EA200200733A1 - Новые гетероарильные производные, их получение и применение - Google Patents

Новые гетероарильные производные, их получение и применение

Info

Publication number
EA200200733A1
EA200200733A1 EA200200733A EA200200733A EA200200733A1 EA 200200733 A1 EA200200733 A1 EA 200200733A1 EA 200200733 A EA200200733 A EA 200200733A EA 200200733 A EA200200733 A EA 200200733A EA 200200733 A1 EA200200733 A1 EA 200200733A1
Authority
EA
Eurasian Patent Office
Prior art keywords
crr
derivatives
heteroarrylic
new
receiving
Prior art date
Application number
EA200200733A
Other languages
English (en)
Inventor
Томас Руланд
Кристиан Крог-Енсен
Иван Миккельсен
Марио Роттлендер
Гитте Миккельсен
Айнер Кнуд Молтсен
Ким Андерсен
Original Assignee
Х. Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Publication of EA200200733A1 publication Critical patent/EA200200733A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

Настоящее изобретение относится к гетероарильным производным, имеющим общую формулу (I)любому из их энантиомеров, или любой их смеси, или их кислотно-аддитивной соли, гдеХ представляет -О-, -S- или -CRR-;Y представляет -CRR-, -CRR-CRR- или -CR=CR-; илиХ и Y вместе образуют группу -CR=CR- или -CR=CR-CRR;Z представляет -О- или -S-;W представляет N, С или СН;n равно 2, 3, 4, 5, 6, 7, 8, 9 или 10;m равно 2 или 3;А представляет О или S,где пунктирные линии представляют необязательную связь,которые полезны для лечения аффективных расстройств, таких как общая тревога, паническое расстройство, обсессивно-компульсивное расстройство, депрессии, социальная фобия и расстройства питания, и неврологических расстройств, таких как психоз.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200733A 1999-12-30 2000-12-29 Новые гетероарильные производные, их получение и применение EA200200733A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199901884 1999-12-30
PCT/DK2000/000741 WO2001049683A1 (en) 1999-12-30 2000-12-29 Novel heteroaryl derivatives, their preparation and use

Publications (1)

Publication Number Publication Date
EA200200733A1 true EA200200733A1 (ru) 2002-12-26

Family

ID=8108797

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200733A EA200200733A1 (ru) 1999-12-30 2000-12-29 Новые гетероарильные производные, их получение и применение

Country Status (22)

Country Link
US (1) US20030050306A1 (ru)
EP (1) EP1246820A1 (ru)
JP (1) JP2003519229A (ru)
KR (1) KR20020063286A (ru)
CN (1) CN1414963A (ru)
AR (1) AR027133A1 (ru)
AU (1) AU2352001A (ru)
BG (1) BG106846A (ru)
BR (1) BR0016954A (ru)
CA (1) CA2395984A1 (ru)
CZ (1) CZ20022280A3 (ru)
EA (1) EA200200733A1 (ru)
HU (1) HUP0204084A3 (ru)
IL (1) IL149993A0 (ru)
IS (1) IS6403A (ru)
NO (1) NO20023188L (ru)
NZ (1) NZ519478A (ru)
PL (1) PL355610A1 (ru)
SK (1) SK9432002A3 (ru)
TR (1) TR200201679T2 (ru)
WO (1) WO2001049683A1 (ru)
ZA (1) ZA200204464B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE424825T1 (de) 2001-07-20 2009-03-15 Psychogenics Inc Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
TWI329641B (en) * 2005-08-31 2010-09-01 Otsuka Pharma Co Ltd (benzo[b]thiophen-4-yl)piperazine compounds, pharmaceutical compositions comprising the same, uses of the same and processes for preparing the same
US7893085B2 (en) 2006-08-21 2011-02-22 Genentech, Inc Aza-benzothiophenyl compounds and methods of use
JP4785881B2 (ja) * 2007-02-27 2011-10-05 大塚製薬株式会社 医薬

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK148392D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
IT1266582B1 (it) * 1993-07-30 1997-01-09 Recordati Chem Pharm Derivati (di)azacicloesanici e diazacicloeptanici
AR022303A1 (es) * 1999-01-22 2002-09-04 Lundbeck & Co As H Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion

Also Published As

Publication number Publication date
PL355610A1 (en) 2004-05-04
SK9432002A3 (en) 2002-11-06
HUP0204084A2 (hu) 2003-03-28
NZ519478A (en) 2004-02-27
KR20020063286A (ko) 2002-08-01
IS6403A (is) 2002-05-31
US20030050306A1 (en) 2003-03-13
BG106846A (en) 2003-02-28
ZA200204464B (en) 2003-09-04
HUP0204084A3 (en) 2005-02-28
CN1414963A (zh) 2003-04-30
AR027133A1 (es) 2003-03-12
IL149993A0 (en) 2002-12-01
AU2352001A (en) 2001-07-16
CZ20022280A3 (cs) 2002-10-16
EP1246820A1 (en) 2002-10-09
TR200201679T2 (tr) 2002-10-21
JP2003519229A (ja) 2003-06-17
NO20023188D0 (no) 2002-07-01
CA2395984A1 (en) 2001-07-12
NO20023188L (no) 2002-07-01
BR0016954A (pt) 2003-04-29
WO2001049683A1 (en) 2001-07-12

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