HUP0100607A2 - Trombin receptor antagonisták és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Trombin receptor antagonisták és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0100607A2 HUP0100607A2 HU0100607A HUP0100607A HUP0100607A2 HU P0100607 A2 HUP0100607 A2 HU P0100607A2 HU 0100607 A HU0100607 A HU 0100607A HU P0100607 A HUP0100607 A HU P0100607A HU P0100607 A2 HUP0100607 A2 HU P0100607A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- hydrogen atom
- bond
- optionally substituted
- present
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000003856 thrombin receptor antagonist Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 9
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001924 cycloalkanes Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- -1 oxo- Chemical class 0.000 abstract 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
- 125000000464 thioxo group Chemical group S=* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyridine Compounds (AREA)
Abstract
A találmány tárgyát általános képletű vegyületek - ahol <-adottesetben kettős kötés; == adott esetben egyes kötés; n = 0, 1 vagy 2; Qadott esetben szubsztituált cikloalkán, heterocikloalkán, aromás vagyheteroaromás gyűrű; Het adott esetben szubsztituált mono-, bi- vagytriciklusos heteroaromás csoport; B -(CH2)n3-, -CH2-O-, -CH2S- képletűcsoport, -CH2-NR6-, -C(O)NR6-, -NR6C(O)- általános képletű csoport,<><> képletű csoport, adott esetben szubsztituált alkeniléncsoportvagy adott esetben szubsztituált alkiniléncsoport, ahol n3 = 0, 1, 2,3, 4 vagy 5; X oxicsoport vagy NR6 általános képletű csoport, ha ==egyes kötés, vagy X hidroxicsoport vagy adott esetben szubsztituáltaminocsoport, ha a kötés nincs jelen; Y oxo-, tioxocsoport, kéthidrogénatom, egy hidrogénatom és egy hidroxicsoport, vagy egyhidrogénatom és egy alkoxicsoport, ha == egyes kötés, vagy Yoxocsoport, két hidrogénatom, egy hidrogénatom és egy hidroxicsoport,egy hidrogénatom és egy merkaptocsoport, vagy egy hidrogénatom és egyalkoxicsoport, ha a kötés nincs jelen; R15 nincs jelen, ha == egyeskötés, vagy hidrogénatom, alkilcsoport, adott esetben szubsztituáltaminocsoport vagy alkoxicsoport, ha a kötés nincs jelen; vagy Y vagyáltalános képletű csoport, és R15 hidrogénatom vagy alkilcsoport - ésgyógyszerészetileg elfogadható sóik, valamint ezeket tartalmazógyógyszerkészítmények képezik, továbbá a vegyületek alkalmazásagyógyszerkészítmények előállítására. Ó
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97797997A | 1997-11-25 | 1997-11-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0100607A2 true HUP0100607A2 (hu) | 2002-05-29 |
| HUP0100607A3 HUP0100607A3 (en) | 2002-06-28 |
Family
ID=25525702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0100607A HUP0100607A3 (en) | 1997-11-25 | 1998-11-23 | Thrombin receptor antagonists and pharmaceutical compositions containing them |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP1036072B1 (hu) |
| JP (2) | JP3449620B2 (hu) |
| KR (1) | KR100393492B1 (hu) |
| CN (2) | CN101274929A (hu) |
| AR (1) | AR017189A1 (hu) |
| AT (1) | ATE266025T1 (hu) |
| AU (1) | AU747204B2 (hu) |
| BR (1) | BR9812793A (hu) |
| CA (1) | CA2309352C (hu) |
| CO (1) | CO4990946A1 (hu) |
| CZ (1) | CZ298578B6 (hu) |
| DE (1) | DE69823694T2 (hu) |
| DK (1) | DK1036072T3 (hu) |
| ES (1) | ES2219919T3 (hu) |
| HK (1) | HK1031726A1 (hu) |
| HU (1) | HUP0100607A3 (hu) |
| ID (1) | ID24726A (hu) |
| IL (1) | IL135797A (hu) |
| MY (1) | MY140887A (hu) |
| NO (1) | NO322022B1 (hu) |
| NZ (1) | NZ504218A (hu) |
| PE (1) | PE133799A1 (hu) |
| PL (1) | PL195027B1 (hu) |
| PT (1) | PT1036072E (hu) |
| RU (1) | RU2204557C2 (hu) |
| SA (1) | SA99190972B1 (hu) |
| SK (1) | SK285153B6 (hu) |
| TR (1) | TR200001480T2 (hu) |
| TW (1) | TWI236476B (hu) |
| WO (1) | WO1999026943A1 (hu) |
| ZA (1) | ZA9810685B (hu) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000229961A (ja) * | 1998-12-11 | 2000-08-22 | Sagami Chem Res Center | ヒドロナフト［２，３−ｃ］フラン誘導体およびその製造方法 |
| EP1219607B1 (en) * | 1999-09-02 | 2011-04-06 | Shionogi & Co., Ltd. | Integrase inhibitors containing aromatic heterocycle derivatives |
| US7304078B2 (en) * | 2002-04-16 | 2007-12-04 | Schering Corporation | Thrombin receptor antagonists |
| SI1294714T1 (sl) * | 2000-06-15 | 2007-12-31 | Schering Corp | Antagonisti trobinskega receptorja |
| US7235567B2 (en) | 2000-06-15 | 2007-06-26 | Schering Corporation | Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist |
| JP4642318B2 (ja) * | 2000-06-15 | 2011-03-02 | シェーリング コーポレイション | トロンビンレセプターアンタゴニスト |
| EP1391456B1 (en) | 2001-04-19 | 2009-07-22 | Eisai R&D Management Co., Ltd. | 2-iminoimidazole derivatives |
| AU2004218187C1 (en) | 2003-02-19 | 2011-04-07 | Eisai R&D Management Co., Ltd. | Methods for producing cyclic benzamidine derivatives |
| JPWO2005108370A1 (ja) | 2004-04-16 | 2008-03-21 | 味の素株式会社 | ベンゼン化合物 |
| MY143987A (en) * | 2004-05-28 | 2011-07-29 | Schering Corp | Constrained himbacine analogs as thrombin receptor antagonists |
| JP2008515899A (ja) * | 2004-10-08 | 2008-05-15 | シェーリング コーポレイション | トロンビンレセプターアンタゴニスト |
| JP4775971B2 (ja) * | 2005-01-14 | 2011-09-21 | シェーリング コーポレイション | ヒンバシンアナログのエキソ−選択的合成 |
| ATE500249T1 (de) * | 2005-01-14 | 2011-03-15 | Schering Corp | Synthese von himbacinanaloga |
| ATE530516T1 (de) * | 2005-01-14 | 2011-11-15 | Schering Corp | Exo- und diastereoselektive synthese von himbacin-analoga |
| TWI367112B (en) * | 2006-06-30 | 2012-07-01 | Schering Corp | Immediate-release tablet formulations of a thrombin receptor antagonist |
| EP2069326B1 (en) * | 2006-10-04 | 2015-03-18 | Merck Sharp & Dohme Corp. | Bicyclic and tricyclic derivatives as thrombin receptor antagonists |
| EP2558465B1 (de) | 2010-04-16 | 2014-12-17 | Sanofi | Trizyklische pyridyl-vinyl-pyrrole als par1-inhibitoren |
| EP2558462B1 (de) | 2010-04-16 | 2014-10-22 | Sanofi | Pyridyl-vinyl-pyrazolo-chinoline als par1-inhibitoren |
| CN108658910B (zh) * | 2017-03-29 | 2020-11-03 | 北京新领先医药科技发展有限公司 | 一种沃拉帕沙中间体1-α的制备方法 |
| CN113387947B (zh) * | 2021-07-12 | 2022-07-01 | 中国科学院成都生物研究所 | 调节雌激素受体合成活性的吡唑并吡啶衍生物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL106197A (en) * | 1992-07-30 | 1999-11-30 | Cor Therapeutics Inc | Agagonists for the rhombin receptors and pharmaceutical preparations containing them |
-
1998
- 1998-11-23 BR BR9812793-4A patent/BR9812793A/pt not_active Application Discontinuation
- 1998-11-23 IL IL13579798A patent/IL135797A/xx not_active IP Right Cessation
- 1998-11-23 HU HU0100607A patent/HUP0100607A3/hu unknown
- 1998-11-23 CO CO98068933A patent/CO4990946A1/es unknown
- 1998-11-23 KR KR10-2000-7005679A patent/KR100393492B1/ko not_active IP Right Cessation
- 1998-11-23 SK SK759-2000A patent/SK285153B6/sk not_active IP Right Cessation
- 1998-11-23 ID IDW20000993A patent/ID24726A/id unknown
- 1998-11-23 JP JP2000522101A patent/JP3449620B2/ja not_active Expired - Fee Related
- 1998-11-23 RU RU2000116548/04A patent/RU2204557C2/ru not_active IP Right Cessation
- 1998-11-23 CZ CZ20001856A patent/CZ298578B6/cs not_active IP Right Cessation
- 1998-11-23 AT AT98958039T patent/ATE266025T1/de not_active IP Right Cessation
- 1998-11-23 ES ES98958039T patent/ES2219919T3/es not_active Expired - Lifetime
- 1998-11-23 EP EP98958039A patent/EP1036072B1/en not_active Expired - Lifetime
- 1998-11-23 PT PT98958039T patent/PT1036072E/pt unknown
- 1998-11-23 PE PE1998001140A patent/PE133799A1/es not_active Application Discontinuation
- 1998-11-23 TW TW087119396A patent/TWI236476B/zh not_active IP Right Cessation
- 1998-11-23 CN CNA2008100835852A patent/CN101274929A/zh active Pending
- 1998-11-23 DK DK98958039T patent/DK1036072T3/da active
- 1998-11-23 TR TR2000/01480T patent/TR200001480T2/xx unknown
- 1998-11-23 WO PCT/US1998/024523 patent/WO1999026943A1/en active IP Right Grant
- 1998-11-23 DE DE69823694T patent/DE69823694T2/de not_active Expired - Lifetime
- 1998-11-23 CA CA002309352A patent/CA2309352C/en not_active Expired - Fee Related
- 1998-11-23 ZA ZA9810685A patent/ZA9810685B/xx unknown
- 1998-11-23 AU AU14158/99A patent/AU747204B2/en not_active Ceased
- 1998-11-23 AR ARP980105935A patent/AR017189A1/es active IP Right Grant
- 1998-11-23 CN CN98813307A patent/CN1290265A/zh active Pending
- 1998-11-23 PL PL98341114A patent/PL195027B1/pl not_active IP Right Cessation
- 1998-11-23 NZ NZ504218A patent/NZ504218A/en unknown
- 1998-11-24 MY MYPI98005330A patent/MY140887A/en unknown
-
1999
- 1999-01-10 SA SA99190972A patent/SA99190972B1/ar unknown
-
2000
- 2000-05-24 NO NO20002659A patent/NO322022B1/no not_active IP Right Cessation
-
2001
- 2001-03-16 HK HK01101899A patent/HK1031726A1/xx not_active IP Right Cessation
-
2002
- 2002-10-29 JP JP2002315015A patent/JP2003128670A/ja not_active Withdrawn
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