AR027133A1 - Derivados de heteroarilo, su preparacion y uso. - Google Patents
Derivados de heteroarilo, su preparacion y uso.Info
- Publication number
- AR027133A1 AR027133A1 ARP000106988A ARP000106988A AR027133A1 AR 027133 A1 AR027133 A1 AR 027133A1 AR P000106988 A ARP000106988 A AR P000106988A AR P000106988 A ARP000106988 A AR P000106988A AR 027133 A1 AR027133 A1 AR 027133A1
- Authority
- AR
- Argentina
- Prior art keywords
- cr6r7
- disorders
- disorder
- heteroarilo
- derivatives
- Prior art date
Links
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 208000011688 Generalised anxiety disease Diseases 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 206010041250 Social phobia Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 208000029364 generalized anxiety disease Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Abstract
Un derivado heteroarilo que tiene la formula 1 cualquiera de sus enantiomeros o caulquier mezcla de los mismos, o una sal de adicion de ácido del mismo,donde X es -O-, -S- o -CR4R5- y Y es -CR6R7-, -CR6R7-CR8R9- o -CR6=R7- o bien X e Y juntos forman un grupo -CR4=CR5- o -CR4-CR6R7-, Z es -O- o -S-; W es N, C oCH, n es 2, 3, 4, 5, 6, 7, 8, 9 o 10; m es 2 o 3; A es O o S, donde las líneas de puntos significan un enlace optativo, y R1, R2, R3, R4, R5, R6, R7, R8 y R9son tal como figuran en la memor ia. Los compuestos son considerados utiles para el tratamiento de trastornos afectivos tales como el trastorno de ansiedadgeneralizada, trastorno de pánico, trastorno obsesivo compulsivo, depresion, fobia social y trastornos de la alimentacion, así c omo trastornos neurologicostales como la psicosis.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199901884 | 1999-12-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR027133A1 true AR027133A1 (es) | 2003-03-12 |
Family
ID=8108797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000106988A AR027133A1 (es) | 1999-12-30 | 2000-12-28 | Derivados de heteroarilo, su preparacion y uso. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20030050306A1 (es) |
| EP (1) | EP1246820A1 (es) |
| JP (1) | JP2003519229A (es) |
| KR (1) | KR20020063286A (es) |
| CN (1) | CN1414963A (es) |
| AR (1) | AR027133A1 (es) |
| AU (1) | AU2352001A (es) |
| BG (1) | BG106846A (es) |
| BR (1) | BR0016954A (es) |
| CA (1) | CA2395984A1 (es) |
| CZ (1) | CZ20022280A3 (es) |
| EA (1) | EA200200733A1 (es) |
| HU (1) | HUP0204084A3 (es) |
| IL (1) | IL149993A0 (es) |
| IS (1) | IS6403A (es) |
| NO (1) | NO20023188D0 (es) |
| NZ (1) | NZ519478A (es) |
| PL (1) | PL355610A1 (es) |
| SK (1) | SK9432002A3 (es) |
| TR (1) | TR200201679T2 (es) |
| WO (1) | WO2001049683A1 (es) |
| ZA (1) | ZA200204464B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7504395B2 (en) * | 2001-07-20 | 2009-03-17 | Psychogenics, Inc. | Treatment for attention-deficit hyperactivity disorder |
| TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| AR055203A1 (es) * | 2005-08-31 | 2007-08-08 | Otsuka Pharma Co Ltd | Derivados de benzotiofeno con propiedades antipsicoticas |
| EP2069359B1 (en) | 2006-08-21 | 2014-11-12 | Genentech, Inc. | Aza-benzothiophenyl compounds and methods of use |
| JP4785881B2 (ja) * | 2007-02-27 | 2011-10-05 | 大塚製薬株式会社 | 医薬 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK148392D0 (da) * | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Heterocykliske forbindelser |
| IT1266582B1 (it) * | 1993-07-30 | 1997-01-09 | Recordati Chem Pharm | Derivati (di)azacicloesanici e diazacicloeptanici |
| AR022303A1 (es) * | 1999-01-22 | 2002-09-04 | Lundbeck & Co As H | Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion |
-
2000
- 2000-12-28 AR ARP000106988A patent/AR027133A1/es not_active Application Discontinuation
- 2000-12-29 PL PL00355610A patent/PL355610A1/xx not_active Application Discontinuation
- 2000-12-29 SK SK943-2002A patent/SK9432002A3/sk unknown
- 2000-12-29 CA CA002395984A patent/CA2395984A1/en not_active Abandoned
- 2000-12-29 EP EP00987206A patent/EP1246820A1/en not_active Withdrawn
- 2000-12-29 WO PCT/DK2000/000741 patent/WO2001049683A1/en not_active Ceased
- 2000-12-29 HU HU0204084A patent/HUP0204084A3/hu unknown
- 2000-12-29 JP JP2001550223A patent/JP2003519229A/ja not_active Withdrawn
- 2000-12-29 CN CN00818091A patent/CN1414963A/zh active Pending
- 2000-12-29 TR TR2002/01679T patent/TR200201679T2/xx unknown
- 2000-12-29 CZ CZ20022280A patent/CZ20022280A3/cs unknown
- 2000-12-29 EA EA200200733A patent/EA200200733A1/ru unknown
- 2000-12-29 NZ NZ519478A patent/NZ519478A/en unknown
- 2000-12-29 IL IL14999300A patent/IL149993A0/xx unknown
- 2000-12-29 BR BR0016954-4A patent/BR0016954A/pt not_active IP Right Cessation
- 2000-12-29 AU AU23520/01A patent/AU2352001A/en not_active Abandoned
- 2000-12-29 KR KR1020027008584A patent/KR20020063286A/ko not_active Ceased
-
2002
- 2002-05-31 IS IS6403A patent/IS6403A/is unknown
- 2002-06-04 ZA ZA200204464A patent/ZA200204464B/en unknown
- 2002-06-19 BG BG106846A patent/BG106846A/xx unknown
- 2002-06-25 US US10/183,957 patent/US20030050306A1/en not_active Abandoned
- 2002-07-01 NO NO20023188A patent/NO20023188D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2352001A (en) | 2001-07-16 |
| NO20023188L (no) | 2002-07-01 |
| ZA200204464B (en) | 2003-09-04 |
| TR200201679T2 (tr) | 2002-10-21 |
| JP2003519229A (ja) | 2003-06-17 |
| IL149993A0 (en) | 2002-12-01 |
| EA200200733A1 (ru) | 2002-12-26 |
| CN1414963A (zh) | 2003-04-30 |
| CZ20022280A3 (cs) | 2002-10-16 |
| HUP0204084A3 (en) | 2005-02-28 |
| KR20020063286A (ko) | 2002-08-01 |
| IS6403A (is) | 2002-05-31 |
| BR0016954A (pt) | 2003-04-29 |
| HUP0204084A2 (hu) | 2003-03-28 |
| SK9432002A3 (en) | 2002-11-06 |
| BG106846A (en) | 2003-02-28 |
| WO2001049683A1 (en) | 2001-07-12 |
| NZ519478A (en) | 2004-02-27 |
| NO20023188D0 (no) | 2002-07-01 |
| US20030050306A1 (en) | 2003-03-13 |
| CA2395984A1 (en) | 2001-07-12 |
| PL355610A1 (en) | 2004-05-04 |
| EP1246820A1 (en) | 2002-10-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |