HUP0201300A2 - IL-8 receptor antagonista hatású imidazolidin ilidén-2-imino-származékok és ezeket tartalmazó gyógyszerkészítmények - Google Patents

IL-8 receptor antagonista hatású imidazolidin ilidén-2-imino-származékok és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0201300A2
HUP0201300A2 HU0201300A HUP0201300A HUP0201300A2 HU P0201300 A2 HUP0201300 A2 HU P0201300A2 HU 0201300 A HU0201300 A HU 0201300A HU P0201300 A HUP0201300 A HU P0201300A HU P0201300 A2 HUP0201300 A2 HU P0201300A2
Authority
HU
Hungary
Prior art keywords
group
alkoxy
alkyl
halo
imidazoidinylidene
Prior art date
Application number
HU0201300A
Other languages
English (en)
Inventor
Michael R. Palovich
Katherine L. Widdowson
Original Assignee
Smithkline Beecham Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp. filed Critical Smithkline Beecham Corp.
Publication of HUP0201300A2 publication Critical patent/HUP0201300A2/hu
Publication of HUP0201300A3 publication Critical patent/HUP0201300A3/hu

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88Nitrogen atoms, e.g. allantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
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    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
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    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70One oxygen atom
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány (I) általános képletű vegyületekre - amelynek képletébenképletében R hidroxi-, merkaptocsoport vagy -NHSO2Rd csoport; R1előnyösen hidrogén-; halogénatom; nitro-; ciano-; alkil-; halogén-alkil-; alkenil-; alkoxi-; halogén-alkoxi- vagy azidocsoport; R2alkilén- vagy alkeniléncsoport, amely adott esetben 1-3 oxigén-,kénatomot NR9, karbonil-, szulfinil- vagy szulfonilcsoportottartalmaz; R3 előnyösen alkil-, halogén-alkil-, alkenil-, alkoxi-,halogén-alkoxi-, azido-, -S(O)tR4, -(CR8R8)qS(O)tR4, hidroxi-,hidroxi-alkil- aril-, aralkil-, aril-oxi- vagy aril-alkoxicsoport; Yelőnyösen hidrogén-; halogénatom; nitro-; ciano- vagy alkilcsoport; més n 1, 2 vagy 3 - és a vegyületeket tartalmazó, IL-8a vagy IL-8breceptorhoz kötődő kemokin által mediált betegségek kezeléséreszolgáló gyógyszerkészítményekre vonatkozik. Ó
HU0201300A 1999-05-28 2000-05-26 Il-8 receptor antagonist imidazoidinylidene-2-imino derivatives and pharmaceutical compositions containing them HUP0201300A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13671799P 1999-05-28 1999-05-28
PCT/US2000/014661 WO2000072845A1 (en) 1999-05-28 2000-05-26 Il-8 receptor antagonists

Publications (2)

Publication Number Publication Date
HUP0201300A2 true HUP0201300A2 (hu) 2002-12-28
HUP0201300A3 HUP0201300A3 (en) 2003-02-28

Family

ID=22474057

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0201300A HUP0201300A3 (en) 1999-05-28 2000-05-26 Il-8 receptor antagonist imidazoidinylidene-2-imino derivatives and pharmaceutical compositions containing them

Country Status (27)

Country Link
US (1) US6566387B1 (hu)
EP (1) EP1180028B1 (hu)
JP (1) JP2003500447A (hu)
KR (1) KR20020010674A (hu)
CN (1) CN1353606A (hu)
AR (1) AR029637A1 (hu)
AT (1) ATE352299T1 (hu)
AU (1) AU766082B2 (hu)
BR (1) BR0010843A (hu)
CA (1) CA2375683A1 (hu)
CO (1) CO5170514A1 (hu)
CZ (1) CZ20014247A3 (hu)
DE (1) DE60033145T2 (hu)
DK (1) DK1180028T3 (hu)
ES (1) ES2280217T3 (hu)
HK (1) HK1045257A1 (hu)
HU (1) HUP0201300A3 (hu)
IL (1) IL146046A0 (hu)
MX (1) MXPA01012268A (hu)
NO (1) NO20015775L (hu)
NZ (1) NZ514729A (hu)
PL (1) PL351946A1 (hu)
PT (1) PT1180028E (hu)
SI (1) SI1180028T1 (hu)
TR (1) TR200103448T2 (hu)
WO (1) WO2000072845A1 (hu)
ZA (1) ZA200109628B (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495569B1 (en) * 2001-04-19 2002-12-17 Millennium Pharmaceuticals, Inc. Imidazolidine compounds
US7405234B2 (en) * 2002-05-17 2008-07-29 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
MY143477A (en) * 2002-10-29 2011-05-31 Smithkline Beecham Corp Il-8 receptor antagonists
US7820702B2 (en) 2004-02-04 2010-10-26 Bristol-Myers Squibb Company Sulfonylpyrrolidine modulators of androgen receptor function and method
US7696241B2 (en) 2004-03-04 2010-04-13 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US7388027B2 (en) * 2004-03-04 2008-06-17 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US7625923B2 (en) 2004-03-04 2009-12-01 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
JP2008517054A (ja) * 2004-10-20 2008-05-22 スミスクライン・ビーチャム・コーポレイション Il−8受容体アンタゴニスト
EP2010180A4 (en) * 2006-04-21 2010-10-13 Glaxosmithkline Llc IL-8 RECEPTOR ANTAGONISTS
TWI414517B (zh) * 2006-04-21 2013-11-11 Smithkline Beecham Corp Il-8受體拮抗劑
TW200817006A (en) * 2006-06-23 2008-04-16 Smithkline Beecham Corp IL-8 receptor antagonist

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001501172A (ja) * 1996-08-15 2001-01-30 スミスクライン・ビーチャム・コーポレイション Il―8レセプターアンタゴニスト
EP0939634A4 (en) * 1996-08-15 2001-02-21 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
AR008290A1 (es) * 1996-08-15 1999-12-29 Smithkline Beecham Corp Nuevos compuestos que contienen guanidina utiles como antagonistas de los receptores de il-8, composiciones farmaceuticas que los contienenprocedimiento para la preparacion de dichos compuestos y procedimiento para la preparacion de intermediarios.
JP2000516621A (ja) * 1996-08-15 2000-12-12 スミスクライン・ビーチャム・コーポレイション Il―8レセプターアンタゴニスト
JP2001527519A (ja) * 1996-08-15 2001-12-25 スミスクライン・ビーチャム・コーポレイション Il―8レセプターアンタゴニスト
TR199901710T2 (xx) * 1997-01-23 1999-09-21 Smithkline Beecham Corporation IL-8 resept�r antagonistleri.
UY25842A1 (es) * 1998-12-16 2001-04-30 Smithkline Beecham Corp Antagonistas de receptores de il-8

Also Published As

Publication number Publication date
MXPA01012268A (es) 2002-07-30
EP1180028A1 (en) 2002-02-20
WO2000072845A1 (en) 2000-12-07
KR20020010674A (ko) 2002-02-04
EP1180028A4 (en) 2002-10-23
PT1180028E (pt) 2007-04-30
PL351946A1 (en) 2003-07-14
CO5170514A1 (es) 2002-06-27
DE60033145T2 (de) 2007-10-31
ES2280217T3 (es) 2007-09-16
NO20015775D0 (no) 2001-11-27
AU5169100A (en) 2000-12-18
IL146046A0 (en) 2002-07-25
AU766082B2 (en) 2003-10-09
HK1045257A1 (zh) 2002-11-22
US6566387B1 (en) 2003-05-20
NZ514729A (en) 2003-11-28
DE60033145D1 (de) 2007-03-15
ATE352299T1 (de) 2007-02-15
CA2375683A1 (en) 2000-12-07
ZA200109628B (en) 2002-11-22
NO20015775L (no) 2001-11-27
TR200103448T2 (tr) 2002-06-21
CN1353606A (zh) 2002-06-12
HUP0201300A3 (en) 2003-02-28
SI1180028T1 (sl) 2007-06-30
JP2003500447A (ja) 2003-01-07
CZ20014247A3 (cs) 2002-05-15
AR029637A1 (es) 2003-07-10
BR0010843A (pt) 2002-02-19
DK1180028T3 (da) 2007-05-21
EP1180028B1 (en) 2007-01-24

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