA2574308A1 (en) | 2006-02-02 |
CN1993332A (zh) | 2007-07-04 |
MX2007000788A (es) | 2007-03-23 |
BRPI0513858B8 (pt) | 2021-05-25 |
CA2574308C (en) | 2014-03-25 |
EP1773790B1 (en) | 2012-08-15 |
JP4675959B2 (ja) | 2011-04-27 |
WO2006010545A1 (en) | 2006-02-02 |
AU2005266530B2 (en) | 2012-04-12 |
IL180495A (en) | 2013-12-31 |
CN1993332B (zh) | 2011-04-06 |
JP2008508211A (ja) | 2008-03-21 |
US20060025462A1 (en) | 2006-02-02 |
NO338376B1 (no) | 2016-08-15 |
TWI299334B (en) | 2008-08-01 |
NO20070258L (no) | 2007-01-15 |
US7666891B2 (en) | 2010-02-23 |
RU2007106928A (ru) | 2008-09-10 |
SG148179A1 (en) | 2008-12-31 |
ES2391461T3 (es) | 2012-11-27 |
AU2005266530A1 (en) | 2006-02-02 |
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Legal Events
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 10/11/2020, OBSERVADAS AS CONDICOES LEGAIS. |
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B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/07/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |