BR0009007A - Derivados de piperidina, tetraidropiridina epiperazina; composto; composição farmacêutica;utilização e método - Google Patents

Derivados de piperidina, tetraidropiridina epiperazina; composto; composição farmacêutica;utilização e método

Info

Publication number
BR0009007A
BR0009007A BR0009007-7A BR0009007A BR0009007A BR 0009007 A BR0009007 A BR 0009007A BR 0009007 A BR0009007 A BR 0009007A BR 0009007 A BR0009007 A BR 0009007A
Authority
BR
Brazil
Prior art keywords
tetrahydropyridine
epiperazine
compound
pharmaceutical composition
piperidine derivatives
Prior art date
Application number
BR0009007-7A
Other languages
English (en)
Inventor
Ejner Knud Moltzen
Christian Krog-Jensen
Berith Bjornholm
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of BR0009007A publication Critical patent/BR0009007A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"DERIVADOS DE PIPERIDINA, TETRAIDROPIRIDINA EPIPERAZINA; COMPOSTO; COMPOSIçãO FARMACêUTICA;UTILIZAçãO E MéTODO". Provê-se um derivado de piperidina,tetraidropiridina ou piperazina possuindo a fórmula (1), qualquer umde seus enantiómeros ou qualquer mistura dos mesmos, ou um salcom adição de ácido dos mesmos, onde B é C~ 1-10~-alcileno, C~1-10~alcenileno ou C~ 1-10~-alcinileno; X é -O-, -S- ou -CR^ 4^R^5^-; e Y é -CR^ 6^R^ 7^-, -CR^ 6^R^ 7^ CR^ 8^R^ 9^-, ou -CR^6^=CR^ 7^- ; ou X e Y formam juntos um grupo -CR^ 4^=CR^ 5^-,ou CR^ 4^=CR^ 5^-CR^ 6^R^ 7^-; Z é -O-, ou -S-; W é N, C ouCH, e a linha pontilhada é uma união opcional; A é um anelbicíclico selecionado de (Ia) ou (Ib), onde E^ 1^, E^ 2^ e E^ 3^são selecionados de O, S, N, NR^ 11^, C, CR^ 12^ e CHR^ 13^,e a linha pontilhada indica uma união opcional, contanto que E^2^ e E^ 1^ e/ou E^ 3^ não possam simultaneamente ser O ou S.Os compostos da invenção são considerados úteis para otratamento de distúrbios afetivos, tais como depressão, psicose,distúrbios de ansiedade incluindo distúrbio de ansiedade geral,distúrbio de pânico, distúrbio compulsivo obsessivo e distúrbiosalimentares.
BR0009007-7A 1999-01-22 2000-01-21 Derivados de piperidina, tetraidropiridina epiperazina; composto; composição farmacêutica;utilização e método BR0009007A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199900084 1999-01-22
PCT/DK2000/000026 WO2000043382A1 (en) 1999-01-22 2000-01-21 Piperidine, tetrahydropyridine and piperazine derivatives, their preparation and use

Publications (1)

Publication Number Publication Date
BR0009007A true BR0009007A (pt) 2001-11-27

Family

ID=8089560

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0009007-7A BR0009007A (pt) 1999-01-22 2000-01-21 Derivados de piperidina, tetraidropiridina epiperazina; composto; composição farmacêutica;utilização e método

Country Status (26)

Country Link
US (2) US6596722B2 (pt)
EP (1) EP1149087B1 (pt)
JP (1) JP2002535322A (pt)
KR (1) KR20010101606A (pt)
CN (1) CN1344265A (pt)
AR (1) AR022303A1 (pt)
AT (1) ATE263763T1 (pt)
AU (1) AU767377B2 (pt)
BG (1) BG105781A (pt)
BR (1) BR0009007A (pt)
CA (1) CA2361059A1 (pt)
CZ (1) CZ20012657A3 (pt)
DE (1) DE60009663T2 (pt)
EA (1) EA200100798A1 (pt)
HK (1) HK1045505A1 (pt)
HU (1) HUP0105065A3 (pt)
IL (1) IL144113A0 (pt)
IS (1) IS5983A (pt)
MX (1) MXPA01007226A (pt)
NO (1) NO20013538L (pt)
NZ (1) NZ512732A (pt)
PL (1) PL349909A1 (pt)
SK (1) SK10302001A3 (pt)
TR (1) TR200102089T2 (pt)
WO (1) WO2000043382A1 (pt)
ZA (1) ZA200105548B (pt)

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CZ295937B6 (cs) * 1997-07-25 2005-12-14 H. Lundbeck A/S Indolové nebo 2,3-dihydroindolové deriváty
HUP0203194A3 (en) * 1999-08-23 2004-01-28 Solvay Pharm Bv Phenylpiperazines, pharmaceutical compositions containing them and their use
AR027133A1 (es) * 1999-12-30 2003-03-12 Lundbeck & Co As H Derivados de heteroarilo, su preparacion y uso.
EP1408976B3 (en) * 2001-07-20 2010-08-25 Psychogenics Inc. Treatment for attention-deficit hyperactivity disorder
US7732451B2 (en) 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
US7354923B2 (en) * 2001-08-10 2008-04-08 Palatin Technologies, Inc. Piperazine melanocortin-specific compounds
EP1425029A4 (en) * 2001-08-10 2006-06-07 Palatin Technologies Inc PEPTIDOMIMETICS OF BIOLOGICALLY ACTIVE METALLOPEPTIDES
US7655658B2 (en) 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
US7456184B2 (en) 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
US7718802B2 (en) 2001-08-10 2010-05-18 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US7226755B1 (en) * 2002-09-25 2007-06-05 The Procter & Gamble Company HPTPbeta as a target in treatment of angiogenesis mediated disorders
US7507568B2 (en) * 2002-09-25 2009-03-24 The Proctor & Gamble Company Three dimensional coordinates of HPTPbeta
US7153858B2 (en) * 2003-01-31 2006-12-26 Epix Delaware, Inc. Arylpiperazinyl compounds
US7727991B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Substituted melanocortin receptor-specific single acyl piperazine compounds
US7727990B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine and keto-piperazine compounds
US7968548B2 (en) 2003-05-01 2011-06-28 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine compounds with diamine groups
US7235569B2 (en) 2003-05-02 2007-06-26 Wyeth Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use
US7276603B2 (en) 2003-05-02 2007-10-02 Wyeth Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US7371769B2 (en) 2004-12-07 2008-05-13 Solvay Pharmaceuticals B.V. Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
US20060122175A1 (en) * 2004-12-07 2006-06-08 Solvay Pharmaceuticals B.V. Benzdioxane piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
WO2006061377A1 (en) * 2004-12-08 2006-06-15 Solvay Pharmaceuticals B.V. Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition
US8101619B2 (en) 2004-12-08 2012-01-24 Solvay Pharmaceuticals B.V. Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
DE102004063797A1 (de) * 2004-12-30 2006-07-13 Schwarz Pharma Ag Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
KR100589877B1 (ko) * 2005-12-20 2006-06-19 주식회사 픽슨이앤씨 파형강판 구조물의 보강라이너 설치용 거푸집
RU2473565C2 (ru) * 2006-04-07 2013-01-27 Аерпио Терапетикс, Инк. АНТИТЕЛА, СВЯЗЫВАЮЩИЕ ТИРОЗИН ФОСФАТАЗУ БЕТА ЧЕЛОВЕКА (HPTPβ), И ИХ ИСПОЛЬЗОВАНИЕ
US8846685B2 (en) 2006-06-27 2014-09-30 Aerpio Therapeutics Inc. Human protein tyrosine phosphatase inhibitors and methods of use
US7795444B2 (en) * 2006-06-27 2010-09-14 Warner Chilcott Company Human protein tyrosine phosphatase inhibitors and methods of use
US7622593B2 (en) 2006-06-27 2009-11-24 The Procter & Gamble Company Human protein tyrosine phosphatase inhibitors and methods of use
US7589212B2 (en) 2006-06-27 2009-09-15 Procter & Gamble Company Human protein tyrosine phosphatase inhibitors and methods of use
US7834017B2 (en) 2006-08-11 2010-11-16 Palatin Technologies, Inc. Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents
US9096555B2 (en) 2009-01-12 2015-08-04 Aerpio Therapeutics, Inc. Methods for treating vascular leak syndrome
US8367676B2 (en) 2009-06-30 2013-02-05 Astrazeneca Ab 2-carboxamide-7-piperazinyl-benzofuran derivatives 774
JP5536113B2 (ja) 2009-07-06 2014-07-02 アケビア セラピューティクス インコーポレイテッド がん細胞の転移を予防するための化合物、組成物および方法
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JP2014530244A (ja) 2011-10-13 2014-11-17 エアピオ セラピューティックス， インコーポレイテッド 血管漏出症候群および癌を治療する方法
CN104337812B (zh) 2013-07-29 2018-09-14 广东东阳光药业有限公司 取代的杂芳基化合物及其使用方法和用途
CN104725363B (zh) * 2013-12-20 2019-03-01 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
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FR2670491B1 (fr) * 1990-12-14 1993-02-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant.
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Also Published As

Publication number Publication date
CZ20012657A3 (cs) 2002-02-13
US6596722B2 (en) 2003-07-22
AU767377B2 (en) 2003-11-06
HUP0105065A2 (hu) 2002-07-29
EP1149087B1 (en) 2004-04-07
BG105781A (en) 2002-05-31
EP1149087A1 (en) 2001-10-31
AU2278100A (en) 2000-08-07
US20020035113A1 (en) 2002-03-21
JP2002535322A (ja) 2002-10-22
NZ512732A (en) 2003-10-31
US20020173512A1 (en) 2002-11-21
DE60009663T2 (de) 2005-04-14
EA200100798A1 (ru) 2001-12-24
SK10302001A3 (sk) 2002-01-07
WO2000043382A1 (en) 2000-07-27
ZA200105548B (en) 2002-07-05
MXPA01007226A (es) 2002-04-24
HUP0105065A3 (en) 2003-06-30
IS5983A (is) 2001-06-28
ATE263763T1 (de) 2004-04-15
IL144113A0 (en) 2002-05-23
KR20010101606A (ko) 2001-11-14
CA2361059A1 (en) 2000-07-27
NO20013538D0 (no) 2001-07-17
DE60009663D1 (de) 2004-05-13
NO20013538L (no) 2001-09-17
HK1045505A1 (zh) 2002-11-29
PL349909A1 (en) 2002-10-07
TR200102089T2 (tr) 2002-07-22
CN1344265A (zh) 2002-04-10
AR022303A1 (es) 2002-09-04

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.